Created with Sketch.
The PricePlow Podcast
77 minutes | 25 days ago
#034: Shawn Wells #6 | Mitochondrial Health - Optimize the Power of 'Mito'
The mitochondria are the powerhouses of our cells. But how do they work, how is our food supply damaging them so badly, and what can we do to fix the issue? Prepare to meet the Power of Mito, presented by NNB Nutrition. When looking for an additional boost in energy, we often turn to stimulants and other supplements to provide a jolt. While this usually does the trick temporarily, how often do we take a step back and ask why we needed the kickstart to begin with? Maybe the previous night’s sleep wasn’t great, or a tough week at work or in the gym have left us feeling drained. What if the cause runs deeper than situational circumstances, though? What if, biologically, the body isn’t efficiently producing the energy it so desperately needs? The human body is an extremely complex system. It houses 78 different organs, each of which have unique responsibilities, plus countless pathways/complexes that dictate overall functioning. Containing over 37 trillion cells, this vessel is incredibly complicated – but that doesn’t mean it can’t be understood. At a high level, the human body is effectively a machine, complete with power-generating mechanisms and supportive structures that ultimately enable efficient operation. Every component in the body is important in its own right, but for the purposes of this post, we’d like to hone in one particular piece that is central to optimal functioning – the mitochondria Meet the mitochondrion: the center of it all Mitochondria act as energy converters at the cellular level. They take in chemical energy via food and transform it into adenosine triphosphate (ATP), the energy source that cells need to operate. This fuel is used for virtually every bodily function there is, making the efficient firing of the mitochondria absolutely imperative for our health. Mitochondria vs. Mitochondrion?! Note that mitochondria is actually plural for mitochondrion. One mitochondrion, multiple mitochondria. These tenses are often used incorrectly, although we are generally talking about all mitochondria in the body and not just a single one. However, outside factors can negatively influence the mitochondria, reducing their energy production and the functioning of the body itself. There are ways to right this ship, though. We can provide the body with what it needs to make mitochondria more efficient in creating clean energy. Ensuring these converters are firing on all cylinders can have a massive impact on your overall health, thanks to a steady supply of clean energy that’s sustainable for longevity. In this post, we’re going to dive into everything you need to know in regards to mitochondrial function — what they are, how they work, and what can influence them. We’ll also discuss some sports supplements ingredients that we think have some real potential to optimize the mitochondria, some of which can be amplified when used synergistically. As always, make sure you’re subscribed to PricePlow for the latest news and deals in the sports supplements industry. Also, be sure to check out our social media pages on YouTube and Instagram for supplement reviews and interviews. Subscribe to PricePlow's Newsletter and NNB Nutrition Alerts Topic Blog Posts YouTube Videos Instagram Posts NNB Nutrition Your Email: Sign Up What are the mitochondria? Before we get into the different ways to optimize the mitochondria, we need to take things back to high school biology and discuss what they are. Meet the cell, its mitochondria, and its DNA. For good health, it’s our job to keep them running efficiently. Image courtesy Wikimedia. Mitochondria are organelles housed within cells of almost all eukaryotic organisms, from humans to plants. Their main function is to convert chemical energy, ingested as food, into a form of usable cellular energy. Without these organelles, the cells would struggle greatly to perform their necessary operations. Cells that demand higher amounts of energy, such as human liver cells, can contain up to as many as 2,000 mitochondria. These rod-shaped structures are the batteries that make living possible. Origin and structure Despite their importance within their home, mitochondria didn’t always take up residency in cellular walls. Scientists believe that cells evolved to inherit mitochondria. It’s highly likely that mitochondria (and their plant-based cousin, chloroplasts) were independent organisms at one point in time, only to be consumed by eukaryotic cells. This belief, also called “endosymbiotic theory”, is mainly based on a trait unique to mitochondria. While each of the 13 parts of a cell serve a specific purpose, mitochondria are the only component that hold their own DNA. With the majority of DNA being stored in the nucleus of the cell, mitochondrial DNA (mtDNA) makes up only a small portion of the DNA within each cell. Housing its own genetic coding, mitochondria are often referred to as “a cell within a cell.” Compared to typical DNA, mtDNA is much smaller. It contains only 11,000 to 28,000 base pairs of genetic material, whereas human DNA is built upon 3 billion base pairs. Its function is rather specific, as well— the 37 genes encoded within mtDNA mainly facilitate the energy conversion that takes place in the organelle. A singular mitochondrion is built as a nesting structure of sorts. It consists of five distinct parts, each gaining importance with every step closer into its center: A single mitochondrion, labeled by its components. Image courtesy Wikimedia. Outer membrane – a thin layer of phospholipids that allow small molecules, such as ions, nutrients, ATP, and ADP, to pass through to the organelle. Intermembrane space – the space between the outer and inner membranes that helps facilitate oxidative phosphorylation, the key process that occurs within the mitochondria. Inner membrane – built of the phospholipid cardiolipin, the inner membrane houses a large portion of the proteins integral for mitochondrial function. These proteins facilitate electron transport reactions, ATP synthase, and metabolite transport. Cristae – folds of the inner membrane that increase the surface area of the inner membrane, which in turn increases the capacity for energy conversion. Matrix – located inside the inner membrane, the mitochondrial matrix is the working part of the organelle. This component contains many of the proteins and enzymes necessary for energy conversion. The majority of the reactions that take place within the mitochondria take place within the mitochondrial matrix, though each outside layer serves its own role in the process. What are these reactions, and what enzymes and proteins trigger them? How mitochondrial function works – oxidative phosphorylation! The macronutrients consumed through food – carbohydrates, fats, and protein – all go toward providing the body with energy, but each nutrient needs to be properly converted in order for it to be utilized. Cells do not have a “calorie receptor”, after all. Mitochondria from human lung cells, as shown by electron scanning microscope. Image courtesy Wikimedia. Following initial reduction within the digestion tract, the amino acids, sugars, and lipids move from the small intestine into the bloodstream. From there, the body carries out conversions that ultimately transform nutrients into compounds that function within the citric acid cycle. Also called the tricarboxylic acid or Krebs cycle, this operation allows for mitochondria to go to work! Glucose, lipids, and amino acids all contribute to this process, but each enters the fold at a different step. Before entering the Krebs cycle, glucose undergoes a transformation within the cytosol of the cell. Glycolysis is a 10-step process that breaks down glucose obtained from food into pyruvate, a compound that’s one step away from the Krebs cycle. Via pyruvate dehydrogenase, pyruvate is decarboxylated (a carboxylic acid group is removed) upon entering the mitochondria, yielding acetyl coenzyme A (acetyl-CoA). Alternatively, fatty acids are directly converted into acetyl-CoA through beta oxidation. Amino acids are broken down into pyruvate, acetyl-CoA, or intermediates of the Krebs cycle, depending on their makeup. Once acetyl-CoA has been formed, the Krebs cycle begins. Within the mitochondrial matrix, acetyl-CoA reacts with oxaloacetate to form citrate, a six-carbon molecule. In a succession of seven reactions, this citrate is oxidized back into oxaloacetate. The Krebs cycle is a closed cycle, yielding an end product that also serves as a kickstarting component. In the process of creating new oxaloacetate, however, an important byproduct is made — excess carbon that had been stripped away during chemical reactions was reduced to two atoms of carbon dioxide and two electrons, the latter of which are passed to the produced cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH2). The Electron Transport Chain, as described above and below. This process gets broken due to age, genetic issues, or processed foods/oils! But we can help improve it. “Charged” with this picked-up energy, NADH and FADH2 move the electrons to the mitochondrial electron transport chain (more commonly referred to as the respiratory chain). The electrons facilitate the activity of multiple enzymatic processes by interacting with proteins housed within the mitochondrial inner membrane. Their charge pumps protons from the matrix into the intermembrane space, creating a potential difference across the inner membrane. This potential difference does two things: It neutralizes the electrons, whose purpose has been served. Waiting at the end of the respiratory chain is oxygen, which reacts with the electrons to form water. As the protons move down this created electrochemical gradient, they pass through ATP synthase, activating the enzyme that attaches adenosine diphosphate (ADP) to a third phosphate atom, making ATP. The bonds holding ATP together are somewhat unstable and easily broken during hydrolysis, a reduction that yields ADP and a free phosphate molecule. This reduction creates the cellular energy that powers almost every function within the body. Serving as the catalyst that turns chemical energy into molecular energy, the mitochondria serve a vital function. As with most bodily processes, however, things don’t always work as efficiently as they should. Mitochondrial dysfunction — more of an issue than we think? A key cog in the machine that is the human body, the mitochondria bear a ton of responsibility in maintaining healthy functioning. Under normal circumstances, they are entirely capable of serving their role. Things aren’t always “normal,” however, as potential imbalances and other outside factors can interfere with proper functioning and inhibit mitochondrial production, leading to insufficient cellular energy. Mitochondrial decline is a part of healthy aging, but our food choices and inactivity can absolutely expedite the process. This reduced efficiency in ATP production is called mitochondrial dysfunction, and believe it or not, it’s quite prevalent in today’s world. Not only is such dysfunction a byproduct of aging, but it’s also found in practically all chronic diseases, as well. Research has identified mitochondrial dysfunction in individuals dealing with various issues, ranging from neurodegenerative diseases,[12,14] to neurobehavioral diseases, and metabolic issues. While suppressed mitochondrial function isn’t a central symptom of the majority of these wide-ranging issues, it certainly plays a role in the general exhaustion felt when dealing with these problems, and also reduces the amount of energy available to fight such issues. What happens at the molecular level Mitochondrial dysfunction can occur when any of the following circumstances emerge: a loss of mitochondria within cells, suppressed production of substrates and enzymes necessary for proper functioning, or direct dysfunction of the respiratory chain. Each situation is a result of genetic mutations, as genes regulate the proteins and enzymes produce to facilitate mitochondrial function. While these deficiencies are sometimes passed down genetically, there seems to be a common culprit tied to the development of inefficient mitochondrial function — free radicals. Free radicals, proton leaks, and loss of efficiency Though the respiratory chain manufactures energy for the body, it also creates a troubling byproduct. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are two highly reactive free radicals, which are molecules that cause oxidative stress within the body. Their production mainly comes from the mitochondria, a “necessary evil” produced alongside ATP. We need ROS to burn fat and perform metabolic processes, but when left unchecked, these substances damage cellular DNA, proteins, and lipids. The body uses various enzymes and antioxidants to neutralize these reactive species, though excess build-up is possible. On its own, the production of free radicals isn’t that troubling. However, its effects can be exacerbated by another irregularity in the electron transport chain. The respiratory chain can create uncoupling proteins, which yields a leak of protons across the gradient back into the mitochondrial matrix. This leak results in suppressed ATP production amidst oxygen consumption. This consumption, alongside ROS production, leads to damage of the inner mitochondrial membrane, further amplifying the leakage of protons and the inefficiency of the respiratory chain. What causes the “traffic jam” of electrons that creates local insulin resistance? New theories suggest that it is the glut of polyunsaturated fats that have entered our diets over the past several decades.[19,20] Image courtesy Wikimedia and Michael Eades / Protein Power. Antioxidants, both those inherently produced in the body and those consumed through food, typically help prevent such damage. When they are unable to subdue these free radicals, though, mitochondria are susceptible to significant damage that can cause them to malfunction. Leads to general fatigue With the mitochondria compromised, the production of ATP pales in comparison to the amount of ROS made in the electron transport chain. This leads to a rather obvious outcome — insufficient cellular energy. An individual can develop fatigue in countless ways, though research has shown that moderate to severe chronic fatigue typically relates to cellular energy systems.[13,21] With cells unable to manufacture adequate amounts of energy, they simply cannot function normally. As such, it’s no surprise that those with mitochondrial dysfunction commonly deal with things such as muscle fatigue, muscular weakness, and exertional fatigue. While this is seen in individuals as a result of aging and chronic disease, fatigue induced via diminished mitochondrial function isn’t exclusive to any one demographic — there are various conditions linked to it. Aging plays a key role in development of diseases linked to mitochondrial dysfunction The mitochondria sites implicated in various neurodegenerative diseases It’s difficult to pinpoint the development of onset diseases on any one factor. Some are linked to genetic coding, others lifestyle choices, while others come about with almost no explanation. The specific biological mechanisms responsible for the development of many diseases have yet to be identified. This is true for age-related diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and diabetes. However, research suggests that aging itself has a significant effect on the development of these diseases, mainly through cellular death caused by mitochondria-produced free radicals.[22-24] Of course, humans become more susceptible to health issues as we age. The body can longer operate at the efficiency it once did, and some biological processes begin to waver. Research seems to posit that such wavering begins at the cellular level with mitochondrial dysfunction. ATP production falters, free radical production grows in excess, and cellular damage ensues. Thus, it seems that mitochondrial dysfunction is somewhat more common in older age – but what about in our younger years? Metabolic syndrome – significant relationship with mitochondrial inefficiencies According to researchers at the University of North Carolina at Chapel Hill’s Gillings School of Global Public Health, only 12% of Americans are in optimal metabolic health. Defining metabolic health using five metrics — blood glucose, triglyceride levels, high-density lipoprotein cholesterol levels, blood pressure, and waist circumference — this study analyzed data of 8,721 individuals collected by the National Health and Nutrition Examination Survey from 2009 to 2016. Their findings suggest that roughly 88% of Americans are vulnerable to issues related to poor metabolic health, such as type 2 diabetes and cardiovascular disease. 88% of Americans are metabolically sick! Only 12% of Americans are metabolically healthy! It wasn’t like this a few generations ago. What was the most major change? Our food, especially our choices of fats. The estimate provided in this study makes intuitive sense – multiple studies suggest that the Western diet and lifestyle of Americans increases the likelihood of metabolic syndrome, obesity, and chronic disease.[26,27] Research from 2018 investigated the effects of 38 different dietary patterns in 4,000 individuals aged between 45 and 67. Using indicators of metabolic syndrome as response variables, the team ranked a reduced-rank regression model in order to determine which, if any, dietary patterns explained variation in the response variables. Their findings concluded that the Western diet — one that’s high in sugar and chemically-processed foods — is positively associated with detrimental effects of metabolic health. Metabolic syndrome bears a relationship with oxidative stress and mitochondrial dysfunction. Conditions such as insulin resistance, obesity, high cholesterol, and diabetes are associated with excess cellular oxidative stress. Individuals with poor metabolic health also tend to feel general fatigue, yet another symptom shared with mitochondrial dysfunction. In 2010, researchers from the Department of Internal Medicine at Yale University published a study that furthers this relationship. Their aim was to identify how insulin resistance arises in older adults. Using healthy, lean, elderly and young test subjects, they compared lean body mass, fat mass, and biological markers. Though they found that the elderly subjects were much more insulin-resistant than the younger subjects, the “why” behind their findings is significant. The researchers saw that the differences in insulin sensitivity were associated with a 40% reduction in mitochondrial oxidative and phosphorylation activity. While this conclusion supports the notion of age-related mitochondrial dysfunction, it also connects poor mitochondrial function to subpar metabolic health. Modern foods trash the liver – and the mitochondria’s energy transport systems In a study published in 2008, scientists from the University of Alabama studied the relationship between mitochondrial dysfunction and non-alcoholic steatohepatitis (NASH), a common issue related to metabolic syndrome. They found that a diet high in processed unsaturated fats (from corn oil, safflower oil, and olive oil) led to a hypoxic state in the liver of mice, simulating NASH. However, they found that the diet increased mitochondrial susceptibility to RNS damage, increased protein modification, and decreased respiration in liver cells, explaining the hypoxic conditions. Increased Linoleic Acid Consumption… Increased Linoleic Acid bodyfat Composition… increased obesity. We believe that this omega-6 fatty acid, coming mostly from industrialized processed seed oils, is the true culprit in the obesity crisis. In a 1999 study published in The Journal of Biological Chemistry, researchers found that obesity decreases metabolic respiration and increases uncoupling protein-2 expression in hepatocytes. Studying hepatic mitochondrial function in mice, the team saw 500 to 600% more uncoupling protein-2 expression in obese mice, compared to the leaner control group. Expectedly, this increase in uncoupling proteins led to markedly lower ATP content in hepatic cells. The mitochondria within the liver cells of the obese subjects were compromised, providing evidence of the relationship between metabolic syndrome and mitochondrial dysfunction. Metabolic disease and its associated conditions are a widespread issue in today’s world. Many individuals fail to maintain a healthy diet free of processed foods and industrial oils, and are subsequently challenged with prevalent issues that can lead to metabolic dysfunction. This puts a significant burden on one’s health, be it through daily fatigue or more severe problems. Whether it’s because of age, metabolic inefficiency, or a diet laden in processed foods and oils, mitochondrial dysfunction is likely more widespread than we think. The things that it can lead to — general fatigue, weakness, insulin resistance — are not conditions conducive to living a healthy life. In addition to perhaps cleaning up one’s diet, there seem to be nutritional supplements that can help increase mitochondrial efficiency and help your body produce the clean energy it needs! Increasing mitochondrial efficiency — getting cellular energy back Poor mitochondrial function isn’t permanent, so long as one provides the body with the things it needs to right the ship. Fortunately, there are multiple ways to do just that! Improving the diet: remove processed seed oils When looking to improve mitochondrial efficiency, the first area one should focus on is their lifestyle, specifically diet and activity levels. Foods that can wreak havoc on metabolic functioning, such as those prevalent in the Western diet, are alarmingly accessible and thus difficult to avoid. Moving toward more natural, nutrient-rich foods can help shift mitochondrial functioning back to normal. One example of how it happens. The main constituent breaks down into known inflammatory acids that general dieters do not need more of. The first step towards a cleaner diet is to remove all processed fats, including any trans fats or “vegetable oils”, better known as industrial processed seed oils. This includes corn oil, canola oil, safflower oil, sunflower oil, cottonseed oil, and likely worst of all, soybean oil. These processed fats are high in unstable omega-6 polyunsaturated fatty acids (namely linoleic acid) that are easily oxidized and rancid, and subsequently wreak inflammatory havoc on the mitochondria and the electron transport chain discussed above.[33,34] Sadly, these oils are literally everywhere, but there is a resurgence of traditional cooking led with butter and beef tallow, both which contain healthy and stable saturated fats that do not cause problems discussed above. In addition, foods with antioxidants do a number of things for the body, though most of their benefits are tied to scavenging free radicals. These compounds work to rid the body of free radicals such as ROS and RNS, in turn protecting from the negative effects these reactive species can cause. Foods like organ meats, berries, and pomegranate pack strong antioxidant contents, and have even displayed the ability to protect against cognitive decline.[35,36] B vitamins, which also act as antioxidants, are another excellent protector of mitochondrial function. In a review published in 2006, scientists from the Department of Pharmaceutical Sciences at the University of Toronto noted that deficiencies in any B vitamin can compromise mitochondria. Furthermore, the review discusses how the B vitamins act coenzymes for many of the enzymes at work in oxidative phosphorylation. Increasing B vitamin consumption through fruits, cruciferous vegetables, whole grains, and red meat can help facilitate proper cellular energy production. SOYBEAN OIL?! This is not a vegetable. And it’s loaded with unstable omega-6 polyunsaturated fatty acids that are terrible for heating/cooking! Image courtesy Wikimedia Omega-3 fatty acids such as alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are typically touted for their heart health benefits, though research suggests these healthy fats have more to offer. A study published in the Journal of Physiology in 2014 found that young men supplementing with omega-3 fatty acids displayed signs of increased mitochondrial capacity without increasing oxidative damage. Their analysis suggests that the fatty acids are incorporated into mitochondrial membranes, helping to fortify the organelles. Red meat and fish are among the best sources of omega-3 fatty acids available. Note, however, that there is only so much omega-3 you can intake, and if you do not drop the processed omega-6 fats listed above, it will be tough to make a dent in the ever-critical omega-3:omega-6 ratio. Other foods, such as magnesium-rich vegetables and olive oil also have antioxidant properties that can protect cellular integrity and increase mitochondrial efficiency.[40,41] When it comes to providing the body with nutrients to combat free radicals and improve mitochondrial function, there are plenty of great options to consider. Staying active In addition to improving one’s nutrition, research suggests that staying active is another way to encourage healthy mitochondrial function. The relationship between exercise and the mitochondria has been long understood, with research published by the Department of Preventive Medicine at Washington University in 1967 noting that exercise forces mitochondrial adaptations. A better fat for active individuals: MCT Oil, or Medium Chain Triglycerides. Can be easily found in coconut oil and butter. Additional research has unearthed what exactly those adaptations seem to be. In 1969, a study published in the American Journal of Physiology found that exercise induces increases in mitochondrial size and quantity. Furthermore, scientists have studied what this effect could lead to in terms of energy production and muscular performance. In a 2001 study published in the Journal of Applied Physiology, both endurance and resistance training increased skeletal muscle mitochondrial content, ATP supply, and muscular performance. Of particular note, different types of exercise at different intensities have demonstrated this link. An obvious relationship exists with endurance exercise, which relies on an aerobic capacity to prolong activity. Research from 2018 saw a 55% increase in muscular mitochondrial volume density in men following a six-week endurance training program. In 2017, researchers found that high-intensity interval training (HIIT) increases oxidative phosphorylation. A review published in Sports Medicine in 2018 perhaps summarizes this relationship best. This study notes that different exercise variables promote diverse mitochondrial adaptations, specifically in terms of mitochondrial function. Interestingly, the researchers also suggest that training volume may be more influential in altering mitochondrial content. These findings truly drive home that point that staying active helps promote mitochondrial functioning. Nutritional supplements for mitochondrial health Improving one’s diet and activity levels are two excellent ways to promote healthy mitochondrial function. But there are more ways to get additional mitochondrial gains. For additional help, specific nutrients provided through supplementation can be explored. In addition to the vitamins we discussed earlier, there are some common supplement ingredients that seem to promote positive effects in terms of mitochondrial function. In a review published by the National Institutes of Health, the following ingredients were cited for potential benefit: After reading a new review based upon 100 citations, we are finding fewer and fewer reasons not to take ~2g L-Carnitine each day Alpha-lipoic acid increased energy availability in the brain, displayed by a 72% increase in brain phosphorylation potential, after one month of supplementation with a 600mg daily dose. In a study published in 2015, carnitine supplementation improved lung functioning and aerobic exercise capabilities during intense, prolonged exercise. This led researchers to suggest that the test subjects, who took a 3g daily dose of carnitine for eight weeks, benefited from improved mitochondrial function. Creatine supplementation specifically for mitochondrial health has shown conflicting results. In a study from 2003, creatine was been shown to increase muscular performance by 12% in individuals with mitochondrial deficiencies. Research published in 2000 conducted a similar study, yet found no significant changes in mitochondrial function. However, given the ingredient’s ability to increase phosphocreatine stores, there’s potential in its ability to increase ATP production. There are additional ingredients that have shown potency in affecting the mitochondria and potentially improving their operation. Although these ingredients are not as commonly discussed as some of the previously mentioned compounds, existing research suggests that they should be! Ergothioneine The benefits of using MitoPrime branded ergothioneine, as taken from NNB Nutrition’s website L-ergothioneine is a naturally-occurring thiol derivative of the amino acid histidine and one of the more powerful antioxidants available. Abundant in shiitake and oyster mushrooms, organ meats, and black beans, the body distributes ingested ergothioneine exclusively with the cation transporter ETT (formerly known as OCTN1). ETT moves the antioxidant throughout the body, storing it in vital locations where fighting free radicals is important, such as the blood and organs. Where this transporter is located, however, is what makes it important in the context of mitochondrial function. ETT is strongly expressed in the mitochondria where it uses ergothioneine to protect mitochondrial DNA from free radicals. In a study published in 2010 by the Solomon H. Snyder Department of Neuroscience at Johns Hopkins University School of Medicine, researchers found that ergothioneine treatment effectively prevented free-radical induced DNA damage in a dose-dependent manner. Due to the location of the protein that transports it, ergothioneine uses its antioxidant abilities to defend mitochondrial function against substances that could potentially damage it. Thus, the antioxidant capabilities of ergothioneine have been shown to improve cellular functioning in various parts of the body. Supporting mitochondrial function allows for proper cellular operation, which can help defend against ailments and diseases across the body. Studies have cited protective effects in cognitive health, cardiovascular functioning, and more vital organs. MitoPrime from NNB Nutrition Found in mushrooms and organ meats, ergothioneine is the oldest — and most overlooked — antioxidant on the market. MitoPrime from NNB Nutrition is one of the most well-formulated ergothioneine products currently available. Using a patented extraction process, the formulators at NNB are capable of isolating ergothioneine in its highly bioavailable L-isomer form. This 100% natural, 100% pure ingredient is capable of delivering the powerful antioxidant directly to the front lines of mitochondrial defense. Protecting mitochondrial functioning and enabling it to efficiently create ATP, the L-ergothioneine variant of MitoPrime neutralizes harmful molecules that could potentially lead to dysfunction. Interested in introducing ergothioneine into your regimen? Consider MitoPrime, for which NNB Nutrition recommends a daily dose of 5 to 10mg taken 1 to 3 times per day. β-Aminoisobutyric acid (L-BAIBA) β-aminoisobutyric acid (BAIBA) is an amino acid generated as a byproduct of the breakdown of valine during exercise. This signaling molecule differs from amino acids that build muscle within the body in that it is used strictly to stimulate biological processes. Specifically, L-BAIBA is formed in the mitochondria following L-valine metabolism. Valine is one of the three branched-chain amino acids (BCAAs), and is rather abundant in most protein sources available to us through food. As valine is oxidized, cells form L-BAIBA – and it’s used as a messenger signal – but how? Beta-aminoisobutyric acid (BAIBA), induces beneficial effects on lipid homeostasis in mice. PGC-1 alpha is a protein whose expression increases during and after physical exercise. It serves as an activator of various biological responses to such exercise, controlling how the body expends energy and responds to exertion. Located exclusively in muscle tissue, PGC-1 alpha stimulates BAIBA to carry out the exercise response throughout the body. These responses consist of multiple things related to exercise, such as metabolic stimulation and blood pressure regulation. Importantly, however, BAIBA expression via PGC-1 encourages mitochondrial biogenesis. BAIBA also helps turn white adipose tissue into brown adipose tissue, a type of fat that yields greater energy expenditure. While white fat is the fatty tissue layer that exists to store energy and secrete the hormone leptin (the hunger-controlling hormone), brown adipose tissue generates heat due to increased mitochondrial functioning compared to white fat. For the purposes of increasing metabolic rate and losing body fat, brown fat is advantageous. Though BAIBA doesn’t turn white fat directly into brown fat, it seems to create a “beige” fatty tissue that works like brown fat but is located in white fat.[62,63] Thus, when activated, this tissue can generate heat from stored body fat that otherwise wouldn’t be able to do on its own.[62,63] This process is triggered by BAIBA’s ability to trigger proliferator-activated receptor alpha (PPAR alpha) activity, a key regulator of fatty acid breakdown via beta oxidation. NNB Nutrition has finally brought us a trusted and tested form of L-BAIBA, which we call an “exercise signal” that kickstarts incredible metabolic processes! It’s known as MitoBurn and it’s also part of the “Mito” Stack! Increased heat generation in white adipose tissue was tested in a mice-model study published in 2008. Mice who were deficient in leptin were fed BAIBA daily over the course of four months. Not only did their leptin levels increase, but the mice also saw 27% reductions in obesity and 40% reductions in fat gain compared to controls. As L-BAIBA has also been shown to improve markers of inflammation and insulin sensitivity, this amino acid attenuates multiple conditions that are linked to mitochondrial dysfunction — obesity, fat gain, and insulin resistance. It’s noteworthy, then, that BAIBA seems to accomplish these effects through signaling an increase of mitochondrial content in white adipose tissue. MitoBurn from NNB Nutrition Knowing the link between L-BAIBA, mitochondria biogenesis, and potential fat mass reduction, NNB Nutrition released their aptly-named L-BAIBA formulation, MitoBurn. The forward-thinking ingredient is lab-tested, stabilized, bioactive, and packed full of the potent, research-study identical form of L-BAIBA. MitoBurn utilizes L-BAIBA to signal “beige” fat activation via mitochondrial proliferation, increasing thermogenesis while attenuating other markers of obesity and metabolic dysfunction. NNB recommends 200 to 250 milligram servings taken 1 to 2 times per day is an effective range to yield mitochondria-based benefits! Grains of paradise They’re not just for cooking anymore! The proper extract from these seeds can be used for weight loss and body recomposition! Grains of paradise (GP), or Aframomum melegueta, is a spice native to the Zingirberaceae family of plants. Anecdotally used as a spice, GP has grown in popularity in recent years due to a strong profile of potential nutritional/supplementation uses. It has four main bioactive compounds, 6-gingerol, 6-paradol, 6-shogaol, and 6-gingeredione — though 6-paradol is thought to be the key behind its effects. Grains of Paradise acts as a thermogenic aid, generating heat and kickstarting the metabolism using means similar to L-BAIBA — brown adipose tissue. As we discussed in the previous section, a higher ratio of brown-to-white fatty tissue can potentially increase heat generation, total energy expenditure, and decrease body fat. Having more brown adipose tissue to utilize generally bodes well for increasing metabolic rate and shedding excess fat. This is why L-BAIBA is so interesting — it works to raise the ratio of energy-spending fat. However, GP works in a different, albeit complimentary, fashion. Research published in Autonomic Neuroscience: Basic & Clinical in 2011 found that GP stimulated nerve activity within brown adipose tissue for as long as three hours. This led to an overall increase in internal temperature, confirming the additional heat generation caused via this stimulation. This effect brings about expected benefits in practice, too. A study published in 2013 in the British Journal of Nutrition administered an acute 40mg dose of GP to 19 men aged 20 to 23 years old. After only two hours from initial ingestion, those given GP had already raised energy expenditure levels 5% higher than the placebo group. Long-term usage yields similar effects. The same research group tested a 30mg daily dosage of GP over one month in 20 to 23 year-old females. They found that the ingredient significantly raised energy expenditure compared to placebo. On average, the test subjects on GP burned an additional 100 calories more daily! This ultimately led to the GP group showing significant decreases in visceral fat when compared to controls, as well. If you really want some fat burning effects, stack ZinjaBurn with CaloriBurn! The way in which brown adipose tissue generates heat is by expending energy, which happens via respiration powered by the mitochondria in its cells. By promoting mitochondrial activity, grains of paradise stimulates brown adipose tissue, which leads to an increased caloric burn that could be beneficial for losing body fat. CaloriBurn Yet another science-backed NNB product, CaloriBurn delivers a full-spectrum GP extract, complete with the clinically-studied dose of 12.5% 6-paradol. Supported by HPLC and HPTLC purity tests, CaloriBurn is an extremely pure, unadulterated extract — something that, believe it or not, isn’t common in most GP supplements. CaloriBurn comes with all the hallmarks one would expect in an NNB ingredient: it’s bioactive, 100% complete, potent, and exact. This ingredient provides a bit of a jolt to the mitochondria in brown adipose tissue, increasing energy expenditure and aiding fat-loss efforts! Tetrahydrocurcumin and dehydrozingerone Tetrahydrocurcumin (4-HC) and dehydrozingerone (DHZ), both of which come from the ginger family, are two powerful antioxidants that are somewhat similar in chemical structure. Their ability to scavenge free radicals allows them to yield similar effects in supplementation, as well. However, their existence as antioxidants begs the question of whether or not they can act at the cellular level. Tetrahydrocurcumin / 4-HC attenuates mitochondrial dysfunction… A “suped up” version of curcumin is here, and there are some excellent new benefits it brings! Tetrahydrocurcumin is a major bioactive derivative of curcumin, the active ingredient in turmeric that has been used for treating various ailments in natural medicine practices. Science has found why these practices found curcumin so useful — it encourages cell proliferation through increasing antioxidant enzyme activity,[69,70] reduces inflammation, and inhibits protein kinases linked to developing diseases. The issue with curcumin, however, is that it has poor bioavailability. Not only is 4-HC more bioavailable than curcumin, but it’s also the root’s main active metabolite, responsible for many of the parent compound’s abilities. In fact, research even suggests that it’s more powerful and more efficient as well. In 1982, researchers found that 4-HC reduced inflammation by 56.6% at only half the dosage of what was needed to yield similar decreases using curcumin. Additionally, 4-HC has been shown to improve blood glucose and cholesterol levels — both key metrics when assessing metabolic health.[76,77] All of these effects sound awfully close to mitochondrial function, and recent research suggests that tetrahydrocurcumin operates in a mitochondrion-protective way to accomplish these things. A study published in Neurochemistry International in 2018 tested the effects of 4-HC in mice with brain ischemia. This condition, a shortage of oxygen reaching the brain, also encourages mitochondrial dysfunction. The researchers found that 4-HC reduced mitochondrial oxidative stress, restored ATP production, and protected mitochondrial integrity. …and so does DHZ! Dehydrozingerone also comes from curcumin and is a half analog of the potent turmeric-derived constituent. Much of what has been studied in regards to 4-HC applies to DHZ, as the later also possesses higher bioavailability, antioxidant activity, and anti-inflammatory properties than curcumin.[79,80] DHZ is also similar to 4-HC in that it alleviates symptoms of metabolic dysfunction. A comprehensive study published in 2015 from Korean researchers studied the effects of DHZ on metabolic functioning and observed some impressive results. They found that the ingredient is capable of suppressing weight gain, regulating blood sugar, and maintaining proper insulin activity. They also identified how the metabolite operates. Dehydrozingerone’s Effects with respect to its chemical structure. AMP-activated protein kinase (AMPK) is a key kinase used to send cellular signals throughout the body. Specifically, it’s mainly used to control metabolism, regulating energy production and consumption at the cellular level. AMPK dysregulation holds a positive correlation with symptoms of metabolic dysfunction. In other words, one generally occurs alongside the other. AMPK also bears a relationship with the mitochondria. Originally published in the International Journal of Molecular Medicine in 2018, a team of Chinese researchers studied the role of AMPK in mitophagy regulation, a process in which the body degrades unhealthy mitochondria in order to create newer, healthier organelles. The team found that AMPK activation led to increased mitochondrial biogenesis, creating new organelles and ridding of dysfunctional ones. CurcuPrime: Curcumin’s better half for diet and cardio support How is AMPK increased? Well, there are few ways to do that, and DHZ supplementation seems to be one of them. In the previously mentioned Korean study, the researchers found that DHZ stimulated AMPK activity, which happened to be the driving mechanism behind improvements in metabolic markers the researchers also saw. Stimulating AMPK creates a demand for energy production, which encourages the creation of functional mitochondria to fill the order. As such, more well-functioning mitochondria can help treat symptoms of metabolic dysfunction. NNB offers both of these curcumin-based ingredients Venturing after mitochondrial health through yet another means, NNB Nutrition has formulated versions of 4-HC and DHZ, dubbed CurcuPrime and ZinjaBurn, respectively. Each are unadulterated, lab-tested, highly bioactive ingredient formulations, and both products bring the potential benefits of these ginger-based compounds into the fold, and potentially into your supplement regimen. Ketones and keto-focused ingredients The ketogenic diet has become immensely popular in the past 15 or so years, thanks to its wide array of well-demonstrated health benefits. The ketogenic diet essentially shifts the body’s main fuel source from glucose to ketone bodies, which is known as a state of ketogenesis. This means adapting to an ultra low-carb diet while prioritizing healthy fats in the diet as the main source of fuel. One enters ketogenesis when the body is unable to use enough glucose reserves for adequate oxidation in the Krebs cycle, and it subsequently turns to ketone bodies generated from excess acetyl-CoA production. This process takes place within the mitochondrial matrix, as the body learns to use ketones to generate ATP in order to continue operating. How ketones are oxidized The body is fully capable of using ketones for fuel, but it does involve a slightly altered process than that of glucose. Ketogenesis mainly takes place within the mitochondrial matrix of hepatic cells, at rates proportional to total fat oxidation. Once acetyl-CoA has been generated, 3-hydroxymethylglutaryl-CoA synthase 2 acts as catalyst to generate HMG-CoA, which is then cleaved to generate acetoacetate (AcAc). AcAc is reduced to D-β-hydroxybutyrate (D-BHB) by a mitochondrial enzyme called βOHB dehydrogenase (BDH1). This enzyme is crucial in this process—it is the final reaction of ketogenesis and the first reaction of ketone oxidation. Beta Oxidation of fatty acids leading to Ketogenesis. Why would you NOT want to live in a state where this is easily accessible and not blocked by insulin spikes from carbs? Note that BHB is the primary ketone made — we were highlighting acetone for another blog post in the past. Sadly, by gaining a pound per year, few every really get to really experience the glory of this process. These ketone bodies are then transported to extrahepatic mitochondria via monocarboxylate transporters — the known transporters in mammals are MCT 1 and MCT 2. Once at non-hepatic cells, ketone bodies cross the inner membrane (through mechanisms that are not yet known). From there, they’re used for terminal oxidation, converted through the Krebs cycle to yield ATP. At the end of the day, the cells still create ATP for energy. However, all of this raises an obvious question: how does relying on ketones affect mitochondrial health? Ketone bodies provide efficient fuel for healthy mitochondria operation There is significant evidence that ketone bodies demonstrate a protective effect on mitochondrial function. In a 2007 study published in Neuroscience, a team of scientists studied the effects of ketones in the electron transport chain. They find that mitochondria exposed to glutamate-induced free radicals were treated with both β-hydroxybutyrate (BHB) and acetoacetate. The ketones decreased mitochondrial production of reactive oxygen species by increasing NADH oxidation. In essence, βOHB and acetoacetate enhanced mitochondrial respiration in an effort to neutralize surrounding free radicals. There’s additional research suggesting that ketones don’t necessarily eradicate of free radicals, but rather maintain levels that can be beneficial. Mitohormesis is a process in which ROS produced by the mitochondria in small amounts is used to signal other biological processes that can protect cellular health. Despite not being researched in high-level organisms, scientists are encouraged by the potential of mitohormesis as a means of disease treatment and prevention. In 2010, researchers from the University of Colorado published a study that tested the effects of the ketogenic diet on mitochondrial adaptation. Having previously found that ketones increased antioxidant biosynthesis, the team was interested in analyzing the responses of NF E2-related factor 2 (Nrf2), a main transcription factor signaled by the body to activate antioxidant synthesis to heal oxidative damage. Mice were fed a ketogenic diet for three weeks, after which analysis was conducted of their mitochondria. The scientists found that Nrf2 levels were elevated after one week in ketosis and remained elevated after three weeks. Interestingly, this triggered an adaptive response to ROS, as after three weeks mice mitochondria were producing less free radicals than controls. This suggests that while ketone bodies initially produce oxidative stress, they also signal mitochondrial adaptation to improve cellular health. These protective effects are not exclusive to endogenous ketones, either. Supplemental ketones, also called exogenous ketones, have been shown to upregulate antioxidant defense, signal bioenergetic proteins, and decrease mitochondrial ROS production. These can either be consumed directly as salts, or even in foods that promote ketone production, such as medium-chain triglycerides, often called MCT Oil. Not only has research shown that MCTs are highly ketogenic, but it has also displayed the ability to increase mitochondrial biogenesis and functioning. According to existing research, ketones, either generated due to ketosis or consumed through food or supplementation, are capable of defending against mitochondrial dysfunction. KetoVantage and C8Vantage When looking for quality MCT Powder, C8 (Caprylic Acid) is the way to go, and C8Vantage from NNB Nutrition is where to get it. Read more here and on NNBNutrition.com NNB offers two ingredients that are specifically designed not only for those on the ketogenic diet, but really anyone interested in increasing ketone body content. KetoVantage is a pure, isomer form of BHB designed specifically to be more effective than other BHB products on the market. Eliminating the inclusion of unnecessary salts, KetoVantage is more potent than other BHB products, using more of its chemical (and physical) space to deliver ketones to the body. In C8Vantage, NNB is offering another way to supply ketones to the system — through medium-chain triglyceride 8 (MCT C8), this ingredient utilizes the most ketogenic MCT to provide a fat source that’s readily converted into ketones. In fact, MCT C8 also is beta-oxidized at a faster rate than other MCTs. Both KetoVantage and C8Vantage are excellent ways to introduce exogenous ketones into the body, providing the mitochondria with fuel that allows them to work efficiently. Their effects hold even for those not in full ketosis, as well. Make sure to read our full post on C8Vantage for more information about what keto-focused products from NNB have to offer. NNB Nutrition – chasing optimal health through optimal mitochondrial function The group of aforementioned ingredients has something rather interesting in common, other than their abilities to improve mitochondrial health — high-quality variants of them are made by an influential ingredient formulator. Founded in 2015 by Kylin Liao, NNB Nutrition was launched specifically to insert itself at the forefront of Ingredientology, using technology and innovation to create new ingredients and push the boundaries of what supplementation is capable of. NNB has wasted no time promoting copious amounts of experience, knowledge, and talent in effort to reach such heights. NNB brought Shawn Wells onto the team — one of the industry’s most influential ingredient formulators — and named him chief science officer. Wells not only brought his expertise to the company, but also his mission: creating healthier humans, not just healthier ingredients. With a simple slogan of “We create ingredients”, the NNB Nutrition team led by Founder/CEO Kylin Liao and Chief Science Officer Shawn Wells are bringing desparately-needed novel metabolic-enhancement ingredients to the industry! NNB strives to create innovative, potent ingredients, but does so through a specific lens. Their entire product profile is backed by scientific research citing purported benefits, but virtually each ingredient accomplishes such effects through affecting mitochondrial function. Cellular functioning lies at the base of human health, and as the mitochondria are the power sources of the cell, ensuring their efficiency is key to unlocking clean health. Targeting clean energy To some degree, all of NNB’s ingredients interact with the mitochondria — some, such as MitoPrime, restore mitochondrial function, while others, like MitoBurn, encourage mitochondrial biogenesis. By restoring mitochondrial efficiency, CurcuPrime helps regulate blood glucose levels, in turn reducing advanced glycation end products that are associated with pain, inflammation, and aging. On the surface, NNB has created ingredients that fit in different spheres of health, and they all lead to the brand’s goal of clean energy. Their Burn Series seems to focus solely on encouraging effective fat-burning, while Vantage Series mostly focuses on producing ketones for additional fuel. To the common eye, only the Prime Series explicitly states interactions with the mitochondria. Look a bit deeper, however, and you can easily see that each ingredient was created with optimal mitochondrial function in mind. Healthier mitochondria can lead to a host of benefits, but they all amount to one thing — a healthier you. Listen to Shawn Wells of NNB Nutrition Discuss the Power of Mito Shawn Wells comes back onto the PricePlow Podcast to discuss mitochondrial health, which underlies our ability to maintain health and high-energy life! In this video, we talk about what the mitochondria are, and how to keep them running optimally. Going beyond sleep and diet, we also talk about NON-stimulant supplements, many of which are powered by NNB Nutrition: Mitochondria Podcast Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud Conclusion: Mitochondrial efficiency lies at center of your health Have an ingredient idea? Team NNB will co-develop it with you! “Health” is an extremely broad term, one that depends immensely on context and situation. In general, however, health for most of us means to feel good and perform well. The human body is a machine, and if it’s firing on all cylinders, you’re setting yourself up for success. Achieving this level of efficiency is tough work, though. It takes a nutrient-rich diet, effective training program, and otherwise “healthy” lifestyle to get there. In our world, maintaining these three things aren’t easy — life often gets in the way and throws things off-kilter. Whether a poor diet has encouraged metabolic dysfunction (which is more common than you might think) or life has turned more stressful, it’s almost too easy for our health to falter. When it does, it’s difficult to know exactly what’s wrong, or how to go about fixing it. What if one of the most effective ways to get your health back is something so small yet so influential that, without awareness and a microscope, it often goes unnoticed? The mitochondria are the energy-generating components of the cell that are responsible for virtually every bodily process. These “powerhouses” convert chemical energy into usable energy, creating ATP and dispersing it to keep things running. The mitochondria aren’t invincible, however. When conditions such as illness, metabolic dysfunction, free radical accumulation, and inflammation occur, mitochondrial dysfunction becomes a real issue. NNB Nutrition is an innovative ingredient development company with an elite team of over 100 scientists from over 10 countries. Given how important the mitochondria are to our health, it’s imperative that we address their functioning and ensure that they’re running efficiently. Not only will these literally create more energy for us to use, but it also helps facilitate proper functioning elsewhere in the body. Exercising appropriately, eating nutrient-rich foods, and even introducing science-backed supplement ingredients are all ways to promote effective mitochondrial health. It’s awfully difficult to stay energized, stay motivated in the gym, or shed a few extra pounds when the body isn’t running as efficiently as it’s built to do. Instead of reaching for that next cup of coffee or a product touted as a “magic fix,” consider looking deeper on a micro-level. Restore optimal health by feeding your mitochondria the nutrients they need to work as the robust energy-generators they’re meant to be! Subscribe to PricePlow's Newsletter and Alerts on These Topics Topic Blog Posts YouTube Videos Instagram Posts C8Vantage CaloriBurn CurcuPrime KetoVantage MitoBurn MitoPrime NNB Nutrition ZinjaBurn Your Email: Sign Up References “Anatomy.” MedlinePlus, U.S. National Library of Medicine. 20 Aug. 2020. https://medlineplus.gov/anatomy.html Alberts, Bruce. “Energy Conversion: Mitochondria and Chloroplasts.” Molecular Biology of the Cell. 4th Edition., U.S. National Library of Medicine. 1 Jan. 1970. https://www.ncbi.nlm.nih.gov/books/NBK21063/ “Mitochondrion – Much More than an Energy Converter.” British Society for Cell Biology. https://bscb.org/learning-resources/softcell-e-learning/mitochondrion-much-more-than-an-energy-converter/ “The Origin of Mitochondria and Chloroplasts.” Nature Education. https://www.nature.com/scitable/content/the-origin-of-mitochondria-and-chloroplasts-14747702/ G. Steinert, et al. “Diversity of Mitochondrial Genome Organization.” Biochemistry (Moscow), SP MAIK Nauka/Interperiodica. 1 Jan. 1970. https://link.springer.com/article/10.1134/S0006297912130020 “Mitochondrial DNA – Genetics Home Reference – NIH.”. U.S. National Library of Medicine. National Institutes of Health. https://ghr.nlm.nih.gov/mitochondrial-dna “Structure of Mitochondria.” Mitochondria Structure. https://www.ruf.rice.edu/~bioslabs/studies/mitochondria/mitotheory.html Schenkel, Laila Cigana, et al. “Formation and Regulation of Mitochondrial Membranes.” International Journal of Cell Biology. Hindawi. 22 Jan. 2014. https://www.hindawi.com/journals/ijcb/2014/709828/ Alberts, Bruce. “The Mitochondrion.” Molecular Biology of the Cell. 4th Edition., U.S. National Library of Medicine. 1 Jan. 1970. https://www.ncbi.nlm.nih.gov/books/NBK26894/ Osellame, Laura D et al. “Cellular and Molecular Mechanisms of Mitochondrial Function.” Best Practice & Research. Clinical Endocrinology & Metabolism vol. 26,6 (2012): 711-23. doi:10.1016/j.beem.2012.05.003. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513836/ “Pyruvate Dehydrogenase and the Citric Acid Cycle.” http://watcut.uwaterloo.ca/webnotes/Metabolism/TCAcycle.html Reddy, P H, and T P Reddy. “Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases.” Current Alzheimer Research vol. 8,4 (2011): 393-409. doi:10.2174/156720511795745401. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295247/ Nicolson, Garth L. “Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements.” Integrative Medicine (Encinitas, Calif.) vol. 13,4 (2014): 35-43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449/ Swerdlow, Russell H. “Brain Aging, Alzheimer’s Disease, and Mitochondria.” Biochimica et Biophysica Acta vol. 1812,12 (2011): 1630-9. doi:10.1016/j.bbadis.2011.08.012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210037/ Konradi, Christine et al. “Molecular Evidence for Mitochondrial Dysfunction in Bipolar Disorder.” Archives of General Psychiatry vol. 61,3 (2004): 300-8. doi:10.1001/archpsyc.61.3.300. https://pubmed.ncbi.nlm.nih.gov/14993118/ Nicolson, Garth L. “Metabolic Syndrome and Mitochondrial Function: Molecular Replacement and Antioxidant Supplements to Prevent Membrane Peroxidation and Restore Mitochondrial Function.” Journal of Cellular Biochemistry vol. 100,6 (2007): 1352-69. doi:10.1002/jcb.21247. https://pubmed.ncbi.nlm.nih.gov/17243117/ “Mitochondrial Myopathy Fact Sheet.” National Institute of Neurological Disorders and Stroke. U.S. Department of Health and Human Services. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Mitochondrial-Myopathy-Fact-Sheet Rich, Peter R et all. “The Mitochondrial Respiratory Chain.” Essays in Biochemistry vol. 47 (2010): 1-23. doi:10.1042/bse0470001. https://pubmed.ncbi.nlm.nih.gov/20533897/ Eades, Michael; “A New Hypothesis of Obesity”; February 12, 2020; https://proteinpower.com/a-new-hypothesis-of-obesity/ Dobromylskyj, Petro; “The Protons Theory of Obesity”; 2013-2020; http://high-fat-nutrition.blogspot.com/ Kroenke, K, et al. “Chro
50 minutes | 5 months ago
#033: Ben Hartman - Morphogen Nutrition
In June of 2020, Ben and Heather interviewed Ben Hartman of Morphogen Nutrition. They discuss Ben and Morphogen’s background, the insane formulations in their arsenal, the lack of studies on interactions between ingredients, the future of Morphogen, and more! Meet Ben Hartman of Morphogen Nutrition! Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post Ben Hartman - The Rise of Morphogen Nutrition | Podcast #033 first appeared on The PricePlow Blog.
42 minutes | 8 months ago
#032: Shawn Wells #5 | MCT Oil (Medium Chain Triglycerides)
Prepare to learn everything you need to know about MCT Oil, or Medium Chain Triglycerides Lifestyle, training, and diet are the three overarching umbrellas that affect our health and fitness goals, and figuring out how to best balance them is unique from person to person. For instance, someone trying to lose body fat trains differently, eats differently, and goes about their day differently than a powerlifter on a strength cycle. But central in almost any fitness plan is nutrition. Although needs shift from person to person, eating nutrient-dense foods full of essential minerals, fats, and amino acids (protein) is at the root of any diet. MCT Oil: The saturated fat for training both your body and your mind! When we say “nutrient-dense” and “essential”, there is a great amount of misunderstanding. Our take is that a highly-misunderstood “essential” fat is saturated fat, and a group of these increasingly popular fats are in the group of medium chain triglycerides, which boast powerful health benefits. Otherwise known as MCT (or MCT Oil), these critically useful fatty acids are finally getting recognition like other important fatty acids. As a high-quality source of dietary fat, MCTs have a ton to offer, with evidence supporting it can yield positive effects in your training, your body, and your mind! TL;DR (Article Summary) MCT Oil, short for medium chain triglycerides, are a group of saturated fatty acids that are quickly-absorbed for rapid energy thanks to their shorter structure. Saturated fat is healthy. There is no causal link whatsoever between saturated fat and heart disease or obesity. In fact, the obesity crisis began when we collectively replaced saturated fat with omega-6 polyunsaturated fats from “vegetable oils”. (See the saturated fat discussion) The medium chain triglycerides, or “MCTs”, are a group of saturated fatty acids with “medium” chain lengths, ranging from six to twelve carbon bonds. These fatty acids caproic acid (C6), Caprylic acid (C8), Capric acid (C10), and Lauric acid (C12). (See the MCT Intro section) When supplemented, MCTs demonstrated the following benefits: Decreased appetite (through increased satiety), increased cognition, improved beta-oxidation (fat burning) rates, better gut health, and potential immune system improvements. (See the MCT oil benefits section) When looking for quality MCT Powder, C8 (Caprylic Acid) is the way to go, and C8Vantage from NNB Nutrition is where to get it. Read more here and on NNBNutrition.com Due to unfavorable characteristics of C6 and C12, C8 and C10 are the preferred MCTs to supplement, with C8 having the best data in terms of beta oxidation and ketone generation. (See the MCT Supplements section) Preferred MCT Oil Products: For powdered MCT Oil, we prefer C8Vantage, which is made by NNB Nutrition and is a nearly-pure C8 formula that is GMO-Free, vegan-friendly, and has no glycemic impact since it is plated on tapioca prebiotic fiber and pea protein, bt other dairy-based options are available as well. For liquid MCT Oil, we prefer Nuton Brainfood, which comes in C8-only and C8+C10 versions. (See the MCT oil products section) In this post, we’re going to take a deep dive into MCTs – what they are, why they’re different, how to use them, and where you can find the best ones – both in liquid and powder form. We’re also going to look at published research focused on MCTs, which will help us paint a clearer picture of their benefits. Brace yourself for an in-depth, science-backed look at a food seemingly built for athletic and cognitive performance! Before going further, feel free to subscribe to our notifications to get alerted on deals, videos, and blog posts on any of the topics on this page, as there are always ongoing updates and newer research: Subscribe to PricePlow's Newsletter and Alerts on These Topics Topic Blog Posts YouTube Videos Instagram Posts C8Vantage MCT Oil NNB Nutrition Your Email: Sign Up MCTs – the optimal fat source for efficient energy? Before we can get into medium-chain triglycerides (MCTs) and all they have to offer, it’s imperative that we begin by discussing dietary fats in general, and what separates the MCTs from the rest. Saturated Fat is back on the menu, folks! And if you still don’t want red meat, MCTs are a great source of healthy saturated fats. Read the research and see how saturated fat is not associated with heart disease. Not so long ago, dietary fats were portrayed as a common enemy by Western governments and their sponsors. The distorted theory that “dietary fat leads to body fat” only paints half of the picture, and we’ve begun to understand the importance of quality dietary fat within the sphere of living a healthy lifestyle. In appropriate amounts, fats are imperative for overall health, especially in regards to keeping your heart in check. That being said, not all fats are created equal – there are multiple “groups” of fats, some of which are superior to others – and others that are downright toxic and obesogenic. For instance, it’s well-agreed that monounsaturated fats from meat, nuts, and fruits like olives and avocados are quite beneficial, and omega-3 polyunsaturated fatty acids from fish are incredibly healthy. However, not all polyunsaturated fats are the same — omega-6 polyunsaturated fats from “vegetable oils” are highly obesogenic and inflammatory. But what about saturated fats? What to make of saturated fats The “saturation” of Saturated Fats’ carbon atoms makes it more stable and less prone to oxidation or rancidity. The less we eat of them, and the more omega-6 polyunsaturated fats like linoleic acid we eat… the sicker we get. The picture seems to be a bit cloudier when discussing another important group of fats, saturated fats. This family of dietary fats are different in a couple of ways, especially in their construction: saturated fats have no double bonds between any carbon atoms, whereas unsaturated fatty acids do. In other words, each carbon atom is completely saturated with hydrogen atoms, yielding a far more stable bond structure, and less likely to go rancid like polyunsaturated fats. Saturated fats are commonly found in animal products, heavy dairy products, and coconut oil, one of the top MCT sources available. But as we’ll see below, coconut oil itself isn’t the best way to get MCTs in. First, let’s dive deeper into the controversy of saturated fat: The research on saturated fat conflicts with modern recommendations from “authorities” While there seems to be a consensus in the stances on unsaturated fats, there is a high level of dissonance regarding saturated fats. There seems to be an unwarranted stigma towards them, even though science doesn’t support the notion that saturated fats are hazardous: Research suggests that saturated fats actually improve cholesterol levels and composition by enlarging the size of low-density lipoprotein (LDL) cholesterol molecules. This is important, considering that larger LDL molecules may reduce the risk of heart disease! A 2015 meta-analysis of 76 studies found no relationship between saturated fat and heart disease. The data is simply not there to connect saturated fat and heart disease risk. Other factors must be at play. But two things are for sure: trans fats are bad news and omega-3’s are very good. A 2019 re-analysis of the research used by the “American Heart Association” suggesting limits on saturated fat intake actually determined that their trials contained methodological flaws and didn’t even meet acceptable modern standards for inclusion. The “4 Core Trials” used by the American Heart Association to push saturated fat elimination are woefully poorly done and out of date. It included a meta analysis of 19 studies (10 of which were randomized controlled trials) showing a lack of association between saturated fatty acid intake and heart disease. Americans did listen to the food guidelines.. and we got sicker and fatter than ever. Are we sure red meat, saturated fat, and cholesterol are really the issue?! If saturated fat is unhealthy, then why did we get sicker when we stopped eating them? As you can see, the bad rap that saturated fats get are quite overstated. There was no obesity epidemic when we were eating plenty of red meat and butter. In fact, the epidemic started when we stopped eating saturated fats, and switched to the toxic omega-6 polyunsaturated fats from vegetable oils. The data supports that saturated fat intake is something that’s fine in amounts that don’t cause you to gain weight. As a dieting adult, you shouldn’t eat anything to the point of fat gain, and you certainly shouldn’t be completely excluding it either! Now that we’ve briefly touched on the different types of fats and the research around them, we can start discussing MCT oil, a type of saturated fat that has significant benefits when consumed responsibly! Medium-chain triglycerides – faster metabolization, faster availability Also known as Caproic Acid, Hexanoic Acid (C6) is a potent MCT, but yields a burning sensation in the throat, which is why it’s not used in supplements. Earlier, we mentioned the carbon construction of fatty acids, and this becomes pertinent with MCTs. The name “medium-chain triglycerides” is actually derived directly from that molecular build – MCTs are fatty acids with somewhere between six to twelve carbon atoms. There are four different MCTs, some combination of the which ultimately comprise MCT oil: Caproic acid (C6) – six carbon bonds* Also known as octanoic acid, Caprylic Acid (C8) is the most effective MCT for oral supplementation. Caprylic acid (C8) – eight carbon bonds Capric acid (C10) – ten carbon bonds Lauric acid (C12) – twelve carbon bonds** *Caproic acid (C6), also known as Hexanoic acid, is normally filtered out because it causes a burning sensation in the throat and great gastrointestinal distress, although it is very ketogenic. Capric Acid (C10) is also known as decanoic acid and is an effective MCT to supplement, although not as effective as C8 in some research. **Lauric acid (C12) is hotly debated, as it behaves more like a long-chain fatty acid and doesn’t provide the near-immediate energy like C8 and C10. It’s typically suggested to use MCT oils without it, which is discussed later. The overall length of these acids is the key differentiator between them and other fats – long-chain triglycerides (LCTs), as the name suggests, have more carbon bonds. Why does this matter? Because the length of the molecule is ultimately a key factor in terms of how the body absorbs and utilizes the fatty acid! Smaller construction allows for faster breakdown Lauric Acid (C12) is the most inferior of the MCTs, and behaves more similarly to a long-chain fatty acid than the others. The best MCT Oil supplements remove it. When most dietary fats are consumed, the digestive system calls on pancreatic lipase and bile to help break them down. This is not the case for MCTs, however – MCTs bypass this mechanism and are instead absorbed through intestinal cells directly into the portal vein. Thus, MCTs are digested faster than LCTs. Research suggests that MCTs are absorbed at rates that rival glucose, one of the fastest-absorbed nutrients in foods. Beta oxidized into ketones and ATP – not stored as body fat! Once within portal circulation, MCTs are swept up by the liver, where they then enter the mitochondria and undergo beta-oxidation, resulting in usable energy. This process yields excess acetyl coenzyme A (acetyl-CoA), which is re-routed for a rather interesting use – ketone production! It’s also worth noting that virtually all of this excess acetyl-CoA goes towards ketogenesis, with almost nothing going towards body fat creation! 8.3 calories per gram? Several studies and books state that there are “8.3 calories per gram of MCTs”[15,16] as opposed to 9.1 calories per gram in longer-chained fatty acids. However, upon further inspection, we cannot find the original source data for that claim, so it may need to be re-tested with modern equipment. MCTs undergo an incredible breakdown within the body – they essentially turn into two forms of usable energy – adenosine triphosphate (ATP) and ketones. ATP is the body’s preferred energy source, and the body can efficiently burn through ketones to produce more ATP — realize that glucose isn’t the only energy substrate! When ingested, MCTs are quickly made readily available, making them attractive to someone looking to rev up their metabolism and get their day going. Believe it or not, that’s not all MCTs bring to the table, either! There are numerous benefits that can be had, including potential weight loss, enhanced cognitive performance, and fending off cardiovascular disease: MCT Oil Benefits: Research supporting MCTs Although the term medium chain triglyceride was first mentioned in literature in 1949, the first MCTs were discovered in 1818 by Michel Chevreul, who discovered both capric acid and caproic acid and lived to be 102 years old.[18,19] There has been a great deal of research on them throughout time, especially in the 1960s, and it has continued into the 2000s as neurodegenerative diseases took hold of people’s lives, and they were seen as potential solutions. Below are the main areas of research that drive people to try MCT supplements: Weight-loss agent The mechanisms at play in the digestion and absorption of MCTs propose the possibility of an energy source that is fully utilized, but that’s not entirely the case – you still have to move enough to burn the readily-available energy! However, assuming your diet and activity is in check, MCTs can potentially bring some weight loss benefits to the table. Modulating hunger via increased satiety Research published in 2001 set out to understand the effect MCTs could have in overall satiety after a meal, since weight loss really involves satiating hunger without overeating. It turns out that saturated fats are incredible for doing so. In 10 male subjects, scientists tested the effects of four different meals – a “normally-structured” meal, one with an extra 300 calories of LCTs, another with an extra 300 calories from MCTs, and one with 215 calories from carbs and 75 calories from LCTs. While the overall energy expenditure remained consistent across meals, the scientists found that the meals heavier in fats, as expected, increased fat oxidation. But more importantly to most dieters, they also found that the MCT lunch significantly reduced dinner food intake compared to the other lunches. Averaged across four tests, those who received large amounts of MCT for lunch at significantly less at dinner! This suggests that MCTs may be able to keep you feeling full longer, which can help you keep caloric intake down when dieting! It is possible that one of your hunger signals is actually a signal for more saturated fat or even MCT itself, and by eating it, your body will not need to signal hunger as frequently, as it is getting what it requested. Stimulating appetite-controlling hormones: Leptin and PYY improvements MCT Oil leads to better short-term effects on blood sugar, insulin, and triglycerides than long-chain fatty acids. Another study from 2015 may explain why MCT oil can have this satiety-enhancing effect. In two single-blind, crossover studies, a total of 17 men were recruited in an effort to study the effects MCT and LCT oils had on hormones and other genetic expressions after consumption. They utilized a concept called “pre-loading”, in which subjects were given yogurt mixed with oil prior to lunch. In cross-analyzing the two studies, scientists found that the MCT oil-rich yogurt resulted in less food intake than the LCT oil-rich yogurt. Thanks to blood tests conducted, they were also able to identify why that was – MCT oil consumption elevated leptin and peptide YY (PYY) levels. Leptin, the hormone responsible for controlling appetite, and PYY, a powerful gut hormone, are both positively correlated to satiety. As evidenced in this study, elevated leptin and PYY activity can help you feel full longer. It’s important to note that this study did find some unexpected results regarding the hunger-stimulating hormones ghrelin and GLP-1, and stated more investigation was necessary to understand the overall effects of MCT oil. But improvements to leptin and PYY signaling is incredibly important, given that obese individuals have damaged leptin response. More caloric expenditure There is also research supporting the notion that MCT oil can fire up the metabolism and increase energy expenditure, something incredibly important when discussing weight loss. A study from 1991 analyzed the metabolic function of a mixture of lean and obese men, split into two groups – one was given MCT oil, while the other was given LCT oil. They found that six hours after consumption, those given MCTs burned more calories than those who did not, with a 48% increase shown in the lean subjects and a 65% increase shown in the obese subjects. These numbers are clearly nothing to scoff at! Following a meal with MCT as opposed to LCT, energy expenditure is far higher in both lean and obese subjects. Circumnavigating the pitfalls of CICO When it comes to weight loss, caloric expenditure is a major piece – you’ve heard it before, “calories in versus calories out.” Burn more calories than you consume, for a prolonged period of time, and you should see a few drops in body weight. Makes sense, but we’ve been told that for decades and it’s obviously not working. What nobody mentions is that the types of “calories in” affects the “calories out”. Further, the types of “calories in” also affect downstream hunger. With both increased energy expenditure and suppressed appetite seemingly at its disposal, it reasons that MCT oil should help an individual lose weight by both increasing the “O” and helping you decrease the “I” in that dreaded CICO paradigm! Fat loss in overweight individuals These appetite-blunting, metabolism-boosting effects were put to a more direct test in a study from 2008. In this experiment, 49 overweight individuals consumed between 18g to 24g per day of either MCT oil or olive oil, which consists heavily of the monounsaturated omega-9 fatty acid, oleic acid. The metrics of interest here were body weight, fat mass, and waist circumference, which were measured at the beginning of the study and after 16 weeks following the outlined protocol. Upon completion of the study, they found that the MCT oil subjects lost more body weight than the olive oil group, while also seeing significantly more total fat loss and less abdominal adipose tissue in the MCT group as well! Though this study didn’t explicitly credit the appetite-controlling properties MCTs have displayed in other research, one can posit that they played a crucial role here! Attack hunger, not “calories”. Meta analyses confirm modest weight loss benefits In this study, both MCT oil and olive oil based diets worked, but MCT worked far better. The above studies were not flukes, either. In 2015, two different meta analyses were published, analyzing 11 and 13 trials, all where MCTs replaced LCTs.[26,27] Both concluded that MCTs yielded statistically significant (yet sometimes modest) reductions in body weight, body composition, and waist circumference without adversely affecting lipid profiles. Both studies also concluded that more rigorous trials would be helpful, as always is the case. A realistic perspective: omega-6:omega-3 ratio is still in the driver’s seat for health It’s imperative to understand that losing weight is generally a multi-pronged effort. Despite the science supporting MCT oil in terms of burning some extra calories, you can’t reasonably expect it to do all the work for you. We liken adding MCT oil to a diet full of addictive processed foods to putting “lipstick on a pig”. For instance, if your omega-6:omega-3 ratio is still massively high, you’re still putting yourself at risk for a serious number of hazardous conditions. Yes, a little MCT can surely help, but remember, MCT oil is a supplement to a weight-loss regimen, not the nucleus of it! MCT oil and the ketogenic diet While we won’t spend too much time discussing MCT oil and the ketogenic diet, it’s almost impossible to talk about one without mentioning the other! The keto diet is among the most popular diets/lifestyles in the fitness world today, so you’ve likely heard of it before. Without getting too complex, it means going ultra low-carb, forcing the body to produce ketones as its primary fuel source (as opposed to glucose). For the purposes of this post, we focus on how MCT oil can help those in a ketogenic state. Beta Oxidation of fatty acids leading to Ketogenesis. Why would you NOT want to live in a state where this is easily accessible and not blocked by insulin spikes from carbs? Note that BHB is the primary ketone made, but we were highlighting acetone for another blog post. Sadly, by gaining a pound per year, few every really get to really experience the glory of this process. As we’ve seen thus far, there is some pretty convincing research suggesting that MCT oil can help generate ketone bodies, particularly beta-hydroxybutyrate, upon ingestion.[14,28] Further, it may induce transition to ketosis faster, and alleviate symptoms of the “keto flu”! “You burn what you eat” Most people have heard the phrase “you are what you eat”, but Shawn Wells, Chief Science Officer of NNB, prefers to say “you burn what you eat”. If you eat a diet whose calories are mostly from fat sources, you become efficient at burning fat. If you eat a diet whose calories are mostly from carbohydrates, you become efficient at burning sugar. The carbs + fat combo is where the real trouble lies.. but MCT may be the outlier there The trouble often lies when mixing carbohydrates and fats together, which is generally only found in processed foods like pizza, ice cream, chocolate, potato chips, cookies, french fries, etc. The issue in these cases is that the blood sugar spikes and the ensuing elevation of insulin both displace beta-oxidation (fat burning),[30,31] so when you ingest both carbs and fats at the same time, your body must prioritize burning the sugar and has nothing to do with the fat but to store it! You can’t burn fat as well while you’re busy burning sugar! MCT, however, may work around this! Given that it doesn’t act like a normal fat, and gets oxidized into acetyl-CoA and ketones as opposed to stored directly as fat,[13,14] there’s a better chance it can be used by all types of dieters: Ketosis not necessary to generate ketones with MCT! What’s interesting about the ketone production effect is that it doesn’t seem to require one to be in ketosis. Instead, MCT oil seems to promote ketone production regardless, meaning that, in theory, the brain-boosting effects should be attainable for “sugar burners” too. Low-carb and ketogenic diets definitely bring many metabolic benefits, but it’s unclear if they’re due to the reduction of glucose and insulin or the benefits of ketones. The truth is likely somewhere in the middle. But if there are indeed any therapeutic benefits of the ketones themselves, then it stands to chance that MCT ingestion can be helpful for anyone, even if they don’t follow a strictly ketogenic diet. For someone in ketosis who is fat-adapted, however, the effects from MCT anecdotally seem heightened, as there is little glucose to compete for “oxidative priority”. Gut-health booster One key variable often linked to weight loss that’s received more attention lately is gut health. Keeping the gut microbiota in good shape has been linked to various benefits, including its ability to help ward off disease, particularly metabolic diseases linked to obesity. Inversely, non-optimal gut microbiota has been related to disease states ancillary to obesity, such as excess inflammation and insulin resistance.[32,33] An analysis from 2016 provided evidence for a potential way to address such microbiota imbalances – MCT oil! This review, citing five separate (non-human) studies, suggests that MCT supplementation can help improve gut bacteria balance and overall intestinal health. Given the importance of keeping the gut happy for your total well-being, not to mention its relevance in any weight-loss effort, MCT oil may be a great way to help your gut work the way it’s supposed to. Some exercise benefits Although the readily-available energy supplied by MCT oil doesn’t necessarily give you a super-heroic energy boost in the gym, it does have some training-specific benefits that are worth pointing out: Decreased lactate levels MCT Oil greatly increased the time to exhaustion in these cyclists. Research published in 2009 drew some noteworthy conclusions when testing the effects of MCT oil on lactate levels in trained individuals. Lactate buildup is notorious for hindering workout performance, mainly related to both soreness and fatigue. In this study, trained cyclists were split into two groups – one was given 6g of MCTs daily, while the other received 6g of LCTs. After following this regimen for 14 days, those given MCTs had lower lactate levels and lower rate of perceived exertion (RPE). These two effects are positively related – feeling less tired and sore generally leaves you feeling less exhausted as well. In addition, this same study also found that MCT oil increased fat oxidation, an effect that should jump out to anyone chasing fat loss goals. By enhancing fat oxidation, or shifting towards the burning of fat for energy, the body may be more willing to shake some hard-to-lose body fat! The trick, there, being that you want to burn more fat beyond the MCTs you’re putting in — eg. your own body fat! The study concludes by suggesting the potential of MCT oil supplementation of boosting exercise performance, which even in the slightest amounts, is something we can all appreciate! MCTs and cognition The other major area of focus regarding medium chain triglycerides is their supposed ability to improve cognition. If MCTs yield ketones, and ketones are an incredibly effective source of energy for the brain — the relationship here makes sense. But let’s look at the research on some disease states. Alzheimer’s Disease as “Type 3 Diabetes”? First, note that there is a great deal of research demonstrating a connection between neurodegenerative disease and insulin resistance, where there is so much “energy toxicity” or “sugar saturation” that the cells refuse to accept more glucose. The connection is so strong that many consider Alzheimer’s Disease to be “diabetes of the brain”, or “Type 3 Diabetes”.[38,39] With the brain no longer responding well to glucose, researchers began investigating if brain cells would prefer ketone bodies. And one way to quickly get and test those ketones without severely modifying the diet is to supplement with MCT oil: Research on MCT for neurodegenerative disorder MCT yielded incredible memory improvements in memory-impaired adults without the APOE-ε4 allele. Research from 2004 tested the effects of MCTs in older adults with memory issues, specifically Alzheimer’s disease. On two different days, 20 subjects were given either a drink containing 40ml of MCT oil or placebo, and were tested on the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-cog). They found that those given MCT oil performed better on the ADAS-cog, however, only those who did not possess APOE4 (a genetic risk factor of Alzheimer’s) showed improvement. Inhibited glucose uptake? Send in ketones via MCTs! A study published in 2018 presents a possible explanation for how MCT oil was able to improve cognition in those Alzheimer’s patients. One particular symptom of Alzheimer’s is an inhibition of glucose uptake by the brain, which plays a role in the overall cognitive decline experienced by those diagnosed with the disease. This study administered two different MCT oil supplements, each with different concentrations of specific fatty acids, to Alzheimer’s patients and tested for two metrics: brain ketone and glucose uptake. They found that both MCT oil supplements increased plasma ketones, brain ketone uptake, and total brain energy metabolism without affecting glucose uptake. MCT oil effectively provided a source of energy for the brain, and did so in a very challenging environment. While the above two studies used a very specific group of people, they do leave some hope for a more widespread application – working around insulin resistance. If glucose isn’t able to be utilized, MCT oils offer a viable, efficient (and potentially preferred) alternative for fuel. This potential ability is useful in and of itself, but its importance is only heightened when the conversation shifts to a niche within the weight loss world – keto dieters! Immune system support? The in vitro data suggests it! It’s a very large dose, but taking 30g high-quality MCT Oil 3x/day will greatly reduce the ‘keto flu’ and decrease time to ketosis Researchers have been fascinated by the ways MCTs modulate characteristics of the immune system, since they behave very differently than other fatty acid chains in terms of its anti-inflammatory responses. It’s important to realize that the following studies are in vitro, but given that MCTs are largely transported “as is” until beta-oxidation, the following data is of extreme interest. Studies have recently shown that MCTs have an overall anti-inflammatory effect, but actually activate human neutrophils,[42-46] which are a type of white blood cell that respond to “injury” sites and help defend against invading pathogens. Highly interesting is that much this research was on respiratory immune cells. This seems to present a “best of both worlds”, in which MCTs are simultaneously anti-inflammatory in the greater picture, but activate the protective pro-inflammatory compounds for the immune system! Of course, more in vivo human data is required in order to make actual immune claims, but MCTs are promising and the above effects do not happen with longer-chain fatty acids! The keto / immunity question: growing animal data supports low-carb. Will humans follow? In 2019, a major immune study on mice and influenza was published, with an accompanying news article titled “Ketogenic Diet Helps Tame Flu Virus”. This caught headlines and controversy around the world, given that it was performed on mice, but it adds a useful data point. The surprise finding was that the ketogenic diet “activates a subset of T cells in the lungs not previously associated with the immune system’s response to influenza, enhancing mucus production from airway cells that can effectively trap the virus”. To further this case, in 2019 and 2020, it was discovered that infection of a novel virus was most harmful to patients with hypertension and type 2 diabetes[49-51] (as diagnosed with chronically elevated blood sugar levels and HbA1c). It is debated whether or not the drugs for those conditions play a role, or the conditions themselves do, but regardless, the connection is quite strong. Does MCT belong in the picture of an immune-boosting ketogenic diet? We believe it does. Learn about C8Vantage from NNB Nutrition here and on NNBNutrition.com It has been demonstrated that well-managed (e.g. calorie-controlled) low-carbohydrate diets improve both glycemia[52-56] and hypertension,[54-56] with the studies lasting four months, one year, and then two years, respectively. In a significant number of patients, the ketogenic diet lowered HbA1c levels to the point where their diabetes diagnosis was reversed, and for many, in remission! It can be debated if those patients would suffer long-term consequences of their former lifestyles that would hamper their immune systems, but connecting the dots, it can be strongly argued that a well-constructed ketogenic diet is beneficial to the immune system, especially for those who are hypertensive and/or diabetic and are able to use them to reduce those conditions and lose weight. What does this have to do with MCT? As mentioned above, low-carb diets go hand-in-hand with MCT oil supplementation. But given MCT’s ability to simultaneously suppress appetite[21,22,25] and increase beta-oxidation,[13,57] they can play a dual role in getting to those lowered metabolic numbers more quickly. Is keto-adaptation beneficial? To be determined in humans However, in the 2019 ketogenic mice influenza study, the researchers found that merely providing more ketones was not protective against influenza. The mice that received the most protection were truly fat adapted via diet, leading researchers to require further study into the mechanisms at hand. This leads us to believe that MCT supplementation on top of a poor diet may not improve immune function nearly as MCT as a part of low-carb diet that lowers hypertension and HbA1c, but more research is definitely needed. MCT oil supplements: What to get and why? As the market for health foods has grown exponentially in the past decade, we’ve been introduced to countless nutritious “superfoods”. The ones that are truly impactful, such as MCT oil (or even coconut oil, which has MCTs), find themselves incorporated into different products and supplements, too. But not all MCTs are alike, especially when looking at the constituents of coconut oil! Coconut oil: too much C12 and C14! With so much evidence supporting the presence of MCT oil within your diet, you must be wondering the best places to find it. When cooking and looking for an added sweet flavor, look no further than coconut oil, perhaps the easiest source of MCTs to find. However, coconut oil suffers from a major problem: a less-than-optimal MCT profile! Lauric Acid has some great benefits, but there’s tons of it in coconut oil. When you want the efficient MCTs, you want C10 and C8… and sometimes only C8. When breaking down the fatty acids in the medium chain triglyceride group earlier in this article, we listed Caproic acid (C6), Caprylic acid (C8), Capric acid (C10), and Lauric acid (C12). However, we briefly disclaimed that C6 is intensely unpleasant, and C12 is arguable because it does not work as quickly as C8 and C10, requiring additional processing in the liver. While lauric acid C12 is technically an MCT, it’s not the best one because of this. Meanwhile, C14 and up are LFAs, or Long-Chain Fatty Acids. And unfortunately, if you look at the data, you’ll see that coconut oil is composed of 47% C12 lauric acid, 16.5% C14 myristic acid, and 7.5% C16 palmitic acid.[58,59] This means that 71% of coconut oil is non-optimal if you want the best MCTs! So what’s wrong with C12? The issue with lauric acid (C12): Additional steps in the liver When looking at the metabolism speeds of fatty acids, the shorter chains work fastest, and the longer chains go slowest – with lauric acid (C12) somewhere in the middle, but up there with the longer chain fatty acids. Is lauric acid really a “medium chain triglyceride”? Not 100% – and that’s why it’s not in Nuton or C8Vantage! It is often said that lauric acid requires an additional “pit stop” in the liver, which is good enough for the layperson, but the research more specifically states that “[lauric acid] has a higher propensity to be absorbed via the lymphatics (presumably reflecting its greater capacity for incorporation into triglycerides), and so its access to the liver is delayed,” citing two further studies to boost this argument.[62,63] While that may not seem too bad — C12 still eventually yields some ketones and has great therapeutic benefits… there’s a bigger problem looming, and it may be the C12 causing these issues: gastrointestinal distress! And unfortunately, standard MCT oil has way too much of it. Standard MCT oil: too much lauric acid… and too much diarrhea! Just like coconut oil has too many long chains, regular MCT oil may as well. Some research shows that lauric acid (C12) may constitute about 30% of standard MCT oils on the market. This isn’t bad, but it’s not optimal. Is lauric acid the gut buster in MCT studies? But it gets worse – far worse. High doses of MCT (such as 50g per day) yielded to a 100% diarrhea incidence in one study! It is also a commonly observed side effect in other studies. However, anecdotally, when removing the C12 from MCT, the diarrhea side effect seems to go away! This information helps us hone in on our ideal MCT supplement – especially when you see the uniquely specific benefits of C8: C8 Caprylic Acid: Four times better at producing ketones! C8 MCT Oil does some amazing things compared to the other fatty acid chains over the next few hours! As opposed to C12, C8 caprylic acid, also known as tricaprylin, is both fast and effective: A research study showed that MCT C8 (yielded 300% (4x) more ketones than coconut oil and 21% more ketones than “standard” MCT oil! In addition, it gave the best ketogenic effect in the 4-8 hour window, yielding longer-lasting effects. This is extremely interesting because its effects are both faster and longer-lasting! C8 Beats C10 in Fat Oxidation Another research study published in 2017 found that C8 gave a 4x rate of beta-oxidation over C10! The researchers explained the difference by stating C10 depends more on CPT1 (carnitine palmitoyltransferase I) activity. So just like C12 has additional processing and absorption in the liver, there are a few dependencies that C10 has more so than C8. This leads us to recognize that C8 is the superior MCT, but C10 is not far behind. Which you get ultimately depends on availability and budget. MCT oil vs. powder: depends on the application The popularity of MCT oil has created quite the market for it within the supplement industry. You could always get your hands on liquid MCT, but there are now powders and several types of supplements that utilize MCTs inside as well! MCT oil: C8 or C8+C10 options from Nuton Brainfood In 2017, we wrote about Nuton Brainfood, which originally came as a C8 + C10 combination. They’ve since created a C8-only option, given the most recent research. As you’d expect, the C8-only option is a bit more expensive, so you can choose according to your budget. These have been our go-to MCT oils, and Nuton’s spill-free pour spout is a nice touch. Nuton Ultra Premium MCT Oil (C8 only) - Deals and Price Drop AlertsGet Price AlertsGet Ultra Premium MCT Oil (C8 only) Price AlertsGet Nuton alertsGet MCT Oil price drops Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. MCT powder: More convenient but beware of the “binders” – Go with NNB C8Vantage Because of their versatility and ease-of-use, we’re huge fans of powdered MCT oil, which can be easily tossed into some coffee, protein powder, or any other food or drink when needed! If looking for a convenient option, MCT powders are where it’s at. The benefits of MCT, especially with respect to C8Vantage. Image courtesy NNBNutrition.com But there’s an issue with many of the powders on the market though: they use high-glycemic carbs as binders! You see, in order to take liquid MCT to powder form, it needs to be sprayed against a dry surface and bound to a dry agent. And that agent is far too often maltodextrin, which is an extremely high-glycemic carbohydrate that might as well be labeled as “sugar”. If your MCT powder doesn’t state exactly what it’s bound to… then there’s a great chance it’s bound to a carbohydrate like maltodextrin — the exact opposite of what MCT users want! The solution? A trusted supplier. One like NNB Nutrition: C8Vantage from NNB Nutrition solves the MCT powder puzzle One of the top MCT powders available is C8Vantage from NNB Nutrition, which brings forth a high-quality, optimized formula to help deliver everything we’ve talked about above! C8Vantage gets its name from its source – nearly 100% caprylic acid, or C8. NNB takes all-natural palm oil and isolates this MCT from everything else, removing any LCTs that may accompany it in its base form. What’s left is nearly pure C8 (over 95%!), which we believe is the main driving force behind the powers of MCTs, as shown in the research cited above.[28,57] Plated on plant-based tapioca fiber and pea protein, with other options available In order to create C8Vantage powder, NNB Nutrition plates the MCT on plant-based fiber (tapioca fiber) and pea protein, giving an end product with negligible blood glucose or insulin effect! This also makes it dairy-free, vegan-friendly, GMO-free, and sustainably-sourced. Ben showed the blood sugar effects (or lack thereof!) on our YouTube channel too: In addition, NNB Nutrition has options available, such as a coconut oil based one (rather than palm fruit), but that comes at a slightly higher price. Milk protein options are also available, which make it creamier for use in applications such as MCT coffee creamers for consumers that are fine with dairy. Taken from NNBNutrition.com, C8Vantage hosts several benefits over other MCT powders When it comes to providing the improved energy, cognition, and performance that MCT oil is capable of, C8Vantage may just be one of the best powdered options available. Don’t sleep on NNB Nutrition NNB Nutrition has been at the forefront of our feed for some time now, as they’ve been putting out a continuous stream of cutting-edge, high quality, lab-tested ingredients. We recently covered C8Vantage specifically as well, so if you want to read more about this product (and get the science specific to it), make sure you check out the article on it! Watch our videos on MCT Oil Mike from PricePlow and Shawn Wells of NNB Nutrition got together on IG Live to talk about MCT Oil, and then did a great round of Q&A: Mike’s older MCT / Ketone video You can also see Mike’s original video, exploring MCTs and their role with keto: Stacking opportunities On its own, MCT oil has a ton to offer. But use it in synchronization with other like-minded supplements, and you can build an effective stack that complements itself wonderfully. The easiest way to take MCT is alongside a quality protein powder (you’ll still need water) or in a homemade salad dressing. But in terms of your entire supplement stack, here’s what we’d suggest as the top stacking options: Glucose Disposal: Your Secret Weapon with GlucoVantage Dihydroberberine There’s no better GDA ingredient than berberine, and there’s no better form of berberine than dihydroberberine in GlucoVantage! To amplify the metabolic functioning benefits of MCT oil, you can benefit from using any glucose disposal agent (GDA) in tandem with MCTs. GDAs are best for optimizing blood glucose levels with meals, helping to shuttle nutrients to muscles where they’re needed and keeping them from being stored as body fat. When it comes to GDAs, nothing beats a high-quality berberine. NNB Nutrition offers one of the most innovative and powerful berberine ingredients in GlucoVantage. This ingredient actually uses dihydroberberine, a compound that is the next big thing in the GDA market! The enhanced fat-loss stack If MCT oil is a part of your regimen for its potential fat-oxidation and energy expenditure properties, using it in conjunction with popular fat-loss ingredients such as caffeine, L-carnitine, yohimbine, ashwagandha, synephrine, and grains of paradise could be great options too. These ingredients are all among our favorites here at PricePlow, and any combination of these, used responsibly, can make for an excellent fat-burning stack! L-Carnitine, for instance, is used as a fatty acid transporter, which will be necessary to get the fats to your mitochondria! Yet too many people are deficient, as people are eating less meat that is high in L-carnitine. Grains of paradise is a spice that helps convert white adipose tissue to the more thermogenic brown adipose tissue. NNB Nutrition makes CaloriBurn️, a highly-trusted form of this ingredient. BAIBA may add to the “exercise effect” NNB Nutrition has finally brought us a trusted and tested form of L-BAIBA, which we call an “exercise signal” that kickstarts incredible metabolic processes! If that’s not enough fat burning for you, allow us to introduce MitoBurn️, yet another innovative NNB Nutrition product. This next-level fat burner uses L-BAIBA to level up metabolic efficiency and can really help get your weight loss efforts in tow, making it a great partner for MCT oil. Satiety / Appetite Suppression: Look into stearic acid In terms of the satiety effects, we’ve become big fans of other forms of saturated fat as well. Consider stearic acid, which is found in animal fat as well as cocoa butter. Many are realizing that the MCT / stearic acid combination is an absolute appetite-killer. The authorities told us to stop eating saturated fat, and then everything went off the rails – including our hunger! Bring things back to normal by giving your body the “essential” saturated fats it needs, from both ends of the spectrum. Perhaps all of this hunger is due to our bodies requesting these saturated fats, which includes MCT! Yohimbine and caffeine, both mentioned above, may also help with appetite. Another ingredient to consider is saffron. Supplements for cognitive focus In terms of focus and cognition, there are tons of nootropic supplements out there. For beginners, our favorite three with incredible safety profiles are choline (specifically alpha-GPC or citicoline), acetyl L-carnitine (ALCAR), and L-tyrosine. We argue that anything that stabilizes blood sugar levels will also help with long-term cognition, so GlucoVantage dihydroberberine discussed above may also be useful. Supplements for Deeper Ketosis Looking to really hone in on the ketogenic aspects of MCT oil, one can benefit by adding other ketogenic supplements into their arsenal. Supplements that help promote ketone production, such as BHB salts, make for an excellent pairing with MCT oil. Our recommendation there? Check out NNB‘s KetoVantage, a high-quality BHB salt formula! MCT oil can be a regular part of any regimen, even if you’re simply looking to clear up a bit of brain fog. However, most stacking opportunities that are highly advantageous are related to either weight loss or the ketogenic diet, perhaps even both! Conclusion: Saturated Fat is Healthy. And MCT is very healthy! When looking for quality MCT Powder, C8 (Caprylic Acid) is the way to go, and C8Vantage from NNB Nutrition is where to get it. Read more here and on NNBNutrition.com It’s easy to get upset at the decades of disinformation provided by the “authorities” regarding saturated fat. It does not cause heart disease, and when we replaced it with all kinds of “frankenfats” from omega-6 polyunsaturated fatty acids (n-6 PUFA), literally everything went wrong. But the time for dietary regret is over. Now is the time for the solution, and the solution is bringing saturated fats back and dumping those disgusting “vegetable” oils (read: “seed oils”). Using MCT is a major piece to this puzzle. Showing the potential of providing efficient energy, increasing energy expenditure, correcting metabolic imbalances, and improving cognition, MCT is an incredibly well-rounded ingredient. It comes with caloric value as a dietary fat, sure, but is what we consider an essential fat you should have in your diet anyways! Especially when driven closer to C8, it’s superior to so many other fats, not only in absorption but also in its effects mentioned above. While fitness goals may vary – powerlifting, bodybuilding, cross-training, fat-loss, cognition, etc – MCT fits in the picture – regardless of diet. It’s time to bring back saturated fats. And it starts with MCT, mainly from C8. Subscribe to PricePlow's Newsletter and Alerts on These Topics Topic Blog Posts YouTube Videos Instagram Posts C8Vantage MCT Oil NNB Nutrition Your Email: Sign Up All Blog Posts with MCT Oil The Power of "Mito": Optimizing the Mitochondria to Unlock Clean Energy! Posted on: November 7, 2020The NNB Nutrition Story: Supplement Ingredient Solutions for the New Decade Posted on: September 21, 2020Nutrex Plant Protein Strawberries & Cream, What a Dream Posted on: September 17, 2020RYSE Supps Loaded Protein: A High Quality Protein Powder Packed With Flavor! Posted on: July 24, 2020Ryse Supps Loaded Bar: A Whey-Powered Meal Replacement Bar Posted on: July 15, 2020MCT Oil: The Dietary Fat Source Built for Efficient Energy Posted on: March 29, 2020Home Made: Axe and Sledge Makes MRPs Great Again Posted on: March 23, 2020C8Vantage: C8 MCT Powder for Maximum Energy, Clarity, and Performance Posted on: February 17, 2020Alpha Lipoic Acid (ALA): The Cognitive-Boosting Antioxidant Posted on: February 3, 2020Nutrex Lipo-6 Keto goFAT Gel: Energy Gels for Low Carb Athletes Posted on: December 3, 2019Nutrex IsoFit: Whey Protein Isolate That Tastes Like a Cheat Posted on: November 25, 2019SteelFit Steel Pump: Pre-Workout Strength Amplifier with Peak ATP Posted on: October 29, 2019MFIT Victus: A Hunger-Defeating, Comprehensive MRP! Posted on: September 24, 2019Nutrex Plant Protein: Vegan & Natural, yet Stevia-Free! Posted on: June 3, 2019SMRTCoffee is Coming! High-Focus Low-Carb Coffee on the Go! Posted on: January 9, 2019Fighting Disease with Shawn Wells | Podcast Episode #014 Posted on: September 11, 2018Beast BCAA Ripped: A BCAA Supplement Unlike Anything Else Posted on: May 5, 2018RedCon1 MRE Bar: Low-Dairy Protein Bar Stuns the Masses Posted on: February 27, 2018RAW Synergies Thermo Pre: 2-in-1 Fat Burning Pre Workout Posted on: December 21, 2017Keto Connect Podcast with Mike from PricePlow: Supplements for Keto | #4 Posted on: October 15, 2017Nuton Brainfood: Ultra-Pure MCT Oil with No Lauric Acid Posted on: August 21, 2017Ambrosia Ritual AM: Low-Carb Coffee Creamer by Marc Lobliner and Friends Posted on: June 21, 2017BPI "Best PRE Workout" - Is it Really Though? Posted on: May 10, 2016NutraBio Muscle Matrix MRP: An Athlete's Meal Posted on: January 25, 2016Animal MASS: Universal's Answer to Weight Gainers Posted on: August 25, 2015 References Zong, et al; “Monounsaturated Fats from Plant and Animal Sources in Relation to Risk of Coronary Heart Disease among US Men and Women.”; OUP Academic; Oxford University Press; 16 Mar. 2018; https://academic.oup.com/ajcn/article/107/3/445/4939332 Simopoulos, A; “Omega-3 fatty acids in inflammation and autoimmune diseases”; Journal of American College of Nutrition; 21(6):495-505; December 2002; https://pubmed.ncbi.nlm.nih.gov/12480795 Simopoulos, Artemis P; “An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity”; Nutrients; vol. 8,3 128; March 2, 2016; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808858/ Sebley, Caroline, and Tyler Cymet; “Saturated Fat”; Encyclopædia Britannica; Encyclopædia Britannica, Inc.; 1 Aug. 2016; https://www.britannica.com/science/saturated-fat Siri-Tarino, Patty W, et al; “Saturated Fat, Carbohydrate, and Cardiovascular Disease.”; The American Journal of Clinical Nutrition; American Society for Nutrition; Mar. 2010; https://pubmed.ncbi.nlm.nih.gov/20089734 Dreon, D M, et al; “Change in Dietary Saturated Fat Intake Is Correlated with Change in Mass of Large Low-Density-Lipoprotein Particles in Men.”; The American Journal of Clinical Nutrition; U.S. National Library of Medicine; May 1998; https://pubmed.ncbi.nlm.nih.gov/9583838 Chowdhury, Rajiv, et al; “Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-Analysis.”; Annals of Internal Medicine; American College of Physicians; 18 Mar. 2014; https://annals.org/aim/article-abstract/1846638/association-dietary-circulating-supplement-fatty-acids-coronary-risk-systematic-review Heileson, Jeffery L; “Dietary saturated fat and heart disease: a narrative review”; Nutrition Reviews; December 16, 2019; https://academic.oup.com/nutritionreviews/advance-article-abstract/doi/10.1093/nutrit/nuz091/5678770 Kaunitz, et al; “Medium Chain Length Fatty Acid Esters and Their Medical and Nutritional Applications.”; Journal of the American Oil Chemists’ Society; Springer-Verlag; 1 Jan. 1970; https://link.springer.com/article/10.1007/BF02666072 Mattes, Richard D; “Oral thresholds and suprathreshold intensity ratings for free fatty acids on 3 tongue sites in humans: implications for transduction mechanisms”; Chemical Senses; vol. 34,5: 415-23; 2009; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720690/ You, Yi-Qian Nancy et al; “Effects of medium-chain triglycerides, long-chain triglycerides, or 2-monododecanoin on fatty acid composition in the portal vein, intestinal lymph, and systemic circulation in rats.”; JPEN; Journal of parenteral and enteral nutrition; vol. 32,2; 2008; 169-75; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202979/ Iber, F L.; “Relative Rates of Metabolism MCT, LCT and Ethanol in Man.”; Zeitschrift Fur Ernahrungswissenschaft; Journal of Nutritional Sciences; Supplementa; U.S. National Library of Medicine; 1974; https://pubmed.ncbi.nlm.nih.gov/4532880 Bach, A, et al; “Effect of the Fatty Acid Composition of Ingested Fats on Rat Liver Intermediary Metabolism.”; Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme; U.S. National Library of Medicine; Sept. 1976; https://pubmed.ncbi.nlm.nih.gov/976936 Yeh, Y Y, and P Zee; “Relation of Ketosis to Metabolic Changes Induced by Acute Medium-Chain Triglyceride Feeding in Rats.”; The Journal of Nutrition; U.S. National Library of Medicine; Jan. 1976; https://pubmed.ncbi.nlm.nih.gov/1245892 Widlak, Neil; “Physical Properties of Fats, Oils, and Emulsifiers”; The American Oil Chemists Society; 1999; https://books.google.com/books?id=FvVyiOoWJroC Łoś-Rycharska, Ewa et al; “Medium chain triglycerides (MCT) formulas in paediatric and allergological practice”; Przeglad gastroenterologiczny; vol. 11,4: 226-231; 2016;https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209465/ Google NGram Viewer; “Medium Chain Triglyceride”; https://books.google.com/ngrams Thomson, Thomas; “A System of Chemistry of Inorganic Bodies, Volume 2, Seventh Edition”; Baldwin & Cradock; 1831; https://books.google.com List, Gary R; “Michel Eugène Chevreul (1786-1889)”; https://lipidlibrary.aocs.org/resource-material/the-history-of-lipid-science-and-technology/michel-eug%C3%A8ne-chevreul-(1786-1889) Van Wymelbeke, V, et al; “Substrate Oxidation and Control of Food Intake in Men after a Fat-Substitute Meal Compared with Meals Supplemented with an Isoenergetic Load of Carbohydrate, Long-Chain Triacylglycerols, or Medium-Chain Triacylglycerols.”; The American Journal of Clinical Nutrition; U.S. National Library of Medicine; Nov. 2001; https://pubmed.ncbi.nlm.nih.gov/11684530 St-Onge, M-P et al; “Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men”; European Journal of Clinical Nutrition; vol. 68,10; 1134-40; 2014; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192077/ Karra, Efthimia, et al; “The role of peptide YY in appetite regulation and obesity”; The Journal of Physiology; vol. 587,1: 19-25; 2009; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670018/ Myers, Martin G Jr et al; “Obesity and leptin resistance: distinguishing cause from effect”; Trends in endocrinology and metabolism: TEM; vol. 21,11: 643-51; 2010; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967652/ Scalfi, L, et al; “Postprandial Thermogenesis in Lean and Obese Subjects after Meals Supplemented with Medium-Chain and Long-Chain Triglycerides.”; The American Journal of Clinical Nutrition; U.S. National Library of Medicine; May 1991; https://pubmed.ncbi.nlm.nih.gov/2021124 St-Onge, Marie-Pierre, and Aubrey Bosarge; “Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss than does olive oil”; The American Journal of Clinical Nutrition; vol. 87,3: 621-6; 2008; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874190/ Bueno, N, et al; “Dietary medium-chain triacylglycerols versus long-chain triacylglycerols for body composition in adults: systematic review and meta-analysis of randomized controlled trials”; Journal of the American College of Nutrition; 34(2):175-83; 2015; https://pubmed.ncbi.nlm.nih.gov/25651239/ Mumme, K, Stonehouse, W; “Effects of medium-chain triglycerides on weight loss and body composition: a meta-analysis of randomized controlled trials”; Journal of the Academy of Nutrition and Dietetics; 115(2):249-63; February 2015; https://pubmed.ncbi.nlm.nih.gov/25636220/ Vandenberghe, C., et al.; “Tricaprylin Alone Increases Plasma Ketone Response More Than Coconut Oil or Other Medium-Chain Triglycerides: An Acute Crossover Study in Healthy Adults”; Curr Dev Nutr; 2017; 1(4), e000257; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998344/ Cliff J. d C. Harvey, Grant M. Schofield, Micalla Williden, and Joseph A. McQuillan, “The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial,” Journal of Nutrition and Metabolism, vol. 2018, Article ID 2630565, 9 pages, 2018. https://doi.org/10.1155/2018/2630565 Sidossis, L, et al; “Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed”; American Journal of Physiology; 270(4 Pt 1):E733-8; April 1996; https://pubmed.ncbi.nlm.nih.gov/8928782 Bonadonna, R; “Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans”; The American Journal of Physiology; 259(5 Pt 1):E736-50; November 1990; https://pubmed.ncbi.nlm.nih.gov/2240211 Turnbaugh, Peter J, et al; “An Obesity-Associated Gut Microbiome with Increased Capacity for Energy Harvest.”; Nature; U.S. National Library of Medicine; 21 Dec. 2006; https://pubmed.ncbi.nlm.nih.gov/17183312/ Cani, Patrice D, et al; “Metabolic Endotoxemia Initiates Obesity and Insulin Resistance.”; Diabetes; U.S. National Library of Medicine; July 2007; https://pubmed.ncbi.nlm.nih.gov/17456850/ Rial, Sabri Ahmed et al. “Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals.” Nutrients; vol. 8,5 281. 12; May. 2016; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882694/ Nosaka, Naohisa, et al; “Effect of Ingestion of Medium-Chain Triacylglycerols on Moderate- and High-Intensity Exercise in Recreational Athletes.”; Journal of Nutritional Science and Vitaminology; U.S. National Library of Medicine; Apr. 2009; https://pubmed.ncbi.nlm.nih.gov/19436137 Henderson, S; “Ketone bodies as a therapeutic for Alzheimer’s disease”; Neurotherapeutics; 5(3):470-80; July 2008; https://pubmed.ncbi.nlm.nih.gov/18625458 Ferreira, Laís S S et al; “Insulin Resistance in Alzheimer’s Disease”; Frontiers in Neuroscience; vol. 12; 830. 13; Nov. 2018; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277874/ de la Monte, Suzanne M, and Jack R Wands; “Alzheimer’s disease is type 3 diabetes-evidence reviewed”; Journal of Diabetes Science and Technology; vol. 2,6: 1101-13; 2008; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/ Kandimalla, Ramesh et al; “Is Alzheimer’s disease a Type 3 Diabetes? A critical appraisal”; Biochimica et Biophysica acta. Molecular Basis of Disease; vol. 1863,5: 1078-1089; 2017; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344773/ Reger, Mark A, et al; “Effects of Beta-Hydroxybutyrate on Cognition in Memory-Impaired Adults.”; Neurobiology of Aging; U.S. National Library of Medicine; Mar. 2004; https://pubmed.ncbi.nlm.nih.gov/15123336 Croteau, Etienne, et al; “Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease.”; Journal of Alzheimer’s Disease : JAD; U.S. National Library of Medicine; 2018; https://pubmed.ncbi.nlm.nih.gov/29914035 Yu, Seungmin et al; “Medium Chain Triglyceride (MCT) Oil Affects the Immunophenotype via Reprogramming of Mitochondrial Respiration in Murine Macrophages”; Foods (Basel, Switzer
56 minutes | 8 months ago
#031: Dr. Kaleb Redden - Kaged Muscle's Team Doctor
In late 2019, Mike and Ben interviewed Dr. Kaleb Redden, an orthopedic surgeon who is also Kaged Muscle‘s team doctor! As someone who can repair spines, enhance strength, and help you get big, it’s no wonder why Kris Gethin brought him on the team. Welcome Dr. Kaleb Redden to Team Kaged Muscle! Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post Dr. Kaleb Redden - Kaged Muscle's Team Doctor | Podcast #031 first appeared on The PricePlow Blog.
31 minutes | 9 months ago
#030: Mike Yewdell - BEAM: A Brand with a Message
Are you ready to Be Amazing? Be inspired. Be motivated. Be Amazing. Michael Yewdell is. And once you hear his story, you’ll want to join the amazing movement. Every year, countless supplement companies launch, seemingly popping up out of thin air. Some stick around, few flourish, but many vanish back into the thin air where they came from. What’s the difference between these winners and losers? Purpose. Too many new brands have no true purpose, direction, or meaning. They follow the industry trends to a tee, use cookie-cutter formulas, charge unreasonable prices, and may even use poor quality manufacturing facilities. In other words, they stand for nothing and do nothing to stand out. Easy come, easy go. Be Amazing. But today, we meet a man with a different direction. A sense of purpose. A message that means something. He’s here to show you that regardless of your circumstances, you can Be Amazing. But before we dive into the incredible story behind BEAM, be sure to subscribe to our BEAM news and deal alerts so you stay up to date with everything regarding BEAM’s outstanding products: BEAM - Deals and Price Drop AlertsGet Price AlertsGet BEAM alerts Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. Introducing BEAM: More Than a Brand, It’s A Movement BEAM is here to provide exceptional products to help you Be Amazing. A truly successful company must start with a great leader — someone with years of experience who knows how to inspire and direct others and has a passion for every aspect of the brand. Meet Michael Yewdell: a fitness fanatic, foodie, supplement industry veteran, and cancer survivor. Mike has over nine years of experience, and throughout the time he spent working with some of the biggest names in the industry, he knew there was still something missing. Mike has tried nearly every supplement. While he found some that he liked, most were well below average. The best way Mike could solve this problem was to branch out and create his own brand. Having been so involved in the industry, he knew a thing or two about branding. And he knew what was missing. Thus, BEAM was born, which stands for Be Amazing. But what most people don’t know is there’s a lot more meaning to the brand’s name than you may think. BEAM may not sound like a supplement company name, but that’s because BEAM goes well beyond supplements, health, and fitness. For many, it’s truly life-saving. BEAM: Cancer Treatment or Supplement Brand? BEAM is going to create a team of people who are all amazing in their own way. As mentioned, Mike is not only an entrepreneur and supplement guru, he’s a cancer survivor. And as you’ll see, it was BEAM that brought Mike another chance, so now he wants to help you Be Amazing too. In 2017, Mike was unfortunately diagnosed with a rare form of lymphoma, which is a cancer of the lymphatic system. He was told not to worry, because with the advancements in modern medicine, he would be cured – his form had a 95% success rate. Mike was mentally and physically prepared for a battle, little did he know it was going to be the fight of his life. After failing three chemotherapy treatments, Mike’s cancer was winning. Some people would give up throughout this process, but not Mike – he’s a fighter and would not let anything slow him down. Hiding the fight of his life in plain sight Although admittedly starting to lose hope, Mike didn’t want anyone to feel sorry for him or know that he was hurting. He still went to work, acted as if nothing was wrong, and went to the gym because of how much he enjoys being active. Mike never wanted cancer to affect him to the point where he stopped doing what he loved, even if that meant some suffering. “When you die, it does not mean you lose to cancer, you beat cancer by how you live, why you live and in the manner in which you live.” –Stuart Scott, American Sportscaster BEAM: The Treatment That Saved Michael’s Life After several unsuccessful attempts at chemotherapy, Mike transferred to a hospital in New York, where they offered an alternative treatment, known as beam. Beam is a type of treatment that uses protons rather than x-rays to treat cancer. Protons are positively charged ions, and at a high enough energy, can destroy cancer cells. It doesn’t always cure everyone, but fortunately for Mike, it was effective. Half a year to envision the next step Following the beam therapy, Mike had to be in isolation for 4-6 months due to a compromised immune system. During that time, he spent long days reflecting on his life and planning what would accomplish once this period ended. He kept thinking of the name beam, because not only did it help cure him, he loved the name. Mike also came to the discovery that beam could represent something more than a proton beam – to him, it truly meant to Be Amazing. BEAM: A Supplement Company was Born A 100% Whey Protein Isolate that features digestive enzymes and trace minerals for extra benefits! Ever since Mike started working in the supplement industry, he wanted to start his own brand, but never felt like it was the right time. But after battling against cancer, Mike was more inspired than ever to create a brand. A brand that meant something. He knew it would be more than just selling products, it would be a movement to influence others to fight against any obstacle that comes their way. Mike’s family and friends told him this was the perfect time to do something big, because of how many people he would help, inspire, and motivate to be amazing. You don’t have to be an influencer to be an influence — there’s always something you can do to help others. And that’s exactly what Mike is trying to show thousands of people, by building a brand and a team that’s all amazing in their own way. Now let’s see what BEAM has in store for 2020, because Mike doesn’t only want to share a message, he wants to give you exceptional products. BEAM’s First Launch of Products Mike knows exactly what it takes to formulate products that blow past competitors, but now is his chance to show you just what they’re all about. BEAM launches March 4th, 2020 with an epic supplement line-up. We will be doing reviews and more in-depth articles on each product, but belo is a glimpse of what BEAM has coming. You’ll quickly notice they’re releasing supplements in “standard” product categories like protein powder and pre workout, but each formula has a unique twist. 100% Whey Protein This premier protein will contain 100% whey protein isolate, and will launch in two delicious flavors: Chocolate Fudge and Salty Peanut Butter. But this is not just protein powder, BEAM has added some unique ingredients, such as trace minerals from red algae (Aquamin) and a digestive enzyme blend that features: amylase, lactase, protease, lipase, cellulase. Collagen Peptides BEAM Collagen peptides feature Amino9 and 10g of Bovine Collagen Peptides! The Collagen Peptides will include 10g of Bovine Collagen Peptides to provide you with 9 grams of protein. But it also includes Amino9, which is a registered trademark of Compound Solutions, a leading ingredient supplier. Amino9 is a leucine-enhanced blend of all nine essential amino acids, which consists of L-Leucine, L-Lysine, L-Threonine, L-Isoleucine, L-Valine, L-Phenylalanine, L-Methionine, L-Histidine, and L-Tryptophan. The Collagen Peptides will be unflavored so you can add them to virtually any drink! This is a brilliant move. We’ve found that too many people take collagen-based products for muscle growth, all because it has “protein” on the label. But that’s not how collagen works best, given its amino acid profile. However, just in case someone were to take this collagen for that purpose, they are still covered, thanks to the essential amino acids added in! Vegan Protein Next on our list is a premier Vegan Protein, and BEAM spent a lot of time to make sure this product tastes amazing. In order to deliver a complete protein source, BEAM uses a blend of pea protein, mung bean protein, and pumpkin seed protein. In order to ensure they are the highest quality sources, BEAM uses SmoothProtein from Compound Solutions. Just like their whey protein, they also included trace minerals from red algae in the form of Aquamin. The Vegan Protein will launch in two flavors: Blueberry Muffin and Chocolate. Mike from BEAM swears this is one of the best tasting vegan proteins out there, and one ingredient that really helps deliver a smooth, creamy texture, is Clean Cream. It’s another ingredient from Compound Solutions that helps get rid of the gritty consistency most plant proteins have and doesn’t contain any unwanted ingredients found in other creamers. Therefore, it’s the best choice for having a clean label, but not sacrificing taste or quality. Pre Workout Last, but certainly not least is BEAM’s comprehensive Pre Workout formula. It features several key ingredients that are backed by science and dosed to give you the best results. Here’s a quick rundown on what’s included in Pre Workout! An epic formula with clinically dosed ingredients that comes in amazing flavors, is there anything better? Pre Workout features a one (12.1g) or two scoop (24.2g) serving size option, but here’s the ingredients and dosages for two scoops: L-citrulline – 5g Carnosyn Beta-Alanine – 3.2g Betaine Anhydrous – 3g Taurine – 2g L-Tyrosine – 2g KSM-66 Ashwagandha Root Extract – 300mg Caffeine (from CoffeeBerry Whole Coffee Fruit Extract and Green Coffee Beans) – 250mg Cocoa Bean (Theobroma cacao L.) Seed Extract – 250mg Grape Seed Extract – 200mg L-Theanine – 100mg AstraGin – 50mg Resveratrol – 40mg BEAM’s Pre Workout is loaded with everything you need to crush a hard training session. It comes in two amazing flavors: Mango Lime and Watermelon Candy! Listen to Mike Yewdell discuss BEAM Mike joined Ben on the PricePlow Podcast to share his story: Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud BEAM: The Beginning of a Brand and A Movement! BEAM stands for Be Amazing, and it’s meaning goes way beyond the supplement industry. BEAM is here to not only put out top-tier products with unique ingredients, they’re here to bring together people from all over the world to create a positive impact. Mike wants BEAM to be more than just another brand, he wants BEAM to take the industry to another level. He’s driven and fueled by passion, experience, and determination. BEAM has huge plans for 2020 and beyond. PricePlow is thrilled to have the opportunity to help deliver such an incredible and powerful message. There’s no doubt the industry needs more brands looking to stand out for the right reasons, rather than just following the same old trends. Sure, every company may have the standard products we are familiar with, but there’s so much innovation and change that can occur. Social media is a powerful tool, and BEAM will fully utilize that to increase brand awareness, start a movement, and grow into becoming an industry leader. They’re off to a great start, but there’s a lot more exciting things on the way. Make sure you follow along on social media (@youcanbeam on Instagram) and our blog to get all the details! BEAM - Deals and Price Drop AlertsGet Price AlertsGet BEAM alerts Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. References Proton Therapy; Cancer.net; 2020; https://www.cancer.net/navigating-cancer-care/how-cancer-treated/radiation-therapy/proton-therapy The post BEAM Supplements: Something Amazing Has Arrived! first appeared on The PricePlow Blog.
51 minutes | 10 months ago
#029: Heather Jacques - Introducing PricePlow's Digital Content Manager
In January of 2020, PricePlow hired Heather Jacques as the team’s new digital content manager. We got together on video and introduced her to PricePlow Nation, and asked all of the pertinent questions – including how to pronounce her last name! Heather does much of the writing, blogging, research, and content scheduling for PricePlow. Welcome Heather to Team PricePlow! Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post Introducing Heather | Podcast #029 first appeared on The PricePlow Blog.
72 minutes | 10 months ago
#028: Shawn Wells #4 - Berberine - The Best Glucose Disposal Agent Ingredient
Meet Berberine, the powerhouse of supplement ingredients for blood sugar control! The most appealing beauty of the supplement industry is its ability to innovate. While most formulas are not groundbreaking revelations, every once in awhile, we’re hit with something that completely redefines the industry. Berberine, a unique plant alkaloid that has been shown to improve the body’s response to insulin — to the point of working better than some pharmaceutical drugs — is one such exciting compound. This alkaloid has displayed some impressive abilities, specifically in the realm of insulin sensitivity, fasting glucose levels, HbA1c reduction, and nutrient partitioning. While berberine has been available as a supplement ingredient for quite some time, it wasn’t always as impactful as one would hope, since it has poor bioavailability and there are many low-quality extracts on the market. The good news is that we are on the brink of another ingredient renaissance event thanks to NNB Nutrition, an ingredient innovation company who has released a new variant of berberine. Dihydroberberine: The better part of berberine NNB Nutrition has discovered a better way to maximize berberine’s potential. In their patented new ingredient, GlucoVantageⓇ, the science-backed team is incorporating a superior form of the ingredient – dihydroberberine (DHB). Recent research suggests that this form of berberine is as much as six times better than its base form, which could potentially be huge for the body composition and anti-aging markets. GlucoVantage from NNB Nutrition is a pure form of Dihydroberberine (DHB) and is known as “The Super Berberine”. See more on NNBNutrition.com Even with lower-quality extracts on the market, berberine is still effective in and of itself, and is backed by a significant amount of human research. But recent studies suggest that DHB may be what powers its insulin-optimizing abilities. If so, we will see a rise in the popularity of dihydroberberine — and thus NNB’s GlucoVantage — very soon. In this post, we’re going to dive deep into berberine – what it is, its applications, the science behind, and the potential of its hydrogen-bonded derivative, DHB. Fair warning, though – this article is going to be very science-heavy, so make sure you’ve got yourself ready to jump into some complex terminology and mechanisms! TL;DR: Berberine is a bioactive plant alkaloid often used for its anti-diabetic effects in supplements known as Glucose Disposal Agents (GDAs) or Nutrient Partitioners. When supplemented, berberine demonstrates strong improvements in fasting blood sugar, HbA1c, insulin sensitivity, and lipid profiles in both humans and animals. A landmark study of 1.5g/day berberine demonstrated identical effects to the pharmaceutical drug metformin in terms of HbA1c reduction, fasting blood glucose, and post-prandial blood glucose levels… and berberine bested metformin in terms of triglyceride reduction! Berberine suffers from two issues: poor bioavailability and low-quality extracts on the market. This has led to a new generation of supplements: Dihydroberberine is a derivative of berberine that is more bioavailable and can be taken at lower doses with greater results. Once absorbed, it reassembles back into berberine in the bloodstream. GlucoVantage from NNB Nutrition is a pure form of Dihydroberberine (DHB) and is known as “The Super Berberine”. See more on NNBNutrition.com GlucoVantage from NNB Nutrition is a patented and trademarked form of pure dihydroberberine that is created from pure berberine and is lab-tested. Recommended GlucoVantage-based berberine supplements include: The Genius Brand Genius Blood Sugar Evogen Evolog Dosage: Standard Berberine is best dosed 3x/day at 500mg per serving, while GlucoVantage can be dosed 3x/day at 100-200mg per serving. These are best taken before meals, but can also be taken when fasting if already fat-adapted. Berberine’s most notable side effect is GI distress, which is best solved with the lower doses of the more bioavailable GlucoVantage. Understanding the role of insulin Before we get into berberine, however, it’s imperative that we understand the basics of insulin. As this is the primary hormone that berberine interacts with, it doesn’t do us much good if we’re not aware of what the hormone does prior to any supplementation! How insulin does its job Insulin is one of the most integral hormones secreted by the body, and is often called “the energy storage hormone”. Constructed via two chains of amino acids, insulin is synthesized within the pancreas prior to being released into the bloodstream. The body signals its release via a complex chain of reactions, starting with an initial recognition of the amount of glucose in the body at a given point of time. 1: Insulin binds to its receptor, 2: activating various protein cascades, including translocation of GLUT4 transporter to the plasma membrane. 3: The influx of glucose. 4: The synthesis of glycogen. 5: Glycolysis. 6: Triglyceride synthesis. Image courtesy Wikimedia. Think of the body constantly monitoring blood sugar levels, and once they rise above a certain threshold, beta cells in the pancreas release insulin in an effort to return your blood sugar to normal levels. The driver (insulin), the car (GLUT4), and the passenger (glucose) Insulin activates the insulin receptor tyrosine kinase (IR), which then phosphorylates, making for fertile ground for chemical bonding between itself and other signaling compounds. Phosphoinositide 3-kinase (PI3K) is one of these signals, acting as the primary catalyst in this second stage. PI3K then goes to work, triggering a multitude of other compounds and proteins within the body. Thus, this kinase is extremely crucial in various processes, specifically in the signaling of mTOR and Akt, protein kinases concerned with protein synthesis and glucose uptake, respectively. The signaling of Akt successively activates GLUT4, perhaps the body’s most powerful glucose transporter. GLUT4 then completes this chain of events, picking up blood sugar and carrying it into cell membranes. Once released into the blood, insulin essentially pushes glucose out of the bloodstream and into fat and muscle cells via the transport GLUT4.[6,7] An analogy to use is that GLUT4 serves as a vehicle while insulin is its driver, telling it where to go and pick up a rider, and where to drop it off. Glucose hitches a ride and reaches the cell, effectively lowering blood sugar levels back to normal – but where it puts that glucose and how quickly make all of the difference in the world. The effects of insulin Insulin and GLUT4 work best in small fat cells. It’s important to be insulin sensitive, and we can best accomplish this through low-carb diet, appropriate intermittent fasting, high-intensity training, and proper supplementation. The bulk of what makes insulin so interesting is what happens because of the process outlined above, and how it can be altered, both for better and worse. The action of insulin can happen at varied speeds: having it work too fast (which can lead to hypoglycemia) or too slow (hyperglycemia and hyperinsulinemia) can both be dangerous. Hyperglycemia, the case in which the body struggles to reduce blood sugar levels, can lead to the development of various ailments, with type 2 diabetes chief among them. Storage into fat or muscle The speed of its effects aren’t all that’s important, however. Glucose ultimately enters one of two types of cells – fat and muscle – thanks to being transported by GLUT4. When it’s stored, it’s converted into glycogen, whose storage depends on which type of tissue it resides. If it’s been moved into adipose tissue, it’s used to build more fat tissue. Alternatively, if the glucose has entered into muscle tissue, it helps build new muscle tissue. In other words, glycogen fed to fat cells makes more fat, whereas glycogen shuttled to muscle helps build more muscle. This relationship is ultimately one of the reasons why insulin activity is so important, but it is not the only reason! Insulin sensitivity You can consider insulin resistance to mean “sugar saturation” – at some point, overfilled adipocytes refuse to store more energy. Waist-to-Height ratio makes for an excellent proxy to insulin resistance. Image courtesy Dr. Ted Naiman. Putting aside how well the body produces insulin, there’s another sphere in which the effects of insulin can differ. Insulin sensitivity is a term used to describe how well the body responds to insulin. Being more insulin sensitive means that the cells cooperate extremely well, and thus need only a small amount of insulin secreted to move glucose. Being less insulin sensitive, also known as insulin resistant, is undesirable, as it means the body must produce more insulin than normal. Insulin resistance leads to hyperinsulinemia leads to disease When insulin levels are chronically elevated due to the body’s lack of response to the hormone (insulin resistance), it enters a state of hyperinsulinemia. An alarming amount of research has shown hyperinsulinemia to be the connection between diet and disease, and its presence is documented with regards to obesity, diabetes, hypertension (high blood pressure), renal failure, nonalcoholic fatty liver disease, polycystic ovary syndrome (PCOS), sleep apnea, certain cancers, atherosclerosis, cardiovascular disease, and likely far more. The body’s response to (and clearance of) insulin is central to disease prevention. There are three areas in which insulin sensitivity is relevant – peripheral, hepatic, and pancreatic – but our concern in this article is ultimately with peripheral insulin sensitivity. While hepatic and pancreatic types are concerned with how well the liver and pancreas work, peripheral insulin sensitivity deals with fat and muscle cells and their ability to absorb glucose – and this is a sports nutrition blog dealing mostly with fat loss and muscle growth. Factors that influence peripheral insulin sensitivity Fasting insulin levels predicts metabolic disease NINE years in advance, so why do doctors so rarely check it? While genetic predisposition likely dictates a “starting point” of sorts, insulin sensitivity can be strongly influenced by various lifestyle choices. Research has shown that exercise — both aerobic and anaerobic — can increase insulin sensitivity.[10,11] In particular, weight lifting (a form of anaerobic exercise) has been shown to increase muscle mass as well, which makes sense – the body uses insulin to shuttle glucose to depleted muscles, where it’s then used to rebuild them anew. This newfound muscle tissue now gives your body more places to put future glucose, creating a positive feedback loop! Alternatively, there seems to be quite a few ways to reduce insulin sensitivity. Obesity, poor sleep habits, and high levels of stress have all been linked to insulin resistance. Cortisol, the “stress hormone”, plays a huge role in insulin sensitivity, and when the body produces more cortisol, it struggles to respond to insulin effectively. In all of these situations, the body is stretched past its normal limits – each circumstance puts the body in a state it’s not meant to operate within, and as such, it begins to malfunction. By simply trying to stay healthy through exercise, proper sleep, and a proper diet, one can effectively boost their insulin sensitivity. As we’re sure you know, this requires prioritization and discipline — but it is worth it. But life often gets in the way, making something like insulin sensitivity and dietary choices incredibly important. In an insulin resistant state, you can find yourself struggling to gain muscle or lose fat…. or in the long-term, if on a poor Standard American Diet (SAD), may end up with one of the many diseases above. Luckily, there are means in which one can optimize insulin sensitivity – and one such way is supplementally. What is berberine? Berberine, scientifically known as 2,3-methylenedioxy-9,10-dimethoxy-protoberberine, is a bioactive alkaloid found in various plants. Many of these plants, such as those from the Berberis family (berberis aristata for example), have been used in the practices of both Ayurvedic and Traditional Chinese Medicine (TCM) for centuries. Berberis Aristata Bark is high in berberine, especially during the fall season – a great time for seasonal“energy storage”! These practices typically utilized the compound for its antimicrobial and antiprotozoal characteristics, which modern science have actually validated: berberine has been shown to successfully defend against strains such as cholera and salmonella.[17-19] A reactive herb with many uses Berberine has a rather unique chemical structure, as well. The alkaloid possesses a quaternary ammonium ion, a highly attractive ion that can form various chemical bonds. Depending on the other compounds present within the body, berberine and its properties can be slightly altered to deliver different effects. Many of these interactions studied have examined berberine and its relationship with other herbs in Chinese Medicine. For example, baicalin, a flavonoid that may possess neuroprotective capabilities, has a carboxylate ion that can bond to berberine’s ammonium ion. Research has shown that this baicalin-berberine complex has higher bioavailability than either of the two ingredients alone. This is not only just an example of the many relationships that berberine has, but also shows one of the two major issues we need to solve with berberine – its bioavailability! (The second major issue, extract quality, is also discussed below.) Berberine has poor absorption How does the best glucose disposal ingredient in berberine get any better? It’s known as dihydroberberine! Aside from too many untrustworthy extracts on the market, perhaps the biggest issue with berberine is its low bioavailability. Research has tagged the compound’s absorption yield at a mere 5%, meaning that that body fails to fully utilize the vast majority of the alkaloid when ingested. This poor absorption is a product of a rather unfortunate relationship with P-Glycoprotein. This protein, located within cell membranes, rejects the absorption of berberine into the cell. That’s not all, however – berberine has been shown to increase P-Glycoprotein activity within the intestine, essentially encouraging its own demise! Make no mistake – this does not mean that berberine fails to deliver potential benefits. They can still be had, but only in taking relatively large doses of the alkaloid. In addition, taking a lot of it all at once has been linked to stomach issues, so it’s advised that one split a full dosage into multiple, smaller doses. We can — and have — solved these issues, but let’s continue with the science. So, once berberine does get absorbed, what exactly happens? Metabolism and interactions Berberine is typically broken down into four metabolites – thalifendine, jatrorrhizine, berberrubine, and demethyleneberberine. While the four all interact with different enzymes and proteins, they seem to all act on the same mechanisms, albeit to a lesser degree than their parent compound. And with those, we finally get to the interactions berberine (and its metabolites) have within the body! AMPK Berberine and its metabolites Finally, we return to the some of the mechanisms that relate to insulin. Adenosine mono-phosphate kinase (AMPK) is a protein that’s integral in maintaining energy balance, specifically by inducing glucose and fatty acid uptake. When the cells are in need of energy replenishment, AMPK takes charge and rushes fuel to where it needs to go. We didn’t directly talk about AMPK in our discussion about insulin earlier, however, we did discuss a few kinases directly affected by it! AMPK activation stimulates PI3K and Akt activity in an interesting fashion – it upregulates insulin-stimulated Akt activity by regulating PI3K. This allows it to enhance insulin sensitivity in multiple ways. Not only does it stimulate PI3K, but AMPK inhibits mTOR’s impact on insulin activity, further raising insulin sensitivity! Given its powerful impact on insulin and its reception within the body, wouldn’t it be great if there were ways to stimulate AMPK? There are: Berberine has been shown to enhance AMPK activity in a dose/time-dependent manner. How, you ask? Well, scientists are still working to uncover the totality of it, but preliminary studies suggest that it inhibits mitochondrial respiratory complex 1. This effect, which increases AMPK levels, is similar to that of some pharmaceuticals used to treat diabetes. It also seems to inhibit protein tyrosine phosphatase 1B (PTP1B), which further amplifies an AMPK-induced insulin sensitivity boost. This upregulation stems throughout the body as well, affecting both muscle and fat cells. This interaction is vital to the effectiveness of supplementing with berberine, as it’s ultimately what makes this compound so appealing. Now let’s jump into what the research has to say about this relationship between berberine and insulin sensitivity: The science supporting berberine There’s an extraordinary amount of research on the powers of berberine: Increases adiponectin, which in turn raises insulin sensitivity diponectin can activate AMPK and PPARα in the liver and skeletal muscle. We recently explored PPARα in our articles on BAIBA and MitoBurn. Adiponectin is a protein hormone that improves cellular responses to insulin when secreted by fat cells. It works in ways similar to what we’ve already discussed, stimulating AMPK activity in tissues. The body produces the protein in three different forms, though its “high molecular weight” form has been deemed most relevant in terms of improving insulin response. Research has shown that berberine can increase adiponectin production through a process called adiponectin multimerization, which in turn improves insulin sensitivity. This makes sense, given that both berberine and adiponectin stimulate the same system. Can increase glucose uptake into fat if liver and muscles are full Thus, it should come as no surprise that berberine increased glucose uptake in fat cells. It should be remembered that the glucose from those carbohydrates eaten have to go somewhere, after all. Similar to a type-II diabetic shooting insulin after a carbohydrate-laden meal, berberine can promote fat storage just as much as muscle storage in non-optimal situations, which is why we always recommend weight training and high intensity exercise if ingesting any carbohydrates. All-around improved glucose response There’s good news, however. While berberine has been shown to improve insulin response within fat cells, it doesn’t necessarily do so in a singular fashion. Research suggests that berberine affects multiple glucose uptake-related mechanisms: It’s not called a “glucose disposal agent” for nothing! Berberine improves the overall glucose disposal rate![https://pubmed.ncbi.nlm.nih.gov/18397984] Stimulates AMPK activity to improve glucose uptake, Increases GLUT1 transporter activity. GLUT1 is one of the least active glucose transporters in the body, yet berberine seems to call it into action! Inhibits PTP1B enzyme activity, effectively mimicking the actions of insulin. This effect promotes overall glucose uptake, pushing glucose into both fat and muscle cells. Though the effects of berberine are most impactful on AMPK production, the compound seems to take aim on glucose uptake in a holistic sense. It doesn’t just focus on one mechanism, it turns its attention to multiple — those that are both insulin-dependent and insulin-independent. The encompassing nature of this effect serves as evidence that supplementing with berberine to effectively improve insulin response, specifically in individuals that struggle to manufacture insulin naturally, could be a worthy use. Improves blood glucose uptake, particularly in Type 2 diabetics Type 2 diabetes is in ailment in which an individual struggle to either produce enough insulin or effectively respond to it. There are pharmaceuticals typically used by these individuals to help improve both of those factors. However, given that science continuously has its eyes set on uncovering new information, researchers were intrigued by the hypoglycemic properties displayed by berberine. They wondered whether it could perform in similar ways to diabetic medicines. Outperforming metformin One could very easily argue that berberine outperformed metformin in most measures! In a landmark study from 2009, 36 adults recently diagnosed with type 2 diabetes were split into two groups – one received 1.5g of berberine daily, while the other was administered metformin, a popular antidiabetic drug. After 13 weeks of treatment, multiple markers of glucose metabolism – hemoglobin, fasting blood glucose (FBG), postprandial (post-meal) blood glucose (PBG) , and blood triglyceride levels – were compared to baseline readings. At the 13-week mark, the researchers came to some incredible findings. Not only did berberine “exhibit identical effects” as metformin on hemoglobin, FBG, and PBG levels, but it also regulated lipid metabolism to a higher degree than metformin. Berberine improved markers of glucose metabolism just as well as the drug, but also lowered triglyceride and total cholesterol levels more than metformin did! These findings were corroborated in similar research from 2010. In that study, scientists found similar decreases in hemoglobin and fasting blood glucose, while also observing how berberine accomplished these effects. They saw elevated insulin receptor expression in peripheral blood lymphocytes, which displays the body reaching higher levels of insulin sensitivity post-supplementation. …and we can still do better What’s really interesting about this landmark study is that it was performed with standard berberine. Discussed below, we get into a more specific metabolite of berberine (dihydroberberine) that performs even better, and we’re confident that it would leave some of these pharmaceuticals in the dust! Improves insulin levels and insulin sensitivity Tangible and direct results of improved insulin sensitivity exist as well! Research from 2012 was interested in the effects of berberine in individuals with metabolic syndrome. 37 subjects were given 900mg of berberine daily for 12 weeks, with key metrics being assessed both before and after the study’s conclusion. They found similar results as the two studies from the previous section – significantly lower levels of fasting blood glucose, hemoglobin, triglycerides, and cholesterol. They also saw significant improvements in adiponectin activity and reductions in leptin, validating the findings of previous studies. However, these researchers also examined insulin levels directly. Using homeostasis model assessment insulin resistance index (HOMA-IR) as its measurement, they found that berberine ultimately reduced HOMA-IR by 41%. Considering that HOMA-IR incorporates both fasting insulin and fasting glucose (it multiples them, then divides the product by 22.5 to form an index), the substantial reduction of this comprehensive metric is an incredibly impressive find here. Enhanced glucose uptake in muscle cells Berberine significantly improved every lipid and metabolic attribute measured! One of the keys of proper glucose uptake is being able to shuttle sugar to the cells that need it most. When discussing this in terms of body composition, that translates to improving glucose uptake in muscle cells. Not only does this prevent glucose from being stored as fat, but it also helps you recover and build muscle. Thus, something that can help increase insulin sensitivity while also encouraging uptake in muscle cells makes for quite the body recomposition agent. Berberine, via its AMPK-stimulating effects, has been shown to increase glucose uptake in skeletal muscle cells. Specifically, berberine accomplishes this by also increasing mitochondrial synthesis within muscle cells. Forming more mitochondria increases energy needs within these cells, thus being able to utilize more glucose! Research has also displayed the two-pronged way berberine does this. By stimulating the insulin receptor (IR) in cells, while also inhibiting PTP1B to further improve its functioning, berberine creates a highly desirable environment for muscle cells to intake glucose. Interestingly, this effect seems relevant only in specific situations. Scientists have studied glucose uptake in muscle cells with varied levels of insulin sensitivity. There seems to be a significant increase in insulin sensitivity only in insulin resistant muscle cells, with research failing to find significant effects in muscle cells that are already insulin sensitive. What about berberine as a weight loss agent? More incredible berberine before-and-after results, especially with body mass index on top of the usual metabolic and lipid profile improvements! With all of this talk about insulin sensitivity and a more optimal blood glucose dispersion, there should be some sort of weight loss benefits, right?! Sort of. The 2012 study that tested berberine on adults with metabolic syndrome found decreases in BMI, which, as we know, is an imperfect measure of a healthy weight. However, the 2009 study on type 2 diabetics offers a bit more insight into how berberine can be used for weight management. This study, while seeing no significant differences in BMI or body weight, did see decreases in hip and waist width. This suggests that berberine can be used for body recomposition – rather than it helping you lose weight, it can help you redistribute weight. In inhibiting the fueling of fat cells while pushing glucose towards muscle cells, this essentially means it encourages more muscle growth in place of fat growth! Remember, for many people, weight is not actually the number to track – it’s body composition and incredibly important metrics such as waist-to-height ratio! Now, all of the above sounds great, doesn’t it? Improved insulin response, more sensitive muscle cells, and potentially improved body composition are things many of us would love to have. However, the issues with berberine aren’t with its effects. The Drawbacks of [Standard] Berberine Ingredients As we alluded to earlier, the bigger problems are finding a quality extract and the ingredient’s poor bioavailability. The first catch – most berberine on the market is junk All of the research up above comes with one major caveat: it was lab-tested and verified by the researchers, who have trusted suppliers. The materials used in their studies are almost guaranteed to be better than the standard berberine you’ll find on Amazon and elsewhere. The loudest voice regarding the ongoing problems we face with berberine supply in the supplement community is Shawn Wells, a formulator who tested 40 different raw material samples in 2015 and found that 37 were underdosed, or spiked/adulterated. How can you be sure you’re getting a pure berberine? Pictured: Berberis Aristata Fruit. Image courtesy Wikimedia Commons Getting real berberine is expensive, and too many raw material suppliers rely on the fact that rookie supplement formulators and brands do not spend the time or money to properly test it — or simply do not know how. The search for a pure product led Shawn to partner with an ingredient development company known as NNB Nutrition, and together, they devised a far better approach to the problem, isolating a pure form of the compound known as dihydroberberine (sold as GlucoVantage) that works better and at a lower dose. The second catch – high doses can cause serious gastrointestinal discomfort! Because the body yields such a small amount of a given dose of berberine, it takes a large amount (such as 1g, which was used in multiple studies cited above) to see improved insulin sensitivity. In isolation, that’s not much of an issue – if it takes larger doses to get there, then just take more of the ingredient. However, that short-sighted viewpoint is immediately dispelled in this case in two ways: cost and comfort. High doses of bulk berberine cost more First, and perhaps most obviously, that would be expensive. Berberine isn’t exactly the most abundant compound on earth, and purchasing it in supplemental form costs hard-earned cash. Large doses mean buying larger amounts, and this practice can get pricey very quickly. High doses of bulk berberine cause more GI discomfort Second, and more importantly, large doses of berberine have been linked to serious gastrointestinal pain. In the above 2009 study that compared berberine to metformin, 34.5% of subjects given berberine reported gastrointestinal issues within the first four weeks of the study. A meta-analysis from 2012 cited a common occurrence of such discomfort in the 14 studies included in the analysis. However, it is worth noting that this was the only adverse effect found in the studies testing berberine supplementation. If only there was something that brought all of the benefits of berberine without the high doses and occasional stomach pain… Dihydroberberine – a better berberine? Luckily, such a compound does exist! Dihydroberberine (DHB) is a derivative of berberine, and on a chemical level, is simply berberine bonded with two hydrogen atoms. This might not sound too exciting, but the presence of these two atoms seems to do wonders! Preliminary research suggests that dihydroberberine is more bioavailable than berberine. It also may be able to deliver the benefits of berberine without the adverse gastrointestinal effects! Better intestinal absorption = higher bioavailability! The true appeal of DHB is its elevated bioavailability compared to berberine. How it achieves this, however, is actually pretty interesting. When ingested, berberine breaks into 17 metabolites throughout the course of its life cycle within the body. One of these metabolites is DHB, a product of reduction via nitroreductases within the gut microbiota. Once DHB is absorbed into intestinal tissues and dispersed throughout the blood, it oxidizes back into berberine. Simply put by the researchers: “DhBBR [Dihydroberberine] has a better intestinal absorption than BBR.” This conversion from berberine to dihydroberberine and back to berberine is rather inefficient, considering that it ultimately results in less berberine than what was originally ingested, but it does work. So what if we were to take DHB directly? Direct Dihydroberberine ingestion for the win Research from 2015 tested whether or not orally-ingested DHB could effectively bypass this conversion, thus yielding effects similar to that of a larger berberine dose! Analyzing the intestinal absorption rate in vitro, scientists found that DHB was absorbed five times faster than berberine. In order to validate these findings, they conducted another test using another model. Because berberine needs gut bacteria in order to be effectively absorbed, these scientists tested the absorption of standard berberine in mice with low intestinal bacteria. They found that the lack of gut bacteria limited the amount of plasma berberine within mice, further supporting the hypothesis that intestinal bacteria is the limiting factor in proper berberine absorption. In completely bypassing breakdown within the gut, DHB can be fully absorbed by the intestines. It takes gut bacteria almost entirely out of the equation, which ultimately means that a lesser dose of DHB is equivalent to a larger dose of berberine. Just as potent in improving insulin sensitivity Better bioavailability only goes so far, as the real test is whether or not DHB is as effective as berberine in regulating blood glucose levels. If the former is absorbed better but less effective than the latter, then we find ourselves in a bit of a situation. Thankfully, we don’t even have to have that discourse! Researchers from the Garvan Institute of Medical Research in Sydney, Australia provide an excellent comparison of the two compounds. Their experiment was constructed into a two-step process – first, they would examine the AMPK activation of berberine, then they would compare it to the stimulation caused by DHB. Using mice fed a high-fat diet, they formed two groups of mice – one group received 560mg/kg daily of berberine, while the other was fed 100mg/day of DHB. Dihydroberberine: Stronger than berberine at a lower dose! This comparison of berberine and its derivative proved notable, as DHB was significantly better than berberine in fighting both adiposity and triglyceride build-up, as well as improving insulin sensitivity. The DHB group also displayed a 44% increase in insulin sensitivity compared to control. DHB improved virtually every marker that warrants berberine supplementation, yet did so to a higher degree and at a lesser dose! Inhibits pancreatic lipase Amazingly, dihydroberberine converts back into berberine, and you ultimately end up with more! There seems to be another way in which DHB attenuates fat gain. Pancreatic lipase (PL) is the main enzyme that converts triglycerides into fatty acids, and is thus integral in fatty acid absorption. In fact, high activity of this enzyme is linked to excess caloric intake, thus, regulating this enzyme can be a useful tool in managing obesity. Orlistat is the most popular inhibitor that limits PL activity. However, it often brings some painful gastrointestinal side effects with it. Therefore, scientists and dieters alike have continued to search for an equivalent, more safe alternative. Research from 2013 investigated whether or not DHB could serve as such an alternative. They conducted two tests – the first was a simulation that analyzed the docking system in which berberine and DHB molecules would operate with on a molecular level, while the second test was concerned with the actual potency of each substance in inhibiting PL. They found that both compounds bonded in a similar fashion, but berberine suffered from a molecular structure that would ultimately limit its effectiveness in practice. The in vitro study that followed further supported this – while both berberine and DHB were able to inhibit PL, dihydroberberine was just as effective but at a much lower dose. At equal doses, berberine wouldn’t be nearly as effective as DHB. This information corroborates the “do more with less” theme we’ve touched an already regarding DHB. How berberine interacts and docks with its target binding sites. Some cardiovascular benefits, too! There’s also a bit of research that focuses on the cardiovascular effects of dihydroberberine, too! Atherosclerosis is the build-up of fatty plaque within major arteries in the body. Without diving too deep into how one develops atherosclerosis, there are various matrix metalloproteinases (MMP) expressed by macrophage cells that make arteries more susceptible to plaque build-up. Two of these are MMP-9 and extracellular matrix metalloproteinase inducer (EMMPRIN), which are frequently considered targets when looking to improve symptoms of atherosclerosis. A study from 2014 looked into how DHB affected EMMPRIN in mice, testing its effects against berberine. They found that in macrophages, dihydroberberine reduced plaque size and improved plaque stability compared to berberine, while also seeing a significant reduction in EMMPRIN expression. Thus, there seems to be some backing to the claim that DHB can help improve cardiovascular health, specifically in those susceptible to atherosclerosis. Ultimately, every time we see a new dihydroberberine study, we realize that this is the form that we want to take. Dihydroberberine Safety: Lower Doses, Improved GI 1g of berberine daily produces some fantastic results! But with DHB, we can do even better with less, saving you from GI discomfort! One of the most evident advantages of dihydroberberine over berberine, other than its higher bioavailability, is the lack of stomach issues it seems to cause. Unlike berberine, DHB seems to be relatively easy on the stomach, with multiple studies citing less adverse effects in supplementing with DHB.[44,45] However, a review of the safety of these two ingredients suggests that gastrointestinal issues may be unavoidable simply due to passing through the digestive system. This same review also experimented with transdermal DHB, which yielded less discomfort, albeit with less bioavailability. This suggests that there seems to be a sort of a trade-off between the two, where perhaps the best option seems to be the compound that maximizes bioavailability while still passing through the digestive system. DHB does just that, and with multiple studies citing little to no gastrointestinal issues when supplementing with it, it just may be the best option! Learn more with Shawn Wells on the PricePlow Podcast Shawn Wells, chief science officer of NNB Nutrition, joined us to talk more about berberine on the PricePlow Podcast: Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud GlucoVantage in one minute Listen to Mike talk about GlucoVantage in this quick one-minute video explainer: Ben’s Experiment with NNB Nutrition’s GlucoVantageⓇ! Ben decided to perform an experiment to assess how GlucoVantageⓇ stacked up against his favorite glucose disposal agent products. Can a single ingredient really outperform a fully loaded formula? What the video to find out the surprising results! Supplements with dihydroberberine GlucoVantage from NNB Nutrition is a pure form of Dihydroberberine (DHB) and is known as “The Super Berberine”. See more on NNBNutrition.com While DHB certainly has some strong clinical research behind it, it actually hadn’t broken into the supplement industry…until now! GlucoVantageⓇ from NNB Nutrition is the first commercially available product containing DHB. This powder is 100% DHB – lab tests and all: there’s no manufacturing malpractice, no spiking, nor any other ingredients! Delivering a high-quality, all-natural DHB, GlucoVantageⓇ is truly the first of its kind! NNB Nutrition was incredibly smart to go with dihydroberberine here as opposed to standard berberine. As research shows, DHB has a higher bioavailability that makes it an incredibly cost-effective form of berberine – you can yield great benefits with a smaller amount! This not only benefits NNB Nutrition and the brands who work with them, but consumers as well. Branded Supplements Containing GlucoVantage The Genius Brand Genius Blood Sugar One of the most innovative brands on the market, The Genius Brand’s Genius Blood Sugar has a solid 170mg GlucoVantage in each capsule alongside a very strong 10:1 cinnamon extract! The Genius Brand Genius Blood Sugar - Deals and Price Drop AlertsGet Price AlertsGet Genius Blood Sugar Price AlertsGet The Genius Brand alertsGet Glucose Disposal Agents price drops Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. Evogen Evolog Run by the famous Hany Rambod, every capsule of Evogen’s Evolog sports 84mg GlucoVantage alongside three other GDA ingredients and a digestive enzyme complex! Evogen Evolog - Deals and Price Drop AlertsGet Price AlertsGet Evolog Price AlertsGet Evogen alertsGet Glucose Disposal Agents price drops Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. Using GlucoVantage, you can get more out of less, meaning that a container can take you longer to go through. Due to the lower dosing below (and less work in finding a quality berberine extract), GlucoVantageⓇ has a lower price tag on the aggregate than berberine, making it a great addition to many weight loss and glucose disposal-improving regimens! It’s worth noting that dihydroberberine is made directly from real berberine, so it’s quite intensive to do it the right way – but well worth it for users who want something better. Mike’s GlucoVantage Review A supplement that had GlucoVantage inside provided some amazing results: The product is in reformulation, however, so check the other products listed above to get similar results. Berberine and GlucoVantage (Dihydroberberine) Dosage The standard berberine dose, for those who can afford it, is 500mg three times a day, preferably with meals. The effective Dihydroberberine Dosage is 30% the dose of standard berberine, giving it far more applications and less GI discomfort! There isn’t yet a definitive clinical dosage for dihydroberberine yet, but we can deduce a suggested range from the studies that exist. Most studies used a dosage around 20mg per kg of bodyweight per day, which was substantially less than most berberine dosages. A daily dose depends drastically on your weight, which makes a range of dosages a fitting estimate. Thus, the suggested daily dose of DHB seems to be somewhere between 200mg to 600mg. Sure enough, GlucoVantageⓇ is recommended within that range! NNB Nutrition suggests that a serving is between 100mg to 200mg, with one to three servings per day. Splitting up servings in this fashion is an excellent way to keep DHB in your system, especially when taken before each major meal! Lower doses: opening the doors to new applications Compare to 500mg of standard berberine: once the excipients are added, this takes up an entire large full-sized (0/00) capsule, while the DHB could be in a gum, transdermal (at 30x better absorption than standard berberine!), super small capsule, sublingual, etc. Stacking with DHB There are two different stances, other than general insulin sensitivity improvement, where DHB seems to be most applicable: Fat loss When trying to lose body fat, there are a multitude of things one needs to ensure are in check before introducing supplements – diet, training frequency/intensity, stress levels, and sleep are just a few! However, once you have these things accounted for, there are various products and ingredients that can help you aid you as you progress towards your goals: Any of your common weight-loss formula ingredients, such as caffeine, L-carnitine, synephrine, yohimbine, ashwagandha, and grains of paradise are some of our favorites! Supplement formulators will likely pair GlucoVantage with other glucose disposal agents. Some popular ones are Na-R-ALA (Alpha Lipoic Acid), Banaba Leaf Extract, Nutrition 21’s Chromax Chromium Picolinate, Gymnema Sylvestre, and several others. NNB Nutrition has finally brought us a trusted and tested form of L-BAIBA, which we call an “exercise signal” that kickstarts incredible metabolic processes! Medium-chain triglyceride (MCT) supplementation is another great option, as well, especially on low-carb diets. MCTs are an excellent source of fat for efficient fuel and appetite control, keeping you on your game despite a lower caloric intake. NNB Nutrition has you covered here, too, with C8VantageTM, their high-quality MCT powder! Somewhat new to the block, MitoBurnTM from NNB Nutrition (L-BAIBA) is one of the more exciting entrants into the fat-burning market these days. For more on this metabolic-boosting ingredient, be sure to check out our latest post about it! GlucoVantage fits in right at home with any of these ingredients. Improving insulin sensitivity makes it easier to fuel muscles instead of body fat, which can go a long way in losing fat. When dieting, you want to maintain as much of your hard-earned muscle as possible, and shuttling glucose to it helps prevent it from breaking down. Add GlucoVantage to your diet supplement stack and you now have an effective way to do just that! Clean bulking Bulking seems to have a dirty connotation these days, thanks to countless “bro-experts” who preach that bulking is synonymous with crushing endless junk food calories daily (let’s not ignore the fact that many of them are already artificially “insulin sensitive” due to other hormones they inject themselves with). For us mere mortals, however, this is not how proper bulking should be done – eating in a slight caloric surplus is a much better way to put on some muscle while minimizing fat gain. Every time you eat carbohydrates, you stop burning fat! So why are you wasting time? BURN FAT, NOT SUGAR! Image courtesy @TedNaiman Some of our favorite ingredients to help put on lean mass are whey protein, creatine, betaine, and plenty of nutrient-dense food like red meat and even organ meat! Carb sources should come from those that you can best digest without gas or bloating – we prefer white rice and yams / sweet potatoes. Depending on your preferences, looking into pre-workouts as a way to raise in-the-gym intensity is a great option, too! Again, DHB slides in seamlessly – especially with those carbs and before training. When bulking, you should want as much of what you’re eating to be put to good use, which in this case, happens to be rebuilding, recovering, and growing from training. By using GlucoVantage in a glucose disposal agent (GDA), you can better prepare the body for an uptick in calories, especially when eating a meal high in carbohydrates. This a relatively common (and often recommended!) use for GDAs, but we’ve just laid out all that may separate DHB from the rest! Dihydroberberine acts a transporter, moving nutrients to the muscles that need them in order to help promote gains! Conclusion: Berberine (and its more effective derivative) blow up the GDA market! How does one avoid the berberine bioavailability problem? WIth dihydroberberine, as The Genius Brand figured out! One of the biggest issues that presents itself in all health-related situations is insulin resistance. Being in this state chronically is very bad for your health, and can ultimately lead to more serious issues. If on a poor Standard American Diet full of processed food and toxic seed oils, or your training falls off, problems such as type 2 diabetes can become a reality. In order to prevent these issues, one can help their body keep its efficient functioning earlier down the line. In doing so, they can keep nutrients going where they should be, ultimately keeping their fat-loss or muscle-building goals in sight! To do so, we often turn to glucose disposal agents (GDAs). GDAs help insulin to better shuttle glucose from the blood to muscles, keeping the body from storing the sugar as fat. Berberine seems to be an effective way of doing this, with its derivative dihydroberberine (DHB) showing to be even more potent. The days of low-bioavailability, high-discomfort, untrustworthy berberine extracts are over. NNB Nutrition has finally released the first commercially available dihydroberberine product, GlucoVantageⓇ. Made from 100% DHB, this ingredient can be effectively used to keep your insulin sensitivity in check and bash through muscle gain and fat loss barriers. It can potentially make you more responsive to insulin levels, which helps the body properly process and store blood glucose the way you want it to be stored. If you’re looking for a bit of extra help in maintaining muscle while trying to drop body fat, or need an extra boost on you’re lean bulk, make sure you consider introducing GlucoVantage into your supplement arsenal! GlucoVantage from NNB Nutrition is a pure form of Dihydroberberine (DHB) and is known as “The Super Berberine”. See more on NNBNutrition.com Subscribe to PricePlow's Newsletter and Alerts on These Topics Topic Blog Posts YouTube Videos Instagram Posts Berberine GlucoVantage Glucose Disposal Agents NNB Nutrition Your Email: Sign Up All Blog Posts about Berberine AP Sports Regimen Non-Stim: Boost Your Metabolism Without Stimulants Posted on: November 24, 2020Alpha Lion Gains Candy GlucoVantage Optimizes Nutrient Partitioning and Gains Posted on: June 5, 2020Arms Race Nutrition Stabilize: Optimize Your Hormone Levels Posted on: May 14, 2020Berberine: The Best Glucose Disposal Ingredient Just Got Better Posted on: January 26, 2020GlucoVantage: Dihydroberberine for Superior Insulin Sensitivity Posted on: January 15, 2020Revive MD Glucose RX: The 'Mic Drop' of Glucose Disposal Agents Posted on: January 8, 2020PEScience LipoVate: Shift Into Fat Burning Mode Faster Posted on: March 4, 2019Fighting Disease with Shawn Wells | Podcast Episode #014 Posted on: September 11, 2018SNS GlycoPhase Turns Carbs into Gym-Smashing Pumps Posted on: August 8, 2018Outbreak Nutrition ADAPT: Carb-Load For The Zombie Slaughter Posted on: April 9, 2018Performax Labs SlinMax: MAX Out Your Carbs.. and Your Gains! Posted on: October 26, 2017RedCon1 RPG: Take a Grenade to Glucose Posted on: July 17, 2017Blackstone Labs Glycolog - Putting Carbs in their Place Posted on: July 5, 2017Metabolic Nutrition's ThermoKal Caffeine-Free Fat Burner Posted on: May 25, 2017Magnum Mimic: Strong GDA for your Biggest Carb Meal Posted on: January 13, 2016iSatori LipoDrex - Nutrient Partitioning Thermogenic Posted on: January 7, 2016 References Bentley, G, et al; “Structure of Insulin in 4-Zinc Insulin.”; Nature; U.S. National Library of Medicine; 13 May 1976; https://pubmed.ncbi.nlm.nih.gov/1272390 Seymour, Philip A, and Maike Sander; “Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development.”; Diabetes; vol. 60,2; 2011; 364-76; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028333/ Watson, R T, and J E Pessin; “Intracellular Organization of Insulin Signaling and GLUT4 Translocation.”; Recent Progress in Hormone Research; U.S. National Library of Medicine; 2001; https://pubmed.ncbi.nlm.nih.gov/11237212 Shepherd, P R et al; “Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.”; The Biochemical journal; vol. 333; Pt 3; 1998; 471-90; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219607/ Corvera, S, and M P Czech; “Direct Targets of Phosphoinositide 3-Kinase Products in Membrane Traffic and Signal Transduction.”; Trends in Cell Biology; U.S. National Library of Medicine; Nov. 1998; https://pubmed.ncbi.nlm.nih.gov/9854311 James, D E, et al; “Molecular Cloning and Characterization of an Insulin-Regulatable Glucose Transporter.”; Nature; U.S. National Library of Medicine; 2 Mar. 1989; https://pubmed.ncbi.nlm.nih.gov/2645527 KEGG PATHWAY: Insulin Signaling Pathway – Homo Sapiens (Human); https://www.genome.jp/kegg/pathway/hsa/hsa04910.html Physiologic Effects of Insulin; https://www.vivo.colostate.edu/hbooks/pathphys/endocrine/pancreas/insulin_phys.html Wilcox, Gisela. “Insulin and insulin resistance.”; The Clinical biochemist; Reviews; vol. 26,2; 2005; 19-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204764/ Goulet, Eric D B, et al; “Aerobic Training Improves Insulin Sensitivity 72-120 h after the Last Exercise Session in Younger but Not in Older Women.”; European Journal of Applied Physiology; U.S. National Library of Medicine; Oct. 2005; https://pubmed.ncbi.nlm.nih.gov/16032415 Black, Laurie E, et al; “Effects of Intensity and Volume on Insulin Sensitivity during Acute Bouts of Resistance Training.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; Apr. 2010; https://pubmed.ncbi.nlm.nih.gov/20093961 Mason, Caitlin et al; “Dietary weight loss and exercise effects on insulin resistance in postmenopausal women.”; American journal of preventive medicine; vol. 41,4; 2011; 366-75; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185302/ González-Ortiz, M, et al; “Effect of Sleep Deprivation on Insulin Sensitivity and Cortisol Concentration in Healthy Subjects.”; Diabetes, Nutrition & Metabolism; U.S. National Library of Medicine; Apr. 2000; https://pubmed.ncbi.nlm.nih.gov/10898125 Adam, Tanja C et al; “Cortisol is negatively associated with insulin sensitivity in overweight Latino youth.”; The Journal of clinical endocrinology and metabolism; vol. 95,10; 2010; 4729-35; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050109/ Grycová, Lenka, et al; “Quaternary Protoberberine Alkaloids.”; Phytochemistry; U.S. National Library of Medicine; Jan. 2007; https://pubmed.ncbi.nlm.nih.gov/17109902 Schor, Jacob, et al; “Clinical Applications for Berberine.”; Natural Medicine Journal; https://www.naturalmedicinejournal.com/journal/2012-12/clinical-applications-berberine Vuddanda, Parameswara Rao, et al; “Berberine: a Potential Phytochemical with Multispectrum Therapeutic Activities.”; Expert Opinion on Investigational Drugs; U.S. National Library of Medicine; Oct. 2010; https://pubmed.ncbi.nlm.nih.gov/20836620 Cernáková, M, and D Kostálová; “Antimicrobial Activity of Berberine–a Constituent of Mahonia Aquifolium.”; Folia Microbiologica; U.S. National Library of Medicine; 2002; https://pubmed.ncbi.nlm.nih.gov/12422513 Kaneda, Y, et al; “Effects of Berberine, a Plant Alkaloid, on the Growth of Anaerobic Protozoa in Axenic Culture.”; The Tokai Journal of Experimental and Clinical Medicine; U.S. National Library of Medicine; Nov. 1990; https://pubmed.ncbi.nlm.nih.gov/2131648 Sowndhararajan, Kandhasamy et al; “Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review.”; Brain sciences; vol. 8,6; 104; 11 Jun. 2018; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025220/ Wang, Jing-Rong, et al; “Formation and Conformation of Baicalin-Berberine and Wogonoside-Berberine Complexes.”; Chemical & Pharmaceutical Bulletin; U.S. National Library of Medicine; 2012; https://pubmed.ncbi.nlm.nih.gov/22689420 Pan, Guo-yu, et al; “Inhibitory Action of Berberine on Glucose Absorption.”; Yao Xue Xue Bao = Acta Pharmaceutica Sinica; U.S. National Library of Medicine; Dec. 2003; https://pubmed.ncbi.nlm.nih.gov/15040083 Zhang, Xinfeng, et al; “Intestinal Absorption Mechanisms of Berberine, Palmatine, Jateorhizine, and Coptisine: Involvement of P-Glycoprotein.”; Xenobiotica; the Fate of Foreign Compounds in Biological Systems; U.S. National Library of Medicine; Apr. 2011; https://pubmed.ncbi.nlm.nih.gov/21319959 Zhang, Yifei, et al; “Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine.”; The Journal of Clinical Endocrinology and Metabolism; U.S. National Library of Medicine; July 2008; https://pubmed.ncbi.nlm.nih.gov/18397984 Li, Yi et al; “Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.”; Journal of translational medicine; vol. 9 62; 15 May. 2011; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103436/ Richter, Erik A, and Neil B Ruderman; “AMPK and the biochemistry of exercise: implications for human health and disease.”; The Biochemical journal; vol. 418,2; 2009; 261-75; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779044/ Tao, Rong et al; “AMPK exerts dual regulatory effects on the PI3K pathway.”; Journal of molecular signaling; vol. 5,1 1; 18 Feb. 2010; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848036/ Cheng, Zhe, et al; “Berberine-Stimulated Glucose Uptake in L6 Myotubes Involves Both AMPK and p38 MAPK.”; Biochimica Et Biophysica Acta; U.S. National Library of Medicine; Nov. 2006; https://pubmed.ncbi.nlm.nih.gov/17049164 Turner, Nigel, et al; “Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: a Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action.”; Diabetes; U.S. National Library of Medicine; May 2008; https://pubmed.ncbi.nlm.nih.gov/18285556 Chen, Chunhua, et al; “Berberine Inhibits PTP1B Activity and Mimics Insulin Action.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 2 July 2010; https://pubmed.ncbi.nlm.nih.gov/20515652 Kadowaki, Takashi, and Toshimasa Yamauchi; “Adiponectin and Adiponectin Receptors.”; Endocrine Reviews; U.S. National Library of Medicine; May 2005; https://academic.oup.com/edrv/article/26/3/439/2355263 Wang, Yu, et al; “Post-Translational Modifications of Adiponectin: Mechanisms and Functional Implications.”; The Biochemical Journal; U.S. National Library of Medicine; 1 Feb. 2008; https://pubmed.ncbi.nlm.nih.gov/18177270 Li, Yun, et al; “Activation of AMPK by Berberine Promotes Adiponectin Multimerization in 3T3-L1 Adipocytes.”; FEBS Letters; U.S. National Library of Medicine; 23 June 2011; https://pubmed.ncbi.nlm.nih.gov/21536037 Chen, Chunhua, et al; “Berberine Inhibits PTP1B Activity and Mimics Insulin Action.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 2 July 2010; https://pubmed.ncbi.nlm.nih.gov/20515652 Cok, Alexandra et al; “Berberine acutely activates the glucose transport activity of GLUT1.”; Biochimie; vol. 93,7; 2011; 1187-92; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526940/ Yin, Jun et al; “Efficacy of berberine in patients with type 2 diabetes mellitus.”; Metabolism: clinical and experimental; vol. 57,5; 2008; 712-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/ Zhang, Hao, et al; “Berberine Lowers Blood Glucose in Type 2 Diabetes Mellitus Patients through Increasing Insulin Receptor Expression.”; Metabolism: Clinical and Experimental; U.S. National Library of Medicine; Feb. 2010; https://pubmed.ncbi.nlm.nih.gov/19800084 Yang, Jing et al; “Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients.”; Evidence-based complementary and alternative medicine : eCAM; vol. 2012; 2012; 363845; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310165/ Gomes, Ana P et al; “Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.”; Biochimica et biophysica acta; vol. 1822; 2; 2012; 185-95; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366688/ Kong, Wei-Jia, et al; “Berberine Reduces Insulin Resistance through Protein Kinase C-Dependent up-Regulation of Insulin Receptor Expression.”; Metabolism: Clinical and Experimental; U.S. National Library of Medicine; Jan. 2009; https://pubmed.ncbi.nlm.nih.gov/19059538 Liu, Li-Zhong, et al; “Berberine Modulates Insulin Signaling Transduction in Insulin-Resistant Cells.”; Molecular and Cellular Endocrinology; U.S. National Library of Medicine; 12 Apr. 2010; https://pubmed.ncbi.nlm.nih.gov/20036710 Liu, Li-Zhong, et al; “The Pivotal Role of Protein Kinase C Zeta (PKCzeta) in Insulin- and AMP-Activated Protein Kinase (AMPK)-Mediated Glucose Uptake in Muscle Cells.”; Cellular Signalling; U.S. National Library of Medicine; Oct. 2010; https://pubmed.ncbi.nlm.nih.gov/20570724 Dong, Hui et al; “Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis.”; Evidence-based complementary and alternative medicine : eCAM; vol. 2012; 2012; 591654; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478874/ Feng, Ru, et al; “Transforming Berberine into Its Intestine-Absorbable Form by the Gut Microbiota.”; Nature News; Nature Publishing Group; 15 July 2015; https://www.nature.com/articles/srep12155 Turner, Nigel, et al; “Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: a Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action.”; Diabetes; U.S. National Library of Medicine; May 2008; https://pubmed.ncbi.nlm.nih.gov/18285556 Lunagariya, Nitin A et al; “Inhibitors of pancreatic lipase: state of the art and clinical perspectives.”; EXCLI journal; vol. 13; 897-921; 22 Aug. 2014; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464291/ Kaila, Brinderjit, and Maitreyi Raman; “Obesity: a review of pathogenesis and management strategies.”; Canadian journal of gastroenterology = Journal canadien de gastroenterologie; vol. 22,1; 2008; 61-8; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659122/ Mohammad, Mohammad, et al; “Inhibition of pancreatic lipase by berberine and dihydroberberine: An investigation by docking simulation and experimental validation.”; Medicinal Chemistry Research; 22(5); April 2013; 2273-2278; https://www.researchgate.net/publication/255979651_Inhibition_of_pancreatic_lipase_by_berberine_and_dihydroberberine_An_investigation_by_docking_simulation_and_experimental_validation Major, Terry C., et al; “Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Is Induced Upon Monocyte Differentiation and Is Expressed in Human Atheroma.”; Arteriosclerosis, Thrombosis, and Vascular Biology; 9 May 2002; https://www.ahajournals.org/doi/full/10.1161/01.atv.0000021411.53577.1c Fang, Lu, et al; “Berberine Derivatives Reduce Atherosclerotic Plaque Size and Vulnerability in ApoE −/− Mice.”; Journal of Translational Medicine; BioMed Central; 26 Nov. 2014; https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-014-0326-7 Buchanan, Beth et al; “Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine.”; PloS one; vol. 13,3; e0194979; 26 Mar. 2018; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868852/ Kelly, CT, et al; “Hyperinsulinemic syndrome: the metabolic syndrome is broader than you think”; Surgery; 156(2):405-11; August 2014; https://pubmed.ncbi.nlm.nih.gov/24962189 Ashwell, Margaret, et al; “Waist-to-height ratio is more predictive of years of life lost than body mass index”; PloS one; vol. 9,9 e103483; September 8, 2014; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157748/ Kuwahara, Keisuke et al; “Body mass index trajectory patterns and changes in visceral fat and glucose metabolism before the onset o
57 minutes | 10 months ago
#027: The 2020 ABH Scandal - Brent Laffey (Armada Nutrition) & Mark Glazier (NutraBio)
Update: Nutrex Research has released a statement regarding this recall. See our brand statements section at the bottom of this post to learn more. Many consumers quickly glance at the label on a dietary supplement, blindly purchase it, and never question where it was made or if what’s listed on the label is actually in the bottle. But what if you don’t even know what you’re buying? Has the product been tested to meet label claims, where is it manufactured, and how pure really is it? After years of failed inspections, warning letters, meetings with the FDA, and recalls… ABH Pharma and their owner Mohammed Jahirul Islam have been indicted by the US Department of Justice Regardless of the myths that surround the supplement industry of ‘not being regulated by the FDA’, this news story will change your mind. Because this one involves a serious indictment after plenty of warning letters, strikes, and failed audits. FDA indicts major contract manufacturer in ABH Pharma After years of playing “whack-a-mole” by sending warning letters to small brands, the FDA — and now the Department of Justice — have gone after the root of the supplement industry’s biggest problem: underhanded contract manufacturers. These are the companies that are actually bottling the products, and we have long stated that they are a better “pinch point” for strict enforcement of current Good Manufacturing Practices. On January 17th, 2020, a major contract supplement manufacturer under the names of ABH Pharma, ABH Nature’s Products, and Stocknutra.com published a press release on BusinessWire issuing a nationwide recall on all lots of dietary supplements manufactured and sold between January 2013 – November 2019, after an indictment was posted in New York on December 26, 2019.[2,3] Major offenses over several years After numerous failed inspections, warning letters, and even meetings, the FDA and DOJ had finally had enough The DOJ indictment, which names Mohammed Jahirul Islam (“Islam”) as the owner of the three companies, alleges that their facilities distributed adulterated and misbranded dietary supplements and unapproved and misbranded drugs. They signed a consent decree forcing Islam to destroy all dietary supplements (and drugs) in their possession within 15 days, which has now also been posted on the FDA’s website. The DOJ indictment report stated that ABH failed 6 FDA audits over the years, had warning letters dating back to 2012, and neglected to conduct at least one appropriate test for ingredient identity. The indictment itself (which is linked at the bottom of the DOJ’s report web page) includes new infractions from a November 2018 inspection. Such infractions include some egregious drug claims made on products they manufactured, such as “Whey protein in the form of protein powder can help in reducing the symptoms associated with anxiety and depression”. In addition, ABH Nature’s products had a voluntary recall in June 2017 and January 2018 due to possible salmonella contamination. “As demonstrated by the consent decree, this Office and the FDA will work tirelessly to protect consumers who take dietary supplements, ensuring that manufacturers comply with good manufacturing practices and do not distribute unapproved and misbranded drugs in violation of the Food, Drug, and Cosmetic Act.” — Richard P. Donoghue, U.S. Attorney for the Eastern District of New York A long time coming The indictment lists several inspections at the Defendants’ Edgewood, NY facility, including inspections that occurred in or about July 2012, May 2013, August 2013, November 2016, and February 2018, on top of the most recent November 2018 inspection. The FDA’s warning letter from 2012 lists seven major cGMP (Current Good Manufacturing Practice) violations, such as adulteration, mislabeling, misbranding, failure to verify finished supplements, failure to monitor, and failure to follow control processes, and failure to qualify suppliers. The FDA even held regulatory meetings with Islam and his management team on March 23, 2017, in order to discuss previous deviations, so this indictment was most certainly not out of the blue. Impending recalls This is a massive deal considering the list of over 800 supplement brands for whom ABH produced supplements. Any products that made it to market are subject to recall. To see the full list of supplement companies potentially involved in this recall check out the pdf below: See the ABH Customer List (archived here from BusinessWire) Note that the list above allegedly includes companies that ordered just a single lot from ABH (many of which never made it to market), as explained below. Defrauded customers? These are just a couple of the egregious drug claims made by ABH Pharma. To make matters worse, we’ve received first hand reports that they allegedly defrauded several companies by withholding products and/or money from them. Therefore, multiple brands included on this list may have never shipped products from them or only worked with them for a small period of time before moving on to another manufacturer. Long story short, just because a company is on the above list doesn’t mean that their current product offerings are mislabeled or adulterated. However, we’ll do our best to stay updated with relevant recalls that do occur. What consumers can do about this… This should be taken very seriously since it involves a large time frame, widely-used manufacturer and hundreds of supplement companies. Consumers are being recommended to check the list of companies who sell products manufactured by ABH Pharma to see if they issue a recall in the near future. You may also wish to contact those brands, and many may put out statements on social media. With that information, you will be able to decide if the product needs to be returned to the company or properly disposed of. ABH is supposed to be contacting all of its customers/distributors over email to request a return of all recalled products. If anyone has any questions, they should email email@example.com. Also, if you ever have an adverse reaction, you can report it to the FDA’s MedWatch Adverse Event Reporting program by completing and submitting a report linked here. “A lot of people say the industry is not regulated, this is a perfect example of how testing, proving label claims for strength, purity, and composition is a requirement by the law. And if you don’t do it, you’ll eventually be caught.” -Benjamin Kane, PricePlow Co-Host Final Thoughts: Stay tuned for more information… We’ve covered this topic in the past with NutraBio’s Mark Glazier, who explains that Supplements are regulated, going over the laws on our YouTube channel. Before you completely write off the supplement industry, just know there are a ton of great manufacturers and companies doing the right thing, and many incredible certification programs and third-party lab tests available. However, there are bad apples, and for years, we’ve called on the FDA to enforce their laws at the manufacturing level, not just at the brand level. Despite the bad news, this type of enforcement is the only kind that can work, and we’re happy to see the FDA and DOJ joining forces to properly level the playing field rather than play “whack a mole” with one-off brands who aren’t the ones doing the actual manufacturing. We will be adding more information as this major story unfolds and companies start to speak out. PricePlow has contacted ABH and some of the companies on the above list to get their comments and find out more details. There will be plenty more to share, so make sure you are subscribed to PricePlow’s supplement news alerts and follow us on social media to our take on this topic! Mark Glazier (NutraBio) and Brent Laffey (Armada Nutrition) Discuss Brent Laffey of Armada Nutrition and Mark Glazier of NutraBio came on to discuss this indictment and how we all can improve this industry, whether you’re a manufacturer of dietary supplements, brand owner, or retailer: Statements from Supplement Companies The following companies have issues statements regarding this situation: Nutrex Research On January 24, 2020, Nutrex Research published a statement indicating that only three lots of their CLA 180ct supplement were manufactured at ABH Nature’s Products in January of 2018. The lots are as follows: Lot #0116119 Lot #0117179 Lot #0117594 Read Nutrex Research’s Statement (PDF) or watch their explanation on IGTV below: View this post on Instagram In light of a national recall of products made by ABH Nature’s Products, Inc.; ABH Pharma, Inc.; and Stocknutra.com Inc., for failing to meet current good manufacturing practice regulations that has affected over 800 companies. We at Nutrex Research, Inc. want to reassure you that our company has not manufactured or sold any of those businesses’ products cited, with the exception of one limited, single production run in January 2018: CLA 180ct with the following Lot Numbers: Lot#0116119 Lot#0117179 Lot#0117594 Consumers who bought CLA 180ct with these specific lot numbers can return the unused portion for a full refund. No other Nutrex branded products were ever made by these companies or are part of this recall. In our nearly 20 years in business, our priority has always been focused on manufacturing and distributing the highest quality products for our customers’ specific needs. Sincerely, Jens Ingenohl President/CEO Nutrex Research, Inc. If you have any questions or concerns, please give us a call at (407) 359-0734 or email us at firstname.lastname@example.org. Go to this link to view the statement: https://bit.ly/36qqalL A post shared by Nutrex Research (@nutrexresearch) on Jan 24, 2020 at 10:50am PST The above section will stay up-to-date as information develops. Subscribe to PricePlow's Newsletter and Alerts on These Topics Topic Blog Posts YouTube Videos Instagram Posts ABH Pharma Recall Supplement Industry News Your Email: Sign Up References “ABH NATURE’S PRODUCTS, INC, ABH PHARMA, INC., and STOCKNUTRA.COM, INC. Issues Nationwide Recall of All Lots of Dietary Supplement Products”; BusinessWire; January 17, 2020; https://www.businesswire.com/news/home/20200117005507/en/ Marzulli, John; “District Court Orders Three Long Island Companies and Their Owner to Stop Distributing Adulterated and Misbranded Dietary Supplements and Unapproved and Misbranded Drugs”; United States Department of Justice; Eastern District of New York; December 26, 2019; https://www.justice.gov/usao-edny/pr/district-court-orders-three-long-island-companies-and-their-owner-stop-distributing United States District Court, Eastern District of New York; “Consent Decree of Permanent Injunction”; December 23, 2019; https://www.justice.gov/usao-edny/press-release/file/1230056/download United States Food and Drug Administration; Recalls, Market Withdrawals, & Safety Alerts; “ABH NATURE’S PRODUCTS, INC, ABH PHARMA, INC., and STOCKNUTRA.COM, INC. Issues Nationwide Recall of All Lots of Dietary Supplement Products”; January 21, 2020; https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/abh-natures-products-inc-abh-pharma-inc-and-stocknutracom-inc-issues-nationwide-recall-all-lots United States Food and Drug Administration; “Warning Letter NYK-DO 2013-2: ABH Nature’s Products, Inc. 10/24/12”; October 24, 2012; https://wayback.archive-it.org/7993/20171115100918/https://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2012/ucm375464.htm The post Supplement Manufacturer ABH Pharma INDICTED After Years of FDA Violations first appeared on The PricePlow Blog.
95 minutes | a year ago
#026: 2019 Supplement Industry Recap
In December of 2019, Ben visited Mike in Texas to film some videos to recap the year. But first, they sat down to catch up on their personal lives and recapped 2019 in the supplement industry. Ben and Mike Catch Up and Recap 2019 in the Supplement Industry Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post 2019 Supplement Industry Recap | Podcast #026 first appeared on The PricePlow Blog.
38 minutes | a year ago
#025 - Joseph Mencel (Massive Joe's) - 2019 Australian TGA Changes
On October 22nd, 2019 Australia’s TGA released “Consultation: Proposed clarification that certain sports supplements are therapeutic goods”, a document outlining proposed amendments to the Therapeutic Goods Act 1989. This proposed amendment would make most supplements under the regulation of the TGA, similar to the FDA’s drug office in the USA. We sat down with Joseph Mencel of Massive Joe’s to hear his thoughts. As a major importer, distributor, retailer, and someone with a legal background in Australia, he offers a unique point of view in the discussion. Joe is traveling so please forgive the lapses in connection. The update was later published by the Australia TGA in March of 2020. Joseph Mencel of Massive Joe’s Breaks Down the 2019 Australian TGA Update Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud References https://www.tga.gov.au/consultation/consultation-proposed-clarification-certain-sports-supplements-are-therapeutic-goods https://www.tga.gov.au/update-proposed-clarification-certain-sports-supplements-are-therapeutic-goods The post Joseph Mencel (Massive Joe's): 2019 Australia Legislation on Supplements | Podcast #025 first appeared on The PricePlow Blog.
53 minutes | a year ago
#024: Shawn Wells #3 | BAIBA (β-Aminoisobutyric Acid) - Weight Loss Ingredient Mimics Exercise?!
This amino acid has a similar structure to beta alanine and taurine, and is created naturally when you exercise. But can ingesting it make your body kick into “exercise mode” without lifting a finger?! We’re always on the lookout for supplement ingredients that could be the “Next Big Thing”, and it’s very possible we just found one for dieters. Its name is BAIBA (pronounced “BAY-buh”), and it may be able to mimic certain fat-burning processes that occur in your body when exercising – even when you’re not working out! Of course, we never suggest avoiding exercise, but research published in 2014 definitely got our attention, which is why we originally wrote this article in 2015. Four years later, we finally found a trustworthy ingredient supplier in NNB Nutrition’s MitoBurn, allowing us to pursue more research. TL;DR BAIBA (or β-aminoisobutyric acid) is an “amino acid” generated during exercise. It is involved in several healthy processes, such as the thermogenic browning of white fat and exercise-based prevention of bone and muscle loss. When supplemented, it is pro-ketogenic and increases fatty acid oxidation in the liver while protecting against fat gain and improving glucose tolerance in mice. (See the BAIBA Research section) There are two isomers of BAIBA, L-BAIBA and D-BAIBA, research shows L-BAIBA is superior for supplementation because it leads to more positive metabolic health outcomes. The preferred BAIBA Supplement ingredient is MitoBurn by NNB Nutrition. (See the BAIBA Supplements section) Interested in trying NNB Nutrition’s MitoBurn for your brand’s formulas? Contact us and we’ll arrange a sample for you or email NNB Nutrition directly at email@example.com! Suggested doses are 250-500mg, 1-2 times per day. (See the BAIBA Dosage section) There are no currently known side effects at the above doses, but because it is a new ingredient with limited human research, caution is suggested. In 2019, safety data was conducted on mice and showed L-BAIBA’s LD50 (lethal dose for 50% of animals) was well over 2,000mg/kg of body weight, which means we’re very comfortable with the suggested dose. Under DSHEA, BAIBA is by definition a dietary supplement since it covers several sections. No statements on this page are approved by the FDA and you should seek a doctor’s approval before beginning any new supplement or dietary program. This article was originally written in 2015, but updated in 2019 after finally finding a reputable raw material source from NNB Nutrition. This ingredient is incredibly interesting, especially to aggressive dieters, but is definitely not for the conservative or cautious user — at least until more human-based research is published. This article is science-intense, so get ready: What is BAIBA? Table of Contents TL;DRWhat is BAIBA?L-BAIBA vs. D/R-BAIBA: Which Form is Best?BAIBA’s Connection to Valine and ThymineValine: The underrated BCAA due to its metabolism to BAIBAWhy L-BAIBA is Superior to R-BAIBAWhat is BAIBA used for?Discovery of BAIBA“Exercise in a pill”??Watch our BAIBA video with Shawn WellsBAIBA’s role in the bodyPPAR alpha and PGC1 alphaPGC1 Alpha’s rolePPAR Alpha – Closer to the end gameBrown vs. White Adipose TissueWhite Fat: The ugly kind we all want to burnBrown Fat: The Energy UserHow BAIBA works: the ‘exercise in a pill’ partConverting to a hybrid fat with the best of both worldsPartial leptin deficiency: incredibly promising for obesityThe hazardous leptin negative feedback loop – can it be stopped?Other BAIBA Research Studies: Various positive effectsA pro-ketogenic moleculeHepatic fatty acid oxidation: clear liver fat faster?Prevention of Disuse-Based Bone and Muscle LossImprovement of glucose tolerance and insulin resistance related issuesImprovements from a high-fat dietImprovements to diabetic miceProtection against renal fibrosis in miceBAIBA SupplementsMitoBurn by NNB Nutrition: The Trusted and Tested form of BAIBAMitoBurn Lab Test ProvidedInterested in trying MitoBurn?BAIBA dosageDosage timingBAIBA’s Safety Data: Exceptionally High LD50 in MiceWhat Does LD50 Represent?NNB Nutrition’s MitoBurn’s LD50: Greater than 2,000mg/kg!Heat stability (for use in liquid / “RTD” applications)FDA ComplianceWhere Does BAIBA Fit Into The DSHEA Standards?BAIBA Has an Additional Foundation in Nature (Botanicals)BAIBA is Isolated in Wedgewood IrisWho will benefit from BAIBA use?Stacking BAIBAYohimbine HClHigenamine or SynephrineGrains of ParadiseOlive Leaf ExtractPutting it all togetherAttempting to go where no fat burner has gone beforePreventing new fat deposits?The potential overall health impactsSome Anecdotal Experience: Mike’s BAIBA ReviewConclusion: “BAIBA, when I think about you…”Subscribe to PricePlow’s Newsletter and Alerts on These TopicsReferences BAIBA, or β-aminoisobutyric acid, is an amino acid generated during exercise (an “exercise-induced muscle factor”) that is not naturally found in the genetic code of any organism — it’s formed when either thymine or valine are broken down. This means that BAIBA, while an amino acid, is not a building block for proteins but rather is used as a signaling molecule within the body. Because of this, consuming it will not contribute to the development of muscle mass like traditional essential amino acids (often used for recovery during or after a workout), but it may hold promise for fat-loss – and weight loss. L-BAIBA vs. D/R-BAIBA: Which Form is Best? There are two forms of BAIBA discussed in the literature: L-BAIBA (S-BAIBA) and D-BAIBA (R-BAIBA).[28,29] These two types are also referred to as enantiomers, which means they’re a pair of molecules that are mirror images of each other. You could also think of them as “right-handed” and “left-handed” notations because they are similar to your left and right hands – similar structure, similar components, but do not “map” on top of each other. Most researchers suggest that D-BAIBA is the most prevalent enantiomer in urine,[28,30] but newer research confirms that L-BAIBA is most major in plasma. BAIBA’s Connection to Valine and Thymine The two forms of BAIBA are also linked to two amino acids, thymine and valine. L-BAIBA is formed from the mitochondrial reactions of L-valine, a branched-chain amino acid (BCAA), whereas D-BAIBA is formed from thymine metabolism. Many athletes already take BCAA supplements, which contains a decent amount of valine. There are a total of three amino acids that collectively make up the BCAA group: Leucine, Isoleucine, and Valine. The first two are widely known for their ability to initiate muscle protein synthesis. However, in the past the importance of valine was not very well understood. Valine: The underrated BCAA due to its metabolism to BAIBA Thanks to the latest research on BAIBA, we’re starting to get a better understanding of just how important valine is. These three amino acids are also part of the nine essential amino acids humans must consume, because the body cannot synthesize them. Therefore, it is crucial to get these from our diets. Why L-BAIBA is Superior to R-BAIBA Given that L-BAIBA comes from valine and R-BAIBA comes from thymine, is one really biologically “better” than the other when taken as a supplement? Research shows L-BAIBA is the form that increases during muscle contractions due to the oxidation of L-valine. Because of this phenomenon, L-BAIBA is also referred to as an “exercise-induced muscle factor”. Since L-BAIBA comes from valine metabolism, this growing body of evidence shines a light on the importance of valine supplementation (and overall complete protein intake) for physically active people or those in a calorie deficit. Although there still may be some benefits to D-BAIBA, the one that is showing the most positive metabolic health effects is L-BAIBA. Next, we investigate BAIBAs effectiveness as a fat-burning / weight-loss product and its potential effectiveness at enhancing performance. What is BAIBA used for? As you know, the increasing obesity rate in the western world has given rise to a host of metabolic conditions that number in the top ten leading causes of death in the world. As such, researchers from around the globe have been searching frantically for ways to combat obesity and reduce the impact of these metabolic conditions. One of these research strategies is targeted at the development of anti-obesity compounds that work to increase fat mobilization and oxidation (freeing up stored fat then burning it for energy) that are also relatively side effect free and effective. It is in this context — severe weight disorders — that BAIBA is being researched.[1,2,3] Discovery of BAIBA BAIBA is also known as β-aminoisobutyric acid, 3-Aminoisobutyric acid, 3-amino-2-methylpropanoate, 3-amino-2-methylpropanoic acid, and 3-amino-isobutanoate In a large ongoing study known as the Framingham Heart Study , the relationship between BAIBA and metabolic risk factors humans came to light. Researchers noted that study participants who were put on an exercise program had higher levels of BAIBA, and that higher levels of naturally occurring BAIBA seemed to coincide with lower levels of circulating glucose, triglycerides and cholesterol. “Exercise in a pill”?? The findings were so substantial that they even made their way into online news sites that claimed BAIBA may be ‘exercise in pill form’ — if BAIBA could be synthesized and placed in a capsule. The idea being that BAIBA could either be used in conjunction with exercise to enhance its effects, or instead of, to still gain some of the metabolic benefits of exercise without actually lifting a finger – though it remains to be seen if the reality matches the media’s hyperbole. Watch our BAIBA video with Shawn Wells Mike brought industry guru Shawn Wells on to discuss BAIBA – check out the video below if you’d rather listen than read! Now let’s get to the fun part: BAIBA’s role in the body BAIBA mimics the role of exercise through a few interrelated pathways, however, it must be emphasized that BAIBA does not augment structural changes in muscle (hypertrophy) or cause an increase in strength in any way. Instead, BAIBA’s effects are based around metabolic changes in the liver and in fatty tissue. Some of these are: New research has shown that BAIBA may protect from disuse-based bone loss thanks to it preventing osteocyte cell death that would have been induced by reactive oxygen species (ROS). Changes the characteristics of energy storing white adipose tissue into energy burning brown-like adipose tissue via PPAR alpha.[1,3] Increases liver (hepatic) beta oxidation (fat burning) though a PPARa mediated mechanism. Protect against fat gain in mice with partial leptin deficiency.[1,3,5] Increase plasma beta-hydroxybutyrate, which is the primary ketone body generated when beta-oxidizing fat (especially on a ketogenic diet) Improve glucose tolerance and insulin sensitivity through AMP-activated protein kinase (AMPK) and PPARa[23,25] Prevent disuse-based bone and muscle loss through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria and cell death due to reactive oxygen species (ROS) The below diagram highlights the process by which BAIBA is increased and how it exerts its effects: The process by which BAIBA is increased and how it exerts its effectsAt this point, we need to dig deeper and discuss the functions mentioned above, which will help explain how BAIBA works and how it is expressed. PPAR alpha and PGC1 alpha As stated above, BAIBA performs most of its roles through PPAR alpha activation, however, it is only released when another protein is expressed in muscle tissue – PGC1 alpha.[1,3,7] PGC1 Alpha’s role PGC 1 alpha is a protein that is increased during and after aerobic exercise. It contributes to the way our bodies respond to an exercise stimulus — by performing the following tasks: increasing development of mitochondria (cell powerhouses), regulating blood pressure, regulating cholesterol, and by changing the composition of our fat cells. PGC1 alpha is restricted to muscle tissue so in order to exert its effects elsewhere in the body, it uses ‘messenger’ molecules , called myokines, such as irisin and BAIBA to do its bidding in other areas of the body. PPAR Alpha – Closer to the end game BAIBA acts on PPARa to perform the roles of white adipose browning, increase of beta oxidation and decrease in fat creation.[1,3,8] “BAIBA is released from the muscle after an exercise bout, promoting differentiation of brown adipocyte-like cells within subcutaneous fat depots and fat oxidation in the liver.”In short hand, exercise increases PGC-1alpha, PGC-1alpha increases BAIBA, BAIBA increases PPAR alpha activity, and PPARa activity does a lot of the work we ultimately desire when exercising. PPAR alpha is a major regulator of lipid metabolism in the liver, involved in the breakdown of fatty acids and increases in energy utilisation. It performs its work through increasing fatty acid transport, binding, and activation and through beta oxidation.[5,9] Beta oxidation is the process in which fat is broken down for use as energy in the body. Next, let’s take a look at the different forms of adipose in the body to see how BAIBA influences these, and why it matters. Brown vs. White Adipose Tissue In the body, we have two major types of adipose tissue: brown and white.[3,10]. White Fat: The ugly kind we all want to burn The most predominant one is white adipose tissue, which represents the store of energy in our bodies. This form is the type we can see and grab on our bodies, which can be broken down for energy during periods of low intensity exercise and in periods of calorie deficits. White adipose tissue also creates the hormone leptin.[3,10] Brown Fat: The Energy User Brown adipose tissue on the other hand is more of an energy spender than a saver . Its role is more obvious in animals that hibernate throughout the winter and need to keep warm whilst they are in their slumber. Brown fat generates this heat through mitochondrial uncoupling (a form of thermogenesis that expends energy as heat) and allows these animals to stay warm without shivering. However, in humans, brown fat only constitutes a very small amount of the fat we carry as we mostly shiver, heat our house, or put on warmer clothes in order to warm up. Brown adipose appears brown due to the increased mitochondria and enhanced blood supply.[3,10] The regulation of brown and beige adipocyte development. How BAIBA works: the ‘exercise in a pill’ part So when a person exercises, concentrations of BAIBA dramatically increase within both skeletal muscle and within other tissues.[1,3] BAIBA then signals for an increase in the expression of brown adipocyte-specific genes via PPAR alpha, which triggers the “browning of white fat”. Brown adipose cells generates heat from fat, increasing the body’s metabolism and therefore expending more calories during rest and exercise. Converting to a hybrid fat with the best of both worlds Interestingly, however, BAIBA doesn’t turn white fat completely brown but instead turns it into a third type known as “beige” fat.[1,10] This adipose form has the characteristics of brown fat but exists within white fat cells, thus allowing for heat generation from within the stored fat. BAIBA also influences liver fat burning and cholesterol regulation through PPAR alpha activation: when PPAR alpha is activated, it increases the expression of lipoprotein lipase and apolipoprotein A-V, and decreases expression of apoC-III in the liver.[11,12] These three changes allow the breakdown of triglycerides and cholesterol and the transport of fatty acids out of the liver to be either stored again or burned for energy. Going further, PPAR alpha activation also increases hepatic apoA-I and apoA, which increases levels of the ‘good’ cholesterol, HDL.[11,12] Simplified scheme of BAIBA metabolism, valine degradation, and thymine catabolism Partial leptin deficiency: incredibly promising for obesity BAIBA also has the potential to limit the development of obesity in mice with partial leptin deficiency when eating a hypercaloric diet. This study mimics what we might observe in humans who are eating a hypercaloric diet and have higher levels of body fat. What makes this point interesting is that leptin is created in white adipose tissue, so the more fat you have, the greater amount of leptin that is produced. The hazardous leptin negative feedback loop – can it be stopped? Getting caught in the “Leptin Negative Feedback Loop” is one of the biggest challenges you can create for yourself. Can BAIBA supplementation help anyone break the cycle? While this seems like a good thing given leptin signals the body that it is full, overstimulation can desensitize the leptin receptors in the brain and therefore stop this mechanism from working, creating a feeling of constant hunger in obese people as well as decreasing metabolic rate; essentially mimicking a leptin deficiency.[14,15] The above situation is known as leptin’s “negative feedback loop” and is a monumentally serious detriment to heavily overweight individuals who cannot seem to kick out of the “downward spiral” of hunger and weight gain. In this study, BAIBA was able to curb adiposity by 27% and reduce fat mass by 40%! Other BAIBA Research Studies: Various positive effects A pro-ketogenic molecule This article was originally written in 2015, just before the surge of the ketogenic diet. It turns out that it had been known since 2004 that BAIBA increases plasma levels of beta-hydroxybutyrate in mice – despite unchanged food consumption. Beta-hydroxybutyrate, or BHB, is the primary ketone body generating when beta oxidizing fat. It becomes the main fuel source for anyone who has not ingested carbohydrates recently, and is created from either dietary fat or bodyfat when fasted or in caloric deficit. Hepatic fatty acid oxidation: clear liver fat faster? The researchers suggested that BAIBA “increased hepatic fatty acid oxidation and ketogenesis”, which becomes extremely important for dieters because many researchers (including ourselves) postulate that bodyfat won’t get seriously worked off until the liver‘s is first cleared out. There are several ways of doing this, such as high intensity interval training (HIIT), but many obese individuals simply cannot partake in this type of activity. Thus, any molecule that safely makes this happen faster is of immediate interest. Prevention of Disuse-Based Bone and Muscle Loss In 2018, already knowing its white fat browning and insulin sensitization capabilities, a team of researchers investigated some alternate pathways BAIBA could operate on. They connected BAIBA to the well-known ability for exercise to prevent bone loss. Their research showed that the molecule “prevents osteocyte cell death induced by reactive oxygen species (ROS)”: L-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. While we once again always recommend regular exercise, it’s simply not always possible for some individuals. Supplementing BAIBA may provide at least some (but likely not all) of the osteoprotective benefits of exercise. It’s important to note that BAIBA supplementation worked best in the younger subjects when it came to bone loss prevention. Improvement of glucose tolerance and insulin resistance related issues Insulin resistance is believed by many to be central to most modern diseases. Two recent studies have shown improvements to glucose sensitivity and insulin resistance. Improvements from a high-fat diet Despite eating the most calories, the high-fat diet mice that also received BAIBA had far less weight gain and better blood glucose scores than their non-BAIBA counterparts.In the first study from 2015, mice were put on a high-fat diet (“HFD”: 60% energy from fat) and eventually became “glucose intolerant” due to their lack of use of glucose. Some of these mice were given BAIBA, others were not, and both of those HFD groups were compared to placebo.Treatment with BAIBA for eight weeks significantly improved HFD-induced glucose tolerance and insulin resistance, and did so in the muscle cells. This could have serious implications for ketogenic dieters looking to remain metabolically flexible. Meanwhile, it also decreased the weight gain from the high-fat diet, even though the high-fat dieting mice taking BAIBA ingested the most calories! Improvements to diabetic mice Another study published in 2016 showed that “BAIBA attenuates glucose metabolic disturbance and improves insulin resistance in STZ/HFD-induced type 2 diabetes in mice.” In this study, the researchers stressed the bodies of the mice (especially the livers) through various mechanisms involving AMPK, and were able to attenuate the damage each time with BAIBA treatment. The primary novel findings in the present study are that oral administration of BAIBA attenuates hepatic ER (endoplasmic reticulum) stress, apoptosis and glucose/lipid metabolic disturbance in type 2 diabetes. Protection against renal fibrosis in mice Looking at the mechanisms discussed above, in 2018, a team of researchers hypothesized that BAIBA may slow kidney fibrosis by slowing the formation of fibroblasts (a common type of connective tissue) in the kidneys. They tested several known pathways and gene expressions and had some seriously successful results with some of them: “Taken together, our data provide the first demonstration that BAIBA significantly alleviated the fibrotic responses and renal functional impairment in the obstructed kidneys. Inhibition of Ang II / IL-17 / ROS signaling pathway was responsible for the role of BAIBA in attenuating renal fibrosis. BAIBA may be useful for the treatment of patients with chronic kidney diseases.” Now before anyone dismisses this idea purely because it was established in mice, be mindful that most preliminary trials are first conducted in rodents to assess potential mechanisms that warrant further investigation in humans, as well as for the obvious ethical reasons. We’re not saying that if you jump right on board, you’ll reduce your fat mass by any appreciable amount. We’re saying that this research looks incredibly promising, and then some — and we can’t wait to see more of it. BAIBA Supplements MitoBurn from NNB Nutrition has been tested out to be a pure form of BAIBA on the market! Now that you have some background, it’s time to talk about supplements. However, remember that there is little-to-no published human research at this point, and this is not for anyone who is even remotely cautious or conservative. It goes without saying that absolutely no statements on this page have been evaluated by the Food and Drug Administration, and that this compound is not intended to diagnose, treat, cure, or prevent any disease. Discuss any new diet and/or supplementation protocol with a licensed physician, and that is doubly true for a prospective new ingredient such as this one. MitoBurn by NNB Nutrition: The Trusted and Tested form of BAIBA NNB Nutrition’s MitoBurn is the premier form of BAIBA on the market With that disclaimer in mind, there is currently one company who has a BAIBA raw material ingredient: NNB Nutrition, who has an L-BAIBA ingredient named MitoBurn️. MitoBurn sports the following features: HPLC tested and purity verified, with lab tests available L-isomer confirmed via optical rotation testing (this is the more important / active isomer, as the D-isomer is from the breakdown of thymine and is biologically inactive) Comes in “Free acid” form, which is more potent A fine white powder that is stable in aqueous solution and also perfect for encapsulation. MitoBurn Lab Test Provided We asked NNB for an HPLC test, and they immediately provided one (Full PDF available here): NNB Nutrition provided this HPLC lab test for MitoBurn, with one central peak and no additional “noise” or impurities. Full PDF Available Here Interested in trying MitoBurn? Formulators and brands looking to get a sample of BAIBA should check out NNBNutrition.com, email NNB Nutrition directly at firstname.lastname@example.org, or contact us and we will arrange for a test! BAIBA dosage The data surrounding the optimal oral dosage of BAIBA in humans is seriously lacking. When dealing with powders – especially potent ones, it’s critical you use a digital scale that measures down to the milligram. From the studies performed on mice, we are able to calculate the human equivalent dose which is normalized for body surface area. The successful BAIBA studies done mice equals about 0.016g per kg of bodyweight. For example a 60kg (132lb) human would need roughly 1g/day and a 100kg (220lbs) human would need closer to 1.5g/day. However, those studies used mixed isomers, while newer data shows that L-BAIBA is the active one. Therefore, when using pure L-BAIBA, we can cut those converted doses in half, leading us to the aforementioned recommended 250-500mg, 1-2x per day. This is indeed the recommendation from NNB Nutrition, who recommends 250-500mg per serving with 1-2 servings taken per day. Dosage timing There is no clinical data testing the timing, but looking at the mechanism, it’s clear to see that the two doses should be split apart in the day, with one of the doses used in a pre workout setting. In the mice trials the BAIBA was given through the drinking water which the mice drank throughout the day. BAIBA’s Safety Data: Exceptionally High LD50 in Mice What Does LD50 Represent? Before we dive into L-BAIBA’s LD50, we must first have a good understanding of what it means and why it’s important. Virtually every supplement or medication has an LD50 which stands for “Lethal Dose 50%” or “median lethal dose”. This represents the dosage of a given substance required to kill 50% of the tested population (typically in the context of the subject’s body weight). This is crucial for making sure the product is safely dosed, because too much of nearly anything can lead to negative effects. NNB Nutrition’s MitoBurn’s LD50: Greater than 2,000mg/kg! Late in 2019, NNB Nutrition provided PricePlow with a third-party analysis that assessed the LD50 dosage of L-BAIBA (MitoBurn) in mice. The data is provided below, but in summary the results show MitoBurn’s LD50 is more than 2,000mg/kg of body weight since there were no adverse clinical reactions or mortality experienced at that dose. Based on our recommendations on how much BAIBA you should take per day, 2,000mg/kg is way above that, so this is great safety news. Interestingly, you can count this as yet another “weight loss success”, although that was obviously not the purpose in the LD50 trial.Even at extremely high doses, the LD50 in mice has not yet been discovered.It’s also important to note, that 2000mg/kg was the max dose tested, and even at that insanely high dose, the LD50 still remains unknown in mice. Although, higher doses lead to greater weight loss, we still recommend following the amounts discussed earlier. Discovering that L-BAIBA is extremely safe makes us even more comfortable with our suggested dosing. Heat stability (for use in liquid / “RTD” applications) For use in “RTD” (ready-to-drink) applications that require pasteurization, MitoBurn has been tested for heat stability. It is currently known to be stable up to 212°F, but note that this is the upper tested limit. If necessary, so greater temperatures can be tested. Additionally, MitoBurn is stable in carbonated beverages. FDA Compliance IMPORTANT: No statements on this page have been approved by the FDA. The following information is based upon our thorough research, but we are not lawyers. If you are a supplement manufacturer considering using BAIBA and would like further confirmation, please consult your legal team or contact us for DSHEA subject matter experts. Here is the U.S, dietary supplements definitions and standards are governed under the Dietary Supplement Health and Education Act (DSHEA) passed in 1994. According to DSHEA, written and passed by Congress, a dietary supplements are defined as any of the following: (A) a vitamin; (B) a mineral; (C) an herb or other botanical; (D) an amino acid; (E) a dietary substance for use by man/woman to supplement the diet by increasing the total dietary intake; or (F) a concentrate, metabolite, constituent, extract, or combination of any ingredient described in clause (A), (B), (C), (D), or (E); (These clauses are in addition to the fact that the ingredient in question cannot be a scheduled drug, is intended for ingestion, and a few other stipulations.) Where Does BAIBA Fit Into The DSHEA Standards? BAIBA (β-Aminoisobutyric Acid) is an amino acid naturally found in both plants and animals, and it’s also a metabolite of two amino acids. As you can see from the list above, BAIBA is covered multiple times by DSHEA 1994, in section (D) as well as twice in section (F). In section (D), BAIBA is covered because it’s an amino acid. We also have two more forms of coverage in section (F) crossed with section (D), since BAIBA is a metabolite of two different amino acids in thymine and valine. BAIBA Has an Additional Foundation in Nature (Botanicals) BAIBA is found in multiple plants such as theobroma cacao, fabaceae, glycine max, cucurbitaceae, and glycine max, thus it also covers the constituent of a botanical. Which means it crosses sections F and C. However, it’s important to note that this information was supplied by the Canada Foundation for Innovation, and they do not cite any peer-reviewed research. BAIBA is Isolated in Wedgewood Iris A study published in 1958 titled “Isolation of β-Aminoisobutyric Acid from Bulbs of Iris tingitana var. Wedgewood”, stated the researchers were able to extract BAIBA from Wedgewood iris. This further strengthens the argument that BAIBA is covered as a botanical, since Wedgewood Iris is a plant. After summing together all the evidence, we’re confident that L-BAIBA (MitoBurn) is in fact classified as a dietary supplement. This is great news, because this naturally-occurring amino acid can provide a host of benefits when added to a sound diet, which is the exact purpose of a supplement! Who will benefit from BAIBA use? There are many types of users who may appreciate BAIBA’s effects: Dieters with a leptin deficiency who are looking for appetite suppression assistance Liberal supplement users who are bulking (or in periods of weight gain) and have an excessive amount of body fat will most likely benefit the most from BAIBA. However, it can potentially be used to help those who have a high carbohydrate diet as high carbohydrate diets increase blood triglyceride levels which can interact with VLDL particles and potentially lead to heart disease in the long run. People who are unable to exercise due to injury or excess bodyweight / obesity (see your doctor before beginning) Keto dieters looking to increase ketone levels Stacking BAIBA Truthfully, any new supplement such as this one should first be run 100% standalone in order to assess its efficacy without any confounding variables. After some use, if there is success and you wish to maintain, the following compounds may provide additional synergy: Yohimbine HCl Our top-rated fat burner, SteelFit Shredded Steel, has a few ingredients that may synergize with BAIBA. Yohimbine is thought to increase noradrenaline and contribute to fat mobilisation in humans. It also inhibits regulatory processes which normally stop fat loss from occurring. Higenamine or Synephrine Higenamine and Synephrine are beta2 adrenergic receptor agonists that are responsible for the fat loss by increasing cAMP levels in the body. They both follow the same processes which made Ephedrine a huge hit for fat loss, just to a lesser degree. Grains of Paradise Grains of Paradise is a spice that contains 6-paradol, which has been shown to increase brown fat cells and thus thermogenesis, and may synergize strongly with BAIBA due to its similar effects. Olive Leaf Extract Research suggests that olive leaf helps reduce lipogenesis and may decrease fat mass in the body. Its effects can be largely contributed to its increase in triiodothyronin and thyroxin, which are thyroid hormones that are important in regulating metabolism. But once again, any new ingredient should be run standalone first. Putting it all together BAIBA works to restore metabolic function and prevent obesity in animal models through several related mechanisms. Attempting to go where no fat burner has gone before When it comes to weight loss, some products can increase the breakdown of triglycerides into fatty acids. However, if there is no stimulus for them to be used for energy, they are simply reformed back into adipose tissue elsewhere. This is why it’s so important to take most fat burners discussed elsewhere on this site in a pre-workout dosage. Come on BAIBA Light My Fire BAIBA, on the other hand, increases the breakdown of triglycerides and then increases the body’s metabolic rate through the browning of white fat, which increases the loss of energy as heat, which should allow for released fatty acids to be burned as heat. This is what makes it so exciting. Preventing new fat deposits? When it comes to preventing fat gain, BAIBA seems to display promising results in mice by preventing the increase of fat tissue in periods of overfeeding. The mechanism involved is thought to be related to leptin levels, however more research is needed to determine the mechanism behind this. The potential overall health impacts Finally, when it comes to health, overweight people tend to have higher levels of circulating triglycerides, which are transported through the blood by very low density lipoproteins (VLDL). These smaller LDL particles are cleared from the blood plasma at a slow rate (increased residence time) where they accumulate in circulation and can penetrate the walls of arteries and cause a response from white blood cells. Triglyceride accumulation can also interact with HDL cholesterol by reducing its residence time and thus decreasing reverse cholesterol transport (the removal of fat away from arteries and cell walls). This process allows triglyceride-rich LDL particles to spend far too much time in places where they can do serious damage. There’s a possibility that BAIBA may antagonise this process by decreasing LDL and triglyceride levels, and through increasing HDL levels in the body — but, again, more research is required. Beta-aminoisobutyric acid (BAIBA), induces beneficial effects on lipid homeostasis in mice. Some Anecdotal Experience: Mike’s BAIBA Review Listen to Mike discuss his experience with BAIBA, regarding training, heart rate, and more. The long story short? “Half a gear extra”, which we always love to take from a non-stimulant ingredient!! Conclusion: “BAIBA, when I think about you…” Interested in trying MitoBurn from NNB? Contact us and we’ll arrange a sample for your brand! This article was originally written in 2015, when we were very excited about it, but there have been sourcing issues that made it next to impossible to find. Four years later, we came back to update the article and found a trusted and tested supplier in NNB Nutrition who has the ingredient, and came to realize that there was even more research behind the ingredient. Meanwhile, the diet world seems to have caught up with the effects of BAIBA, given that ultra low carb ketogenic diets have exploded during this timeframe, and this is an extremely pro-ketogenic supplement. At the end of the day, we’re definitely more confident that BAIBA is a potential Next Big Thing, but still want to see human research before we can 100% get on board. With that said, we’re always excited about new compounds and new products, and as time has passed since our original publication, we’ve grown far more interested in the ingredient. Subscribe to PricePlow's Newsletter and Alerts on These Topics Topic Blog Posts YouTube Videos Instagram Posts BAIBA MitoBurn NNB Nutrition Your Email: Sign Up Interested in trying NNB Nutrition’s MitoBurn for your brand’s formulas? Contact us and we’ll arrange a sample for you! References Roberts, L et al. (n.d.). b-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic b-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors. Cell metab.; 2014 Sayols-Baixeras, S., Lluis-Ganella, C., & Elosua, R. (2014). Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. Appl Clin Genet, 7 : 15-32. Bostrom, P., et al. (2012). A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481: 463-482. Johnson, C.; Mass. General scientists discover molecule that may underlie benefits of exercise; 2014 Liang, H., Ward, W. (2006). PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ, 30 (4): 145-51 Kammoun, H; Come on Light My Fire; Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute; 2014 Lira, V., Benton, C., Yan, Z., Bonen, A (2010); PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity; Am J Physiol Endocrinol Metab, 299 (2): 145-161 Wenz, T., Diaz, F., Spiegelman, B., & Moraes, C. (2008). Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype; Cell Meta, 8 (3):249-56 Barbera, M., Schluter, A., Pedraza, N., Iglesias, R., Villarroya, F., & Giralt, M. (2001). Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell; J Biol Chem, 12 (2): 1486-93 Harms, M., & Seale, P. (2013). Brown and beige fat: development, function and therapeutic potential; Nature Medicine, 19, 1252-1263 Harrington, W., Britt, C., Wilson, G., Milliken, N., Binz, J., Lobe, D., Oliver, W., Lewis, M., Ignar, D. (2007). The Effect of PPARalpha, PPARdelta, PPARgamma, and PPARpan Agonists on Body Weight, Body Mass, and Serum Lipid Profiles in Diet-Induced Obese AKR/J Mice; PPAR Res. Gross, B., & Staels, B. (2007). PPAR agonists: multimodal drugs for the treatment of type-2 diabetes; Research in Endocrinology Metabolism, 21 (4):687-710 Begriche, K., Massart, J., Abbey-Toby, A., Igoudjil, A., Letteron, P., & Fromenty, B. (2008). β-Aminoisobutyric Acid Prevents Diet-induced Obesity in Mice With Partial Leptin Deficiency; Journal of Obesity, 16, 2053-2067 Shimizu, H., Shimomura, Y., Hayashi, R., Ohtani, K., Sato, N., Futawatari, T., & Mori, M. (1997). Serum leptin concentration is associated with total body fat mass, but not abdominal fat distribution; Int J Obes Relat Metab Disord, 21 (7): 536-541. Baile, C., Della, F., Martin, R. (2000). Regulation of metabolism and body fat mass by leptin; Annual Reviews of Nutrition, 20 :105-127. McNamara, J., Jenner, J., Wilson, P., & Schaefer, E. (1992). Change in LDL particle size is associated with change in plasma triglyceride concentration; Atherioscler Thromb, 12 (11): 1284-1290. Krauss, R., Blanche, P., Rawlings, R., Fernstrom, H., & Williams, P. (2006). Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia; Am J Clin Nutr, 83 (5): 1025-1031 Maisonneuve, C., Igoudjil, A., Begriche, K., Letteron, P., Guimont, M., Bastin, J., Laigneau, J., Pessayre, D., & Fromenty, B. (2004). Effects of zidovudine, stavudine and β-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting; Antiviral Therapy, 9: 801-810. Ostojic, S. (2006); “Yohimbine: the effects on body composition and exercise performance in soccer players”; Res Sports Med, 14 (4): 289-299; https://pubmed.ncbi.nlm.nih.gov/17214405 Feng S, et al (2012). “A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects”; Acta Pharmacol Sin; https://pubmed.ncbi.nlm.nih.gov/23085737 Omar SH. (2010). Oleuropein in olive and its pharmacological effects; Sci Pharm KEGG Pathway; Valine, Leucine, and Isoleucine Degradation Pathway Map; Kanehisa Laboratories; 2014; https://www.genome.jp/kegg/pathway/map/map00280.html Jung, Tae Woo, et al; “BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice”; Diabetologia; September 2015, Volume 58, Issue 9, pp 2096–2105; https://link.springer.com/article/10.1007/s00125-015-3663-z Kitase, Yukiko et al; “β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor”; Cell reports vol. 22,6 (2018): 1531-1544; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832359/ Shi, Chang-Xiang et al; “β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes”; Scientific Reports; vol. 6 21924; 24 Feb. 2016; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764829/ Wang H, et al; “b-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis”; Journal of Pharmacological Sciences; 133(4):203-213; April 2017; https://pubmed.ncbi.nlm.nih.gov/28433566/ Roberto, Mike; “MitoBurn: β-Aminoisobutyric Acid (L-BAIBA) from NNB Nutrition”; The PricePlow Blog; December 10, 2019; https://blog.priceplow.com/supplement-ingredients/mitoburn Solem, Eivind, et al; “The absolute configuration of β-aminoisobutyric acid in human serum and urine”; Clinica Chimica Acta; Volume 50, Issue 3, Pages 393-403; February 15, 1974, https://www.sciencedirect.com/science/article/abs/pii/0009898174901594 Vemula, Harika et al; “Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers”; Analytical Biochemistry; vol. 516: 75-85; 2017; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137252/ Van Gennip, AH, et al; “Linear relationship between the R- and S-enantiomers of a beta-aminoisobutyric acid in human urine”; Clinica Chimica Acta; 116(3):261-7; November 11, 1981; https://pubmed.ncbi.nlm.nih.gov/6945923/ Mo C., Wang Z., Bian L., Isaacson J., Recker R., Lappe J., Bonewald L., Brotto M; “A Direct LC-MS/MS Method for the Simultaneous Quantification of Isomeric Aminobutyric Acids in Biological Fluids and Its Application in Bone-Muscle Studies”; Proceedings of the 2018 Annual Meeting of the American Society for Bone and Mineral Research; Montréal, QC, Canada; 28 September–1 October 2018; p. 213; [scholar.google.com] Tanianskii, Dmitrii A et al; “Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism”; Nutrients; vol. 11,3 524; February 28, 2019; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470580/ Rowe, R Grant, and George Q Daley; “Stem cells: Valine starvation leads to a hungry niche”; Nature; vol. 541, 7636: 166-167; 2017; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377926/ Vedic Lifesciences; “Acute Oral (Gavage) Toxicity of L-3-Aminoisobutyric Acid in Female Sprague Dawley Rats”; December 27, 2019; https://blog.priceplow.com/wp-content/uploads/mitoburn-l-baiba-ld50.pdf U.S. Department of Health & Human Services, National Institutes of Health; “Dietary Supplement Health and Education Act of 1994; Public Law 103-417; 103rd Congress”; Approved October 25, 1994; https://ods.od.nih.gov/About/DSHEA_Wording.aspx FooDB; “Showing Compound (S)-3-amino-2-methylpropanoate (FDB030157)”; Updated 2019-11-27; https://foodb.ca/compounds/FDB030157 Asen, Sam, et al; “Isolation of β-Aminoisobutyric Acid from Bulbs of Iris tingitana var. Wedgewood”; Journal of Biological Chemistry; 234, 343-346; February 1, 1959; https://www.jbc.org/content/234/2/343.long The post BAIBA: New Weight Loss Ingredient Generates Exercise in a Pill?! first appeared on The PricePlow Blog.
62 minutes | a year ago
#023: John Meadows Tells All | Granite Supplements at the 2019 Mr. Olympia
In September of 2019 at the annual Mr. Olympia convention, Ben and Mike interviewed one of our favorite sports nutrition and bodybuilding experts – John Meadows of Granite Supplements. This bodybuilder, former banker, business founder, and family man lets us in on some of the cutting practices used back in the day, his thoughts of the importance of sleep, how to bulk, and much more. At the end of this interview, he alludes to the new Granite Supplements Protein, and it’s as good as he said it would be! John Meadows Tells All | Mr. Olympia 2019 Audio Version Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post John Meadows Interview at Mr. Olympia 2019 | Podcast #023 first appeared on The PricePlow Blog.
91 minutes | a year ago
#022: Mike and Ben Catch Up
In July of 2019, Ben visited Mike in Texas to film some content. But first they sat down, stimmed up with their favorite caffeine sources, and caught up on the industry and where they’ve been. Ben and Mike Catch Up | July 2019 Audio Version Timestamps: :45 catch up on life 7:15 Ben’s training 15:20 Coming from “NutraBio University” 19:00 Ghost hitting the industry 34:00 Mfit’s launch 40:00 Mike’s new mission in the industry 50:30 Insulin talk 1:09:00 What we’re excited for in the second half of the year Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post Catching Up with Ben | Podcast #022 first appeared on The PricePlow Blog.
57 minutes | a year ago
#021: Robert Tauler #2 - How to Avoid False Advertising Lawsuits
While we at PricePlow love to talk about new brands, product releases, and new flavor variations, we strive to remain up-to-date with the business side of things within the supplement industry. It’s sometimes easy to neglect the inner workings of the industry – regulations, suits, etc. But, its extremely important to us that we cover this area and keep our readers in the know! Thanks to Robert Tauler of Tauler-Smith LLP for coming on to educate us! In April of 2019, PricePlow founder and CEO Mike Roberto sat down with Robert Tauler of Tauler-Smith LLP to discuss legal workings within the supplement industry. Robert, an attorney who earned his law degree from Harvard in 2005, has spent many years dealing with various legal situations in the world of food and dietary supplements, and specializes in the area of branding and marketing. In this video interview, Mike and Robert talked specifically about false advertising lawsuits – the rules in place, how issues arise, and how to avoid them! The interview is extremely informative, and we highly recommend checking it out. We’ll link it below, but if you’re someone who’d just rather have some of the key points, we have you covered there, too! Below are the comprehensive show notes for readers, but first, be sure to subscribe to our podcast! Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The regulatory bodies, laws, and regulations Issues in the supplement industry seem to consistently circulating, and that’s due to a number of factors! Our world is highly entrepreneurial, and in regards to the supplement industry in particular, there are low barriers to entry. Many of these firms are small businesses, looking to provide supplements that they believe in to the masses! Laws have been set into place in order to keep consumers safe, however. The “Dietary Supplement Health and Education Act of 1994″ (DSHEA) is the dominating federal law that regulates the industry. It outlines everything – what constitutes a dietary supplement, labeling, claims that can/cannot be made, and even proper manufacturing practices! Some states can even have their own additional laws. California is one such example – they enforce their own regulations, which is noteworthy given the state is such a vast market! There are two main enforcers of these regulations are the FDA and FTC. Despite the two being separate federal agencies, they actually overlap quite a bit in most cases. The FTC governs marketing specifically! They tend to focus more on “big-ticket, nationwide” items, and are more interested in regulating highly profitable, large companies. They also enforce FDA regulations, as well, in addition to being able to hand down their own punishments. The FDA establishes most of the rules and regulations regarding what people ingest, be it food or supplements. They can investigate and police their policies, and recommend troublesome cases to the Department of Justice. Common supplement and food industry false advertising lawsuits Now that you have a brief overview of the structure of the industry and its policing agencies, let’s get into what some of the issues that come up are! While the laws in place are essential, they can sometimes be quite confusing, especially for those who aren’t well-versed in them! Common issues within the industry One cannot claim to cure/mitigate a disease in nutritional supplements! Implied disease claims are even problematic – you can’t say something like “improves your joints” in marketing! One cannot claim to alter the structure or function of any part of the human body in a dietary supplement, without valid evidence! This makes phrases like “speeds the metabolism” are tricky – you can use them if you have research studies to back them up! Substantiation of effects applies to individual ingredients as well as to potential synergistic relationships between ingredients! One cannot imply any pharmaceutical association! Even using “Rx” in your branding is against the rules – it implies the supplement is a pharmaceutical drug! Having products that are applied transdermally and alters organs (i.e. caffeine patches) are extremely problematic! Cross-investigational entanglement Relationships within business are key – and knowing your partners is important! If you’re working with another company, even if you’re simply selling their products, you can end up in trouble. If they aren’t adhering to the rules and are under investigation, your own business can get roped in as a co-conspirator! How to avoid false advertising suits Robert Tauler of Tauler Smith LLP teaches us how to avoid false advertising lawsuits… and more!How to avoid these issues: Don’t mention any disease or ailment whatsoever! Be cognizant of the wording in your marketing pitch – and have published research available to defend ingredients! Stay away from any references to the pharmaceutical/medical field! Know (and trust) your business partners! This includes sales representatives of your own company. Make sure their sales pitches are compliant! Take ownership of your business, and hold yourself accountable to adhering to the laws in place! And finally, if you’re facing issues due to any of the rules/regulations in place, call a legal firm (like Robert’s) that knows them inside and out! Forecasting the future? Civil suits… Finally, Robert predicts a spike in civil litigation – he foresees companies going after each other if they aren’t adhering to the rules and regulations in place. These rules are not a bad thing, however… While some may see this level of complex, hard-to-navigate regulation a bit overzealous, it really isn’t. It’s important to understand that these rules are in place to keep people safe, and at the end of the day, they’ve done much more good than bad. Even with these laws in place, the supplement industry is thriving – pre-workouts help people get through training sessions, protein powders help people build muscle, and fat-burners help some shed an extra pound or two. In fact, it’s because of these regulations that we’re able to have so many trusted, quality brands and products out there! Conclusion – be responsible! Robert makes it pretty clear that a lot of these issues can be completely avoided if companies hold themselves accountable, and make an effort to understand the rules and regulations that control their industry. If you’re selling a supplement, learn how to properly do so, either on your own or with a little help! Thanks to Robert Tauler of Tauler-Smith LLP for coming on to educate us! There’s no shame in needing help, either! Firms like Tauler-Smith LLP exist to help prevent running into any problems in the future. Robert and his team specialize in food and supplements, but also work in the fashion and cosmetics industries, too! Having a second pair of eyes, especially from people who really understand the complexities at play, on your marketing/branding can go a long way! Thanks again to Robert Tauler for coming on and educating us. If you want to see another wild video with him, watch this one! The post How to Avoid False Advertising Lawsuits in the Food & Supplementation Industry first appeared on The PricePlow Blog.
27 minutes | a year ago
#020: Guerrilla Chemist - Beast Sports Nutrition and Chemix
In June of 2019, we had The Guerrilla Chemist on the PricePlow Podcast after the successful release of Chemix Pre Workout and Beast Super Test MAX, both of which formulated by “TGC”. We get into his background a bit, and then he teases Neuro Beast, which we downright love! Our Guerrilla Chemist Interview from June 2019 Check out our Beast Sports Nutrition and Chemix pages to sign up for news alerts and save! The post Guerrilla Chemist Interview: Chemix and Beast Sports Nutrition | Podcast #020 first appeared on The PricePlow Blog.
31 minutes | 2 years ago
#019: Dave Palumbo - Species Nutrition, Snake Breeding, and Dave's Style of Low-Carb
We were lucky enough to have the legendary Dave Palumbo of RX Muscle, Species Nutrition, and Muscle Serpents University join us for thirty minutes to introduce himself to the channel and focus on his well-known supplement company, Species Nutrition: Our Dave Palumbo Interview from May 12, 2019 In the video, we discuss Species Nutrition, Dave’s high-protein Ultra Low-Carb Diet, being ahead of the curve (maybe Dave should get that macadamia nut oil supplement going now!), and much more, including Dave’s snake breeding hobby/passion! We spent a good amount of time talking about Species Nutrition Isolyze. Some of the Species supplements discussed are Isolyze, Testolyze, and Fiberlyze. Snake Breeding?! That’s right, bodybuilding will always be Dave’s first love, but another passion of his is snake breeding. You can see more about this on Palumbo’s Pythons and check out his other YouTube channel, Muscle Serpents University. He also has a channel named Muscle Fish, but definitely seems to be into the snakes a bit more lately. Interesting stuff from one hell of an interesting and experienced guy! Check out our Species Nutrition page to save on Dave’s supplements, and sign up for the alerts below! Species - Deals and Price Drop AlertsGet Price AlertsGet Species alerts Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. The post Dave Palumbo Interview: Species Nutrition, Diet, & Snake Breeding?! Podcast #019 first appeared on The PricePlow Blog.
77 minutes | 2 years ago
#018: Matt Mosman - EndurElite and Supplements for Endurance Athletes
Get ready for a high-energy discussion with Matt Mosman of EndurElite, where we introduced Matt and covered his background, and then got into the Best Supplements for Endurance Athletes! Our Matt Mosman Interviews from Fall of 2018 The YouTube Videos were broken into two sections, but the audio feed is one segment: Quite a bit of knowledge dropped here, as we discuss things like carbohydrates, beta alanine, caffeine, creatine, PeakO2, betaine, taurine, and even fat adaptation for ultra endurance athletes! Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post Matt Mosman: EndurElite and Endurance Supplements | Podcast #018 first appeared on The PricePlow Blog.
49 minutes | 2 years ago
#017: Todd Spear - Velositol: Nutrition21's Muscle Protein Synthesis Amplifier
What is Velositol? Velositol is a unique chromium / amylopectin complex that increases muscle protein synthesis (MPS) when combined with protein and exercise. It is GRAS affirmed (generally recognized as safe) at the recommended serving of 2 grams per day in protein drinks (including ready-to-drink and powder), meal replacement bars, energy and protein bars, with the consideration that these products can be taken up to three times a day. Nutrition21’s Velositol is finally making its way out there – and the research is too! Velositol is manufactured and sold by one of the most prominent supplement ingredient suppliers, Nutrition21. You may know them from their other patented ingredients, Nitrosigine (a popular nitric oxide enhancing ingredient) and Chromax (a form of chromium supported by over 50 studies). Thanks to Nutrition21’s extensive knowledge of chromium and its ability to assist insulin (often for purposes of glucose metabolism and weight management), the creation of Velositol for muscle-building purposes was a logical next step. Nutrition21, the creators of Velositol, assisted with the scientific research in this article. This is a promising new ingredient, to say the least. There has been some highly-successful preliminary human research on Velositol (but with smaller protein doses), while newer animal-based research with higher doses of protein combined with the ingredient also proved successful, although to a lesser degree. In this article, we will cover this research and the mechanisms behind the ingredient, thanks to the help of Nutrition21’s science team and the products using Velositol listed at the bottom of this post. What is Velositol? Watch our Interview with Todd Spear from Nutrition21! If you’d rather listen and watch than read, then check out PricePlow’s founder, Mike Roberto, talking to Nutrition21’s Todd Spear about Velositol: What does Velositol do, and how? Velositol increases muscle protein synthesis (MPS) in combination with protein and exercise and it works by enhancing insulin sensitivity, resulting in greater uptake of amino acids into muscle, fueling MPS. Chromium Picolinate has a very interesting effect on rats. If we drive it with a part of a starch (amylopectin), can we take advantage of this?!Chromium picolinate, one of the main ingredients in Velositol, has been shown to improve insulin action, as well as increase the metabolism of nutrients. Increased insulin action causes various anabolic effects such as increases in the metabolism of nutrients (such as carbohydrates, lipids, and protein) and increases in the rate of glucose and amino acid uptake in muscle cells. Therefore, Velositol is thought to stimulate MPS via improved insulin activity. Insulin means everything The pros seem to far outweigh the cons… so why not give it a try? Healthy insulin activity is vital for MPS because in the presence of a protein containing essential amino acids, insulin aids in the transportation of amino acids into muscle cells to stimulate MPS. Therefore, when combined with adequate sources of protein, Velositol can increase insulin action and in turn, stimulate MPS. Moreover, Velositol has been shown to significantly increase enzymes involved in the MPS signaling pathway (such as mTOR, S6K1, and 4E-BP1), providing evidence of the cellular pathway by which Velositol enhances MPS. The Myokine connection Finally, an additional mechanism of action may be through increased myokines, such as musclin and fractalkine, which are cytokines released by muscle during exercise that lead to MPS and hypertrophy. Both clinical and preclinical studies have shown that groups taking Velositol had the greatest levels of myokines. Therefore, another mechanism by which Velositol increases muscle protein synthesis is through enhancement of the myokine signaling pathway. The Velositol Research: Clinical and preclinical findings Clinical research shows Velositol effectively doubles the power of “suboptimal doses of protein” when the two are consumed together. We’re cautious when we see graphs like this, so keep reading for the larger doses. In a double-blind, crossover design, active-controlled trial, ten healthy subjects (6 men and 4 women) were given 6g of whey protein plus 2g of Velositol or 6g whey protein alone, after an overnight fast. After a single dose and resistance exercise, MPS, as measured by the fractional rate of protein synthesis (FSR) in skeletal muscle, was significantly higher in the Velositol group (p < 0.05 between groups, which means this data beat the standard cutoff for statistical significance). Specifically, Velositol was shown to double the amount of MPS seen versus whey protein alone. Moreover, the study’s results showed that cytokine levels were highest in Velositol treated subjects. It’s important to note that this was with a “suboptimal” dose of protein, as the study is titled. While we often take more than 6g protein post workout, this was a great first-step pilot study, and BCAA/EAA doses are often near this 6g dose, so it’s not completely out of line. But with that said, the research must continue: The second study: Velositol with larger protein doses This chart is based upon a rat study, but uses more reasonable amounts of whey protein – and the results are more reasonable as well, but still great! In order to see if the above clinical findings could be applied to various forms of protein and increasing doses of protein, a preclinical study was carried out in which rats were dosed with escalating doses of whey protein (from 6g to 40g human equivalents), pea protein (6g human equivalent), or BCAA (6g human equivalent) with or without Velositol (2g human equivalent). The study data showed that after treadmill exercise, the Velositol plus protein groups showed significantly greater MPS in muscle compared to the corresponding protein alone groups (p < 0.05 between groups). At the larger protein doses, MPS wasn’t double like it was in the 6g human study, but a significant increase was still there, and this could mean something very big for an athlete who’s going after every last drop of gains. Additionally, all groups supplemented with Velositol plus whey protein again had significantly higher musclin levels compared to whey protein alone groups (p < 0.05 between groups). The increases in musclin levels, seen in the Velositol plus whey protein treatment group, were significantly correlated (p < 0.0001) with increases in muscle protein synthesis (r2 = 0.921). So the ingredient can increase Muscle Protein Synthesis with protein… but NOT add to an increase blood glucose levels?! Color us interested… Potential additional research Why do they say it works “in combination” with protein and exercise? Simply put, Velositol’s effects have only been tested in combination with protein after exercise, so those are the claims that can be made at this point. The reason they performed studies in this fashion is because it is easier to compare to these known use cases: we already know that both protein and exercise individually are known to increase MPS, so the best way to show that Velositol boosts the power of protein was to test it against those factors! So can Velositol help with general muscle maintenance when not training, ie. for older populations who have a harder time retaining muscle mass? Maybe, but this hasn’t been tested and claims cannot be made. Note that MPS still occurs on days following exercise, taking Velositol on post-workout rest days could still have beneficial effects on the MPS that is occurring during muscle recovery – there’s just no scientific proof here, so Nutrition21 is wise in playing it safe with any such claims. For those who need more “real life” information, a clinical outcomes study is currently being designed to examine the effects of Velositol plus protein taken for two months on muscle growth, strength, and exercise performance in healthy subjects. We’re told this could be at some point in Q1-2019, so the best thing to do is sign up for PricePlow’s newsletter and subscribe to PricePlow’s YouTube channel, as we hope to have Nutrition21’s researchers on our channel to explain this in person as well! Safety/Certifications Velositol is a GRAS ingredient (at the recommended 2g per day with protein) and has not been shown to have any reported adverse effects in any of the research studies or anecdotal use. Moreover, although chronically high protein intake (ie over 3.5g/kg body weight for long periods of time) can have detrimental effects on liver and kidney function at higher doses, Nutrition21’s preclinical data has shown that Velositol does not negatively affect liver and kidney function, and even potentially promotes healthy liver function, as shown by decreased levels of enzymes, aspartate transaminase (AST) and alanine transaminase (ALT), which are common indicators of kidney and liver disease. Meanwhile, with chromium picolinate itself, a 2-year NTP toxicity study showed that it was safe in doses up to 50,000ppm (equivalent to a dose of 2,400 mg chromium picolinate per kilogram of bodyweight per day), showing that even at that extremely high dose for a long exposure time, “CrPic” was not toxic. What is PricePlow’s favorite product containing Velositol? Big bold claims inside! Alpha Lion’s G.O.A.T.EIN boasts a powerful raw whey isolate and three protein amplifiers, one of which being Velositol! Users looking to try Velositol in a protein powder have a couple of excellent options. If looking to keep the carbs lower, then take a look at Alpha Lion G.O.A.TEIN, which is fully loaded with other absorption amplifiers, or BN Labs Ultimate Whey Isolate, which is what we consider the “purist’s protein” in that it contains over 90% protein by weight — and that’s after including the Velositol, flavors, and thickeners! Graham cracker was our favorite flavor when Mike explained it in our BN Isolate reivew here (and also had a lively discussion about Velositol inside). Note that BN Labs is so intense about keeping their powder with over 90% protein by weight that they don’t have a chocolate flavor, because the cocoa would take up too much room! So if you’re a protein purist and want to give Velositol a go, this is about as clean as it comes! Formulation Note: the Amylopectin adds carb(s) to the label If using 2g Velositol, we are told that the manufacturer must add 2g carbohydrates to the label due to the amylopectin starch. This is one reason why Velositol-based proteins have a bit more carbs. It also leads us to believe that BN Labs is only using 1g Velositol in theirs to keep carbs low and protein-by-weight ratio high. Long story short? It’s important to keep things in context and take a realistic look at Velositol. Don’t forget to watch Todd Spear of Nutrition21 talk about Velositol on the PricePlow YouTube channel! When we first saw the “suboptimal protein dose” study showing 2x muscle protein synthesis rates, red flags begin waving. There’s obviously something cool happening there, but we’re typically not interested in what happens with 6g protein. With the exception of some hydrolyzed whey based intra workout supplements, we typically drink more than 6g whey protein at a time. However, the second research study, which was admittedly an animal one, seems more realistic. Some gains at reasonable protein doses, yet with data that doesn’t involve towering bar graphs. Reasonable gains from reasonably-increased insulin activity. So with that said, at this point, the pros seem to far outweigh the cons already, if you’re looking to gain that additional edge, we see no reason not to try a product with Velositol – especially if you’re dialed into your body’s response to food and training. There doesn’t seem to be an additional cost markup in these products, and that would have been our only real concern given that we’re already comfortable with chromium and amylopectin. Ultra-conservative users who need more human-based research may wish to wait until more in-depth studies, but for everyone else, we simply ask, why not? Alpha Lion G.O.A.TEIN - Deals and Price Drop AlertsGet Price AlertsGet G.O.A.TEIN Price AlertsGet Alpha Lion alertsGet Whey Protein Isolate price drops Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. All Blog Posts with Velositol Velositol Increases Exercise Performance: New University Study Previewed Posted on: September 18, 2020Core POST: A Post-Workout Recovery Matrix Enhanced with Velositol Posted on: September 15, 2020Alpha Lion G.O.A.T.EIN: The Greatest Of All Time Protein Powder? Posted on: July 15, 2019Velositol: Enhancing Muscle Protein Synthesis with Science Posted on: October 28, 2018Olympus Labs Superior Protein Delivers Huge on the "Extras"! Posted on: October 15, 2018BN Labs Ultimate Whey Isolate: 90% Protein by Weight, with Velositol! Posted on: April 3, 2018Ambrosia Ritual AM: Low-Carb Coffee Creamer by Marc Lobliner and Friends Posted on: June 21, 2017 Subscribe to PricePlow's Newsletter and Alerts on These Topics Topic Blog Posts YouTube Videos Instagram Posts Nutrition21 Velositol Your Email: Sign Up References Bechtel, David H; “Summary Expert Opinion Concerning the Generally Recognized as Safe (GRAS) Status of Velositol Amylopectin/Chromium Complex as Generally Recognized as Safe (GRAS) in Select Food Categories”; Bechtel Consulting; May 25, 2017; https://blog.priceplow.com/wp-content/uploads/nutrition-21-velositol-gras-opinion-20170525.pdf Cefalu WT, Wang ZQ, Zhang XH, Baldor LC, Russell JC. Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. J Nutr. 2002;132(6):1107-1114; https://academic.oup.com/jn/article/132/6/1107/4687907 Komorowski J, Perez Ojalvo S. The effects of Velositol on exercised-induced myokines. 2017; https://blog.priceplow.com/wp-content/uploads/velositol-effect-on-myokines-ACN-2017.pdf Ziegenfuss TN, Lopez HL, Kedia A, Habowski SM, Sandrock JE, Raub B, Kerksick CM, Ferrando AA. Effects of an amylopectin and chromium complex on the anabolic response to a suboptimal dose of whey protein. JISSN. 2017;14:6; https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0163-1 Wu G. Dietary protein intake and human health. Food Funct. 2016;7:1251-1265; https://www.researchgate.net/publication/290213882_Dietary_protein_intake_and_human_health The post Velositol: Enhancing Muscle Protein Synthesis with Science first appeared on The PricePlow Blog.
46 minutes | 2 years ago
#016: Mark Glazier - Lobbying Congress for Better Protein Labeling Laws
Mark Glazier of NutraBio explains why he was lobbying Congress for better protein labeling laws In May of 2018, Mike and Mark Glazier talked about Mark’s recent trip to Washington D.C. (posted here on Mark’s Facebook and embedded below), where the NutraBio founder and CEO was lobbying for better protein labeling laws. Mark explains some of the issues he commonly sees, and while we believe that customer education is the best way to go, there are many things that could be done from the top down view that could certainly help keep the bad actors from scamming and winning lawsuits, especially in the case of protein amino acid spiking. The conversation on the YouTube comments below are interesting, with many not wanting more regulation. Mark typically agrees, but he also knows the loopholes in the current laws, and would like to see them patched up for the industry. We discuss where those problems lie: Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud Mike’s Interview with Mark Glazier, NutraBio CEO Follow Mark and Genius on Social Media Mark’s Instagram: @TheMarkGlazier NutraBio’s Instagram: @NutraBio NutraBio Facebook: Facebook.com/nutrabio The original Facebook Post that started this As always, sign up for our news and deal alerts on PricePlow’s NutraBio page, or check out some of the products below: NutraBio - Deals and Price Drop AlertsGet Price AlertsGet NutraBio alerts Also get hot deal alertsNo spam, no scams.Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.Posts are sponsored in part by the retailers and/or brands listed on this page. The post Mark Glazier Lobbies Congress for Better Protein Labeling Laws | #016 first appeared on The PricePlow Blog.
55 minutes | 2 years ago
#015: Dr. Benjamin Bikman: New Research on Ketones and Muscle Health
Note: The show notes for this article have moved to Mike’s Personal Site: Ketones Boost Muscle Health, Says New Research by Dr. Benjamin Bikman. See the show notes on MikeRoberto.com. Subscribe to the PricePlow Podcast on Your Favorite ServiceiTunesGoogle Play StitcherSoundCloud The post Ketones and Muscle Health: Dr. Benjamin Bikman's New Research first appeared on The PricePlow Blog.
Terms of Service
© Stitcher 2020