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In this episode, we'll be going over a new study that wanted to find out the effects a saturated fat heavy consumption would have on insulin resistance and signaling against an unsaturated fat heavy consumption. Video: https://youtu.be/QfII7CANt14 Study: https://www.physionic.org/examine/%5Bs30%5D-dietary-palmitate-and-oleate-differently-modulate-insulin-sensitivity-in-human-skeletal-muscle MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Sarabhai, T., Koliaki, C., Mastrototaro, L., Kahl, S., Pesta, D., Apostolopoulou, M., Wolkersdorfer, M., Bönner, A. C., Bobrov, P., Markgraf, D. F., Herder, C., & Roden, M. (2022). Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia, 65(2), 301–314. https://doi.org/10.1007/s00125-021-05596-z

In this episode, we continue our quest for understanding the effect saturated fats have on muscle insulin signaling and mitochondrial health - however, beyond that, we'll be looking at how unsaturated fats may protect against the deleterious effects of saturated fat? Let's see.. Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs28%5D-different-effects-of-oleate-vs.-palmitate-on-mitochondrial-function%2C-apoptosis%2C-and-insulin-signaling-in-l6-skeletal-muscle-cells%3A-role-of-oxidative-stress- Video: https://youtu.be/TiO16KoH0Fs Study Title: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Larysa Yuzefovych

In this episode, I'm kicking off a new format that's more tailored to the podcast listeners, so there's less need to head to the video versions of the podcast to understand half of what I'm talking about. In this episode, we'll be discussing saturated fat (palmitate) and it's effects in relation to insulin signaling in muscle cells, as well as mitochondrial function. What are the effects? What are the implications? Video: https://youtu.be/zMkV91E2Bic Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249685/

In this episode, I attempt to make sense of calories in vs out and reconcile that with the hormone argument for fat loss. Video Podcast: https://youtu.be/x1ZjjDzCdc0 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Mitochondria have a dark side, find out how. Video Podcast: https://www.youtube.com/watch?v=HPx7cv1I7eU MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this podcast, we look at a study that investigates how weight loss affects hormones and long term weight regain - is the deck stacked against you? Study: https://www.nejm.org/doi/full/10.1056/nejmoa1105816 Video Podcast: https://youtu.be/-t5d0S5MRwE 0:00 - Introduction 2:47 - Study Design 6:58 - Weight Loss & Weight Regain Results 9:45 - Long Term Hormonal Changes from Weight Loss 34:12 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

How does intermittent fasting affect your health, even when you do not lose weight with it? Let's find out. Study: https://pubmed.ncbi.nlm.nih.gov/29754952/#:~:text=Men%20with%20Prediabetes-,Early%20Time%2DRestricted%20Feeding%20Improves%20Insulin%20Sensitivity%2C%20Blood%20Pressure%2C,Cell%20Metab. Video Podcast: https://youtu.be/1t0HUSlFNiQ MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 3:23 - Study Design 9:03 - Intermittent Fasting on Health Results 18:24 - "Fasting Increases Inflammation" 20:08 - Intermittent Fasting on Health Continued 23:00 - Conclusions/Take Aways

Title says it all... Video Podcast: https://youtu.be/u4XirePJKfg MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we'll be discussing how sirtuins play their role in mitochondrial health and insulin resistance. Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432223/ Video Podcast: https://youtu.be/M9INrzrfsu4   0:00 - Introduction 3:10 - Diabetes Background 8:30 - Mitochondria Background 13:33 - Mitochondria & Insulin Resistance 20:33 - Sirtuins 43:40 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, I summarize the content from a brand new scientific review that discusses the difference between creatine supplementation for the brain vs the rest of the body, as well as a possible alternative. Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916590/ Video Podcast: https://youtu.be/gltKZA6JQr0 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, I cover a study sent to me by a subscriber wherein the researchers discuss a new model for understanding metabolism through their self titled 'Compensation Hypothesis'. Study: https://www.sciencedirect.com/science/article/pii/S0960982221011209 Video Podcast: https://youtu.be/O7TY-HMZkKA MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this podcast, I'll be detailing a brand new study deeply investigating the decline in metabolism with age. Study: https://science.sciencemag.org/content/373/6556/808 Video Podcast: https://youtu.be/cXHxl8dPqG0 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 6:02 - Metabolism over the Lifespan 13:35 - 2 Factors that lead to Metabolism Decline? 23:58 - Conclusion/Take Aways

In this episode, we'll dive into two very similar studies trying to distinguish the effect of the ketogenic diet on cholesterol, blood sugar, insulin, and blood fats (triglycerides). Video Podcast: https://youtu.be/yx2OuoMZBFg Study A: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001988/pdf/nutrients-13-00814.pdf Study B: https://pubmed.ncbi.nlm.nih.gov/12949361/ 0:00 - Introduction 3:40 - Study Design 12:18 - Keto on Cholesterol 20:07 - Keto on Blood Sugar & Insulin 22:25 - Keto on Triglycerides 24:05 - Discussing the Results 37:48 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we'll dissect a study wherein the researchers attempt to find out how an unrestricted intermittent fasting protocol works for overweight individuals in aspects of weight, muscle, metabolism, and cardiovascular outcomes like cholesterol, blood sugar, insulin, and so on. Video Podcast: https://youtu.be/TjEKr7ysbfI Study: https://pubmed.ncbi.nlm.nih.gov/32986097/ MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 5:33 - Study Design 7:26 - Could they Stick to IF? 9:22 - Individual Weight Loss 11:16 - Total Weight Loss 14:40 - Body Composition (Muscle, Fat, etc.) 21:19 - Metabolism 23:25 - Blood Sugar, Insulin, Cholesterol, etc. 26:31 - Conclusions/Take Aways

This week, I return by simply answering questions you guys sent me on Instagram and YouTube. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 2:35 - Thank you 5:25 - Limited Protein Absorption 8:04 - Protein on Lifespan 12:09 - Ideal Body Fat for Testosterone 14:25 - Threshold that Muscle Stops Protein Synthesis 17:40 - Creatine Bloat 20:48 - Origin of the Virus

In this episode, I cover a scientific review on the literature of protein for muscle growth. We'll be covering protein total amount, timing, type, differences in men and women, aging, and more. Enjoy. Video Podcast: https://youtu.be/7h-kLKmknEo Scientific Review: https://link.springer.com/article/10.1007/s40279-019-01053-5 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we investigate how elevated blood fats change how our mitochondria "behave" and its affect on autophagy. Video Podcast: https://youtu.be/g6JJzVkYM7I Study: https://www.sciencedirect.com/science/article/abs/pii/S0026049521001037 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this podcast, I dive deeper into yet another study comparing the ketogenic diet for blood cholesterol, with the added bonus of briefly touching on insulin sensitivity. In this episode, we start to recognize the key difference between a healthy ketogenic diet and an unhealthy ketogenic diet. Study: https://pubmed.ncbi.nlm.nih.gov/15070924/ Video Podcast: https://youtu.be/KEcyW496KGA MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we'll be going again into the ketogenic diet, but the context hath changed as the people being tested are healthy and young, non-overweight, unlike previous studies. There are some other caveats, as well, that we'll go into, so buckle up and let's dive in. Study: https://pubmed.ncbi.nlm.nih.gov/30408717/ Video Podcast: https://youtu.be/bX1cax3zvfQ MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we dive into a study looking at how 16 hour intermittent fasting affects a variety of health outcomes when paired with resistance training in non-beginner lifters. Study: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1044-0 Video Podcast: https://youtu.be/2B99DJwPMCk MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6