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The Downstream Column Podcast
14 minutes | Aug 17, 2021
Evolving Beyond the Status Quo with Next Generation Buffer Prep Solutions
In this podcast, we spoke with Chris Rombach, Vice President of Sales and Marketing at Asahi Kasei Bioprocess America about buffer prep and delivery systems. We discussed current pain points and how next generation buffer prep solutions can greatly improve upon the status quo, including increasing the use of automation and remote operation, while reducing the overall footprint, labor and cost associated with more traditional approaches.
10 minutes | Apr 27, 2021
Integrated Freezing Solutions to Minimize Risk and Preserve Product Quality
Claire Jarmey-Swan, Global Product Manager, Pall Corporation talks about the evolution freeze thaw technologies and how these new methods can streamline the process, minimize loss and maintain the highest product quality.
14 minutes | Jun 28, 2018
Start With The End In Mind. How to facilitate transfer from non-GMP to GMP Manufacturing
Avril Vermunt, bioprocess hardware specialist at GE healthcare talks about transferring a process from non-GMP to GMP manufacturing, particularly how resource-intensive it is for process development and manufacturing groups. Avril has several years of experience working in the technology transfer group at a large pharmaceutical company. We discussed with her best practices and how being proactive and one step ahead can make the process more seamless.
8 minutes | Jun 7, 2018
Modeling Downstream Disruptive Technologies to Improve Downstream Bioprocessing.
Dr. Yuyi Shen, Principal Scientist, Grifols, talks about the benefits of modeling downstream disruptive technologies to improve downstream bioprocessing and evaluating the financial impact of implementing these technologies.
12 minutes | Apr 10, 2018
Cell Harvesting – Selecting a technology compatible with cell density and feed turbidity
Silke Bergheim-Pietza, Global Product Manager Depth Filtration, Pall. discusses challenges faced in the cell harvesting step, in particular, selecting the best cell harvesting method based on the cell density and feed turbidity of the process and meeting the demand of increasing cell densities. Download the cell harvesting technology selection guide and use the guide to compare the latest single-use harvesting technologies.
12 minutes | Mar 6, 2018
Continuous Biomanufacturing Implementation Now and in The Future
Dr. Peter Levison, Senior Marketing Director – Downstream Processing, Pall Biotech talks about the evolution and benefits of continuous biomanufacturing, what implementation looks like today and what still needs to be realized for full industry adoption.
16 minutes | Jan 31, 2018
Addressing Challenges in Downstream Biomanufacturing with a Platform Purification Approach
Jonathan Royce, Business Leader, Chromatography Resins, GE Healthcare Life Sciences, talks about the biggest challenges in Downstream biomanufacturing including overcoming bottlenecks, changing antibody structures and bioburden control. Jonathan shared how a purification platform can address some of these issues and discusses purification challenges that still need to be resolved.
26 minutes | Dec 12, 2017
Protein A Chromatography – A look at where we have been and where we are going
Jonathan Royce, Business Leader, Chromatography Resins, GE Healthcare Life Sciences, talks about the evolution of Protein A including the latest developments in Protein A chromatography resins. We also discussed what the future holds for this purification mainstay and how it can continue to address the changing needs of biopharma.
12 minutes | Nov 29, 2017
Resolving Large Scale Buffer Management Challenges
Joakim Lundvist, Modality Manager, BioProcess™ Hardware, GE Healthcare talks about large-scale buffer management challenges. Buffer preparation is known to be one of the most resource-intensive activities in biomanufacturing as large volumes of buffers and process liquids are often required. So how can this be done in a more efficient way? How can more capacity be added to buffer preparation without adding major capital investment? Are there ways to reduce the manufacturing footprint and time spent on buffers?
14 minutes | Apr 5, 2017
Job Outlook for the Biomanufacturing Industry a Recruiter’s Perspective
Hillary Kaplan, Director, Bioprocess CMC Development & Operations, Klein Hersh talks about the job outlook for the biomanufacturing industry from a recruiter’s perspective.
14 minutes | Jul 19, 2016
Cell Culture Media Optimization – It’s about more than just high protein titer
Dr. Adam Elhofy, Ph.D., CSO, Essential Pharmaceuticals, talks about cell culture media optimization. We discussed the evolution of cell culture media optimization, current goals, and the latest strategies and tools being used.
27 minutes | Jun 14, 2016
Automated Stem Cell Based High Throughput Drug Screening for ALS and Parkinson’s
Dr. Jan Bruder talks about his work at the Max Planck Institute for Molecular Biology in Münster Germany and his group’s use of automated high throughput drug screening program for ALS and Parkinson’s Disease.
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