Donald Kenkel's expertise is in areas of health economics and public sector economics. Broadly speaking, most of his research is on the economics of disease prevention and health promotion. He is the author of the chapter on "Prevention" in the Handbook of Health Economics (2000). With external funding from the National Institutes of Health, he has conducted a series of studies on the economics of public health policies, including: alcohol taxes and other policies to prevent alcohol problems (Journal of Applied Econometrics 2001, American Economic Review Papers & Proceedings 2005); cigarette taxes to prevent youth smoking (Journal of Political Economy 2002, Journal of Health Economics 2008); and advertising to promote smoking cessation (Journal of Political Economy 2007). His more recent research is on the economics of cigarette sales on Indian reservations (National Tax Journal 2015), the economics of tobacco regulation (Journal of Benefit-Cost Analysis 2015, Journal of Economic Literature forthcoming), and the market for e-cigarettes (Journal of Health Economics 2019, Journal of Risk & Uncertainty 2020). Another area of research and teaching interest is in cost-benefit analysis of public policies, especially policies that affect health. Kenkel is a former President of the Society for Benefit-Cost Analysis. From July 2018 through April 2020 he was a Senior Economist and then Chief Economist at the Council of Economic Advisers in the Executive Office of the President. Donald Kenkel received a grant from the Foundation for a Smoke-Free World in 2020.