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It is often said that it is never too late to adopt a healthy lifestyle - never too late to incorporate more exercise into our daily routine or focus on a healthier diet, to reap the rewards as we age. In reality, a message that it is never too early to focus on our wellbeing and longevity, is equally important. Perhaps more so. Cathy Richards is an exercise physiologist and founder of Inspiring Vitality, an online coaching program focussing on the needs of people over 40.  In this LLAMA podcast interview with Peter Bowes, Cathy discusses her mission to encourage more people to take steps - even tiny steps - in their daily lives, to incorporate strength building activity into their routines.  She also highlights the significance of deteriorating hearing for overall health and the likelihood that impaired hearing can lead to social isolation and loneliness. Recorded: January 11, 2021 | Read a transcript and show notes at the LLAMA podcast website.This episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.comTopics covered in this interview include:Adapting to a new way remote way of working out during and likely after CovidLearning about the behavioral trail of very old populations and joining the longevity dotsThe onset of frailty and the snowball effect of muscle declineImplementing resistance training into exercise regimes to maintain muscle strengthDoing the bare minimum exercise to still realize significant result. Small, step and changes that add up and make a difference over timePersuading younger generations that it is never too early to think about being fit at 85. Hearing loss and the impact on our quality life as we age  The stigma associated with hearing loss and dangers The correlations been hearing loss and dementia. Social isolation, poor hearing and loneliness. Personal habits to live a healthy daySleep as a wellness trendThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

As we push the boundaries of human longevity and our expectations for lifespan, mid-life is going to be different.  Our healthy, vibrant decades are being extended. The goal of enjoying more fulfilling years, free of diseases and physical decline is becoming a reality. The trajectory of our lives is changing.  Chip Conley is a veteran executive in the hospitality industry, formerly Head of Global Hospitality and Strategy with Airbnb and a prolific writer.  He's also the founder of the Modern Elder Academy, a self-styled school for midlife wisdom and the author of Wisdom@Work: The Making of a Modern Elder. In this conversation with Peter Bowes, Chip shares his vision of older people as wise, curious and indispensable members of society. He recalls the impact of a near-death experience, the way his life went through a transformation in his 50s and the art of lifelong learning.     Recorded: December 29, 2020 | Read a transcript and show notes at the LLAMA podcast website.Photo credit: Lisa KeatingThis episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.comTopics covered in this interview include:Chip's life-defining brush with death and experience of going to the "other side" during a medical  emergency. Doing business as a "hospitality disrupter," as one of the first boutique hoteliers and later with Airbnb.Creating the Modern Elder Academy (MEA), mid-life wisdom school.What is long-life learning? The unexpected pleasures of aging.Focussing on "great longevity" and a spiritual diet. Upgrading the human operating system - moving from reverence to relevance as a "modern elder." Launching the MEA - a regenerative community - a 21st century version of a retirement community. Taking the less traveling path in life.  Having regrets or no regrets in life?  Metabolizing and cultivating wisdom from life's experiences.Acknowledging and challenging "new year resistances" fears and old habits.  Role models for a living a very long life.  Embracing curiosity as tool to live a long life. The Live Long and Master Aging (LLAMA) podcast is a HealthSpan Media LLC production. LLAMA shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The body's unique ability to repair itself, with a little outside help, is the focus of a growing sphere of longevity science. One area of research concerns a molecule, known as nicotinamide adenine dinucleotide (NAD+), which plays a key role in many biological processes.  NAD+ declines as we age, but research has shown that, through supplementation,  youthful levels can be restored, helping us to age better.   In this episode, Dr Nichola Conlon, a molecular biologist and co-founder of Nuchido Laboratories, based in North -East England, discusses her mission to develop nutraceuticals to stimulate rejuvenation. In conversation with Peter Bowes, Nichola explains her passion for nutritional interventions designed to enhance healthspan; she addresses the need to educate people about the relevance of biogerontology research and the new products that could significantly improve our quality of life. Recorded: December 3rd, 2020 | Read a transcript and show notes at the LLAMA podcast website.“This episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.comTopics covered in this interview include:A career in science driven by Nichola's fascination with the human body - how "it's so intricately designed and perfect to make us tick."How do drugs work - from consumption to the cells where they need to work. What is aging? The steep learning curve involved in aging research.Is it a good thing to try to slow aging and should it be done through supplementation?Translating the science into consumer products. What does Nuchido mean? Explain the role and complexities of NAD+The benefits of elevated NAD levels, related to aging. Why reverse a process (declining NAD) when it appears to be a natural part of aging? Why we are very good at being young but not so good at being old. Being a successful female scientist and entrepreneur in a male-dominated world.The importance of tracking your own health through regular blood tests. Why the sky's the limit in biogerentology.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Optimism, during this tumultuous year, has been in short supply. But as 2021 beckons, there is a real sense of hope that happier, healthier times are ahead. Cheryl Ladd, best known for her role in the 1970s detective series, Charlie's Angels, is also emerging from a rollercoaster of a year.  As well as dealing with the emotional challenges presented by Covid-19, for the first time in her life, the actress says she started to feel old.  But it was the challenge of failing eyesight that motivated her to take on a new mission in life, encouraging others, with optimism and gratitude, to embrace the aging process.  In this LLAMA podcast interview with Peter Bowes, the 69-year old explains why wellness matters; how she has overcome cataracts with new technology; her reluctance to retire and future aspirations in Hollywood. Recorded: September 17th, 2020 | Read a transcript and show notes at the LLAMA podcast website.“This episode is brought to you by AgeUp, a new financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. To find out more, visit Age-Up.comTopics covered in this interview includeThe rocket ship that was Charlie's Angels and a 44-year careerMastering the process of growing old with optimism Dark times through isolation during the pandemic The healing power of a hugAppreciating what we have and expressing gratitudeI'm 69-years old.  How did this happen?Changing sleep patterns as we age.Appreciating what we have and expressing gratitudeDealing with eye cataracts and a fear of driving at night What is there to love about life and keep living for? Retirement or not? Being old and female in Hollywood.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

If the coronavirus pandemic has reminded us of anything, it is that there is nothing more important than our health and wellbeing.  Now that the vaccine is a reality for people in the UK - and the rest of the world soon -  there is real hope that the disease will be brought under control during the first part of next year.  "People in robust good health are massively less vulnerable to bad outcomes during the pandemic and more vital in general," says Dr. David Katz, a physician and co-author of the new book, How to Eat. Highlighting the importance of lifestyles and nutritional interventions, to promote health and vitality, Dr Katz says, there is much to be done tackling the "neglected scourges” of modern living, as we move on from the pandemic. A renowned public health commentator and prolific writer, Dr Katz serves on the Scientific Advisory Board of Amazentis, a Swiss life science company and co-producer of this LLAMA podcast episode. In this interview, with Peter Bowes, he analyzes the current state of Covid-19; the challenge of sorting fact from fiction; the prospect of “herd immunity” and life after the virus. He also delves into the infinitely fascinating world of the microbiome and nutritional products that promote enhanced muscle mass and function as we age.Recorded:  December 1st, 2020 | Read a transcript and show notes at the LLAMA podcast website.This episode of the LLAMA podcast was brought to you in association with Amazentis, a Swiss life science company, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Topics covered in this interview includeHow a rambunctious kid chose a career in medicine and developed a passion for preventing chronic disease, and promoting health.Analyzing the lifestyle practices that determine our state of health.Drama over data and the Covid-19 pandemic. What does herd immunity mean? Pandemic fatigue, opening up society and phasing back to normalcy.The "acute case for chronic health" as we emerge from the pandemic. Mitochondrial health,  the microbiome, pomegranates and urolithin A. Amazentis' nutritional product Mitopure and clinical trials suggesting a positive impact on physical stamina and endurance. Can rejuvenation of mitochondria mimic the health of the world's fittest communities?Sleep, diet and exercise. Related episodesStuart Phillips: Boosting physical strength as we ageStephanie Blum: Embracing and marketing the science of wellbeingJohan Auwerx: Enjoying youthful vitality as we ageNavindra Seeram: The rejuvenating power of plantsPatrick Aebischer: A novel molecule to promote longevityAnurag Singh: Pomegranates, muscle mass and healthy agingThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The concept of healthspan - the number of years that we enjoy optimum health - has come a long way, in recent years.  In fact, Dr. Nir Barzilai, founding director of the Institute for Aging Research at Albert Einstein College of Medicine,  believes we are "ushering in a future where the norm will be for people to be healthy, active and mentally sharp, during the last quarter of their lives."  In his new book, Age Later: Healthspan, Life Span, and the New Science of Longevity, he argues that aging can be "targeted, improved and even cured," and that it should be thought of as not "as a certainty but as a phenomenon."  In this LLAMA podcast episode, with Peter Bowes, Dr Barzilai, discusses his life's work studying some of the world's super agers, people who are enjoying active and productive lives well into their nineties and beyond. Recorded:  September 21st, 2020 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:Dr Barzilai's lifelong interest in longevity and healthspanThe impact of Covid 19 and why it has highlighted issues surrounding agism. Post-covid and finding the right balance with social interactions. The TAME (Targeting Aging with Metformin) study and wider uses for the anti-diabetic drug, relating to aging, coronavirus and cancer. Should we all be taking metformin?  The ethical dilemmas. Why "flexible" biology of aging. What has been learned through the study of 750 centenarians?Learning lessons from Frieda - the grandmother of Dr. Barzilai's wife. Why we should not put off our dreams. The longevity dividend.Caloric restriction, fasting and time-restricted eating.Getting enough sleep.Earlier LLAMA podcast in with Dr. Barzilai: Researching the genetics of exceptional longevity and drugs that could target agingThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Lee Gutkind has spent much of his life denying his age. The Pittsburgh-based writer and teacher, renowned for his skills as an immersion journalist, has long been fascinated by the aging process and the insecurities that come with growing old. Now, aged seventy-seven, he has overcome his anxieties and age-related tensions. It followed a dark period of time, marked by the loss of loved ones and loneliness, when Lee decided to use his journalistic skills to perform a deep dive on himself. The result is a candid memoir, My Last Eight Thousand Days: An American Male in His Seventies, which documents the realities of aging and the transformation in fortunes that Lee enjoys today. In this episode, he explains how, despite a hugely successful career and a naturally outgoing personality, he reached a low point in his life; how he developed a new appreciation of casual friendships and the joy of connecting with other people. Described by Vanity Fair as the Godfather behind creative nonfiction, Lee also reflects on the frustrations that come with being pigeonholed as an old, soon-to-be-retired, man.  Published: November 12, 2020 | Recorded: November 10, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.This episode is brought to you by AgeUp, a new product that helps fill in the financial gaps that are often created once you’ve mastered aging and achieved an exceptionally long life. Small monthly payments to AgeUp stack over time to create a secure income stream for your 90s and beyond. Contributions to AgeUp are shielded from market swings, and once payouts begin at age 91 or above, they’re guaranteed to last for life. AgeUp is backed by MassMutual and sold by Haven Life Insurance Agency. You can find out more at Age-Up.comIn this interview we cover:The life and times of an immersion journalist, who immerses himself into his own storyDispelling the popular image of an older personDefending the vitality of people still working in their seventies The “demeaning” assumption that retirement beckons at 65Lee’s denial of his age and mid-life loneliness Turning the journalistic microscope inward with positive resultsThe realization that casual friends can be a lifelineThe power of human interaction after a lifetime of self-enforced solitude, as a writerThe impact of Covid on friendshipsThe physical prowess of a lifelong athlete in his 70sThe excitement of hot yoga at 70 Moving forward while remaining younger in mind and body

Matters of the mind may be more important to us now, than ever before. The number of new coronavirus cases is continuing to rise in many countries.  The United States - as well as dealing with political uncertainty - is reporting over 100,000 infections every day and England has just gone back into lockdown.  There are encouraging exceptions, like Australia, which, earlier this week, recorded its first day without local cases in almost five months. But our lives have been upended like never before, and as we continue to battle the virus, the pandemic brings into focus our overall health and wellbeing. “When there’s a huge event like Covid, it’s a forced pause for all of us,” says Giovanni Dienstmann, a Sydney-based meditation teacher and creator of the blog, Live and Dare.Is it time to re-think the way we live our lives and contemplate the future?"Perhaps start a different life, perhaps start to focus more on family, on personal growth, on health and longevity and on service."In this episode, we explore the power of meditation to get us through these difficult days.  Giovanni also discusses his personal journey, from troubled child to a place of contentment - and his regimented lifestyle, encompassing meditation, work, exercise, one daily meal, stoicism and family. Published: November 5, 2020 | Recorded: August 27, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.This episode is brought to you by AgeUp, a new product that helps fill in the financial gaps that are often created once you’ve mastered aging and achieved an exceptionally long life. Small monthly payments to AgeUp stack over time to create a secure income stream for your 90s and beyond. Contributions to AgeUp are shielded from market swings, and once payouts begin at age 91 or above, they’re guaranteed to last for life. AgeUp is backed by MassMutual and sold by Haven Life Insurance Agency. You can find out more at Age-Up.comIn this interview we cover:Nurturing the mind as well as the bodyMastering the aspects of our lives that we can controlThe impact of Covid 19 on the demand for meditationGiovanni’s story: from troubled child to a place of restfulness. Almost becoming a monk at 19Is spirituality religious?Classifying meditation into different disciplines: Concentration, awareness, relaxation and standby modeDeveloping the muscle of concentrationShutting out the modern day distractions in life and developing self-disciplineGiovanni’s constantly evolving and adapting daily schedulePracticing biphasic sleep - splitting sleep into to blocks per dayThe importance of routines in daily lifeEating just one meal a day. Starting the day with a cold shower followed by meditation Embracing intermittent fasting for longevity and wellbeingLiving by a stoic philosophy and letting go of what you cannot controlPutting life in perspective during the pandemic The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

They say, 'you’re never too old.' Never too old to do something for the first time, take on a new challenge, push yourself to your physical and mental limits, or step out of your comfort zone. You only live once. But how many of us would embrace such an  adventurous attitude, in our nineties.  in this episode we meet the writer, Heidi Herman, who was inspired by her mother, to “spread more living onto everyday life.” At the age of 93, Íeda Jónasdóttir Herman set out to find ninety-three things she had never done before, with the intention of trying them between her 93rd and 94th birthdays.  In her book, On with the Butter! Spread more living onto everyday life, Heidi tells the inspiring story of her mother’s adventure and the zest for life she shared with her family and friends. Published: October 28, 2020 | Recorded: October 22, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.This episode is brought to you by AgeUp, a new product that helps fill in the financial gaps that are often created once you’ve mastered aging and achieved an exceptionally long life. Small monthly payments to AgeUp stack over time to create a secure income stream for your 90s and beyond. Contributions to AgeUp are shielded from market swings, and once payouts begin at age 91 or above, they’re guaranteed to last for life. AgeUp is backed by MassMutual and sold by Haven Life Insurance Agency. You can find out more at Age-Up.comIn this episode we learn about:Íeda Jónasdóttir Herman's extraordinary enthusiasm for living life to the full. What it means to spread more living onto everyday life. Adopting an adventurous mindset and how it affects our brain function and potential to live a longer life. The simple lifestyle trail and instincts that promote healthy living.Daily exercise routines that don’t involve going to the gym, include doing sit ups and holding an exercise plank while still in bed.Observing the stretching routines of animals. Building extra movement into the day.Taking the long route around the parking lot to pick up the groceriesThe power of communal laughter, even during the days of CovidHow Heidi helped her mother try ninety-three news things between the ages of 93 and 94.

What if we run out of money, as we get older? If we live a very long, healthy and active life, will we be able to afford the kind of lifestyle that we aspire to, as a nonagenarian or centenarian?  The so-called longevity risk poses a dilemma for many people. The goal is to enjoy a vibrant healthspan but it could prove to be expensive.  In this episode of the Live Long and Master Aging podcast we discuss the financial side of living a very long life. We also meet LLAMA’s new sponsor, AgeUp, a novel financial product that provides guaranteed supplemental income for people who worry about the financial impact of longevity. We explore the idea of longevity annuities - sometimes called deferred income annuities - as a way to set up a stream of income for life beyond 90. Blair Baldwin, founder and general manager of AgeUp, explains how the product came about, he shares the research behind the concept, and breaks down how it works. "If you have fewer worries about money and finances, especially when you imagine the future state, that can only help lower your levels of anxiety and can only correlate to a more healthy lifestyle, essentially, and a better chance of living a very long life."Published: October 21, 2020 | Recorded: October 15, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.This episode is brought to you by AgeUp, a new product that helps fill in the financial gaps that are often created once you’ve mastered aging and achieved an exceptionally long life. Small monthly payments to AgeUp stack over time to create a secure income stream for your 90s and beyond. Contributions to AgeUp are shielded from market swings, and once payouts begin at age 91 or above, they’re guaranteed to last for life. AgeUp is backed by MassMutual and sold by Haven Life Insurance Agency. You can find out more at Age-Up.comIn this episode we cover:The story behind AgeUp and how Blair developed an interest in human longevity. The challenge: Creating financially accessible products that “do a little good for the world."Family conversations about money and old age. Attitudes towards extreme longevity and how they affect our perspective on money. Setting in place a financial plan to create an income over the age 90 Why have an income stream so late in life?Weighing the options and assessing the longevity risk. Involving the family and building in a safety net. Longevity and Covid 19 - and the importance of a long-term view

A key pillar of human longevity is our ability to remain physically strong and active as we age. Frailty is an all-too-familiar downside of growing old. But there is much we can do to slow down and even reverse the process that leads to the weakening of our limbs.  In this episode of the Live Long and Master Aging (LLAMA) podcast, we delve into the latest clinical discoveries that could help us stay strong and vital for much longer. Prof. Stuart Phillips, director of the Physical Activity Centre of Excellence (PACE) at the Department of Kinesiology at McMaster University, Hamilton, Ontario, explains how laboratory research into mitochondrial health is being applied to human physiology. Dr. Phillips is a member of the advisory board of Amazentis, the Swiss life science company, which has partnered with the LLAMA podcast to produce this episode. This episode of the LLAMA podcast is brought to you in association with Amazentis, a Swiss life science company, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Published: October 6, 2020 - 3:21PM PTRecorded: July 7, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.In this interview we cover:PACE - a a community access exercise facility for special populations over the age of 55The impact a period of muscular disuse has on the body Why Covid has had such a marked effect on older people through inactivity The classic image of the older, retired person and why the notion of aging being associated with a decline in our physical functions is being challenged. Pursuing a goal of aging as healthily as we can for as long as we can.Understanding the phenomenon of SarcopeniaThe condition known as frailty. Ten thousand steps per day - why that number? Type II diabetes and psychical activity.Working with Amazentis to explore the benefits of Mitopure, a pure form urolithin A, in humans.Making the connection between research in laboratory animals and humans."Lifestyles that give meaning to life.The protein question - how much and what kind? The declining immune system with aging. Why is exercise king and nutrition queen? Is there a recipe for good exercise? Why do we run marathons?The power of walking Spreading the message of healthy aging through social mediaThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The science and marketing sectors don’t often intersect. But when clinically validated advancements emerge from the laboratory, this unlikely alliance comes into play.  In this LLAMA podcast episode we explore how cutting edge research can be applied to our everyday health and longevity. Dr. Stephanie Blum, Head of Translational Science at Nestle Health Science, is responsible for transforming  scientific discoveries to innovative product. In partnership with the Swiss life science company, Amazentis, her work involves identifying how Amazentis’ mitochondrial research and clinical trial data can be leveraged for novel nutrition products with proven health benefits.Dr. Blum received her PhD in pharmacology and immunology. She developed a passion for immunology after gaining a complex understanding of how a person’s immune system can critically affect their health.In this interview with Peter Bowes, Dr. Blum discusses the intricacies involved with marketing a science-focused nutrition product. She also reflects on the ways people have changed their health habits in the face of a world-wide pandemic and the steps we could take to increase our immune health, as we age.This episode is produced in association with the Swiss life science company, Amazentis, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Published: September 21, 2020 - 3.09PM PTRecorded: August 12, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.In this interview, we cover:Striking a balance between exploring exciting research and actually producing a nutritional supplement that consumers will trust.How a healthy immune system could better-position you to fight off infections.With the COVID pandemic, how a well-functioning immune system is the foundation to defend against a viral or bacterial infection.”Dr. Blum’s conviction that we can proactively contribute to manage our health, and not to wait until medication of an illness is neededWhich kind of health supplements consumers have intensively purchased during the COVID-19 outbreak and how the pandemic has changed their outlook on every-day health habits.Why obesity is a risk factor in COVID-19 infection.What simple thing you can do every day to better strengthen yourself against infections and other illnesses.Why your body accumulates "cellular waste" as you age, and what this means for your health.How offering people a choice in the physical form of a nutritional supplement can make all the difference when it comes to buying into the product and being able to stick with it.The quality that makes you an excellent leader, according to Dr. Blum.The advice Dr. Blum has for rising female leaders and the steps she takes in her personal life to ensure a healthy life style.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The science of aging is rapidly evolving. Many of us are more aware of our capacity to live a long healthy life, than ever before. But the quest to understand human longevity - and perhaps figure out how we can slow down the process - is still a huge work-in-progress. Why do we age? Is it due to wear and tear on our bodies, is it all predetermined by our genes - or is there an invisible killer all around us, such as toxins in the environment, that is slowly eating away at our lifespan? These and many other compelling questions about aging are explored in a fascinating new book: Borrowed Time: The Science of How and Why We Age, by Sue Armstrong.  In this episode of the Live long and Master Aging podcast, Sue, a writer and broadcaster, based in Edinburgh, joins Peter Bowes to explore the latest research and the lessons to be learned from our growing understanding of what it means to grow old. Published: September 13, 2020 - 07:25 PTRecorded: August 20, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.In this interview we cover:Delving into the massive canvas that is the enormous issue of aging, and why it parallels climate change in its importance for the future of mankind. Adding life to years rather than years to life, as the main goal. Why the medical profession is behind the curve on the process of aging.Why the goal of living to over a thousand or even forever is overly “narcissistic."Our genetically predetermined fate, and why plays a relatively small role in our actual lifespan.The centenarians that just keep on going and then die quicklyThe goal of compressed morbidityPeter’s meeting Roy Walford, one of the early proponents of a calorie restricted (CR) lifestyle for longevity. The mixed results from CR experiments involving monkeys. How society and marketing is pushing us into unhealthy lifestyles. The scourge of diseases of the mind and the latest theories on what causes dementia and Alzheimer’s disease.   Ayurveda medicine and a holistic, whole body, approach to treating disease.Could air pollution account for a significant proportion of Alzheimer’s cases? What is inflamm-aging?  Low grade inflation that could be accelerating the aging process.  The lessons to be learned from longevity research. The relaxing, stress-reducing impact of yoga. The aging immune system, the dangers of sitting down for too long.The mindful practice of eating: Why mealtimes should be stress-free and peaceful. The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Eventually, we will all face the challenges that come with old age. We will have less strength and energy than we once had. But what if it were possible to rekindle the drive and physical endurance of youth as we grow older? Prof. Johan Auwerx directs the Laboratory for Integrated and Systems Physiology at École Polytechnique Fédérale (EPFL) in Lausanne, Switzerland, where he studies the mechanisms that control how metabolisms are controlled and the factors that make them more or less effective. Focussing on longevity, his team is using multiple animal species to test a specific compound, Urolithin A, which could potentially restore much-needed muscle strength and energy to people as they age. Prof. Auwerx’s peer-reviewed research, including joint studies with the Swiss life science company, Amazentis, has been published in leading scientific journals. In this LLAMA podcast interview, with Peter Bowes, Prof. Auwerx, discusses the critical need for an affordable solution to ensuring a long and healthy life; how a highly pure form of Urolithin A, known as Mitopure, could be the key to improving our cellular health and strength as we age; and the simple steps we can take to mitigate health issues later in life.This episode is produced in association with Amazentis, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Disclosure: Prof. Auwerx is a scientific adviser to Amazentis and several other companies which make products to boost mitochondrial function. Learn more about the science behind Mitopure, a highly pure form of Urolithin A, from Timeline.Full show notes at the Live Long and Master Aging website.In this interview we cover: The downside of a more sedentary life, either enforced by COVID-19, or as a function of growing old.Why each person’s metabolism functions differently and what this means for our diet.Making the transition from treating patients to medical research.Tackling the big questions regarding metabolic diseases and complex interactions of the human body and the environment. The role of the gut microbiome and genetic makeup in long-term health. Why gaining weight has different implications for the young and old Why people Iiving in one region of the world will digest certain foods more efficiently than people living in a different area.Research with nematode worms (C. elegans) as a model for human aging and longevity.Testing worm observations in human cells, using phenotype data.   How studies on extracts from pomegranates led to a better understanding of Urolithin A.Understanding the difference between healthspan and lifespan. Promoting the benefit of physical activity based on observations in worms. It is ethical to work on lifespan? The impact of urolithin supplementation on endurance, based on evidence in mice. The daily rituals that promote healthspan. How lifestyle habits, such as exercise, environment and stress levels, can affect how efficiently your metabolism functions.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

"Let food be thy medicine and medicine be thy food." The quote, attributed to the Greek physician, Hippocrates, encapsulates the importance of nutrition and the extraordinary ability of certain foods to enhance our wellbeing. In this episode of the LLAMA podcast, we explore the rich array of benefits to be gained from plant foods and natural products and discover why foods rich in compounds known as phytochemicals are hugely beneficial in preventing some chronic conditions. Dr. Navindra Seeram is a professor at the University of Rhode Island, College of Pharmacy.  A leading researcher in the science of plant foods,  Dr. Seeram explains how, growing up in South America, with a tradition of using food as medicine, he first became aware of the potent power of plants.  We delve into the unique components of pomegranate and other fruits, which can be used by the body to boost mitochondrial health.  This LLAMA podcast episode is produced in association with Amazentis, an innovative life science company dedicated to employing breakthrough research and clinical science to bring advanced therapeutic nutrition products to life, under its Timeline brand.Disclosures: Dr. Seeram serves on the scientific advisory board of Amazentis, independently from his position with the University of Rhode Island.  In this interview we cover:Growing up in British Guiana, a poor Third World country, learning about the power of plants as medicines. Developing a career as a natural product chemist.Understanding the anthocyanins or the pigments which make cherries red, blueberries blue, strawberries red and pomegranates red.Defining phytonutrients and phytochemicals.Deriving drugs from natural sources like plants.Revealing the multi-layered qualities of the pomegranate.Trillions of gut bacteria and why they are vital to the way we function.The importance of urolithin A as one of the metabolites we get from pomegranates.Understanding why we respond in different ways to the potentially beneficial compounds found in fruits. Being a responder or a non-responder to Urolithin A.Linking urolithin A to mitochondria - the powerhouse of the cell.  Mitopure™ -  a highly pure form of Urolithin A - and why it has the potential to “cut to the chase,” even for non-responders.Personalized nutrition and precision medicine. Simple diets, spices, coffee and red wine. Healthspan science, long-term wellbeing and reasons to keep on living. The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The art and science of aging well is a complex business - a nuanced melding of a finely tuned diet, essential exercise and a healthy mind. For over twenty years, Prof. Luigi Fontana has been studying the lifestyle regimes that could help us live a longer, healthier life. One of the world’s leading experts in the field of human longevity, Dr. Fontana, a physician and professor of medicine and nutrition at the University of Sydney, takes a pragmatic approach to the aging process, railing against aspirations to live an excessively long life. The author of ground-breaking research on fasting and nutrition, he explores the wider issues involved in the aging process in a new book, The Path to Longevity: The Secrets to Living a Long, Happy, Healthy Life. In this LLAMA podcast interview, with Peter Bowes, Prof. Fontana argues that medical systems based on treating sick people should be replaced by a more holistic approach to the human body. He also philosophizes about life's "beautiful journey.” In this podcast we cover:Working as a longevity scientists in Australia, a country with free healthcare.The difference between healthcare and sick care. Like unserviced cars, how unhealthy humans are accidents waiting to happen."The scourge of obesity, especially in children and the relationship with chronic disease.  Why living longer by itself is of "no importance"  Finding happiness and harmony in life.The environmental impact of high protein and keto diets.Living long thanks to the longevity gene? The craziness of magical recipes to live longer. The metabolic and molecular pathways that regulate the accumulation of damage.  Calorie restriction (CR) - the most powerful intervention to slow aging.Getting a phone call from CR pioneer Roy Walford. The confusion of ‘intermittent fasting’ describing multiple, disparate regimes.  The limits of using mice and other animals as models for humans in longevity research. The role of IGF-1 - Insulin-like growth factor 1.The 5:2 diet and what we eat on those non-fasting days. Developing biomarkers that measure our response to interventions focussed on improving health.The importance of waist circumference.  The ‘religious’ extremes of longevity - vegetarians, vegans, carnivores.  Approaching aging like a master conductor or a fine artist. A lack of exercise being the main public health problem of the 21st century. Why sportsmen and women do not live particularly long lives. The role of the matters of mind in longevity and pink noise. The value of sleep in healthy aging and memory consolidation. Stress, addictions and dopamine. A philosophical view of iife and longevity.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

This episode of the Live Long and Master Aging podcast is the first in a series produced in association with the Swiss life science company, Amazentis.  It will explore the history of the company and the science behind its goal of promoting healthy aging. Professor Patrick Aebischer, chairman and co-founder of Amazentis, is a medical doctor, neuroscientist and longtime researcher.  He has held distinguished positions in his home country of Switzerland, as President of the École Polytechnique Fédérale de Lausanne (EPFL) and in the United States at Brown University in Providence.  In this interview we explore how an idea based on little more than “intuition” led to a deeper understanding of muscular strength, as we age, and the role of fruits such as pomegranates. We focus on urolithin A, a bioactive dietary metabolite that is naturally produced when eating certain foods, and how Mitopure, a highly pure, synthetic form of the compound, could help people avoid frailty as they grow older.Read more about the science behind Mitopure from Timeline.In this interview we cover: The importance of good health as we deal with the Covid-19 pandemic.The genesis and big idea behind Amazentis.Putting the spotlight on aging well.Quality of life versus lifespan - living better, not only longer. Putting into perspective the scientific advances that make it possible to defy some of the killer diseases of old age.The intriguing science behind so-called superfoods, like pomegranates. Research built on intuition that led to a breakthrough in diet science.Understanding the role of urolithin A and the development of Mitopure, a pure form of the compound, which boosts mitochondrial health, through mitophagy.  Tackling frailty through supplementation to boost muscle strength as we age. The value of professional, data-driven research in promoting a new dietary product. A multidisciplinary approach to science. The personal aspirations of an artist’s son and lifelong scientist. The precious gift of creativity and a healthy mind. This LLAMA podcast episode is produced in association with Amazentis, an innovative life science company dedicated to employing breakthrough research and clinical science to bring advanced therapeutic nutrition products to life, under its Timeline brand.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.  

We are bombarded with advice and information about diet and exercise, but what about the impact of friendship, optimism and kindness on our longterm wellbeing? It is eye-opening to discover that a strong support network of family and friends lowers mortality risk by about 45 percent, while volunteering your free time reduces the chances of early death by a staggering 20-60 percent, depending on the study. Science journalist Marta Zaraska is the author of Growing Young: How Friendship, Optimism and Kindness Can Help You Live to 100. In this episode of the LLAMA podcast, she discusses the peer-reviewed studies that suggest living to a great age is about more than what we eat or how much we move.  We cover how caring for children motivates us to keep on living and why Marta's long-held beliefs about aging and longevity were shattered through an understanding of the research. Check out our website at LLAMApodcast.com and social media sites @LLAMApodcastIn this episode we cover: Coping with Covid-19 in France, where the outlook is looking better, with no second wave of the virus yet.Becoming a mother and thinking more about health and longevity. Why fixating on nutrition and exercise does not tell the whole story. Delving into the science behind friendship, optimism and kindness. What “Growing Young” means.The folly of “anti-aging."Why hugging and cuddling is good, most of the time.The extremes some people go to for human contact.The blood science that validates acts of kindness as a positive behavioral trail. Oxytocin, serotonin and endorphins. The science behind that fuzzy warm feeling. 

How many times have you heard about an older person doing extraordinary things, despite their great age? In recent weeks the story of the 100-year-old war veteran, Captain Tom Moore, has captivated millions, for his marathon fund raising efforts in the UK. Walking lengths in his garden he has raised more than £30m for the National Health Service, during the Covid-19 crisis. He is amazing. In this episode of the Live Long and Master Aging podcast we explore the lives of amazing people through the eyes of Dr. Noelle Nelson, a California-based psychologist, author of Happy, Healthy...Dead and collector of eye-opening stories through her Facebook page, Meet the Amazings. What are the common traits of older people who live their lives to the full, almost to the end? In this interview we cover:Aspiring to be to be happy, healthy, dead. The lives of the very old - ordinary people doing extraordinary things.Compressed morbidity - reducing the time it takes for the final exit. Why most of Dr. Nelson's longevity achievers are not famous.Joining the dots and connecting the common traits of people who reach a great age. Positivity or optimism: Why it is a major predictor of happy healthy longevity.A passion: From growing tomatoes to looking at the starsA purpose: Sharing knowledge or the joy of competing - in ballroom dancing. Physicality: Walking, climbing, dancing - how exercise has been shown to improve mind and body functioning. The power of always looking forward. The value of friends - or “anchors" - to get through life’s tough times. Dealign with losing everything in one of California’s wildfires. The value of please and thank you and self appreciation. Exploring science-based lifestyle interventions to live better.Editor’s note: This episode of the LLAMA podcast was recorded in Camarillo, California, on February 27th, 2020, three weeks before the state became the first in the U.S. to issue a stay at home order due to the coronavirus.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.  

We are in the war against Covid-19 for the long term. The virus is likely to be with us for many months, if not years, and as we emerge from the global lockdowns, everyday life is looking very different. Re-imagining a post-coronavirus world will likely involve changes that go to the heart of how we live - our diet, personal hygiene, social behavior and work/life balance.  As we learn more about the virus, it is becoming clear that a healthy body is a vital prerequisite to fighting the disease.  In this episode of the Live Long and Master Aging podcast, Dr. Aseem Malhotra, a London-based cardiologist, explains why he believes obesity is a prime risk factor for mortality from Covid-19.  He also suggests that the pandemic should act as a wake-up call for global populations, pursuing unhealthy lifestyles, consuming too much sugar and processed foods.Dr Aseem Malhotra is a National Health Service (NHS) Consultant Cardiologist in the UK, and visiting Professor of Evidence Based Medicine, Bahiana School of Medicine and Public Health, Salvador, Brazil. In the episode we cover: How a "horrendous state” of baseline general health, in many western populations, is relevant to Covid-19Ref. European Scientist: Covid 19 and the elephant in the room (April 16, 2020)The myths surrounding the health of people in Mediterranean countries. What is optimal metabolic health? Blood pressure, waist circumference, blood triglyceride, HDL, and HbA1c levels.Nature:  Endocrine and metabolic link to coronavirus infection (April 2nd, 2020)Lifestyle lessons from Covid-19.Personal hygiene and why it matters. Imagining the post-coronavirus world.  Listen to Dr. Malhotra’s previous LLAMA podcast interviewEpisode 03: Waging war against sugarThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.