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The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Sophia Ambruso With Special Guest: Anna Vinakova Associate Professor of Medicine at Virginia Commonwealth University. NephMadness Executive. Vanuja Java is a transplant nephrologist at Washington University in St. Louis, MO. Her research involves functional characterization of genetic variants in complement-mediated diseases. She co-chairs the ClinGen complement gene curation expert panel. Editor: Sophia Ambruso Show Notes: #NephMadness 2023: Thrombotic Microangiopathy Region TMA Review article in the NEJM from 2014: Syndromes of Thrombotic Microangiopathy Dr. Anuja Java Co-chairs Working Group in an International Committee for Revising aHUS Nomenclature Nephrology Secrets 4th Edition at Amazon University of Iowa Genetic testing for aHUS Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective: Results of the CUREiHUS Study. KI reports. This is the Netherlands study. They used home urine dipsticks to monitor for relapses. Clinical promise of next-generation complement therapeutics Nature reviews. Drug Discovery NephMadness Podcrawl Tubular Secretions Swap: Neuromancer and the works of William Gibson (@GreatDismal) Sophia: The Magicians on Netflix Anna: Recommends nephrology. Says it is awesome. Anuja: Dope Sick on Hulu and Women in Nephrology mentor program Josh: Mobituaries with Mo Rocca. Specifically “Death of a Banana” Joel: Ivory by TapBot

Welcome to the NephMadness PodCrawl The idea behind a podcrawl is for a variety of podcasts to coordinate on timing and topic to push a theme and get each other’s listeners to explore all of the podcasts. One of the first goals behind NephMadness was to build a community and in the early years of Twitter, NephMadness was central to the formation of #NephTwitter and defining the ethos that makes our online community kind, intelligent, vibrant, and interesting. The NephMadness Podcrawl hopes to inspire and grow the nephrology podcast community in the same way. For 2023, our second year,  the PodCrawl has assembled the Avengers of Medical Pods! Go to NephMadness.com/podcrawl for more information and links to all of the podcasts!The Curbsiders gets the skinny on mineralcorticoid receptor antagonists Core IM will be covering Kidney Transplant in their classic Five Pearl format The CardioNerds will be covering the effect of Heart Failure Devices on Kidney Health Freely Filtered will try to understand thrombotic microangiopathy ISN Global Kidney Care goes deep on IgA nephropathy The Cribsiders look at transitions, first the Peditrics to Adult nephrology transition and then from living to death with palliative nephrology  Fellow on Call will be covering Onconephrology And finally, The Nephron Segment looks at Transgender Health and CKD

The Filtrate: Joel Topf Swapnil Hiremath Nayan Arora Sophia Ambruso With Special Guest: Amit Garg @AmitXGarg, Nephrologist at Western University, London, and lead PI of the MYTEMP trial.  Editor: Joel Topf Show Notes: MyTEMP in pubmed: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial MyTEMP Summary on NephJC  It’s really cold in Ontario The NephTrials blog summary on Pragmatic Trials The pragmatic TiME trial on longer time on dialysis (ahem, sabotaged by site investigators like Joel who cut dialysate time) Dember et al in JASN Poor quality of trial data preceding MyTEMP, a systematic review from Mustafa et al in JASN  The 2007 European Best Practice Guideline (EBPG) from 2007, recommending “Cool dialysate temperature dialysis (35–36°C) or isothermic treatments by blood temperature controlled feedback should be prescribed in patients with frequent episodes of IDH (Evidence level I).” in NDT 47% of centres from a DOPPS study of 273 centers routinely use of lower dialysate temperature, Dasgupta et al in JASN How do you convert from C to F? Almanac.com (35.5 C is 96.9 F; 37 C is 98.6 F) More on the rationale and design of MyTEMP: Al-Jaishi et al in CJKHD How big is 4.3 million (the number of hemodialysis treatments in MyTEMP)? Very big indeed. NephJC discussion of another cluster RCT and granular data only on a subset SSASS  Participants in dialysis clinical trials are not representative of the real world dialysis cohorts, Smyth et al in JAMA Int Med Peritoneal dialysis numbers in Ontario are high, Blake et al in PDI, though with ~ 60% CVC rates, Blake et al in Kidney360 Dialysate Magnesium #DreamRCT from Swap, NephTrials discussion of DialMag Statistical analysis plan of MyTEMP, Dixon et al in CJKHD Tubular Secretions Swap: Watch Everything, Everywhere All At Once on Prime Nayan: Read The Midnight Ride from Ben Mezrich (brother of Josh Mezrich from the NephJC Summer Book Club 2021) Sophia: Making nephrology education fun at the UC Denver Amit: The wrestling team at Western U from 1990-91 Joel: House of the Dragon on HBO Max

The Filtrate: Joel Topf Swapnil Hiremath Jordy Cohen With Special Guest: Laurie Tomlinson. @Roxytonin Nephrologist at University Hospitals Sussex and research hero of Jordy. Editor: Priya Yenebere Show Notes: STOP-ACE in pubmed: Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease STOP-ACE Summary in NephJC Prior data showing preservation of renal function by stopping ACEi: The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney disease Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency: NEJM Dr. Tomlinson’s article on creatinine changes in RASi from 2017: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study NephJC | PubMed Accuracy of eGFR at low GFR: A new equation to estimate glomerular filtration rate Strong opinions, loosely held. “Permissive AKI” with treatment of heart failure. Editorial by Chirag Parish and Steven Coca The rational for NICE avoiding RASi in black patients: Hypertension and ethnic group AASK trial showing superiority of RASi in African Americans. JAMA ALLHAT post-hoc analysis of outcomes by self-reported race. JAMA | PubMed Sophisticated Swedish observational study that Swap loved. Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study Target Trials in Nephrology Dr Edouard Fu grand rounds at Ottawa Nephrology, YouTube Target Trial EmulationA Framework for Causal Inference From Observational Data by Miguel Hernán in JAMA Tubular Secretions Jordy: Third season of His Dark Materials on HBO Swap: Movies by Wes Anderson on Disney Plus Laurie: The Book, “Nearly All the Men in Lagos are Mad” Jordy: How Medicine Works and When It Doesn't: Learning Who to Trust to Get and Stay Healthy | Amazon Joel EO | NYT Review

The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Sophia Ambruso Priya Yenebere With Special Guest: Brendon Neuen, Secretariat of the SGLT2 Trialists Consortium and cool guy on Twitter. Editor: Sophia Ambruso Show Notes: Joel’s Conflict of Interest Statement. Sophia is also conflicted with Astra Zeneca and Brendon with everybody in the SGLT2i space. Joel starts off with a history of SGLT2i EMPA-REG Outcomes. First! CANVAS. OMG this signal is reproducible! CREDENCE (🎧). It works in a dedicated population at high risk of kidney disease. And in a study designed for renal end-points. DAPA-CKD (🎧). It’s not just for diabetics! EMPA-Kidney. It works at really low GFR. And without albuminuria. And again in non-diabetics. SGLT Inhibitors for Type 1 Diabetes: Proceed With Extreme Caution Click to find the supplement (requires a subscription)Differences in definition in the decreased renal function component of the composite primary outcomes. EMPA-Kidney 40% DAPA-Kidney 50% CREDENCE doubling of serum Cr Usability Testing of a Sick-Day Protocol in CKD (Pubmed) New Guidelines for Statistical Reporting in the Journal (link, commentary on said guidelines by Frank Harrell) CKD outcomes and the FDA: Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency The Peripheral on Amazon Prime Unsealed the Tylenol Murders Podcast Project Hail Mary by Andrew Weir Lizzy McAlpine Singer Song Writer Rachel Maddow Presents: Ultra Twitter chaos continues. Get your Med-Mastodon handle

The Filtrate: Joel Topf Swapnil Hiremath Nayan Arora Sophia Ambruso Editor: Nayan Arora Show Notes: Joel’s Conflict of Interest Statement The Draft Board EMPA-Kidney is “off the board” Lunch Symposium on Current and Future Approaches to the Diagnostic Assessment and Management of AKI in Patients with Cirrhosis provided by an educational grant from Mallinckrodt Pharmaceuticals The CONFIRM Trial Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome in NephJC Clinical Practice Session Leveraging Social Media to Create, Learn, Teach, Advocate, and Dispel Misinformation The BEST-Fluids Trial: A Randomized Controlled Trial of Balanced Crystalloid Solution vs. Saline to Prevent Delayed Graft Function in Deceased Donor Kidney Transplantation - Michael G. Collins, Magid Fahim, Elaine Pascoe, Carmel Hawley, David W. Johnson, Philip A. Clayton, Steven J. Chadban (ClinicalTrials.gov) The Late Breaking and High Impact Trials Session line up Stop ACEi CLARITY Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial Effects of Pantoprazole on Kidney Outcomes: Post Hoc Analyses From the COMPASS Randomized Controlled Trial by Lonnie Pyne, et al No Stone: Hydrochlorothiazide for the Prevention of Kidney Stone Recurrence by Daniel Foster, et al MyTEMP: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial Clinical Practice Session Best of NephJC “We'd Now Like To Open The Floor To Shorter speeches disguised as questions.” ASN Task Force on the Future of Nephrology Attracting Osteopathic Medical Students Into Nephrology Hasan Minhaj’s joke at the expense of DOs TRANSFORM-HF: Torsemide vs. Furosemide in Treating Patients With HF Point-of-Care Ultrasound in Nephrology specifically VExUS

The Filtrate: Joel Topf Jordy Cohen Nayan Arora Sophia Ambruso Special Guests: Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode (SODIUM-HF). His Google Schoolar page is better than yours. David Ellison @dhekidney is professor of medicine at Oregon Health Science University and head of the Oregon Clinical & Translational Institute. Show Notes: Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome (The CARESS Trial) Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure (The UNLOAD trial) Diuretic Strategies in Patients with Acute Decompensated Heart Failure (The DOSE Trial) Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure (The 3T Trial) Sequential nephron blockade with a thiazide diuretic has a 1 B-NR (non-radomized) grade in the AHA/ACC Heart Failure Guidelines (7.2) Three important acute decompensated heart failure with SGLT2i: 1. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure (SOLOIST-WHF Trial) 2. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (The EMPULSE Trial) 3. Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF) Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review Cardiologist Sues Epic Over Copyright Infringement Outcomes associated with a strategy of adjuvant metolazone or high-dose loop diuretics in acute decompensated heart failure: a propensity analysis. Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance (PubMed) Efficacy and Safety of Spironolactone in Acute Heart Failure (ATHENA Trial) Joel with a video on acetazolamide for altitude sickness. The Butchering Art: Joseph Lister's Quest to Transform the Grisly World of Victorian Medicine(Amazon)

The Filtrate: Joel Topf Swapnil Hiremath Nayan Arora Priya Yenebere Special Guests: Todd Miano, PharmD, PhD @Miano81 Assistant Professor of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine. Show Notes: Early Pip/Tazo article showing nephrotoxicity. Covered by NephJC Linazolid vs Vanco RCT showing excess AKI with Vanco. Yes Vance is a lot less toxic than it was in the Mississippi mud days but your attending telling you it is no longer nephrotoxic is wrong. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study and Vancomycin and the Risk of AKI: A Systematic Review and Meta-Analysis. Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine Vancomycin-Associated Cast Nephropathy: Reality or Fantasy? Molecular Epidemiology of SepsiS in the ICU (MESSI) prospective cohort. Learn about it her: A multibiomarker-based outcome risk stratification model for adult septic shock* Cystatin C in acute kidney injury Changing Definitions of Sepsis Proposed new definitions of AKI incorporating biomarkers: Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference. A Consensus Statement in JAMA Network Open Applications of propensity score methods in observational comparative effectiveness and safety research: where have we come and where should we go? The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort study Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals PulmCrit – Myth-busting the conditional nephrotoxicity of piperacillin-tazobactam by Josh Farkas Sharp Objects on Good Reads Bandon Dunes The Ocean Course at Kiawah Island Golf Resort Be Real follow me: BeRe.al/kidney_boy SNL spoof of BeReal

The Filtrate: Joel Topf Swapnil Hiremath Jennie Lin Special Guests: Priya Yenebere @PriRenalAKI Transplant nephrologist at Indiana University School of Medicine. She is a current NSMC Intern. J Pedro Teixeira @NephCrit_NM ICU Nephrologist at the University of New Mexico. Editor: Priya Yenebere Show Notes: Critical Care Nephrology Critical Care Nephrology: Core Curriculum 2020 by Benjamin R Griffin, Kathleen D Liu, and J Pedro Teixeira. Critical Care Rheumatology Dual-Trained Rheumatologists Take Multidisciplinary Approach to Their Patients Med-Peds to Nephrology Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock by Emanuel Rivers ProMISe: Trial of Early, Goal-Directed Resuscitation for Septic Shock ARISE: Goal-Directed Resuscitation for Patients with Early Septic Shock ProCESS: A Randomized Trial of Protocol-Based Care for Early Septic ShockThe Filtrate: Rinaldo Bellomo and micro circulatory disorders as cause of AKI in sepsis. Septic acute kidney injury: new concepts Comparison of Two Fluid-Management Strategies in Acute Lung Injury (FACTT) The negative trial we accept as a positive trial because of the secondary outcomes. The prime minister of Finland was caught on the dance floor. This is a bad thing? (NY Times) Deferred Consent: A New Approach for Resuscitation Research on Comatose Patients Lactate conversion MediCalc The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters Critical Care Reviews Podcast: CLASSIC Trial Results Presentation What is the most George Constanza-esque reason you broke up with someone? (reddit) Bonferroni correction The Importance of Fluid Management in Acute Lung Injury Secondary to Septic Shock Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery in the NEJM. RELIEF, NephJC discussion Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial in JAMA FEAST Trial: Mortality after Fluid Bolus in African Children with Severe InfectionRings of Power on Amazon Prime Why the Hobbit trilogy sucked Industry on HBO Sandman 2022 on Netflix Where did Liverpool FC go wrong with the 2021/2022 Premier League? (Quora) CRRT Academy at University of Alabama with 2020 Robert G. Narins Award Recipient: Ashita Tolwani, MD, MS (YouTube) Life as a Nephrologist podcast on CritCare Nephrology Continuous KRT: A Contemporary Review by J. Pedro Teixeira, Javier A. Neyra and Ashita Tolwani University of New Mexico Nephrology Program. Apply to their fellowship. The Pledge Drive is over, but you can always support NephJC. NephJC is a 501(3)c registered non-profit and all donations are tax deductible in the US.

The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Sophia Ambruso Special Guests: Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA. His Google Schoolar page is better than yours. And returning for her third time (why sdo we keep inviting her back?)Sadiya Khan @heartDocSadiya Assistant Professor of Medicine (Cardiology) and Preventative Medicine at Northwestern Feinberg School of Medicine. Link Editor: Sophia Ambruso Donate to NephJC Get your Freely Filtered Mug by becoming a Freely Filtered Fan, all proceeds go to NephJC. All donations are tax deductible in the U.S. http://www.nephjc.com/new-products/freely-filtered-fan If you want to support NephJC to a different tune than $200, take a look at the NephJC September Pledge Drive page. Show Notes: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure says: Restricting dietary sodium is a common nonpharmacological treatment for patients with HF symptomatic with congestion, but specific recommendations have been based on low-quality evidence. Concerns about the quality of data regarding clinical benefits or harm of sodium restriction in patients with HF include the lack of current pharmacological therapy, small samples without sufficient racial and ethnic diversity, questions about the correct threshold for clinical benefit, uncertainty about which subgroups benefit most from sodium restriction, and serious questions about the validity of several RCTs in this area. However, there are promising pilot trials of sodium restriction in patients with HF. The AHA currently recommends a reduction of sodium intake to <2300 mg/d for general cardiovascular health promotion; however, there are no trials to support this level of restriction in patients with HF. Sodium restriction can result in poor dietary quality with inadequate macronutrient and micronutrient intake. Nutritional inadequacies have been associated with clinical instability, but routine supplementation of oral iron, thiamine, zinc, vitamin D, or multivitamins has not proven beneficial. The DASH diet is rich in antioxidants and potassium, can achieve sodium restriction without compromising nutritional adequacy when accompanied by dietary counseling, and may be associated with reduced hospitalizations for HF. This is 2a Class of Recommendation (moderate strength) with a C-LoD level of evidence (Limited data). Study acronym: the Study Of Dietary Intervention Under 100 Milimoles in Heart Failure. 100 mmol of sodium is 2300 mg Meta analysis of high versus low sodium diet pulled from Heart due to duplicated and missing data. Retraction Watch. 65 mmol of sodium is 1500 mg The trial design papers: Design and Region-Specific Adaptation of the Dietary Intervention Used in the SODIUM-HF Trial: A Multicentre Study and Rationale and design of the Study of Dietary Intervention Under 100 MMOL in Heart Failure (SODIUM-HF) 3-day food diaries underestimate sodium intake vs 24 hour urine - and this is worse for patients on loop diuretics: Evaluation of 2 methods for sodium intake assessment in cardiac patients with and without heart failure: the confounding effect of loop diuretics PREDIMED trial of Mediterranean diet: retracted, republished, still trusted? DASH Diet trial where they gave food to the participants Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review Development and evaluation of the Seattle Angina questionnaire: A new functional status measure for coronary artery disease Cardiologist Sues Epic Over Copyright Infringement 6-minute walking test: a useful tool in the management of heart failure patients Frank Harrell on Statistical Errors in the Medical Literature ANCOVA versus change from baseline: more power in randomized studies, more bias in nonrandomized studies A-HeFT: Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure TOPCAT: Spironolactone for Heart Failure with Preserved Ejection Fraction SSaSS: Effect of Salt Substitution on Cardiovascular Events and Death Mini Cooper SE Electric hardtop 2 door Taylor Swift can't stop emitting CO2 with her private plane. The Captain (miniseries) Nope. The Mystery of Why Some People Don’t Get Covid For All Mankind (TV series)

The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Jordy Cohen Special Guest: Sean Barbour. Clinical Associate Professor, Division of Nephrology, University of British Columbia Chair, BC Glomerulonephritis Committee and Network, BC Renal Editor: Joel Topf Show Notes: NephJC Summary of TESTING: Re-TESTING Steroids for IgA Nephropathy (have you ever noticed how good the titles for the NephJC summaries are?) TESTING in JAMA STOP-IgA NephJC Summary: Don't just do something, stand there. Another great title, this one from from a long time ago. The British Columbia GN network really owes its existence to TESTING: An overview of the British Columbia Glomerulonephritis network and registry: integrating knowledge generation and translation within a single framework (PubMed) Dunning–Kruger effect Wikipedia Prior Art for steroids in IgA nephropathy: Italian study: Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nephropathy Another, earlier, Italian study: Corticosteroids in IgA nephropathy: a randomised controlled trial Chinese study: Combination therapy of prednisone and ACE inhibitor versus ACE-inhibitor therapy alone in patients with IgA nephropathy: a randomized controlled trial Original TESTING publication from 2017, also in JAMA. Oh, and we covered that in NephJC too, IgA Nephropathy: Testing Steroids Again. NephJC also talked about Sean Barbour’s risk score for IgA Nephropathy: Summary | Freely Filtered Podcast episode 5 A Controlled Trial of Fish Oil in IgA Nephropathy in the NEJM! Stevens-Johnson Syndrome. “When to see a doctor Stevens-Johnson syndrome requires immediate medical attention. Seek emergency medical care if you experience signs and symptoms of this condition.” Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency (PubMed) Adaptive Trials in NephMadness 2016 with Selection Committee Member, Perry Wilson! Treif Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis The MEST score provides earlier risk prediction in lgA nephropathy DAPA-IgA: A pre-specified analysis of the DAPA-CKD trial demonstrates the effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy Swap and Josh fight about SGLT2i in IgA Nephropathy Significance of serum galactose deficient IgA1 as a potential biomarker for IgA nephropathy: A case control study (PubMed) FDA approves first drug to decrease urine protein in IgA nephropathy, a rare kidney disease. FDA has granted accelerated approval for  budesonide delayed release capsules to reduce proteinuria in adults with primary IgA nephropathy at risk of rapid disease progression. It has not been established whether budesonide delayed release capsules slow kidney function decline in patients with IgA nephropathy. Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial (Lancet) Omicron in Ontario. Prescribing Nirmatrelvir/Ritonavir for COVID-19 in Advanced CKD by Swap Star Trek: Strange New Worlds Origins of Renal Physiology: Fellows 2022 Medical Students: Kidney TREKS Application of the International IgA Nephropathy Prediction Tool one or two years post-biopsy (Kidney International) The Triple Crown in Virginia

The Filtrate: Joel Topf Nayan Arora Sophia Ambruso Swapnil Hiremath Josh Waitzman Special Guest: Natalie Bello Director of Hypertension Research at Cedars Sinai Editor: Nayan Arora Show Notes: NephJC summary of CHAP CHiPS TV show CHIPS study: Less-Tight versus Tight Control of Hypertension in Pregnancy Prevention, Diagnosis, and Management of Hypertensive Disorders of Pregnancy: a Comparison of International Guidelines (Pubmed) SFLT in preeclampsia from where else but NephMadness and here. Aspirin Use to Prevent Preeclampsia and Related Morbidity and MortalityUS Preventive Services Task Force Recommendation Statement (JAMA) The NNT for aspirin in pregnancy is like a relationship on Facebook, it’s complicated. Astrologic signs as predictor of aspirin effectiveness in Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group (Pubmed) ACOG revises the guidelines on hypertension: Clinical Guidance for the Integration of the Findings of the Chronic Hypertension and Pregnancy (CHAP) Study Meta-analysis showing treating blood pressure in pregnancy didn’t help. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.

The Filtrate: Joel Topf Nayan Arora Sophia Ambruso Swapnil Hiremath Special Guest: Jade Teakall Jeff Perl, Great Twitter handle, PD_Perls Editor: Joel Topf Show Notes: ISPD 2022 Peritonitis Guidelines NephJC Discussion Dimitrios Oreopoulos obituary in JASN. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis The draft board: Google Doc The PROMPT Study showing delayed peritonitis treatment increases the risk of treatment failure: The Relationship Between Presentation and the Time of Initial Administration of Antibiotics With Outcomes of Peritonitis in Peritoneal Dialysis Patients: The PROMPT Study Embedded PD catheters: Complications and catheter survival with prolonged embedding of peritoneal dialysis catheters Nikhil Shah asking questions about fungal prophylaxis Question 1 Question 2 Icodextrin antibiotic compatibility: Stability and compatibility of antibiotics in peritoneal dialysis solutions or in Tweet Form. Nikhil Shah on having antibiotics at home Tweet thread about the things we do for little reason regarding getting people listed for transplant. Regarding the trend in duration of antibiotics: Duration of Antibiotic Therapy: Shorter Is Better ‘Spelling the Dream’ Review: Netflix’s Inspiring Spelling Bee Doc Is an Unexpected Rallying Cry ABC Kidney Home Dialysis University was May 1, 2 The Grand Canyon, second largest hole in the ground.

The Filtrate: Joel Topf Joshua Waitzman Nayan Arora Jennie Lin Sophia Ambruso Special Guest: Paul A Welling Editor: Sophia Ambruso Show Notes: NephJC Summary on SSaSS Paul Welling’s tweetorial on the potassium switch The 2016 Canadian Hypertension guidelines were the first to suggest adding potassium: Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension Swapnil’s Potassium Trial: Diet or additional supplement to increase potassium intake: protocol for an adaptive clinical trial When Food Firms Cut The Salt, What Do They Put In Instead? From NPR. Effect of increased potassium 🍌 intake on cardiovascular risk factors and disease: systematic review and meta-analyses Effect of lower sodium🧂 intake on health: systematic review and meta-analyses Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study FDA Issues Final Guidance Regarding Use of an Alternate Name for Potassium Chloride in Food Labeling David Ellison and Paul Welling’s reviewing the NEJM: Insights into Salt Handling and Blood Pressure NephTrials on Cluster Randomized Trials: http://www.nephjc.com/news/clusterct Nu-Salt (KCl) 3 oz for $4.97 at Amazon (no afiliate link because we don’t have our act together) Salt for Life looks like it is 75% KCl 25% NaCl and it is 11.99 for 10.5 oz at Amazon (see above disclaimer) Bridgerton, only 8 episodes for Season 2 Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1: The Paper | The Tweet Kansas wins March Madness Work in Josh’s lab. Get in touch: jswaitzm@bidmc.harvard.edu Open Educational Resources (OER) NKF Spring Clinical Meeting 2022 Little Podocye

The Filtrate: Joel Topf Joshua Waitzman Nayan Arora Jordy Cohen Special Guest: Josh Mezrich Editor: Nayan Arora Show Notes: When Death Becomes Life: Notes from a Transplant Surgeon. Amazon Am J Transplant 2022 Jan 20. doi: 10.1111/ajt.16930. PMID: 35049121 Coverage on NephJC First transplant of a pig into a human. NYU transplant. Keith Reemtsma’s experience with chimpanzees transplantation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1408776/?page=1 Infection of human cells by an endogenous retrovirus of pigs United Therapeutics page on xenokidney. Article by Starzl on the early days of kidney transplant, including David Humes experiment grafting kidneys to the arms and grafts of patients. The Early Days of Transplantation Patient in Groundbreaking Heart Transplant Dies Heterotopic heart transplantation: where do we stand? Denton Cooley and the first artificial heart transplant For the First Time in North America, a Woman Gives Birth After Uterus Transplant From a Deceased Donor Blacksburg company raised genetically modified pig for first heart transplant into human Christiaan Barnard and the first human-to-human heart transplant Making The Impossible Possible: A Conversation With Martine Rothblatt. The founder of United Therapeutics and SiriusXM Paige Porrett, M.D., Ph.D. first author Jayme Locke, M.D., MPH senior author Louise Penny author page The Four Questions Chutzpod! Joshua Malina, not the new cantor at Temple Israel. Primitive Technology YouTube Channel

The Filtrate:Joel TopfJoshua WaitzmanNayan AroraSophia AmbrusoJordy CohenSpecial Guest:Kelly HyndmanEditor:Joel TopfPodCrawlMonday, March 14: The Curbsiders An Internal Medicine Podcast…for the Internist. This episode will focus on the Cardiorenal region with Game Maker, Joel Topf @Kidney_Boy, and Selection Committee Member, Sadiya Khan @HeartDocSadiya. Listen on Apple or SpotifyTuesday, March 15: The Drs. WashingtonThe Drs. Washington are three sister physicians who discuss their story and the stories of minority physicians, tips for students interested in careers in medicine, and health-related topics. In this episode, Katie Rizzolo @katierizzolo and Dinushika Mohottige @DMohottige discuss social and physical determinants of health as well as governmental and institutional initiatives that affect health inequities in nephrology.Listen on Apple or SpotifyWednesday, March 16: The CribsidersOn this pediatric podcast, go deep into the Neonatal AKI bracket with the writer, Michelle Starr @mcstarr1. Listen on Apple or SpotifyThursday, March 17: Up My Nursing GameUp My Nursing Game is an educational nursing podcast that uses expert interviews to address common nursing questions and pitfalls. It offers free CE credits through VCU Health. This episode featuring Bourne Auguste @bourneauguste and Daniel Weiner @DanTheKidneyMan will focus on blood pressure and Dialysis. Listen on Apple or SpotifyFriday, March 18: Best Science (BS) MedicineThe Best Science Medicine podcast is all about helping primary care clinicians incorporate the best available evidence into their practice in order to help facilitate shared decision-making. In this episode, Game Makers Samira Farouk @ssfarouk and Matthew Sparks @Nephro_Sparks discuss the tricky issue of albuminuria – who to monitor, what to monitor, and who to treat. They spend a lot of time dribbling and end up deciding that nothing is a slam dunk, so stay until the end for a real buzzer beater.Listen on Apple or SpotifySaturday, March 19: Freely FilteredThe Filtrate break down the Animal House region with Selection Committee Member Kelly Hyndman @DrKeeksPhD.Listen on Apple or SpotifyShow Notes:Kelly Hyndman is an Assistant Professor of Medicine in the Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, at the University of Alabama at Birmingham. She has trained both in comparative physiology and kidney physiology labs and is currently a principal investigator of a basic science lab with research interests in novel mechanisms of fluid-electrolyte balance.From Fish to Philosopher by Homer Smith. Review from 1954 in JAMA.#BlueRibbonFailMarine Iguana Visual Abstract by SophieThe OctonautsThe Oregon TrailCRIC StudyAnimal House 2022 blog post by Tiffany TruongGiraffes sleep 4.6 hours a day. Behavioural sleep in the giraffe (Giraffa camelopardalis) in a zoological gardenTobias WangPeter BieGimli the Corgi GiraffeManBearPig from South ParkMike TysonEmus, not mammelsClimate Change Threats on Black Bears in CaliforniaAs Winter Warms, Bears Can’t Sleep. And They’re Getting Into Trouble.Fat Bear Week has a champion: All hail 480 OtisStillsuit in DuneFreely Filtered 042: Nephrin Antibodies Cause Minimal Change Disease. Wait...What?A molecular mechanism explaining albuminuria in kidney diseaseAmerican Heart Association Hypertension Podcast with Swapnil Hiremath and Carolyn ThomasLink to all the AHA podcastsThe Trojan horse Affair podcastCurbsiders #321 Hypertension FAQ with Jordy CohenThe Alpinist

The Filtrate: Joel Topf Jennie Lin Joshua Waitzman Nayan Arora Sophia Ambruso Special Guest: Astrid Weins (@AstridWeins) renal pathologist at the Brigham and Woman’s Hospital and Harvard Medical School Editor: Nayan Aurora Show Notes: Summary of minimal change disease according to the orthodoxy: Light microscopy of renal biopsy specimens from patients with MCD shows minimal to no change; however, electron microscopy reveals the effacement of podocyte foot processes. To add to the conundrum, immunofluorescent staining of biopsy specimens is negative, and no immune complexes are evident. Minimal change disease and idiopathic FSGS: manifestations of the same disease New Views of the Glomerulus: Advanced Microscopy for Advanced Diagnosis Imaging of the Porous Ultrastructure of the Glomerular Epithelial Filtration Slit Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice Fishing Expedition Koch's postulates Measles in the Nephrotic Syndrome NEPTUNE: NEPhrotic syndrome sTUdy NEtwork Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation Most of these patients have a homozygous truncating mutation (Fin-major mutation) in the nephrin gene (NPHS1), leading to total absence of the major podocyte protein, nephrin. After RTx, these patients develop anti-nephrin antibodies resulting in nephrotic range proteinuria. Nephrotic syndrome relapse in a boy with COVID-19 Minimal Change Disease After First Dose of Pfizer-BioNTech COVID-19 Vaccine: A Case Report and Review of Minimal Change Disease Related to COVID-19 Vaccine Dr. Laurence Beck and the discovery of Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy as published in the NEJM. Cheer Season 2 now on Netflix Cloud Cuckoo Land: A Novel by Anthony Doerr Winter Surfing in Massachusetts?!

The Filtrate: Joel Topf Swapnil Hiremath Matt Sparks Editor: Joel Topf Show Notes: The 2010 RFN Top Nephrology Stories The 2021 NephJC Top Nephrology Stories Number 10: AKIKI AKIKI 2 in The Lancet AKIKI 2 in NephJC AKIKI 2 on Freely Filtered Number 9: Effect of Salt Substitution on Cardiovascular Events and Death The Salt Substitute and Stroke Study (SSaSS) in the NEJM The Salt Substitute and Stroke Study (SSaSS) in NephJC FDA Issues Final Guidance Regarding Use of an Alternate Name for Potassium Chloride in Food Labeling Number 8: AURORA, voclosporin for Lupus Nephritis Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1) in the Lancet AURORA 1 on NephJC AURORA 1 on Freely Filtered Number 7: FIGARO trial of finerenone for CV outcomes Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes in the NEJM Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study by David Juurlink Joel’s intermission FDA Rejections Tricida’s Veverimer Roxadustat Bardoxolone Tenapanor Number 6: Pig Kidney Transplant. As covered in the New York Times Clinical Pig Kidney Xenotransplantation: How Close Are We? from JASN Number 5: KDIGO Blood Pressure Guidelines KDIGO Guidelines As discussed in NephJC And on Freely Filtered Matt’s article on ACCORD he wrote for RFN as a fellow Number 4: Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease (CLICK) CLICK in the NEJM CLICK on NephJC CLICK on Freely Filtered Number 3: Dapagliflozin helps IgA nephropathy The Lancet FDA OKs First Proteinuria Drug for IgA Nephropathy: delayed released budesonide Number 2: New eGFR formulas, now race free. New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race in the NEJM Number 16: Fixing ADPKD in mice Renal plasticity revealed through reversal of polycystic kidney disease in mice in Nature Genetics Press release from Yale Number 1: KDIGO GN Guidelines PDF in Kidney International NephJC Discussion Last Month in Nephrology skeptical of all the Rituximab Tubular Secretions Overcooked! All You Can Eat Lego Porsche 911 Lego Baby Yoda (Grogu) Beyblades

The Filtrate: Joel Topf Swapnil Hiremath Jennie Lin (who was only there because her plans got boxed by covid) Jordy Cohen Josh Waitzman Special Guest: Rajiv Agarwal (@AgarwalRajivMD) Editor: Joel Topf Show Notes: NephJC discussion of CLICK: http://www.nephjc.com/news/click4chlorthalidone CLICK Visual abstract: http://www.nephjc.com/news/2021/12/7/the-click-visual-abstract Hawthorne effect: https://en.wikipedia.org/wiki/Hawthorne_effect A nice discussion run in periods in clinical trials: http://www.nephjc.com/news/run-in-period The ABCD trial Agarwal used to describe the need for a beta blocker to enroll in the trial, but it looks like a review article https://pubmed.ncbi.nlm.nih.gov/12574784/ Canadian trial showing that atenolol did as well as evidence based beta blockers: https://pubmed.ncbi.nlm.nih.gov/31495887/ Associated editorial by Agarwal: https://pubmed.ncbi.nlm.nih.gov/31578572/ Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate by Mark A Peterzan https://pubmed.ncbi.nlm.nih.gov/22547443/ HCTZ vs Chlorthalidone compete to the death: VA CSP Study No. 597: Diuretic Comparison Project https://www.research.va.gov/programs/csp/597/default.cfm Effectiveness versus Efficacy Trials: https://www.ncbi.nlm.nih.gov/books/NBK44024/ Foundation on Apple TV+: https://www.indiewire.com/2021/09/foundation-review-apple-tv-plus-sci-fi-adaptation-1234666972/ The Expanse on Amazon Prime: https://en.wikipedia.org/wiki/The_Expanse_(TV_series) The Beatles: Get Back on Disney+: https://en.wikipedia.org/wiki/The_Beatles:_Get_Back School of chocolate on Netflix: https://www.themarysue.com/school-of-chocolate/ And Just Like That... on Disney+: https://en.wikipedia.org/wiki/And_Just_Like_That... Past-president of AHA forced to make a statement about the Sex and the City episode: https://twitter.com/NMCardioVasc/status/1471627453885997068 https://twitter.com/NMCardioVasc/status/1471817955344371717 Chris Noth is a bad guy and how Peloton dealt with this. https://variety.com/2021/digital/news/peloton-deletes-chris-noth-ad-sexual-assault-allegations-1235135264/ Apply for the NSMC Social Media Internship: https://www.nsmc.blog

The Filtrate: Joel Topf Swapnil Hiremath Nayan Arora Jennie Lin Sophie Ambruso Editor Joel Topf Show Notes: Sign Up for NephSim Nephrons. Deadline 11/30. https://nephsim.com/nephsim-nephrons/ The Draft Board except for Swapnil’s picks because…Calvin Ball: https://docs.google.com/document/d/1Unk_27uqTpMGXrOyrxbI-2csKg2W_qnbbN7IE3wZY_Y/edit?usp=sharing Calvinball per the Calvin and Hobbes Wiki: Calvinball is a game invented by Calvin and Hobbes. Calvinball has no rules; the players make up their own rules as they go along, so that no Calvinball game is like another. https://www.polygon.com/comics/2020/5/13/21254476/calvin-and-hobbes-comic-strips-books-quarantine Swap’s Twitter Moment after he Tweeted all 28 Late Breaking and High Impact Clinical Trial Posters:https://twitter.com/i/events/1456347526936809480 Selena Gomez’s Kidney Transplant: https://www.youtube.com/watch?v=cMgfp0hu5lw and Kidney Transplant drama due to…Justin Bieber! https://www.koimoi.com/hollywood-news/selena-gomez-cut-ties-with-her-kidney-donor-francia-raisa-in-2018-the-reason-was-allegedly-related-to-justin-bieber/