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32 minutes | 5 days ago
41. Electrocution Recovery with Maxime Ruel
My guest is Maxime Ruel from Quebec Canada. Max was a construction worker who was electrocuted on the job.. This led to extreme chronic pain that put him out of work. He eventually became homeless. After trying several medications he discovered kratom, which he says saved his life. This is Maxime Ruel, and this is his kratom story… Music: Risey, “Memories of Thailand” Written and produced by Brian Gallagher for KratomScience.com Twitter @kratomscience Facebook.com/kratomscience The post 41. Electrocution Recovery with Maxime Ruel first appeared on Kratom Science.
42 minutes | 12 days ago
9. Journal Club: Speciofoline, the Understudied Alkaloid
A study on kratom’s chemical composition asks, what does the little-researched kratom alkaloid speciofoline do? And what are the implications for drug interactions and the differences in alkaloid content in kratom products? The brand new study published last week in Scientific Reports examined the chemical composition of 53 kratom products and divided them into two categories: high-speciofoline and low-speciofoline. As in previous studies, the researchers found kratom may be a safer treatment alternative than classical opioids because of how it acts on the mu-opioid receptor, but can kratom create risks for drug interactions if it slows liver metabolism of other drugs? The study of the alkaloid speciofoline may bring us closer to understanding why different kratom products have slightly differing effects. Does the color code of kratom product varieties — red (for bed), white (for flight), and green (in between) — hold water? Study discussed in this episode: Todd DA, Kellogg JJ, Wallace ED, Khin M, Flores-Bocanegra L, Tanna RS, McIntosh S, Raja HA, Graf TN, Hemby SE, Paine MF, Oberlies NH, Cech NB. Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions.Scientific Reports.2020 Nov 5;10(1):19158. doi: 10.1038/s41598-020-76119-w. PMID: 33154449. Full text of study https://www.nature.com/articles/s41598-020-76119-w Dr. Jonthan Cachat can be found on Twitter @jcachat and at ccvresearch.com Music: Captain Bigwheel “Moonrunner” Kratom Science Journal Club is produced by Brian Gallagher for KratomScience.comThe post 9. Journal Club: Speciofoline, the Understudied Alkaloid first appeared on Kratom Science.
61 minutes | 19 days ago
40. Dr. Oliver Grundmann
Dr. Oliver Grundmann is a Clinical Associate Professor with a PhD in Pharmaceutical Sciences and a masters’ in Forensic Toxicology, and expert in the study of kratom. University of Florida College of Pharmacy, where Dr. Grundmann works, has been a recipient of nearly $7 million in NIDA grants in 2018 and 2019 for the study of kratom. Dr. Oliver Grundmann The post 40. Dr. Oliver Grundmann first appeared on Kratom Science.
43 minutes | a month ago
8. Journal Club: Kratom Tea for Opioid Dependence in Mice
This week we look at a study by a team from University of Florida called “Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence”. The science is catching up with what thousands of kratom consumers are saying — that kratom can be a safe and effective harm reduction tool for opioid withdrawal and dependence. In 2018 and 2019, University of Florida College of Pharmacy received close to $7 million in grants from the National Institutes on Drug Abuse to study kratom. Study discussed in this episode: Wilson LL, Harris HM, Eans SO, Brice-Tutt AC, Cirino TJ, Stacy HM, Simons CA, León F, Sharma A, Boyer EW, Avery BA, McLaughlin JP, McCurdy CR. Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence. Drug Alcohol Depend. 2020 Sep 22;216:108310. doi: 10.1016/j.drugalcdep.2020.108310. Epub ahead of print. PMID: 33017752. Find Dr. Cachat on Twitter @jcachat or http://www.ccvresearch.com Music: Captain Bigwheel, “Moonrunner” Written and produced by Brian Gallagher for KratomScience.comThe post 8. Journal Club: Kratom Tea for Opioid Dependence in Mice first appeared on Kratom Science.
39 minutes | a month ago
39. Recovery in the UK with Paul W.
Paul W was prescribed hydrocodone following a car accident… the beginning of a long journey with opioid pain pills. Living in Florida during the golden age of pill mills (early 2000s) didn’t help. After addiction, recovery, and relapse Paul moved to Italy where he met his future husband. They moved to England where Paul relapsed again, starting off with over-the-counter codeine. This time, Paul is using kratom to help in his recovery. Music: Risey, “Memories of Thailand” Written and produced by Brian Gallagher for KratomScience.comThe post 39. Recovery in the UK with Paul W. first appeared on Kratom Science.
45 minutes | a month ago
7. Journal Club: Kratom Use and Mental Health w/ Dr. Marc Swogger and Dr. Jonathan Cachat
Host Brian Gallagher and Dr. Jonathan Cachat welcome Dr. Marc Swogger, social scientist and clinical psychologist at the University of Rochester Medical Center to discuss his 2018 article published in Drug and Alcohol Dependence “Kratom Use and Mental Health: A Systematic Review”. Along with co-author Zach Walsh, Dr. Swogger looked at all the literature published up to 2017 about mental health issues surrounding kratom consumption. We talk about why mostly men use kratom, cultural differences between Eastern and Western kratom consumption, the consistency of outcomes among careful kratom science vs. sloppy studies with foregone negative conclusions. Plus, Dr. Marc answers another Mark E. Smith question. Article discussed in this episode: Swogger MT, Walsh Z. Kratom use and mental health: A systematic review. Drug Alcohol Depend. 2018 Feb 1;183:134-140. doi: 10.1016/j.drugalcdep.2017.10.012. Epub 2017 Dec 7. PMID: 29248691. Music: Captain Bigwheel, “Moonrunner” Written and produced by Brian Gallagher for KratomScience.comThe post 7. Journal Club: Kratom Use and Mental Health w/ Dr. Marc Swogger and Dr. Jonathan Cachat first appeared on Kratom Science.
23 minutes | 2 months ago
38. Psychiatrists Overstate the Dangers of Kratom
In a recent webinar, psychiatrists describe kratom as dangerous with lethal overdose and toxicity potential. Using the studies they cite, Brian Gallagher explains why the dose of mitragyinine to establish LD50 in mice is far beyond the levels consumed in leaf and even extracted kratom, and why one investigation into coroners’ reports disproved claims of so-called “kratom alone” deaths. Plus, will psychiatrists administer buprenorphine for kratom withdrawal? https://www.kratomscience.com/2020/10/06/toxic-levels-of-kratom-and-lethal-dose-of-mitragynine/ “Toxic Levels of Kratom and LD50 of Mitragynine” https://doi.org/10.1021/acs.chemrestox.8b00218 “Lateral Flow Assessment and Unanticipated Toxicity of Kratom” Chem. Res. Toxicol. 2019, 32, 1, 113–121 Publication Date:October 31, 2018 https://www.frontiersin.org/articles/10.3389/fnins.2015.00189/full Ilmie MU, Jaafar H, Mansor SM, Abdullah JM. Subchronic toxicity study of standardized methanolic extract of Mitragyna speciosa Korth in Sprague-Dawley Rats. Front Neurosci. 2015 Jun 17;9:189. doi: 10.3389/fnins.2015.00189. PMID: 26136645; PMCID: PMC4470260. https://www.nejm.org/doi/full/10.1056/NEJMc1811055 Gershman K, Timm K, Frank M, Lampi L, Melamed J, Gerona R, Monte AA. Deaths in Colorado Attributed to Kratom. N Engl J Med. 2019 Jan 3;380(1):97-98. doi: 10.1056/NEJMc1811055. PMID: 30601742; PMCID: PMC6688840. Music: Risey, “Memories of Thailand” Written and produced by Brian Gallagher for KratomScience.comThe post 38. Psychiatrists Overstate the Dangers of Kratom first appeared on Kratom Science.
38 minutes | 2 months ago
6. Journal Club with Dr. Jonathan Cachat – 1972 Animal Study Shows the Promise of Mitragynine
Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. Similar conclusions about the effects of mitragynine and its relative safety in relation to opiates, but why was mitragynine never developed as a pain management drug, especially by the company that conducted this study, that would later merge into pharmaceutical giant Glaxo SmithKline? We examine how a mitragynine dose as high as 920 mg/kg in a mouse produced no evidence of toxicity. And a bit about mitragynine and metabolism. Music: Captain Bigwheel, “Moonrunner” Produced by Brian Gallagher for KratomScience.comThe post 6. Journal Club with Dr. Jonathan Cachat - 1972 Animal Study Shows the Promise of Mitragynine first appeared on Kratom Science.
24 minutes | 2 months ago
37. Sober October Starts Early
Just me this time around. I talk about a soon-to-be-released document I’ve been working on through COVID that’s 200 pages of kratom testimonials from over 800 consumers who posted to KratomScience.com. I talk about a study on kratom and metabolism I blogged about here https://www.kratomscience.com/2020/09/22/study-shows-mitragynine-metabolizes-into-7-hydroxomitragynine/. And I talk about my own history of drinking alcohol and how kratom is helping me kick off Sober October a week early. The Kratom Science Podcast is written and produced by Brian Gallagher for KratomScience.com The post 37. Sober October Starts Early first appeared on Kratom Science.
42 minutes | 2 months ago
5. Journal Club with Dr. Jonathan Cachat – Mitragynine Study in Rats Leads to Interesting Conclusions
Dr. Cachat and I talk about a study that tested rats with morphine, mitragynine, naloxone, buprenorphine, and rimonabant, and measured responses based on food-reinforcement training. The study concluded “The findings suggest that MG does not induce physiological dependence but can alleviate the physical symptoms associated with morphine withdrawal”. We talk about how the rats are trained, what can be concluded from experiments based on responses alone, mitragynine extraction methods, extracted mitragynine vs. kratom methods of administration and effects, how cannabinoid and opioid receptors interact, and why studying kratom alkaloids might lead to the “holy grail” of pain management. Journal article discussed in this episode: Direct link to full text https://sci-hub.tw/10.1007/s00213-019-05418-6 Citation: Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl). 2020;237(3):855-867. doi:10.1007/s00213-019-05418-6 Summary of this study by Brian Gallagher https://www.kratomscience.com/2020/09/07/study-pure-mitragynine-does-not-induce-physiological-dependence-in-rats-treated-morphine-withdrawal-more-efficiently-than-buprenorphine/ How rats in these studies are trained (with video) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354637/ Music: Captain Bigwheel, “Moonrunner” Kratom Science Podcast is written and produced by Brian Gallagher for KratomScience.comThe post 5. Journal Club with Dr. Jonathan Cachat - Mitragynine Study in Rats Leads to Interesting Conclusions first appeared on Kratom Science.
27 minutes | 2 months ago
36. Surviving Abuse and Addiction with Julie Current
Julie Current is a survivor. She had a rough childhood and as an adult she survived physical abuse that led to multiple disabilities like PTSD, chronic pain, and epilepsy. With kratom, kava, and cannabis as tools, she’s coming up on two years sober on October 28. This is Julie Current and this is her kratom story. Music: Risey “Memories of Thailand” The Kratom Science Podcast is written and produced by Brian Gallagher for KratomScience.comThe post 36. Surviving Abuse and Addiction with Julie Current first appeared on Kratom Science.
29 minutes | 3 months ago
35. Kratom in the Workplace with Michael McCunney
Working in a competitive environment in the sales and marketing field, my guest Michael McCunney uses kratom as a stimulant, cognitive boost, and for general well-being. We talk about the importance of doing research, finding a good source, discovering your dose, and staying hydrated. Music: Risey, “Memories of Thailand” The Kratom Science Podcast is produced by Brian Gallagher for KratomScience.com The post 35. Kratom in the Workplace with Michael McCunney first appeared on Kratom Science.
49 minutes | 3 months ago
4. Journal Club with Dr. Jonathan Cachat: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids
This episode, Dr. Jon and I use the journal article “Following the Roots of Kratom” published in 2015 by BioMed Research International as a jumping off point to talk about kratom history, human evolution and psychoactive plants, Terence McKenna’s “Stoned Ape” theory, and drug in religious cults . Plus, we answer listener mail about kratom alkaloids and use as an antidepressant. References featured in this discussion: Cinosi, E., Martinotti, G., Simonato, P., Singh, D., Demetrovics, Z., Roman-Urrestarazu, A., Bersani, F. S., Vicknasingam, B., Piazzon, G., Li, J. H., Yu, W. J., Kapitány-Fövény, M., Farkas, J., Di Giannantonio, M., & Corazza, O. (2015). Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries. BioMed research international, 2015, 968786. https://doi.org/10.1155/2015/968786 Full Text Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657101/pdf/BMRI2015-968786.pdf Raffa, R. B. (2015). Kratom and other mitragynines: The chemistry and pharmacology of opioids from a non-opium source. Boca Raton, FL: CRC Press/Taylor & Francis Group. Link: https://www.amazon.com/Kratom-Other-Mitragynines-Chemistry-Pharmacology/dp/1482225182 Saingam D, Assanangkornchai S, Geater AF, Balthip Q. Pattern and consequences of krathom (Mitragyna speciosa Korth.) use among male villagers in southern Thailand: a qualitative study. Int J Drug Policy. 2013;24(4):351-358. doi:10.1016/j.drugpo.2012.09.004 Full Text Link: https://sci-hub.tw/https://doi.org/10.1016/j.drugpo.2012.09.004# Terence McKenna talks about his “Stoned Ape Theory” https://www.youtube.com/watch?v=ZnEKoFrx1rI Kratom Alkaloids list https://www.kratomscience.com/mitragyna-speciosa-kratom-alkaloids-effects/ The Kratom Science Podcast is Produced by Brian Gallagher for KratomScience.comThe post 4. Journal Club with Dr. Jonathan Cachat: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids first appeared on Kratom Science.
23 minutes | 3 months ago
34. Rod The Steelworker Switches to Kratom From Norco for Chronic Pain
Rod the Steelerworker is from Michigan and has been a steelworker for 24 years. As a young man his hobbies were skateboarding and 4-wheeling. As a result of those hobbies, a career doing repetitive physical labor, along with Degenerative Disk Disease, diverticulitis, and IBS, he suffers from chronic pain. A prescription to Norco led him to an 8 year opiate addiction. He found kratom to be a better alternative. This is Rod the Steelworker, and this is his kratom story… Music : Risey “Memories of Thailand” Written and produced by Brian Gallagher for KratomScience.comThe post 34. Rod The Steelworker Switches to Kratom From Norco for Chronic Pain first appeared on Kratom Science.
60 minutes | 4 months ago
3. Journal Club with Dr Jonathan Cachat: Kratom Addiction, Listener Mail, and Elephants on LSD
Dr. Jon Cachat and I talk about the article “Kratom instrumentalization for severe pain self-treatment resulting in addiction – A case report of acute and chronic subjective effects” – This is an open access article that you can read for free https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378692/ Müller, E., Hillemacher, T., & Müller, C. P. (2020). Kratom instrumentalization for severe pain self-treatment resulting in addiction – A case report of acute and chronic subjective effects. Heliyon, 6(7), e04507. https://doi.org/10.1016/j.heliyon.2020.e04507 We also talk about a report by Muller called “Drugs as instruments: A new framework for non-addictive psychoactive drug use”. Müller CP, Schumann G. Drugs as instruments: a new framework for non-addictive psychoactive drug use. Behav Brain Sci. 2011;34(6):293-310. doi:10.1017/S0140525X11000057 We answer listener mail, including a question from Dr. Marc Swogger, and among other things we talk about an elephant who was given a lethal dose of LSD Music: Captain Bigwheel, “Moonrunner” Produced by Brian Gallagher for KratomScience.com The post 3. Journal Club with Dr Jonathan Cachat: Kratom Addiction, Listener Mail, and Elephants on LSD first appeared on Kratom Science.
48 minutes | 4 months ago
2. Journal Club with Dr. Jonathan Cachat: “The Potential for Kratom as an Antidepressant and Antipsychotic”
This is the Kratom Science Journal Club with Dr. Jonathan Cachat, neuroscientist and expert in psychopharmacology. In each episode we discuss an article in a peer reviewed journal. For episode 2 we discuss the article, “The Potential for Kratom as an Antidepressant and Antipsychotic” published in Yale Journal of Biology and Medicine, edition 93, June 2020 and co-authored by Kratom Science Podcast guest Marc Swogger. How do dopamine, serotonin, and cortisol work to affect psychosis and depression? What effect does mitragynine have on our brains? How is mitragynine metabolized? How does kratom work differently from opiates and psychedelics? And finally why were these substances made illegal, rendering these questions tough to answer even in the 21st century? Full citation of article discussed: Johnson LE, Balyan L, Magdalany A, et al. The Potential for Kratom as an Antidepressant and Antipsychotic. Yale J Biol Med. 2020;93(2):283-289. Published 2020 Jun 29. Dr. Cachat’s website http://jcachat.com/ Music: “Moonrunner” by Captain Bigwheel Produced by Brian Gallagher for KratomScience.com The post 2. Journal Club with Dr. Jonathan Cachat: "The Potential for Kratom as an Antidepressant and Antipsychotic" first appeared on Kratom Science.
23 minutes | 4 months ago
33. Pain Management for Interstitial Cystitis with Maranda Flynn
Maranda was diagnosed at 22 with interstitial cystitis, a painful bladder disease. She went into pain management and became addicted to opiates. After 3 years a friend introduced her to kratom. she got out of opiate hell, and was able to be present for her children and husband, who also used kratom to beat alcoholism. From Tennessee, this is Maranda Flynn, and this is her kratom story… The post 33. Pain Management for Interstitial Cystitis with Maranda Flynn first appeared on Kratom Science.
31 minutes | 4 months ago
32. Angie Childs
Angie Childs says the road to her addiction started with an abusive childhood. She was first prescribed demerol as a teenager for PTSD-related migraines. After several years of opiate addiction and two near-death experiences, Angie found the strength to get sober. She has found kratom to be a powerful tool both to stay off opiates and deal with PTSD and chronic pain. She now holds down a job and has recently reunited with her daughter after two decades. This is Angie Childs, and this is her kratom story… The post 32. Angie Childs first appeared on Kratom Science.
36 minutes | 5 months ago
1. Kratom Science Journal Club with Dr. Jonathan Cachat
Dr. Jonathan Cachat joins Kratom Science Podcast host Brian Gallagher to talk about kratom research. Each episode we pick a study about kratom published in a peer-reviewed journal. This week we discuss “Patterns and Reasons for Kratom (Mitragyna speciosa) Use among Current and Former Opioid Poly-Drug Users” published in Journal of Ethnopharmacology, March 2020. Full citation and link: Singh D, Yeou Chear NJ, Narayanan S, et al. Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users. J Ethnopharmacol. 2020;249:112462. doi:10.1016/j.jep.2019.112462 https://www.sciencedirect.com/science/article/abs/pii/S0378874119331587?via%3Dihub Dr. Cachat’s website http://jcachat.com/ Music by Produced by Brian Gallagher for KratomScience.com The post 1. Kratom Science Journal Club with Dr. Jonathan Cachat first appeared on Kratom Science.
31 minutes | 5 months ago
31. Jacob Ringstad
Jacob Ringstad never liked opiates. But at 18 he was diagnosed with Degenerative Disk Disease. At 19 he was injured in car accidents. This would lead to over a decade of managing chronic pain with opiates. Three years ago Jacob decided to get sober for the sake of his daughter. Using kratom and cannabis, Jacob has managed to stay clean and open his own CBD business. This is Jacob Ringstad, and this is his kratom story… https://www.facebook.com/jacob.ringstad https://www.instagram.com/cbdwhistleblower/ Music: Risey, “Memories of Thailand” Written and produced by Brian Gallagher for KratomScience.comThe post 31. Jacob Ringstad first appeared on Kratom Science.
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