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Dr. Hussein Yassine joins Julie Gregory to discuss the work his lab at the University of Southern California has been doing to understand brain biochemistry with special emphasis on interactions with APOE genotype.

Dr. Sharon Hausman-Cohen joins Julie Gregory to discuss her company, IntellxxDNA, and her experiences using genomics intelligence to drive personalized patient treatment protocols. They discuss several ApoE4-positive patients for whom a comprehensive view was essential to overcoming health challenges and maintaining cognitive capacity.

Dr. Dayan Goodenowe joins Julie Gregory to discuss his new book, “Breaking Alzheimer’s: A 15 Year Crusade to Expose the Cause and Deliver the Cure.” He talks about how his research lead him to plasmalogens and how they relate to neurological health. He explains what goes wrong biochemically as dementia develops and highlights age-related diminishing plasmalogen levels as a major driver of disease. He outlines his research showing that ApoE4 carriers may require more plasmalogens to maintain cognition, and he identifies tests and supplements to support plasmalogen levels. Finally, they discuss the unprecedented results of Dr. Goodenowe’s newly completed clinical trial that he just reported on at the Alzheimer’s Association International Conference.

Dr. Dayan Goodenowe joins Julie Gregory to discuss his research into disease states identified by metabolomic testing. They focus particularly on neurological health. He explains what goes wrong biochemically as dementia develops and highlights age-related diminishing plasmalogen levels as a major driver of disease. He describes his research showing that ApoE4 carriers require more plasmalogens to maintain cognition, and he identifies diet and lifestyle measures that support plasmalogen levels. Finally, they discuss Dr. Goodenowe's newly available ProdromeNeuro dietary supplement and the evidence showing its effect on plasmalogen levels in the body.

Dr. Terry Wahls joins Julie Gregory to share her personal story of triumph over secondary progressive multiple sclerosis using a diet and lifestyle regimen guided by paleo principles. She discusses the overlap between multiple sclerosis and ApoE4 and shares specific strategies that can help ApoE4 carriers mitigate their risk of neurodegenerative disease. Additionally, Dr. Wahls shares her latest research, how her protocol has changed, and provides an overview of her new book, The Revised, Expanded Wahls Protocol: A Radical New Way to Treat All Autoimmune Conditions, available now.