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Evolving Past Alzheimer's
49 minutes | 2 days ago
Methylene Blue & It’s Potential in Alzheimer’s
Part 2 of the conversation with Francisco Gonzalez-Lima. We are talking about Methylene Blue as a potential therapy for Alzheimer’s. This is something that you can access yourself with the proper research needed to obtain a pharmaceutical grade. We talk about its potential as a therapy for early intervention and prevention of Alzheimer’s. Part 1 of this interview was released two weeks ago, where we talk about brain bioenergetics and laser treatments as a therapy for Alzheimer’s. 0:30 - The “magical properties” of Methylene Blue 10:44 - What do people feel like on Methylene Blue? 25:40 - Benefits of Methylene Blue for early intervention and prevention of Alzheimer’s 35:47 - Why it is so difficult to find Methylene Blue. Is it poisonous?
88 minutes | 15 days ago
Brain Energetics & 2 New Potential Therapies in Alzheimer's
This is a super technical episode. The guest is a world leader in brain energy and its impact on cognition and cognitive change that leads to Alzheimer’s. We had to break this episode into two parts. The difference between early-onset Alzheimer’s (which is usually genetic) and late-onset Alzheimer’s that usually happens after age 65. Dr. Gonzalez-Lima argues that there is a common pathway, a problem with the way the brain produces energy, which leads to late-onset Alzheimer’s. The causes of this can be multiple, and the major one is simply getting older. So as individuals, we have to lead healthy lifestyles to push back on these changes. The earliest changes in the brain are different than are commonly understood. They are changes in the way the brain metabolizes energy. These changes show up long before the common atrophies we see in Alzheimer’s patients. Many of the factors that lead to the development of Alzheimer’s are vascular. Test that may help catch Alzheimer’s before cognitive symptoms… Carotid Intima-Media Thickness Test (CIMT) EEG or QEG - brain maps Genetics, head injuries, and brain trauma are other factors that can lead to Alzheimer’s. There are also some infections and viruses that can be associated with the development of the disease. Environmental toxins are a new cause that is being accepted worldwide by even the most conservative organizations. We finish by talking about mitochondria therapy, a low-level laser therapy, where photons are shot into the brain’s photon acceptors. It essentially makes more space, making the cells more likely to bind and use oxygen. The main risk with this laser is the need to protect the eyes. Ultimately, the hope is that this treatment can be done with LED lights, and people can do it themselves. The ketogenic diet can help repair even a damaged brain. We have seen a number of people improve through adopting this diet, even though it can be difficult to sustain, and I don’t recommend sustaining it for long. That conversation will lead us into part 2 which will be released in two weeks. 12:17 - Fundamental problems in the brain and nervous system that are leading to diseases like Alzheimer’s 21:05 - Why are some brains more vulnerable than others to Alzheimer’s? 38:48 - A practical way to assess cerebral brain flow 40:02 - Laser light treatment to help with brain flow 1:09:39 - The ketogenic diet and its potential to help with improving cognition
77 minutes | a month ago
The End of Alzheimer’s with Dr. Dale Bredesen
Dr. Dale Bredesen is a neuroscientist of the first order as well as a truly pioneering doctor in the fields of Alzheimer’s and Parkinson’s research. In 2014, Dr. Bredesen published a widely publicized case series of 10 people who improved from cognitive decline. He has gone on to teach thousands of practitioners his methodology. At the time of recording this episode, there is a clinical trial well underway testing his methodology. Dr. Bredesen is the author of numerous scientific papers as well as the author of New York Times bestseller, The End of Alzheimer’s. Most importantly, Dr. Bredesen’s work brings hope and potential solutions for those struggling with Alzheimer’s and other forms of cognitive decline. In This Episode “The field has argued that some drug is going to be out there that will work, and they haven’t. So we wanted to start from ground zero.” The root cause of Alzheimer’s Subjective cognitive impairment vs mild cognitive impairment Factors that determine if you can reverse cognitive decline and how much you can improve “Chronic illnesses like Alzheimer’s are working against the physician because they are keeping people from coming to you for years.” How long the results hold after cognitive improvement and what you can do to retain the results The “pandemic within the pandemic”, how COVID-19 and Alzheimer’s are connected “The Five Personalities”, sub-types of Alzheimer’s “We should never follow Alzheimer’s with a period. Alzheimer’s due to what?” What is the ketoflex diet, and why ketone energy is so important in Alzheimer’s and cognition? What is detoxification, and how does it play into Alzheimer’s treatment? The role of psychotherapy in Alzheimer’s prevention and how to deal with apathy during treatment Links The End of Alzheimer’s Read Dale’s Publications Evolving Past Alzheimer's
32 minutes | 2 months ago
BrainSee - Early Detection of Alzheimer's
The field of preventive neurology is coming. Detection of early brain damage is critical and our guest this episode, Darmiyan appears to have developed this technology. This interview is with Darmiyan's co-founder, Kaveh Vejdani MD, currently serving as it's chief medical and technology officer. A highly technical, but potentially game-changing episode. Darmiyan is a medical image processing company currently focused on applying ai technology for early detection of neurodegenerative brain conditions like Alzheimer’s. Changes in the brain early on lead to Alzheimer's before symptoms develop. If we can learn to detect these changes before symptoms manifest, then there is more opportunity for prevention. In This Episode: 1:04 - What the technology is and what it can see 5:18 - Discoveries they have made about early Alzheimer’s prevention and how the test works 12:04 - “This is one of the tests that is going to change the course of action.” 14:04 - The accuracy you can expect from the test 17:10 - The criteria for diagnosis with the test 20:22 - What is on the horizon for Darmiyan? 21:50 - “If you wait for the person to be close to dementia that it’s visible on the MRI, that is too late for treatment actions.” 27:26 - Interventions that can improve results after early detection 29:24 - When this technology will be more widely available to people who want to detect degenerative diseases before they have symptoms Links Darmiyan’s Website
43 minutes | 2 months ago
Cognitive Benefits of Crossfit...Yes even for "older" brains and bodies!
In Feb 2018 Michele Mootz started the CrossFit Wellness Program focused on bringing CrossFit to populations that were not being addressed including those with serious chronic diseases as well as aging adults over 65 including those with cognitive impairment. We discuss the tremendous benefits they have seen to date. We also discuss the impact COVID has had on this program and the overall health of this community of individuals. Michele Mootz was a Physical Therapist for 13 years before starting work with CrossFit. She is currently the Program Director for CrossFit Wellness as well as a Flowmaster for CrossFit Training Department. In This Episode: 1:23 - What is Crossfit? 2:29 - Michele’s journey from working as a physical therapist to CrossFit 9:45 - “The recipe to try to get our patients healthier doesn’t change, we are just paying closer attention to more high-risk factors they walk in with.” - Michele Mootz 11:12 - Results Michele has seen with the members of her gym 14:18 - “The foundation of CrossFit has always been that the movements are functional movements.” - Michele Mootz 17:03 - How CrossFit can improve areas of your life outside of just physical fitness 21:33 - “One of the mistakes that have been made by me and other CrossFit gyms is trying to integrate everyone into one class.” - Michele Mootz 22:54 - How likely is an injury in Crossfit? 27:23 - What the senior CrossFit classes look like 29:57 - How long it takes to see the results of CrossFit To inquire about a local class or to join CrossFit's zoom offering: firstname.lastname@example.org OR email@example.com The zoom class discussed in this episode occurs at 9am Pacific time.
39 minutes | 3 months ago
More on COVID-19 & the Brain
In this episode we talk with neurologist Suzanne Gazda MD. Dr Gazda is an authority on neurodegenerative diseases and offers more insight to balancing the "mental" vs "physical" risks in the age of coronavirus and social distancing. We focus on inflammation, auto-immune disease, Alzheimer's, and isolation.
33 minutes | 3 months ago
NeuroCOVID & Alzheimer's. What You Can Do To Protect Yourself
This is a review of the neurological symptoms that are associated with COVID-19. We discuss the implications of COVID-19 on Alzheimer's disease and other dementias. We discuss what you can do to protect yourself. This is not medical advice, please ask your healthcare provider before taking action to find out what is right for you. Protection: -N95 mask (or at least a cloth or surgical mask) -Low Inflammatory diet (low in processed foods that come out of a bag or box) -Increased exercise/movement - 20-30 minutes of moderate intensity 4-5 times per week. -Good sleep - 7-9 hours according to your chronotype (biological rhythm) -Managing stress- we outline box breathing technique Supplements that likely offer immune support -Zinc citrate or picolinate or acetate. about 30-60mg. -Quercetin - 1gram twice a day -N-Acetyl Cysteine (NAC) - 600-900mg by mouth twice a day -Resveratrol - 100-150 mg daily -Curcumin 500-1000mg twice a day -Vitamin D3 -3000-5000 IU per day -Vitamin C - 1000-3000mg daily (can be taken as 1000mg two or three times per day) If you would like information on where and how to obtain high quality supplements, dietary advice, stress management tools please email firstname.lastname@example.org, that is our company. And we can direct you to those resources. If you have questions or comments that you would like us to address please find us on social media or email email@example.com
43 minutes | 4 months ago
Telomerase Therapy for Alzheimer's?
Dr Michael Fossel received his MD and his PhD from Stanford University. He has published numerous articles in both high impact medical journals and popular press. His book The Telomerase Revolution was hailed by the WSJ as one of the five best science books of 2015. In this episode we discuss the promise telomeres and telomerase therapies for Alzheimer's and dementia. Deep dive on epigenetics and the role of glial cells in the process.
51 minutes | 6 months ago
Light Therapy for Alzheimer's - Part 2 transcranial photobiomodulation
This is the second part of a rich discussion between Anita Saltmarche and Dr Nate Bergman. It features transcranial photobiomodulation (PBM), or shining LED light energy into the brain. Anita has led numerous clinical trials and has over 17 years of experience with this technology. A good discussion about which devices, how much to use, and more information about the VieLight product.
41 minutes | 7 months ago
Light Therapy for Alzheimer's - Part 1 transcranial photobiomodulation
This is the first part of a rich discussion between Anita Saltmarche and Dr Nate Bergman. It features, transcranial-photobiomodulation (PMB), or shining LED or low level laser light energy into the brain known. Anita has led numerous clinical trials and has over 17 years of experience with a variety of photobiomodulation applications. We talk about near-infrared and red light, the important wavelengths and intensities of over the counter and prescriber only devices. We specifically look at the research around the VieLight product.
41 minutes | 7 months ago
Light Helmet - One Case of Improvement of Cognitive Impairment
The first of a 3-part series on light therapy (AKA: Photobiomodulation). This is an interesting discussion of light therapy helmet used with a 64 year old woman with significant Alzheimer's type cognitive impairment. With Dr Joe Diduro DC from ProNeurolight.
15 minutes | 8 months ago
Good News! 3 Cases of Improvement in Alzheimer's and Dementia
This is, Dr Nate Bergman on a solocast chatting about 3 cases of improvement with Alzheimer's and cognitive impairment. We are excited to be part of the changing conversation within the Alzheimer's and Dementia communities. Increasingly, the question isn't so much IF someone will improve, it's more of a question of how much.
34 minutes | 10 months ago
Individualized Alzheimer's Prevention is (Just Now) Evidence Based with Richard Isaacson (Part 2)
In the first episode with Dr Richard Isaacson we discussed his journey towards the recent Oct 2019 publication which was the first forward looking designed paper showing improvements in people at-risk for developing or with early symptoms of Alzheimer's. In this second episode we discuss Richard's idea around how mitochondria might be a root-cause for Alzheimer's disease. We talk about different "personalities" of early Alzheimer's and how this might be related to lab levels and cognitive function tests. Other items we discuss towards a personalization of an approach in Alzheimer's are hormone replacement therapy in Alzheimer's disease and prevention. Cocoa flavanols, Intermittent Fasting, Ketogenic diet, metabolic goals and targets, body fat and quite a bit more. One more note, please understand that none of this should be construed as medical advice. Please consult your local qualified medical authority, even if only considering lifestyle modifications like fasting of any kind or nutritional ketosis.
41 minutes | 10 months ago
Individualized Alzheimer's Prevention is (just now) Evidence Based with Richard Isaacson
As our listeners know I get particularly excited about having certain guests on this show. This episode is one of those guests! I have been after Dr Richard Isaacson for over a year now and I had to make a special trip to NYC to go bang on his door to get his attention here...but the reason I am so excited is because the kind of work that Richard is doing is truly pioneering in the Alzheimer's community and his recently published paper. We'll talk about this in great detail, but by way of introduction. Dr Richard Isaacson finished both his undergraduate degree as well as medical school in just 6 years. Completed his neurology residency at Beth Israel Deaconess/Harvard Medical School and now serves as the Director of the Alzheimer’s Prevention Clinic at Weill Cornell in New York City. Finally, and perhaps most important, he and his wife just welcomed their first child into this world....congratulations and Welcome to the show, Dr Isaacson! This is a great episode where we discuss a first-of-its-kind (prospective design) paper showing that early interventions work to prevent Alzheimer's and treat early symptoms. An episode not to be missed. A deep discussion of the research and some of the controversies surrounding Alzheimer's research.
41 minutes | a year ago
Using Electricity to Improve Cognition with Adam Woods
In this episode we explain non-invasive electrical stimulation, specifically transcranial direct current stimulation (tDCS). These techniques are used to alter brain function for the better. They harness and modulate the neuroplastic responses in the brain. Our guest, Dr. Adam Woods, is cognitive neuroscientist and Assistant Director of the Center for Cognitive Aging and Memory (CAM) at the McKnight Brain Institute at Univ of Florida. He is a national leader in the field of transcranial electrical stimulation (tES), leading the largest tES trial in history, publishing the first comprehensive textbook in the field, and led multiple field standards papers. In particular, we focus on transcranial direct current stimulation (tDCS). We talk about how these techniques enhance cognition in the aging brain and potentially Alzheimer's disease. These effects are being observed in pilot trials and now being tried on larger groups. We discuss memory networks and functional MRI findings related to tES interventions. This is highly technical episode, but well worth it for the information. Click here information about Dr Woods and his work.
58 minutes | a year ago
Introducing the Brain Health Coach with Ryan Glatt
Deep Conversation on Brain Health Coaching and finding your edge, with brain health coach extraordinaire. To contact Ryan Glatt or to find out more about the services he offers go to Somatiq.com or Ryanglatt.com. You can follow him on Instagram @glatt.somatiq
47 minutes | a year ago
1+1=3...Stacking Brain & Body Exercises. What's The Evidence?
Dr McEwen explains her study of older adults with cognitive decline and begins by explaining what are the subjective assessment she used in her studies to label cognitive decline. The effects on cognitive functioning social experience and physical challenge of a group exercise class was the focus of the study. Discussion of what is similar and difference between psychosis and Alzheimer’s. The discussion to turns to how Dr McEwen ties together all the various indicators she is researching and the CogFit exercise program is laid out. Dr McEwen also works at Genius Gyms and helps translate some of her research into practical applications for a variety of people who could benefit from the cognitive training. She is also help to develop an app that help people do these exercises on their own as well. The discussion concludes talking about the other ways these exercises can help with emotional, attentional or executive function problems by addressing underlying cognitive problems. Dr. Sarah McEwen is a Cognitive Psychologist, the Director of Research and Programming at Saint John’s - Pacific Brain Health Center in Santa Monica, CA.
49 minutes | a year ago
Neuropsychology is Important in Alzheimer's and Cognitive Function - Here's Why
We're back on track...here's a really helpful discussion covering why neuropsychological testing is important if you are dealing with memory loss, cognitive impairment, Alzheimer's, Traumatic Brain Injury, and even problems with mood (such as anxiety and depression). Kristine Lokken PhD is a functional neuropsychologist with a passion for helping people restore brain health. Her extensive background in clinical research, medical neuropsychology, and holistic wellness merged together to create the Brain Health Institute (BHI). In addition to her work at BHI, she served as the Director of the Rehabilitation Neuropsychology Service at the Birmingham VA Medical Center and instructed as a Clinical Assistant Professor at University of Alabama at Birmingham. She has maintained a private practice for over 15 years, and has seen thousands of patients with varying neurological and psychological issues in her clinical work. Dr. Lokken has published several articles in peer reviewed journals and has lectured extensively on brain health. Since the time of the recording of this episode Dr Lokken has relocated to Seattle, WA to be part of the Brain Health and Research Institute. Neuropsychologic testing is essential to make a diagnosis of Alzheimer’s or other dementia. This episode explores the role of a Neuropsychologist in a holistic approach to cognitive care. Our discussion begins by focusing basic definitions within the field of neuropsychology. We discuss what is coming down the line in terms of early recognition of Alzheimer’s from a neuropsychologist’s perspective. Later we take a deeper dive into the best tests or areas to test for early recognition. We touch on some of Dr Lokken’s recently presented evidence that homocysteine may be one of the more useful and affordable biomarkers to look at. Dr Lokken talks about the value of online cognitive tests versus being evaluated by a Neuropsychologist. The discussion continues by looking at self-reported cognitive decline and what you can do if you feel you are worried about it. We finish talking about how the medical community has changed its perspective on prevention going back to the end of 2018 and what is possible in the future in terms of prevention.
8 minutes | a year ago
Welcome to Season 2. We're back and talking Alzheimer's, longevity and more!
Dr Nate Bergman welcomes you back for season 2 of the Evolving Past Alzheimer's Podcast. This season we're talking Neuropsychology, new approaches that incorporate both the brain and body for better results, begin talking about transcranial electric stimulation approaches to Alzheimer's and issues of cognition. We will also continue to discuss ways to optimally age in our bodies while our minds and spirits continue to soar!
57 minutes | 2 years ago
Dr Sara Gottfried - Women, Perimenopause, and Alzheimer's Disease
Sara Gottfried M.D. is a mother, wife, Harvard-educated physician, keynote speaker, and author of three New York Times bestselling books, The Hormone Cure (2012), The Hormone Reset Diet (2015), and her latest book Younger: A Breakthrough Program to Reset Your Genes, Reverse Aging, and Turn Back the Clock 10 Years (2017). For the past 25+ years, Dr. Sara has been dedicated to helping women feel at home in their bodies with functional medicine. After graduating from Harvard Medical School and MIT, she completed her residency at the University of California at San Francisco. She lives in Berkeley, California with her family. Dr Sara, shares what she learned from her own journey towards health highlighting how jumping straight to bioidentical hormone therapy isn't always the best option. Dr Sara lays out the issues of hormones in perimenopausal and the implications in Alzheimer's disease. The dramatic hormone shifts in perimenopause into the menopausal transition make women more vulnerable to Alzheimer's disease. We discuss the concepts of bioenergetics, glucose "hypometabolism" and mitochondrial changes in pre, peri, and postmenopausal changes. The premenopausal state is protective against brain changes leading to Alzheimer's. The HPA axis, or the control system for stress and hormone system, becomes dysregulated. Dr Sara describes how symptoms such as anxiety and depression may in fact may not be the diseases themselves, but harbingers of Alzheimer's and cognitive impairment. Dr Sara's Basics for Estrogen and Hormone Balance: Food choices: basics of water, increased fiber, magnesium Assessing nutrient gaps (organic acid panels, essential fatty acid, oxidative stress panel) Assessment of microbiome (looking for infection, dysbiosis, beta-glucuronidase, etc) with Functional stool testing. Looking at Estrogen metabolism (estrone, estradiol, estrone) this can be done with dried urine testing and other testing to determine how your body is breaking down estrogen and if it is getting rid of it efficiently stool testing with beta-glucuronidase An approach to identifying and actively managing stress and to develop stress resilience Using a the Perceived Stress Scale to assess Measure blood cortisol, dried urine testing Core supplementation: magnesium, DIM (di-indolylmethane). Advanced maneuvers (of course, in the context of overall lifestyle changes) Phosphatidylserine 300-400mg - in divided doses or all at once or at bedtime Lavela (pill form of Lavender) for anxiousness - can get on Amazon Chasteberry - helps perimenopausal women who still get a menstrual cycle. Helps raise progesterone (a neurosteroid that helps to soothe the female brain). note: this can take 2-4 weeks to see a change Dr Sara often recommends: "Fertility Blend" brand name When does Dr Sara move to using bioidentical hormone replacement? after basic lifestyle changes: Step 1: Navigate stress (less coffee and alcohol). add flax seeds to a morning shake/smoothie (eg 2 tablespoons) Step 2: Chasteberry, Siberian rhubarb, Maca (see Dr Sara's books esp The Hormone Cure for doses and timing and alot more strategy) Step 3: Consider bioidentical hormones estradiol patch with micronized progesterone esp for perimenopausal women. she tries to use the lowest dose for the shortest time possible. she see's about 10% of her patients end up going on hormone replacement. Towards the end of the interview (minute 50) we take a fairly deep dive into using bioidentical hormone therapy in women that are a bit older than perimenopausal ages and the controversy surrounding this issue. Dr Sara also lets the cat out of the bag with a new book on Brain that's coming out soon! listen towards the end of the interview for that. "The Brain, Body Diet" - a Functional Medicine approach. For more information Visit Dr Sara's website at: saragottfriedmd.com Also read her recent article on Women, Hormones, and Alzheimer's.
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