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Trying to burn off some weight from the holidays? Join Anoop as he explains how the processes of weight loss and muscle gain occur at the molecular level. Links to articles cited:Biochemistry, 5th edition by Berg, Tymoczko, StryerThe Mechanisms of Muscle Hypertrophy and Their Application to Resistance TrainingRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Well, kind of. Join Anoop as talks about a new treatment for sickle cell disease and how CRISPR gene editing works. Links to articles cited:Hemoglobin research and the origins of molecular medicineThe CRISPR tool kit for genome editing and beyondCRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-ThalassemiaCRISPR and another genetic strategy fix cell defects in two common blood disordersBluebird prices gene therapy Zynteglo at €1.575M in Europe, to be paid over 5 yearsRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Interested in COVID-19? Join Anoop as he summarizes some recent COVID related research that caught his eye. Links to articles cited:De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2Human recombinant soluble ACE2 in severe COVID-19Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on TestisOn-Mask Chemical Modulation of Respiratory DropletsFacial Masking for Covid-19 — Potential for “Variolation” as We Await a VaccineThe impact of COVID-19 related school shutdown on sleep in adolescents: a natural experimentRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Has COVID-19 disrupted your sleep schedule? Well, you're not alone! Join Anoop as he dives into the research on the importance of sleep and how we can wake up feeling well-rested. Links to articles cited:Neurocognitive Consequences of Sleep DeprivationFatigue, alcohol and performance impairmentThe effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adultsChronic Caffeine Treatment Prevents Sleep Deprivation-Induced Impairment of Cognitive Function and Synaptic Plasticityβ-Amyloid accumulation in the human brain after one night of sleep deprivationSleep Drives Metabolite Clearance from the Adult BrainThe impact of daytime light exposures on sleep and mood in office workersAwakening effects of blue-enriched morning light exposure on university students’ physiological and subjective responsesEffects of thermal environment on sleep and circadian rhythmThe Effects of Acute and Chronic Exercise on SleepDaily Morning Running for 3 Weeks Improved Sleep and Psychological Functioning in Healthy Adolescents Compared With ControlsEffects of an irregular bedtime schedule on sleep quality, daytime sleepiness, and fatigue among university students in TaiwanRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Last time, Anoop discussed the research on the potential health benefits of dietary fiber. In this episode, Anoop discusses what might be considered the opposite of a high fiber diet. Links to articles cited:Ketogenic diet: Old treatment, new beginningKetogenic Diet and Epilepsy: What We Know So FarKetogenic Diet for Obesity: Friend or Foe?Do ketogenic diets really suppress appetite? A systematic review and meta-analysisSystematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factorsThe effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot studyFavourable metabolic effects of a eucaloric lower-carbohydrate diet in women with PCOSAn 8-Week Ketogenic Low Carbohydrate, High Fat Diet Enhanced Exhaustive Exercise Capacity in MiceAdaptation to a ketogenic diet modulates adaptive and mucosal immune markers in trained male endurance athletesKeto-Adaptation and Endurance Exercise Capacity, Fatigue Recovery, and Exercise-Induced Muscle and Organ Damage Prevention: A Narrative ReviewSwitching Host Metabolism as an Approach to Dampen SARS-CoV-2 InfectionRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Is there more to fiber than helping with bowel movements? Join Anoop as he dives into the immune strengthening effects fiber and fiber metabolites might have. Links to articles cited:The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic DiseaseKetogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 CellsDietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized TrialsSecondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and CancerDistinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infectionIntestinal alkaline phosphatase and sodium butyrate may be beneficial in attenuating LPS-induced intestinal inflammationActivation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesisInfluence of diet on the gut microbiome and implications for human healthIt's the fiber, not the fat: significant effects of dietary challenge on the gut microbiomeLong-term dietary fiber intake and risk of chronic obstructive pulmonary disease: a prospective cohort study of womenGut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesisThe Impact of Dietary Fiber on Gut Microbiota in Host Health and DiseaseThe Use of Microbial Accessible and Fermentable Carbohydrates and/or Butyrate as Supportive Treatment for Patients With Coronavirus SARS-CoV-2 InfectionFiber and cardiovascular disease risk: how strong is the evidence?Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetesThe Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain CommunicationRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

To most people, vaccine conspiracies sound crazy but are they actually as outlandish as they seem? Join Anoop as he debunks some common anti-vaccination talking points and shares his thoughts on how you can address these attitudes. Links to articles cited:RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in childrenMeasles, Mumps, Rubella Vaccination and AutismThe MMR vaccine and autism: Sensation, refutation, retraction, and fraudVaccine Ingredients – Fetal TissuesMercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive studyThimerosal and VaccinesVaccine Ingredients – FormaldehydeWhat’s in Vaccines?Historical Vaccine Safety ConcernsRotavirus Vaccine (RotaShield®) and IntussusceptionRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Saliva tests to detect SARS-CoV-2 are all the rage nowadays. Maybe you've taken one yourself to return to college or know someone who has. Tune in as Anoop examines the research on these tests and explains why they can help increase mass testing in the United States. Links to articles cited:Saliva is a reliable tool to detect SARS-CoV-2Comparison of SARS-CoV-2 detection in nasopharyngeal swab and salivaEvaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2FDA clears saliva test for Covid-19, opening door to wider testingSaliva is more sensitive for SARS-CoV-2 detection in                COVID-19 patients than nasopharyngeal swabsRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Interested in all the buzz around COVID-19 vaccines? Join Anoop as he explains how vaccines work and what makes Moderna's vaccine candidate unique. Links to articles cited:Immunobiology: The Immune System in Health and Disease. 5th edition.Understanding How Vaccines Work RNA Vaccine White PaperOpportunities and Challenges in the Delivery of mRNA-Based VaccinesmRNA vaccines — a new era in vaccinologyKey Facts About Seasonal Flu VaccineRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and should not be considered medical advice***

Have the BLM protests contributed to the increases in COVID-19 cases? Tune in as Anoop breaks down the research on why they might not have. And then join him as he welcomes the first guest on to the podcast, Jacob Pierce, as they discuss how the 2020 and future elections will be affected by COVID-19. Links to articles cited:Black Lives Matter Protests, Social Distancing, and COVID-19Indoor transmission of SARS-CoV-2Closed environments facilitate secondary transmission of coronavirus disease 2019 (COVID-19)A considerable proportion of individuals with asymptomatic SARS-CoV-2 infection in Tibetan populationAge-dependent effects in the transmission and control of COVID-19 epidemicsCDC data on COVID-19 cases in the United StatesRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and does NOT constitute medical practice, including the provision of medical advice.***

It probably won't be suitable for everyone but will still hopefully save many lives. Join Anoop as he explains how SARS-COV2 works at the molecular level and why dexamethasone might be an effective treatment in certain patients. Links to articles cited:The SARS-CoV-2 outbreak: What we knowStructural basis of receptor recognition by SARS-CoV-2Coronavirus envelope protein: current knowledgeACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway EpitheliaVirological assessment of hospitalized patients with COVID-2019COVID-19 pathophysiology: A reviewChapter 25 - ACE2 Cell Biology, Regulation, and Physiological FunctionsCytokines, Inflammation, and PainEffect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary ReportRoyalty-free music by Joesph McDade (https://josephmcdade.com/). ***DISCLAIMER: This podcast provides general scientific information and does NOT constitute medical practice, including the provision of medical advice.***

Anoop examines and shares some thoughts on the treatment of African Americans patients in medicine. Links to articles cited:Miss Ever's BoysCDC timeline on the Tuskegee StudyHistory Channel article on the Tuskegee StudyBiDil: Assessing a Race-Based PharmaceuticalA Comparison of Enalapril With Hydralazine-Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart FailureCombination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart FailureAnd some resources on learning about racism in science/medicine and in general:https://www.shutdownstem.com/Medical Apartheid, by Harriett A. Washington The Immortal Life of Henrietta Lacks, by Rebecca SklootRacism and discrimination in health care: Providers and patientshttps://www.maxwellboise.com/actionRoyalty-free music by Joseph McDade (https://josephmcdade.com). 

How can you keep yourself and the people around you safe from the coronavirus and COVID-19 as cities begin to reopen in phases? Anoop and Isaac dive into the interesting history of infectious disease control, what we can learn from the 1918 flu, and the science behind social distancing and masks to provide some answers. Links to articles cited: History of quarantine Quarantine vs isolation Responses to 1918 flu The effect of public health measures on the 1918 influenza pandemic in U.S. cities Public health interventions and epidemic intensity during the 1918 influenza pandemic On Air-Borne Infection Transmission of the Severe Acute Respiratory Syndrome on Aircraft Turbulent Gas Clouds and Respiratory Pathogen Emissions Medical Masks vs N95 Respirators for Preventing COVID-19 in Healthcare Workers: A Systematic Review and Meta-Analysis of Randomized Trials Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 PatientsRoyalty-free music by Joseph McDade (https://josephmcdade.com). ***DISCLAIMER: This podcast provides general scientific information and does NOT constitute medical practice, including the provision of medical advice.***

Digesting science can be hard, but we can help you break it down! Subscribe now on your favorite podcast service to stay up to date and follow us on Instagram (@sciencebitespod). Royalty-free music by Joseph McDade (https://josephmcdade.com/)