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A special focus section highlights the barriers ahead to translating basic discoveries in stem cell biology into regenerative therapies.

We discuss new techniques for supercooling organs, for imaging eye disease and for studying cancer-causing mutations.

We discuss the revitalizing effects of young blood and how exome sequencing could help guide personalized cancer treatments.

We discuss ways to optimize treatment schedules in oncology and how antibiotic use in infants could be contributing to life-threatening infections.

Why drug therapy might be helpful for HIV controllers and a new blood test that can diagnose Alzheimer's disease years before symptoms arise.

We discuss a rapid technique for diagnosing Staph aureus, and look at the impact of large-scale visualization labs on biomedicine.

We talk with Jeremy Farrar, the new director of the Wellcome Trust, and Juan Carlos López, outgoing Chief Editor of Nature Medicine.

We speak with the incoming chief of the NIH alcohol institute and examine how to target self-renewal in cancer stem cells.

We talk with the founders of shared lab facilities and ask why genetic differences in blood clotting may underlie racial disparities in heart disease.

Hedgehog inhibitors show promise in combination therapy for brain cancer and as new way to treat a bone condition called heterotopic ossification.

A two-drug combo guards against the deadly MERS virus in monkeys, and a set of naturally occurring immune cells could form the basis of a universal flu vaccine in people.

We discuss why migraine aura is so difficult to trigger in the lab, and how a newly discovered compound could help in the fight against tuberculosis.