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The Covenant of Water, Stanford University professor Dr Abraham Verghese’s long-awaited follow-up to his 2009 novel Cutting for Stone, traces the lives of a family in southern India negotiating forces of history, fate, and a genetic condition that takes the life of a member in each generation by drowning. In part 2, JAMA Arts and Medicine Section Editor Michael Berkwits, MD, MSCE, talks with Dr Verghese about the craft of writing fiction, the role of the humanities in medicine, of artificial intelligence in literature, and more. Related Content: “The Art of the Craft,” From The Covenant of Water The Covenant of Water – Reflections on Fiction, the Humanities, and Medicine (Part 1 of this interview)

The ACA’s preventive services mandate requires insurers to cover, without charge, nearly 200 basic primary care services. But now, a federal judge has issued a nationwide injunction preventing the Biden administration from enforcing this cost-free care for a significant number of these services. JAMA Executive Editor Gregory Curfman, MD, discusses this and more with Abbe R. Gluck, JD, Solomon Center for Health Law & Policy, Yale Law School. Related Content: Cost-Free Preventive Care Under the ACA Faces Legal Challenge

Most epidemiological studies of heart failure have been conducted in high-income countries. JAMA Senior Editor Kristin L. Walter, MD, MS, interviews Philip George Joseph, MD, from the Population Health Research Institute, Ontario, Canada, about a study of more than 23 000 patients with heart failure in 40 countries. Related Content: Global Variations in Heart Failure Etiology, Management, and Outcomes

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis Infection Among Non–US-Born Adults in the US Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis

The mental health of young people in the US has been an issue of increased concern in recent years. In this podcast, author Tanner Bommersbach, MD, MPH, assistant professor in the Department of Psychiatry and Psychology at the Mayo Clinic in Rochester, Minnesota, and Greg Rhee, PhD, a health services researcher and pharmacoepidemiologist at the University of Connecticut, join JAMA Senior Editor Kristin Walter, MD, MS, in a discussion about mental health-related emergency department visits in the US among children, adolescents, and young adults from 2011-2020. Related Content: National Trends in Mental Health–Related Emergency Department Visits Among Youth, 2011-2020

The Covenant of Water, Stanford University professor Dr Abraham Verghese’s long-awaited follow-up to his 2009 novel Cutting for Stone, traces the lives of a family in southern India negotiating forces of history, fate, and a genetic condition that takes the life of a member in each generation by drowning. JAMA Arts and Medicine Section Editor Michael Berkwits, MD, MSCE, talks with Dr Verghese about the novel’s clinical insights, the craft of writing fiction, the role of the humanities in medicine, of artificial intelligence in literature, and more. Related Content: “The Art of the Craft,” From The Covenant of Water Physician as Writer: Abraham Verghese Reflects on the Art of the Craft of Writing Fiction (Part 2 of this interview)  

Major medical schools are no longer contributing data to the US News & World Report (USNWR) including more than half the schools that are currently ranked in the top 10 medical schools by the survey. In this podcast, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, speaks with author Holly J. Humphrey, MD, from the Josiah Macy Jr Foundation in New York, about the recently published Viewpoint "Medical School Rankings—Bad for the Health of the Profession and the Public." Related Content: Medical School Rankings—Bad for the Health of the Profession and the Public

Differences among countries in how health care is organized could have implications for health equity. JAMA Associate Editor Karen Joynt Maddox, MD, MPH, and Bruce E. Landon, MD, MBA, MSc, professor of health care policy, Harvard Medical School, discuss whether treatment patterns and outcomes for patients presenting with acute myocardial infarction differ for patients with higher vs lower incomes across 6 countries. Related Content: Differences in Treatment Patterns and Outcomes of Acute Myocardial Infarction for Low- and High-Income Patients in 6 Countries

JAMA Executive Editor Greg Curfman, MD, speaks with Robert D. Truog, MD, MA, director of the Harvard Center for Bioethics, who describes the 2 approaches to the determination of death (cardiovascular death and brain death) and discusses the possibility that the determination of brain death may soon undergo substantial change, with important implications for organ transplantation. Related Content: The Uncertain Future of the Determination of Brain Death

Mary Arakelyan, MPH, and JoAnna Leyenaar, MD, PhD, MPH, vice chair of Research in Pediatrics at Dartmouth, discuss increases in pediatric mental health hospitalizations and suicide-related diagnoses over the past decade. Hosted by JAMA Associate Editor Tracy Lieu, MD, MPH. Related Content: Pediatric Mental Health Hospitalizations at Acute Care Hospitals in the US, 2009-2019. Related Content: Pediatric Mental Health Hospitalizations at Acute Care Hospitals in the US, 2009-2019

In 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by early 2014. In this podcast, JAMA Deputy Editor Mary M. McDermott, MD, interviews Jayme E. Locke, MD, MPH, and Babak J. Orandi, MD, PhD, about their JAMA study describing results of the FDA announcement on subsequent rates of hospitalizations for acute liver failure due to toxicity from acetaminophen-containing opioid drugs. Related Content: Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity Acetaminophen (Paracetamol) and Acute Liver Failure

In this JAMA author interview, Peter J. Pronovost, MD, PhD, Chief Quality & Clinical Transformation Officer, University Hospitals, Cleveland, and an internationally recognized expert in patient safety, discusses his recent article in JAMA on “Misdiagnosis in the Emergency Department.” A new report from AHRQ underscores the seriousness of this problem. Related Content: Misdiagnosis in the Emergency Department

Interview with James Stevermer, MD, MSPH, USPSTF member and coauthor of Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Reaffirmation Recommendation Statement Reducing HSV-2 Morbidity and Mortality Reaffirmed USPSTF Recommendation Against Serologic Screening for Genital Herpes: Empowering Clinicians and Reducing Potential Harm Serologic Screening for Genital Herpes: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force Screening for Genital Herpes (Patient Page)

Susanna Naggie, MD, vice dean for research at Duke University's School of Medicine, discusses the ACTIV-6 trial of fluvoxamine for outpatient treatment of COVID-19 and outlines the role of platform trials during the pandemic. Hosted by JAMA Deputy Editor and Editorial Director for Equity Preeti Malani, MD, MSJ. Related Content: Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19

In the wake of new legal challenges to race-conscious admission policies, JAMA Interim Executive Editor Gregory Curfman, MD, discusses racial and ethnic diversity in undergraduate and medical school admission policies with Roy H. Hamilton, MD, MS, from the Perelman School of Medicine, University of Pennsylvania. Related Content: Defending Racial and Ethnic Diversity in Undergraduate and Medical School Admission Policies

JAMA Deputy Editor Preeti Malani, MD, MSJ, discusses potential next-generation COVID-19 vaccines with Peter Marks, MD, PhD, director of the Center for Biologics Evaluation and Research at the US Food and Drug Administration. Related Content: Urgent Need for Next-Generation COVID-19 Vaccines

In this JAMA author interview, we speak with Robert M. Califf, MD, Commissioner of the FDA, about a remarkable advance in the technology of hearing aids. Dr Califf has done important work to secure the entry of over-the-counter hearing aids into the market, providing a less expensive alternative to traditional hearing aids. In this interview, Dr Califf tells the story of how this technology has finally been made available to the public. Related Content: Over-the-counter Hearing Aids: From Research to Policy to Practice

Interview with Chris Zielinski, Visiting Research Fellow and Faculty of Health and Wellbeing at the University of Winchester, UK, James Kigera, Editor-in-Chief, Annals of African Surgery, and James Tumwine, Editor-in-Chief, African Health Sciences, authors of COP27 Climate Change Conference—Urgent Action Needed for Africa and the World. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD. Related Content: COP27 Climate Change Conference—Urgent Action Needed for Africa and the World Conflict and Climate Collide to Create an Acute Hunger Crisis for an Unprecedented 345 Million People Climate Justice and Health Children, Climate Justice, and Lessons From Puerto Rico

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Obstructive Sleep Apnea in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea USPSTF Updates Recommendation for Obstructive Sleep Apnea Screening in Adults

Interview with Carol Mangione, MD, MSPH, USPSTF chair and coauthor of Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons Menopausal Hormone Therapy for Prevention of Chronic Conditions