stitcherLogoCreated with Sketch.
Get Premium Download App
Listen
Discover
Premium
Shows
Likes
Merch

Listen Now

Discover Premium Shows Likes

The Diabuddies -Holistic Diabetes Management and Functional Medicine

49 Episodes

47 minutes | Nov 1, 2022
The Link Between Diabetes, Thyroid Function and Other Autoimmune Conditions
In this episode, Dr. Grady and Dr. Garrett discuss functional medicine and holistic concepts about the thyroid, blood sugar regulation, and how diabetes can impact it.    Topics Discussed: - What does the thyroid do and why it is important? - How to assess thyroid function (What blood work to get) - What impacts your thyroid function? - Link between T1D and Autoimmune Thyroid disease  - How does blood sugar and stress affect thyroid function - Blood sugar, sex hormones, and thyroid hormone - How does thyroid function affect blood sugar - What are the things that cause or promote autoimmune diseases? - The importance of sleep   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com
79 minutes | Nov 1, 2022
The Power of Intermittent Fasting and How To Do As A Type 1 Diabetic
In this episode, Dr. Grady and Dr. Garrett discuss the benefits and problems with intermittent fasting and how to do it as a T1D (type 1 diabetic).   Topics Discussed: - Do we do Intermittent Fasting? - Importance of checking your blood sugar frequently while intermittent fasting - What diet makes it easier to fast? - What is intermittent fasting? - What can you consume during a fast without breaking it? - Should you ride out a low blood sugar or consume sugar during a fast - The importance of changing your basal rate and insulin dosage - Types of fasting - Importance of protein and blood sugar stability - Exercising in a fasted state and its effect on blood sugar and the rest of the body - Benefits of intermittent fasting  - Who should not do intermittent fasting? - How long or how frequent should you do intermittent fasting?   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com
60 minutes | Nov 1, 2022
Managing Stress and Blood Sugar
In this episode, Dr. Grady and Dr. Garrett discuss stress, cortisol, and the potential nightmare of managing your blood sugar through it all.    Topics Discussed: - What is the Dawn Phenomenon?  - How does stress affect it? - What stressors affect cortisol and the Dawn phenomenon? - How does stress affect your blood sugar throughout the day? - The adrenals are not the problem! - How to reduce stress - The importance of having plenty of data to successfully manage blood sugar through stress - Steroid medicine and high blood sugar - How does stress and blood sugar affect the brain - How does stress and blood sugar affect your hormones - How to reduce stress - The importance of long-term stress management and good blood sugar control.   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com
43 minutes | Nov 1, 2022
The Diabuddies Are Back!!
The Diabuddies are back for a limited season. In this episode, Dr. Grady and Dr. Garrett talk about what they have been up to since last year and the new diabetic struggles that they have been dealing with.    PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Topics Discussed: 1:53 - Podcast start 4:45 - Catching up with the Diabuddies -Dario Blood Sugar Monitoring System - Slacking on blood sugar monitoring - Weather Effecting Blood sugar management  - Tinkering with basal rates - Managing Blood sugar without a CGM (continuous glucose monitor) - Freestyle Libre CGM - Good Rx for more affordable prescriptions - Workouts, running marathons  
65 minutes | Nov 1, 2022
Mastering Running As A Type 1 Diabetic
In this episode, Dr. Grady and Dr. Garrett go through everything you should know, think about, and do to successfully be a runner as a T1D (type 1 diabetic).   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Topics Discussed: - Fear of Running as a Type 1 Diabetic - Preparation: Carrying sugar, tester, phone, etc - Start Slow and check your blood sugar often (Get Data!) - Don't be afraid to stop - False High Blood Sugars (sugar on the finger) - Signs of low blood sugar while running - Checking Blood Sugar while running or CGM - Rewards/Benefits of running - What happens to your blood sugar during the running - Strategies for managing your blood sugar before, during, and after the run (short, mid, and long-distance runs) - Running with severe high blood sugar - Different correction factors for severe highs vs moderately high blood sugar - How to track and utilize data to better manage your blood sugar, especially for longer runs (Dr. Garrett gives a real-life example) - How stress and sleep affects your blood sugar differently during a run - How the time of day affects your blood sugar during a run
44 minutes | Aug 23, 2021
Boxes Up #4 - Checking In With The Diabuddies
In this episode, Grady and Garrett talk about some of the diabetic obstacles that they have been working through in the last few months. And we announce the end of season one.    PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 0:25 - Introduction: Checking in with Grady (Handling the AZ heat, inconsistent schedule, HIIT workouts   17:31 - Checking in with Garrett (training for a marathon in the heat, connecting with more Diabuddies    34:06 - Big Announcement
63 minutes | Jul 13, 2021
Boxes Up #3 - The Mental/Emotional Struggle of Living With Diabetes
In this episode, Dr. Grady and Dr. Garrett discuss the daily mental and emotional burden that a type 1 diabetic goes through. This is a great episode to have your non-diabetic friends and family member listen to to get an idea of what you go through on a daily basis.   PLEASE SUBSCRIBE TO THE PODCAST   For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 0:25 - Introduction: Being Called A “Bad Diabetic” 11:11 - The Mental Burden of constantly thinking about your diabetes 17:40 - The Struggle of venting to a Non-diabetic 22:25 - The Fear of Life (foods, exercise, daily activities) 25:17 - The Emotional Tax of Diabetes 40:02 - You are not your number/Chasing Perfection 47:10 - Our Mindset to Take on Diabetes 58:25 - Diabetic WIN  
69 minutes | Jun 21, 2021
E40 - Alzheimer's And Insulin: What's A Diabetic To Do?
In this episode, Dr. Donohoe and Dr. Panno review a research paper that summarizes insulin's role in the brain and the connection between insulin resistance and Alzheimer's disease. Guess what? INSULIN IS NOT ONLY FOR GETTING GLUCOSE INTO THE CELLS!!  The Paper Discussed in this Podcast: Blazquez, E., Velazquez, E., Hurtado-Carneiro, V., & Ruiz-Albusac, JM., (2014). Insulin in the Brain: it’s pathophysiological implications for states related to central insulin resistance, type 2 diabetes, and Alzheimer’s disease. Frontiers in Endocrinology; 5(151). Doi: 10.3389/fendo.2015.00161.     PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 0:25 - Introduction: Big takeaways and Major questions that this paper addresses and generates 8:18 - Glut Transporters in the brain 12:22 - Functions of Insulin in the Brain: Memory and learning 20:47 - Functions of Insulin in the Brain: Neuroprotection 28:13 - Production and Regulation of Insulin in the Brain 42:36 - Why are these things not being talked about more in the medical community? 48:23 - Alzheimer's and Diabetes Connection 58:42 - Burst My Beta Cells  
50 minutes | May 31, 2021
E39 - Usefulness of CGMS for Type 2 Diabetics and NON-Diabetics
In this episode, Dr. Grady and Dr. Garrett discuss the benefits of having the plethora of data that a CGM can give you, but not just for T1Ds but also for Type 2 Diabetics and NON-diabetics as well. We also get into what the costs of these devices cost and what that might look like in a healthcare setting for a type 2 diabetic or a non-diabetic looking to optimize their metabolic health.    PLEASE SUBSCRIBE TO THE PODCAST   For more Diabuddies content visit our website https://thediabuddies.com/    Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 0:25 - Introduction: Why Are CGMs Useful? 5:05 - Why would a type 2 diabetic want to use a CGM? 15:35 - Who needs a CGM and who should get a CGM 23:25 - Using the CGM to tailor your care more specifically to what works for you 25:43 - How expensive are CGMs 38:21 - Are CGMs useful for non-diabetics?  
88 minutes | May 17, 2021
E38 - T1D Running from Disney Land to Disney World, and then some - Don Muchow
In this episode, Dr. Grady and Dr. Garrett have the pleasure of interviewing a truly inspiring T1D Don Muchow. Don recently completed a run across America (Disneyland to Disney World)!! We dive deep into the nitty-gritty of how he was able to accomplish such a journey as a diabetic. What challenges he faced and how he overcame them and his passion for helping T1Ds overcome the fear of exercising for fear of lows.  If you would like to learn more about Don's run you can visit his website which has a detailed account of the entire journey.  https://t1determined.org/ If you would like to contact Don you can email him at: donsolo@t1determined.org   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website https://thediabuddies.com/  Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com  Time Stamps 0:25 - Introduction: How Did You Decide To Run From Disneyland To Disney World? 3:47 - How and why did you start running in your 40s? 11:16 - How Don handles “stress” high blood sugars 14:20 - What diabetic tech do you use to accomplish and ultra run successfully 20:44 - Glucagon (The Liquid Wall) - Don’s Experience with glucagon during a long run 29:38 - What is it like to run across the country? 42:27 - Having ZERO scary lows while running across country and safely managing highs 50:30 - Overcoming the fear of exercise as a diabetic and living with diabetes, not against it. 1:00:42 - What was it like growing up with diabetes in the 70s? 1:07:03 - The tough job of managing diabetes despite having today’s technology 1:12:06 - The specifics of setting a transcontinental record 1:18:13 - What is next for Don? And closing remarks.  
92 minutes | May 3, 2021
E37 - Diabetic Alert Dogs - Zach from Cedar Oak Kennels
In this episode, Dr. Grady and Dr. Garrett have the pleasure of interviewing Zach from Cedar Oak Kennels where he trains Diabetic Aert Dogs (DADs). He walks us through the training process, the breed that is best suited to be a DAD, and his why. All while sprinkling in some great success stories.   If you are interested in getting to know more about what Zach does and how to get ahold of him, you can visit his website, Instagram, or send an email.   Instagram: diabetic_alert_dog_training Website: https://cedaroakkennels.com/ Email: cedaroakkennels@gmail.com   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website www.thediabuddies.com  Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com  Time Stamps 0:25 - Introduction 1:10 - What Is a Diabetic Alert Dog? How Long Has Zach Been Doing This Work? 14:50 - What is the training process? 32:55 - Why British Labs are the best. 41:40 - Are there other breeds that Zach trains? 49:35 - How many people utilize DADs? 55:40 - How much does a DAD cost? 1:16:35 - Burst My Beta Cells  
78 minutes | Apr 19, 2021
E36 - T1D Can't Stop You! - Olympic Lifting, Running, Crossfit w/ Eric Zucaro
In this episode, Dr. Grady and Dr. Garrett interview Eric Zucaro who is a fitness fanatic. He has competed in a wide variety of events such as CrossFit, ultrarunning, obstacle racing, and Olympic lifting. We ask him about his training, diet, and how he was able to do all of this despite being T1D.   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website www.thediabuddies.com  Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com
63 minutes | Apr 12, 2021
E35 - Does Leaky Gut Cause T1D?
In this episode, Dr. Grady and Dr. Garrett review a research article titled "Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives." We define what leaky gut is, how/why it develops, and how that relates to autoimmune and T1D. We discuss the importance of this information and the hope that it provides in the treatment of T1D. Research Article discussed: "Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives" https://diabetes.diabetesjournals.org/content/55/5/1443.long   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website www.thediabuddies.com   Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 0:25 - Introduction 2:10 - What is leaky gut 9:30 - Paper: Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives 21:50 - What causes increased zonulin and leaky gut? 25:00 - How does leaky gut lead to Autoimmune (T1D)? 32:20 - Does what you eat cause diabetes? 35:00 - Can you reverse T1D? Dr. Grady goes without insulin. 44:00 - What are other things that can affect your immune system and impact autoimmune besides diet? 47:00 - What is THE CURE of T1D? 49:50 - Stopping the development of a second autoimmune disease 54:00 - Burst My Beta Cells
56 minutes | Mar 29, 2021
Boxes Up #2 - Diabuddies That Lift Together Stay Together
In this episode, Dr. Grady and Dr. Garrett are "in studio" with each other after a few days of working out and hanging out. We talk what we ate, how we dosed insulin, and managed blood sugar while doing two very different workouts and eating out at a restaurant.   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website www.thediabuddies.com  Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com  Time Stamps 0:25 - Introduction: Garrett Is In Town!! 2:20 - Yesterday’s HIIT Workout And How We Managed Our Blood Sugars Through It 9:03 - Managing BG after the workout and eating and while running out of insulin 15:50 - Today’s “bodybuilding” workout 18:50 - Dosing Our Insulin For Our HUGE Breakfast Before The Workout 27:40 - Not Being Afraid Changing Basal Rates And Dangers of Lows 33:40 - Our BG Post Workout 38:50 - Muggles Thinking That 160 BG Is Way High 40:30 - The Balance Of Enjoying Life And Monitoring Your Diabetes 44:49 - Burst My Beta Cells  
74 minutes | Mar 15, 2021
E34 Sweet Dreams Are Made Of....Good Blood Sugars
In this episode, Dr. Grady and Dr. Garrett discuss all things sleep and blood sugar. We go over how what you do during the day (food, exercise, etc) affects your blood sugars through the night, the impact that your blood sugars have on your quality of sleep, the importance of sleep itself, and how that impacts your blood sugars the next day.    PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website www.thediabuddies.com  Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 1:02 - Introduction: Garrett’s Current Sleep Regime  2:12 - Why is sleep so important for Type 1 diabetics 7:24 - High Blood Sugar Leading to Increased Urination And Yo-Yoing  10:40 - Is Having High Blood Sugar At Night Better Than Being Low? 15:47 - Grady’s Near-Death Experience 26:00 - Having A System To Protect You From Dangerous Lows At Night When Living On Your Own  29:40 - What You Do During The Day Effects What Your Blood Sugar Is Like Through The Night 34:00 - Taking Control of Your Diabetes And Being Comfortable Changing Insulin Dosage 38:36 - How What You Eat And When You Eat Affects Your Blood Sugar Through The Night 44:50 - Exercise’s Effect On Blood Sugar Through The Night 53:35 - How Does Sleep Effect Blood Sugars The Next Day 2:08:55 - Grady And Garrett’s Daily Wins And Losses
73 minutes | Mar 8, 2021
BOXES UP #1 - Wrastlin'
In this episode, Dr. Grady and Dr. Garrett loosen up and shoot the breeze about their "wrastlin" days. We dive into the struggles we faced managing blood sugars throughout our wrestling careers, as well as blood sugar's effect on performance and what could have been. Then we share some "war stories".  PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website www.thediabuddies.com Follow us on: The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 1:02 - Introduction: Boxes Up and Wrastlin’ 2:55 - Garrett’s Terrible Weight Loss Strategies and The Effect on Performance 14:00 - Using Diabetes As An Excuse To Get Out Of Things 23:20 - If You Aren’t T1D Don’t Even Try Talking To Me About It 29:30 - Strategies For Managing BG Through Practices 46:00 - Diabetic Wrestling Stories
67 minutes | Feb 9, 2021
E33 Controversy Over Dexcom Super Bowl Ad
WE HAVE A NEW WEBSITE!!!!! CHECK IT OUT!!!! https://thediabuddies.com   In this episode, Dr. Grady and Dr. Garrett discuss the controversy surrounding the Super Bowl ad that Dexcom made on Sunday. What was the goal/purpose of the ad? Was it to spread awareness of type 1 diabetes? Was it to spread awareness of the high prices of diabetes care? Or was it an advertisement for their product?   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content visit our website www.thediabuddies.com Follow us on: The Diabuddies Podcast Facebook page Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com
64 minutes | Feb 1, 2021
E32 Diabetes Tech: When It Fails and How To Recognize It
In this episode, Dr. Donohoe and Dr. Panno discuss the frustrations of diabetes "tech" failing, such as the pump, glucometer, CGM, insulin, etc. We walk through our thought process when we see a high blood glucose reading. Is it due to food, our physiology, or our "tech?" We also talk about the mental/emotional tax that it has on you when you do everything right and yet you have poor blood sugar control due to something that is so unexpected and not necessarily your fault.    PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content follow us on The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 1:39 - Start/Introduction 3:13 - You See A High BG Reading What Is Your Problem Solving Thought Process 27:05 - When Tech Fails: Pumps and MDIs 31:42 - Glucometer and CGM Failure 39:51 - What Do You Do When One Hand As A Different BG Reading Than The Other? 49:10 - Emotional Impact Of Tech Failing  
64 minutes | Jan 18, 2021
E31 Diabetes 101: Metformin VS Berberine
In this episode, Dr. Donohoe and Dr. Panno discuss two of the most commonly used interventions, both in mainstream medical and functional medicine fields, Metformin and Berberine. Dr. Panno recently wrote a paper on this topic where he read through numerous research articles in order to gain more clarity and understanding of these two products (how they work and how effective they are). We get into the science behind them but also the clinical takeaways and what it all means. Below we reference all the articles used.    PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content follow us on The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com  Time Stamps 1:10 - Start/Introduction 6:25 - Berberine: What Does It Do And How Effective Is It? 16:30 - Where Does Berberine Come From? 22:45 - Where Does Metformin Come From? 31:30 - How Does Metformin Work? (MOA) 39:50 - How Does Berberine Work? (MOA) 44:10 - Can you take Metformin and Berberine Together? 57:30 - Burst My Beta Cells   Resources/Links Discussed in the episode: References Arayne, M., Sultana, N., & Bahadur, S., (2007). The berberis story: berberis vulgaris in therapeutics. Park J Pharm Sci; 20(1): 83-92. PMID: 17337435 Bailey, C., & Day, C., (2004). Metformin: its botanical background. Pract Diabetes Int; 21: 115-117. https://doi.org/10.1002/pdi.606 Bailey, C., & Day, C., (1989). Traditional plant medicines as treatments for diabetes. Diabetes Care; 12(8): 553-564. PMID: 2673695 Center of Disease Control (2020). National Diabetes Statistic Report 2020, Estimates of Diabetes and its burden in the united states. Retrieved at: https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf Chang, W., Zhang, M., Li, J., Meng, Z., Wei, S., Du, H., Chen, L., & Hatch, G., (2013). Berberine improves insulin resistance in cardiomyocytes via activation of 5’adenosine monophosphate-activated protein kinase. Metabolism; 62(8): 1159-1167. PMID: 23537779 Chang, W., Chen, L., & Hatch, G., (2015). Berberine as a therapy for type 2 diabetes and its complication: from mechanism of action to clinical studies. Biochem Cell Biol; 93(5): 479-486. PMID: 19800084 Cheuh, W., & Lin, J., (2012). Protective effect of berberine on serum glucose levels in non-obese diabetic mice. International Immunopharmacology; 12(3): 534-538. PMID: 22266065 Choi, YH., & Lee, MG., (2006). Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1, 3A1/2 for the metabolism of metformin. B J Pharmacol; 149(4): 424-30. PMID: 16940989 ClinCal (2020). The Top 200 Drugs of 2021. Medical Expenditure Panel Survey (MEPS). Retrieved at: https://clincalc.com/DrugStats/Top200Drugs.aspx Dong, H., Wang, H., Zhao, L., & Lu, F., (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence Based complement alternative med; 2012: 591654. PMID: 23118793 Elbere, I., Kalnina, I., Silamikelis, I., Konrade, I., Zaharenko, L., Sekace, K., et al., Klovins, J., (2018). Association of metformin administration with gut microbiome dysbiosis in healthy volunteers. PLoS One; 13(9): e0204317. PMID: 30261008 Foretz, M., Herbrad, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., et al., & Viollet, B., (2010). Metformin inhibits hepatic gluconeogenesis in mice independently of LKB1/AMPK pathway via a decrease in hepatic energy state. The Journal of Clinical investigation; 120(7): 2355-2369. PMID: 20577053 Fullerton, M., Galic, S., Marcinko, K., Sikkema, S., Pulinikunnil, T., Chen, Z., et al., & Steinberg, G., (2013). Single phosphorylation sites in ACC1 and ACC2 regulate lipid homeostasis in the insulin-sensitizing effects of metformin. Nat Med; 19(12): 1649-1654. PMID: 24185692 Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G., (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia, and hypertension. Journal of Ethnopharmacology; 16H: 69-81. PMID: 25498346 Le Bastard, Q., Grégoire, M., Chapelet, G., Javaudin, F., Dailly, E., Batard, E., Montassier, E., Al, G. G. A., & Knights, D. (2018). Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medications. Alimentary Pharmacology & Therapeutics, 47(3), 332. PMID: 29205415  Li, Y., Wang, Y., Kong, W., Yang, P., Wang, Y., Li, Y., Yi, H., et al., & Jiang, J., (2011). Bioactivates of berberine metabolites after transformation throughout CYP450 isoenzymes. Journal of translational medicine; 9(62): 62. PMID: 21569619 Liang, Y., Xu, X., Yin, M., Zhang, Y., Haung, L., Chen, R., & Ni, J., (2019). Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and meta-analysis. Endocrine Journal; 66(1): 51-63. PMID: 30393248 Lyu, Y., Zhang, Y., Yang, M., Lin, L., Yang, X., Cheung, S., et al., & Zuo, Z., (2019). Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life Sciences; 235: 116818. PMID: 31473193 Mao, L., Chen, Q., Gong, K., Xu, X., Xie, Y., Zhang W., et al., & Zhang, Y., (2018). Berberine decelerates glucose metabolism via suppression of mTOR-dependent HIF-1α protein synthesis in colon cancer cells. Oncol Rep; 39(5). 2436-2442. PMID: 29565467 Miller, R., Chu, Q., Xie, J., Foretz, M., Viollet, B., & Birnbaum, M., (2013). Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP. Nature; 494(7436):256-260. PMID: 23292513 Neag, M., Mocan, A., Echeverria, J., Pop, R., Bocsan, C., Crisan, G., & Buzoianu, A., (2018). Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacology; 9: 557. PMID: 30186157 Owen, M., Doran, E., & Halestrap, A., (2000). Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondria respiratory chain. Biochem J; 348; 607-614. PMID: 10839993 Petersen, M., American Diabetes Association. Economic Costs of Diabetes in the U.S. in 2017. Diabetes care; 41(5): 917-928. PMID: 29567642 Pryor R., & Cabreiro F., (2015). Repurposing metformin: an old drug with new tricks in its binding pockets. Biochemical Journal; 471(3): 307-322. PMID: 26475449 Ren, G., Guo, J., Quian, Y., Kong, W., & Jiang, J., (2020). Berberine improves glucose and lipid metabolism in HepG2 cells through AMPKα1 activation. Front Pharmacology; 11: 647. PMID: 32457629 Yin, J., Xing, H., & Ye, J., (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism; 57(5): 712-717. PMID: 18442638 Yue, S., Liu, J., Wang, W., Wang, A., Yang, X., Guan, H., Wang, C., & Yan, D., (2019). Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. Biomed Pharmacother; 116: 109002. PMID: 31154270 Zhang, H., Wei, J., Xue, R., Wu, J., Zhao, W., Wang, Z., et al., & Jiang, J., (2010). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism; 59(2): 285-292. PMID: 19800084 Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., et al., & Moller, D., (2001). Role of AMP-activated protein kinase in mechanisms of metformin action. The Journal of Clinical Investigation; 108(8): 1167-1174. PMID: 27654259
123 minutes | Jan 4, 2021
E30 How Brandon Mouw Kept On Kickin' To Get A New Pancreas And A New Outlook On Life
In this, episode Dr. Grady and Dr. Garrett have the pleasure of hearing Brandon Mouw's incredible journey from developing brittle diabetes to receiving a lifesaving pancreas-only transplant. His story is truly incredible. He has gone through so many struggles from trying to stay alive through years of battling constant lows to jumping through the hoops of trying to qualify and raise the money for a pancreas-only transplant. This is a great interview that you are guaranteed to enjoy. If you would like to connect with Brandon follow him on Instagram (@brandonmouwofficial) or visit his website https://brandonmouw.com/ . And look for his new book coming in 2021!   PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content follow us on The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Time Stamps 1:10 - Start/Introduction 3:45 - Brandon’s Diabetes Management Early In Life 13:35 - The Kidney Stone From Hell That Sabotaged Brandon’s Health 16:35 - Life As a Brittle Diabetic Fighting Constant Lows 25:40 - Trying To Find Answers 31:40 - Starting The Journey Back To Life 36:20 - Brandon’s Motivation To Keep Moving Forward 42:40 - Raising Money To Get A New Pancreas  55:40 - Waiting For THE CALL 1:01:50 - Getting THE CALL And Rushing Into Surgery 1:11:50 - The Uniqueness of A Pancreas-Only Transplant 1:19:10 - Recovering From Surgery And Preventing Rejection 1:36:00 - Coming Out The Other Side A Better Person And Trying To Stay Healthy 1:45:05 - How Does The New Pancreas Work? (I’m A Little Jealous) 1:50:50 - Burst My Beta Cells/ Diabetic Win  1:58:35 - Brandon’s Book and Contact Info  
COMPANY
About us Careers Stitcher Blog Help
AFFILIATES
Partner Portal Advertisers Podswag Stitcher Studios
Privacy Policy Terms of Service Your Privacy Choices
© Stitcher 2023