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An exposé of the corruption of medicine by the pharmaceutical industry at every level, from exploiting the vulnerable destitute for drug testing, through manipulation of research data, to disease mongering and promoting drugs that do more harm than good.Authors, Professor Jon Jureidini and Dr Leemon McHenry, made critical contributions to exposing the scientific misconduct in two infamous trials of antidepressants. Ghostwritten publications of these trials were highly influential in prescriptions of paroxetine (Paxil) and citalopram (Celexa) in paediatric and adolescent depression, yet both trials (Glaxo Smith Kline's paroxetine study 329 and Forest Laboratories' citalopram study CIT-MD-18) seriously misrepresented the efficacy and safety data.The Illusion of Evidence-Based Medicine: Exposing the Crisis of Credibility in Clinical Research (Wakefield Press, 2020) provides a detailed account of these studies and argues that medicine desperately needs to re-evaluate its relationship with the pharmaceutical industry. Without a basis for independent evaluation of the results of randomised, placebo-controlled clinical trials, there can be no confidence in evidence-based medicine.Science demands rigorous, critical examination and especially severe testing of hypotheses to function properly, but this is exactly what is lacking in academic medicine. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Alzheimer’s disease, a haunting and harrowing ailment, is one of the world’s most common causes of death. Alzheimer’s lingers for years, with patients’ outward appearance unaffected while their cognitive functions fade away. Patients lose the ability to work and live independently, to remember and recognize. There is still no proven way to treat Alzheimer’s because its causes remain unknown.Mind Thief: The Story of Alzheimer's (Columbia UP, 2021) is a comprehensive and engaging history of Alzheimer’s that demystifies efforts to understand the disease. Beginning with the discovery of “presenile dementia” in the early twentieth century, Han Yu examines over a century of research and controversy. She presents the leading hypotheses for what causes Alzheimer’s; discusses each hypothesis’s tangled origins, merits, and gaps; and details their successes and failures. Yu synthesizes a vast amount of medical literature, historical studies, and media interviews, telling the gripping stories of researchers’ struggles while situating science in its historical, social, and cultural contexts. Her chronicling of the trajectory of Alzheimer’s research deftly balances rich scientific detail with attention to the wider implications. In narrating the attempts to find a treatment, Yu also offers a critical account of research and drug development and a consideration of the philosophy of aging. Wide-ranging and accessible, Mind Thief is an important book for all readers interested in the challenge of Alzheimer’s. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Ronald Deibert is a professor of Political Science at the University of Toronto and the Director of The Citizen Lab, a public interest research organization that uncovers privacy and human rights abuses on the internet.In his latest book, Reset: Reclaiming the Internet for Civil Society (House of Anansi Press, 2020), Deibert unites a growing corpus of academic literature on the perils of surveillance capitalism to show how today’s data-hungry communications technologies have poisoned our political institutions, our minds, and even our environment. Deibert believes that it is not too late to rescue our politics from our technology, and he argues that the answer lies not in silicon or code but age-old political principles. Look to Montesquieu, not Zuckerberg, Deibert tells us, if you want to find a stable framework for digital governance in the 21st century.On this episode, in addition to all the above, Professor Deibert and I explore the economic engines of surveillance capitalism, the dangers of ritualistic privacy policies, the internet’s immense carbon footprint, and the importance of data privacy law, among other topics.John Sakellariadis is a 2020-2021 Fulbright US Student Research Grantee. He holds a Master’s degree in public policy from the School of International and Public Affairs at Columbia and a Bachelor’s degree in History & Literature from Harvard University. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Digital dualism, or a sharp division between online and offline activity as "virtual" or "real" has long been a feature of liturgical studies and discussions around worship gatherings for theorists and practitioners alike. Teresa Berger's new book @Worship: Liturgical Practices in Digital Worlds (Routledge, 2017) provides a manifesto for more nuanced thinking about digital mediation, materiality, ecclesial gathering, and sacramental presence in our digitally suffused world. While this book was published several years before the COVID-19 pandemic, the careful thinking Berger presents here can certainly guide church leaders and participants in present and future conversations as worshiping communities find themselves facing prolonged seasons of online gatherings and digital devotion.  Ryan David Shelton (@ryoldfashioned) is a social historian of British and American Protestantism and a PhD researcher at Queen’s University Belfast. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Based on a viral article, the gripping medical mystery story of Ron Davis, a world-class Stanford geneticist who has put his career on the line to find the cure for chronic fatigue syndrome, the disease killing his son. For the past six years, Whitney Dafoe has been confined to a bedroom in the back of his parents' home, unable to walk, to eat, to speak. The sound of music causes him pain. At one point, the formerly healthy, young, freelance photographer, faced starvation as his 6'3" frame withered to 115 pounds. In desperation, Whitney and his parents went from one specialist to another, and still no answers. Then, finally, a diagnosis: the mysterious disease myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Whitney's story is heartbreaking, but it's also one of redemption. It reaches far beyond just one family's harrowing tale. Today, ME/CFS affects between 1 and 2.5 million Americans--and 20 million people around the world. Those afflicted largely suffer in silence because the disease is little known and much misunderstood. The question lingers still whether it even exists outside the patient's mind. Often disbelieved, they're abandoned by family and friends. They lose their jobs, and battle with insurance companies over rising medical costs as the chronic disease continues on year after year. In one way, Whitney has been lucky. He could reach out to his father, a world renowned, scientist, for answers. This book is the story of one father's desperate hunt for the insidious illness that stole his son away. The Puzzle Solver follows Ron as he unravels the molecular trail within his own son's donated blood and genome, to began to find answers. He confirms this is a biological disease and uncovers new possibilities for treatments and potentially a cure. At its heart, The Puzzle Solver: A Scientist's Desperate Hunt to Cure the Illness That Stole His Son by Tracie White and Ronald W. Davis (Hachette Books, 2021) is about more than just cutting edge research or a race to find the cure for ME/CFS--it's about the unbreakable bond between a father and his son, and the lengths to which a parent will go to save their child's life. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

It’s hard to avoid innovation these days. Nearly every product gets marketed as being disruptive, whether it’s genuinely a new invention or just a new toothbrush. But in this manifesto on the state of American work, historians of technology Lee Vinsel and Andrew L. Russell argue that our way of thinking about and pursuing innovation has made us poorer, less safe, and—ironically—less innovative.Drawing on years of original research and reporting, The Innovation Delusion: How Our Obsession with the New Has Disrupted the Work That Matters Most (Currency, 2020) shows how the ideology of change for its own sake has proved a disaster. Corporations have spent millions hiring chief innovation officers while their core businesses tank. Computer science programs have drilled their students on programming and design, even though the overwhelming majority of jobs are in IT and maintenance. In countless cities, suburban sprawl has left local governments with loads of deferred repairs that they can’t afford to fix.For anyone concerned by the crumbling state of our roads and bridges or the direction our economy is headed, The Innovation Delusion is a deeply necessary reevaluation of a trend we can still disrupt.Mathew Jordan is a university instructor, funk musician, and clear writing enthusiast. I study science and its history, in the hope that understanding the past can help us make sense of the present and build a better future. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Can your zip code predict when you will die? Should you space out childhood vaccines? Does talcum powder cause cancer? Why do some doctors recommend e-cigarettes while other doctors recommend you stay away from them? Health information―and misinformation―is all around us, and it can be hard to separate the two. A long history of unethical medical experiments and medical mistakes, along with a host of celebrities spewing anti-science beliefs, has left many wary of science and the scientists who say they should be trusted. How can we unravel the knots of fact and fiction to find out what we should really be concerned about, and what we can laugh off?In Viral BS: Medical Myths and Why We Fall for Them (Johns Hopkins UP, 2021), medical journalist, doctor, professor, and former CDC disease detective Seema Yasmin, driven by a need to set the record straight, dissects some of the most widely circulating medical myths and pseudoscience. Exploring how epidemics of misinformation and disinformation can spread faster than microbes, Dr. Yasmin asks why bad science is sometimes more believable and contagious than the facts. Each easy-to-read chapter covers a specific myth, whether it has endured for many years or hit the headlines more recently.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Typhoid fever is a food- and water-borne infectious disease that was insidious and omnipresent in Victorian Britain. It was one of the most prolific diseases of the Industrial Revolution. There was a palpable public anxiety about the disease in the Victorian era, no doubt fueled by media coverage of major outbreaks across the nation, but also because Queen Victoria's husband, Prince Albert, died of the disease in 1861. Their son and heir, Prince Albert Edward, contracted and nearly succumbed to typhoid a decade later in 1871.The Filth Disease: Typhoid Fever and the Practices of Epidemiology in Victorian England (U Rochester Press, 2020) shows that typhoid was at the center of a number of critical debates about health, science, and governance. Victorian public health reformers, the book argues, working in central and local government, framed typhoid as the most pressing public health problem in order to persuade local officials to implement sanitary infrastructure to prevent the spread of disease. In this period British epidemiologists uncovered how typhoid is spread via food and water supplies, disrupting the longstanding idea that typhoid was spread via filth. In the process the modern disciple of epidemiology emerged as the chief science of public health. Typhoid was as much a social and political problem as it was a scientific one, and The Filth Disease provides a striking reminder of the cultural context in which infectious diseases strike populations and how scientists study them.Jacob Steere-Williams is Associate Professor of History at the College of Charleston.Claire Clark is a medical educator, historian of medicine, and associate professor in the University of Kentucky’s College of Medicine. She teaches and writes about health behavior in historical context Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Imagination with a Straight JacketAlan Lightman is a writer, physicist, and social entrepreneur. He has served on the faculties of Harvard and the Massachusetts Institute of Technology (MIT) and was the first person at MIT to receive dual faculty appointments in science and in the humanities. He is the author of many books, both fiction and nonfiction, including the international best seller Einstein’s Dreams and The Diagnosis, a finalist for the National Book Award.This episode goes to both what’s epic in scope and to what’s more intimate and personal. Epic is knowledge now about how the universe began and that it will end with the sun basically engulfing the earth and then burning out. More personal is that the book explores the moral, even religious issues that scientific knowledge brings with it. Most of all, this episode explores the act of intellectual inquiry and exploration through the careers of leading scientists.Dan Hill, PhD, is the author of eight books and leads Sensory Logic, Inc. (https://www.sensorylogic.com). To check out his related “Dan Hill’s EQ Spotlight” blog, visit https://emotionswizard.com. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

For years, cybersecurity experts have debated whether cyber-weapons represent a destabilizing new military technology or merely the newest tool in the spies’ arsenal. In This Is How They Tell Me the World Ends (Bloomsbury, 2021), Nicole Perlroth makes a compelling case that cyber-conflict is quickly spiraling out of control. Worse, the United States set us down the precarious path we’re now on.A cybersecurity reporter at the The New York Times, Nicole makes her case by taking us on a journey from the shadowy underworld of the cyber-arms market, to Silicon Valley, the White House, and the NSA’s elite offensive hacking unit, Tailored Access Operations. On this episode, I talk to Nicole about the nature of the cyber-arms underground, why the NSA has traditionally favored offense over defense, and why no one—not Congress and not the public—seems to understand the gravity of the cyber-threat.We wrap up with a story likely to be of interest to the NBN community: someone—were not sure who yet—is hacking authors’ email accounts and stealing their manuscripts.John Sakellariadis is a 2020-2021 Fulbright US Student Research Grantee. He holds a Master’s degree in public policy from the School of International and Public Affairs at Columbia and a Bachelor’s degree in History & Literature from Harvard University. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Fifteen years ago in Stockholm, Daniel Ek and Martin Lorentzon had a big idea. The music industry was playing a desperate game of whack-a-mole with piracy via file sharing but this was proving as hopeless as the War on Drugs. Why not, they thought, use the new torrenting technologies to bring piracy in from the cold and make themselves rich in the process?In 2006, they founded Spotify with a handful of engineers, no licences and no revenue. Today, Spotify is the world's most popular audio streaming subscription service with 345 million users and a market capitalization of $60 billion.How did the shy computer nerd and hyperactive investor tame hostile music labels and withstand competition from US tech giants more than ten times their size? Still struggling to achieve sustained profitability in cut-throat market segments, will Ek’s latest foray into podcasting eventually free Spotify of its dependency on the music labels or suffer the same fate as Spotify TV?The Spotify Play: How CEO and Founder Daniel Ek Beat Apple, Google, and Amazon in the Race for Audio Dominance (Diversion Books, 2021) is the new English-language update of Spotify Untold – their 2019 Swedish business biography – Sven Carlsson and Jonas Leijonhufvud put Europe’s only tech giant under the microscope using information gleaned from interviews more than 80 sources and a mountain of public and private documents. The book has been translated into 15 languages and will soon be turned into a Netflix Originals miniseries.Sven Carlsson is a technology reporter at Swedish Radio and and Jonas Leijonhufvud a business journalist at Di Digital.*The authors own book recommendations are Super Pumped: The Battle for Uber by Mike Isaac (W. W. Norton, 2019) and Say Nothing: A True Story Of Murder and Memory In Northern Ireland by Patrick Radden Keefe (William Collins, 2018).Tim Gwynn Jones is an economic and political-risk analyst at Medley Global Advisors. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

On Task: How Our Brain Gets Things Done (Princeton UP, 2020) is a look at the extraordinary ways the brain turns thoughts into actions—and how this shapes our everyday lives. Why is it hard to text and drive at the same time? How do you resist eating that extra piece of cake? Why does staring at a tax form feel mentally exhausting? Why can your child expertly fix the computer and yet still forget to put on a coat? From making a cup of coffee to buying a house to changing the world around them, humans are uniquely able to execute necessary actions. How do we do it? Or in other words, how do our brains get things done? In On Task, cognitive neuroscientist David Badre presents the first authoritative introduction to the neuroscience of cognitive control—the remarkable ways that our brains devise sophisticated actions to achieve our goals. We barely notice this routine part of our lives. Yet, cognitive control, also known as executive function, is an astonishing phenomenon that has a profound impact on our well-being. Drawing on cutting-edge research, vivid clinical case studies, and examples from daily life, Badre sheds light on the evolution and inner workings of cognitive control. He examines issues from multitasking and willpower to habitual errors and bad decision making, as well as what happens as our brains develop in childhood and change as we age—and what happens when cognitive control breaks down. Ultimately, Badre shows that cognitive control affects just about everything we do. A revelatory look at how billions of neurons collectively translate abstract ideas into concrete plans, On Task offers an eye-opening investigation into the brain’s critical role in human behavior.Joseph Fridman is a researcher, science communicator, media producer, and educational organizer. He lives in Boston with two ragdoll kittens and a climate scientist.You can follow him on Twitter @joseph_fridman, or reach him at his website, https://www.josephfridman.com/. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

The fallacy sold to many of us is that the penis signals dominance and power. But this wry and penetrating book reveals that in fact nature did not shape the penis–or the human attached to it–to have the upper…hand.Phallacy looks closely at some of nature’s more remarkable examples of penises and the many lessons to learn from them. In tracing how we ended up positioning our nondescript penis as a pulsing, awe-inspiring shaft of all masculinity and human dominance, Phallacy also shows what can we do to put that penis back where it belongs.Emphasizing our human capacities for impulse control, Phallacy ultimately challenges the toxic message that the penis makes the man and the man can’t control himself. With instructive illustrations of unusual genitalia and tales of animal mating rituals that will make you particularly happy you are not a bedbug, Phallacy shows where humans fit on the continuum from fun to fatal phalli and why the human penis is an implement for intimacy, not intimidation.Emily Anthes is a science journalist and author. Her books include Frankenstein’s Cat: Cuddling Up to Biotech’s Brave New Beasts and The Great Indoors: The Surprising Science of How Buildings Shape Our Behavior, Health, and Happiness. Read more about her work at emilyanthes.com or follow her on Twitter at @emilyanthes. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Today we speak to Hannah Marcus, Assistant Professor in the Department of the History of Science at Harvard University in Cambridge, Massachusetts, about her new monograph, Forbidden Knowledge: Medicine, Science, and Censorship in Early Modern Italy (University of Chicago Press, 2020).Forbidden Knowledge explores the censorship of medical books from their proliferation in print through the prohibitions placed on them during the Counter-Reformation. How and why did books banned in Italy in the sixteenth century end up back on library shelves in the seventeenth? Historian Hannah Marcus uncovers how early modern physicians evaluated the utility of banned books and facilitated their continued circulation in conversation with Catholic authorities.Through extensive archival research, Marcus highlights how talk of scientific utility, once thought to have begun during the Scientific Revolution, in fact began earlier, emerging from ecclesiastical censorship and the desire to continue to use banned medical books. What’s more, this censorship in medicine, which preceded the Copernican debate in astronomy by sixty years, has had a lasting impact on how we talk about new and controversial developments in scientific knowledge. Beautiful illustrations accompany this masterful, timely book about the interplay between efforts at intellectual control and the utility of knowledge. Jana Byars is the Academic Director of Netherlands: International Perspectives on Sexuality and Gender. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Few astronomers in the 20th century did as much to expand our understanding of the universe as Vera Rubin. To tell her remarkable story in their biography Vera Rubin: A Life (Belknap Press, 2021), authors Jacqueline and Simon Mitton describe both the range of her accomplishments as well as the barriers she overcame in order to achieve them. As they explain, Rubin was drawn early to the study of the stars, determining early in her life that she wanted to be an astronomer. To become one she had to overcome the assumptions of many of her peers that science was not an appropriate field of study for a woman, or that she would abandon her studies once she married and had children. Defying their expectations, Rubin balanced child-rearing with earning her doctorate in astronomy and undertaking observational work. Though she participated in a number of different studies, her passion was for understanding galaxies, and her discoveries proved critical for the acceptance of the existence of dark matter in the universe. Acclaimed for her work, she used her position to fight for improve the status of women in the sciences, a fight that she continued alongside her research for the rest of her life. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

What does the birth of babies whose embryos have gone through genome editing mean—for science and for all of us?In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos—as dramatic a development in genetics as the 1996 cloning of Dolly the sheep. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences in CRISPR People: The Science and Ethics of Editing Humans (The MIT Press, 2021). Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.The two babies, nonidentical twin girls, were the first “CRISPR'd” people ever born (CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing method). Greely not only describes He's experiment and its public rollout (aided by a public relations adviser) but also considers, in a balanced and thoughtful way, the lessons to be drawn both from these CRISPR'd babies and, more broadly, from this kind of human DNA editing—“germline editing” that can be passed on from one generation to the next.Greely doesn't mince words, describing He's experiment as grossly reckless, irresponsible, immoral, and illegal. Although he sees no inherent or unmanageable barriers to human germline editing, he also sees very few good uses for it—other, less risky, technologies can achieve the same benefits. We should consider the implications carefully before we proceed.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

On January 28 2011 WikiLeaks released documents from a cache of US State Department cables stolen the previous year. The Daily Telegraph in London published one of the memos with an article headlined 'Egypt protests: America's secret backing for rebel leaders behind uprising'. The effect of the revelation was immediate, helping set in motion an aggressive counter-narrative to the nascent story of the Arab Spring. The article featured a cluster of virulent commentators all pushing the same story: the CIA, George Soros and Hillary Clinton were attempting to take over Egypt. Many of these commentators were trolls, some of whom reappeared in 2016 to help elect Donald J. Trump as President of the United States. Nathaniel Greenberg's book How Information Warfare Shaped the Arab Spring: The Politics of Narrative in Egypt and Tunisia (Edinburgh UP, 2019) tells the story of how a proxy-communications war ignited and hijacked the Arab uprisings and how individuals on the ground, on air and online worked to shape history.Marci Mazzarotto is an Assistant Professor of Digital Communication at Georgian Court University in New Jersey. Her research interests center on the interdisciplinary intersection of academic theory and artistic practice with a focus on film and television studies. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Jeremy Black – professor of history at Exeter University, and one of the world’s most prolific writers – has just published an outstanding illustrated history of the twentieth century, in A History of the 20th Century: Conflict, Technology & Rock'n'roll (Sirius Entertainment, 2021). In 250 pages, and with copious and superbly chosen illustrations, he unpacks the realities of rapid population growth and the political, economic and cultural changes that came in its wake. Thinking about the reality of American dominance of the West, and the rise and fall of rival anti-imperial powers elsewhere, while never forgetting the importance of experiences in the so-called “third world,” Black pulls together themes that explain the horrors and achievements of this period – and which never fail to surprise.Crawford Gribben is a professor of history at Queen’s University Belfast. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

Barely a month after the riot on the Capitol Building, the United States is no more adept at fending off foreign information operations than it was four years ago, when “fake news” and “information operations” became household terms. Why has the United States been so slow to adapt, and what can it do to reverse the tide?In How to Lose the Information War: Russia, Fake News, and the Future of Conflict (Bloomsbury, 2020), Nina Jankowicz, a Disinformation Fellow at the Wilson Center, explores how five central and eastern European countries have fared in their battles against Russian information operations. Though Estonia, Georgia, Poland, Ukraine and the Czech Republic still have their struggles, each has lessons to offer the United States—if only it would listen.On this episode, I talk with Nina about what makes Russian information operations so effective, how victims should repair their information ecosystems, and what Alexei Navalny can teach the West about waging information battles against the Kremlin.Please be advised: We get a surprise guest in the middle of the podcast, when Nina’s dog makes a quick cameo!John Sakellariadis is a 2020-2021 Fulbright US Student Research Grantee. He holds a Master’s degree in public policy from the School of International and Public Affairs at Columbia and a Bachelor’s degree in History & Literature from Harvard University. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm

A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer’s disease, and Parkinson’s disease.Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In his book The Future of Brain Repair: A Realist's Guide to Stem Cell Therapy (MIT Press, 2020), neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer’s disease, Parkinson’s disease, and spinal cord injuries.Certainly brain disorders are in need of effective treatments. These disorders don’t just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells—and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson’s and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body.New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair?You can find more about Jack’s work here and here.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm