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Comedian and comic book author Izzy Salhani (@luckysalhani) joins Jesse, Matt and Andy to talk about bear-baiting, fighting a bunch of kids, a Renaissance fair accident, clay quality, octopus-inpired camouflage ink, Richard Branson's rocket plane taking to the skies again, orcas learning to attack boats and orca fads.

Comedian Liz Miele (@lizmiele) returns to the show to talk about her tour documentary Jet-Lagged, growing up in a veterinarian household, Australian wildlife adventures, a koala chlamydia vaccine, aesthetic scrotal preferences, an Onion classic, Liz's book Why Cats Are Assholes, gymnastics limitations and exceeding astrophysics limitations.

Neuroscientist and clinical psychologist Dr. Heather Berlin (@heather_berlin) joins Matt, Jesse and Andy to talk about hosting the upcoming PBS series Your Brain, the hard problem of consciousness, evolutionary mismatches, panic attack strategies, flow state performance, debating Deepak Chopra about god, the Stanford marshmallow experiment, impulse control, the downside of getting a hangry judge, debunking brain myths, creating consciousness in different substrates, the thermal grill experiment and the fact that we're all going to die.

Comedian and host of the podcasts High and Mighty and ActionBoyz Jon Gabrus (@Gabrus) joins Matt, Jesse and Andy to talk about his hilarious show 101 Places to Party Before You Die, the WGA strike, whether AI can write a 30 Rock scene, the shrinking middle class in entertainment, buffet memories, the benefits of an all-female Mars mission team, curing parrot loneliness with video calls, the insane number of pet birds in the US and advice for a precocious young listener.

Longtime Conan writer and co-creator of Eagleheart Andrew Weinberg joins Andy, Jesse and Matt to talk about his ridiculously funny new show Jury Duty, which follows the workings of a jury trial through the eyes of Ronald Gladden, a juror who is unaware the entire case is fake, the insane hoops they had to jump through to bring the show to life, the truth about weed and creativity, and the unsurprising link between arousal and a desire to have sex with a robot.

Comedian Andy Hendrickson (@andyhendrickson) joins Jesse, Matt and Andy to talk about magic tricks that only work on monkeys with opposable thumbs, how mirrors know where eggs are, a math formula for achieving orgasm, how quickly you can create false memories and Andy's neighbor Tony's commentary track on Birdemic 3.

Comedian Nate Craig (@hypeman) returns to the podcast to talk about a deadly fungal infection, terrible maps, building cities on shaky ground, the history of plate tectonics, nanoplastics interfering with chicken embryos and a 3D-printed cake.

Comedian Noman Hosni (@NomanHosni) joins Matt, Jesse and Andy to talk about Tunisia, bad fan art, hair transplants, a bad embryo swap, Paris' City of Science and Industry, a blood test for anxiety, storing carbon dioxide in the ocean as baking soda, how much lift the space shuttle lander can generate and mapping the brain of a fruit fly.

Host of Daily Tech News Show Sarah Lane (@sarahlane) joins Jesse, Matt and Andy to talk about ballerina doppelgangers, Tom Cruise stunts, Cocaine Bear, accidentally ending up on the air, bumblebees learning to solve puzzles by watching their friends, talkin' transoms, more medical tourism, Meta's VR play and DuckDuckGo's new AI-assisted search.

New York Times technology columnist and host of the Hard Fork podcast Kevin Roose (@kevinroose) joins Andy, Jesse and Matt to talk about his infamous, amorous encounter with Bing Chat/Sydney, Sydney's response to his story, getting backhanded compliments from John Oliver, how ChatGPT was dismissed by its own creators, generative AI and the future of deepfakes, AI's capability overhang, explaining LLMs' weirdness with the Waluigi effect, artists' lawsuits over training AI on their creations, whether we care how art is made, which jobs could soon be on the chopping block and Futureproof, Kevin's handbook for the weird times ahead.

Comedian and writer Amanda Brooke Perrin (@brookeperrin) joins Matt, Andy and Jesse to discuss haboobs, a Tony update, a 2200-year-old flush toilet found in China, DIY Poo-Pourri, how soft food gave us the F-word, Andy's consonant invention, ChatGPT developing a theory of mind, and dolphin handjobs.

Comedian Erica Spera (@Spericaa) joins Andy, Jesse and Matt to talk about almost going into dentistry, prehistoric teeth, Andy's Mexican dental tourism, what we're supposed to call mummies now, monster cereals, AI Seinfeld's heel turn, Roko's basilisk, mummy chemicals, ancient stone tools and more stone tools and Soylent.

Comedian/filmmaker Jo Rou (@awkwardlyjazzy) joins Jesse, Matt and Andy to discuss Santana's answer to Beats by Dre, the mystery of a gibbon immaculate conception solved, the tiny radioactive capsule that went missing in the outback, detecting cancer with customer loyalty cards, airbrushing Boris Johnson, Jesse's bad business ideas, the Snickers dick vein, World War I talk, the awful new show Power Slap and Jo's sitcom I Adore Dolores.

Clinical psychologist and misophonia researcher Dr. Jane Gregory (@drjanegregory) and comedian Steve Hall (@astevehall) return to the show to talk with Matt, Jesse and Andy about Jane's work studying misophonia, what to do if your spouse's breathing drives you insane, and what's on the horizon for treating the condition. Trigger non-warning: This episode contains NO examples of misophonia-triggering sounds. That we know of.

Comedian, goalkeeper and coach Michael Magid (@michaelmagid) joins Andy, Matt and Jesse to discuss Michael's football (soccer) podcast Inside the 18, his new social network The Union, quitting your gym with the help of AI, a Tesla that caused a pileup, a Tesla that thwarted a triple murder-suicide, fires in electric vs. gas cars, a breakthrough in reversing aging in mice, ripped old guys, Matt Braunger's Weight Smashers sketch, lab-grown retinal eye cells to treat blindness and Matt and Andy's new favorite podcast If Books Could Kill.

Comedian turned author Christina Martin (@christinamartin) joins Jesse, Matt and Andy to talk about atmospheric rivers, shared names, Christina's book Ashes to Admin: Tales from the Caseload of a Council Funeral Officer, putting on funerals for unidentified decedents, the return of a comet after 50,000 years, Newton's madness, Heaven's Gate sneaker collection, reversing erectile dysfunction in pigs and a real horror show of a pig.

Comedian Sean Patton (@mrseanpatton) returns to the podcast to talk with Andy, Jesse and Matt about his new special Number One, comedian affectations, paradox-free time travel, alternate Hitler histories, water pipe robots to deal with leaks and how the sun put water on the moon.

Comedian Katrina Davis (@katrinasivad) joins Jesse, Matt and Andy to discuss gene-edited hens, baby dinosaurs running on the beach, snake clitorises and the correlation between vaccination status and car crashes.

Comedian David Nihill (@davidnihill) joins Jesse, Andy and Matt to discuss getting kicked out of science class, the potential impact of the release of OpenAI's mind-blowing ChatGPT, big news on the nuclear fusion front, Artemis 1 splashing down, Steve Aoki's upcoming trip to the moon, David Guetta's greatest moment and self-medicating great bustards.

Comedian Mike Bridenstine (@brido) joins Matt, Jesse and Andy to talk about his podcast Hunk, a promising new HIV vaccine, the decline of key changes in popular music, the tyranny of the I V vi IV chord progression, how bin chickens learned to wash cane toads, a blast of light from a black hole, spurious correlations, how long we've known how far away the moon is, Andy's favorite dumb shirt IG account and the Nazi brothers who started competing shoe brands.