Created with Sketch.
20 minutes | Dec 8, 2022
64. Pain in the body and brain
In this episode, we focus on the microbiome and how it is increasingly linked to disease and illness. It seems that this is true for understanding the illness of the body and the brain. Dr Amir Minerbi, the Deputy Director of the Institute for Pain Medicine at Rambam Medical Center in Haifa, Israel talks to us about how the microbiome may hold the secrets of fibromyalgia. This chronic disorder causes widespread pain, fatigue, cognitive dysfunction, and potentially dozens of other symptoms. We are also joined by Prof Illana Gozes, Director of Elton Laboratory for Molecular Neuroendocrinology in the Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine in Tel Aviv University. She elaborates on her research surrounding the role of specific microbiota signatures as a biomarker for PTSD. Show notes Minerbi, Amir, Gonzalez, Emmanuel, Brereton, Nicholas, Fitzcharles, Mary-Anna, Chevalier, Stéphanieh, Shir, Yorama. (2022) ‘Altered serum bile acid profile in fibromyalgia is associated with specific gut microbiome changes and symptom severity’, PAIN Vol.10 (1097). doi:10.1097/j.pain.0000000000002694. Levert-Levitt E, Shapira G, Sragovich S, Shomron N, Lam JCK, Li VOK, Heimesaat MM, Bereswill S, Yehuda AB, Sagi-Schwartz A, Solomon Z, Gozes I. (2022) ‘Oral microbiota signatures in post-traumatic stress disorder (PTSD) veterans,’ Mol Psychiatry. doi:10.1038/s41380-022-01704-6. Keywords: microbiome, pain, ptsd, fibromyalgia, bacteria, gut microbiome, microbiota, bile acids, tel aviv university, veterans, symptoms, composition, biomarkers, patients
18 minutes | Nov 24, 2022
63. Organ on a chip: part 2
In this second episode in a two-part series on organ-on-a-chip technology, we sit down with Christos Michas, R&D scientist and engineer at Curi Bio, and Alice White, professor of mechanical engineering at Boston University. Christos and Alice are taking the organ on a chip to another level with the miniPUMP, a heart on a chip which is the first step in understanding the interaction of therapeutic drugs with the heart. As cardiac disease is one of the leading causes of death in the industrialized world, there is a lot of interest in understanding how this disease emerges, and how we can develop therapeutics. Show notes Christos Michas and Alice White et al. (2022) ‘Engineering a living cardiac pump on a chip using high-precision fabrication’, Science Advances 8(16). DOI: https://doi.org/10.1126/sciadv.abm3791. Keywords: organ on a chip, chip, cells, organ, heart, technology, tissue, structural elements, challenge, structure, model, drugs, photon, system, resin, material, function, miniPUMP.
15 minutes | Nov 10, 2022
62. Organ on a chip: Part 1
In this first in a two-part series on organ on a chip technology, we discuss with Jan Turner, formerly part of Safer Medicines Trust, how these organoids can help us move away from the inefficient animal model. Show notes Emulate study on LiverTox - Liver-Chip Publication | Qualifying a human Liver-Chip for predictive toxicology (emulatebio.com) Keywords: chips, drugs, organ, human, model, cells, technology, testing, animal models, animal testing, microbiome, preclinical testing, animal, organ on a chip, drug development.
27 minutes | Oct 27, 2022
61. Genetic and genomic databases
We have a lot of information at our fingertips, so how do we make sense of it all, especially in human health? Conor and Dodi speak to two experts who are making sense of this information overload by creating genetic and genomic databases. Dr Artem Babaian, a computational biologist and now Assistant Professor leading The Laboratory for RNA-Based Lifeforms at the University of Toronto, explains how he and his team uncovered 100,000 novel viruses in old genetic data that could help us predict future pandemics. Professor Jinchuan Xing, Associate Professor at Rutgers University in the Department of Genetics conducting research on genomic variation, walks us through his study on using genomic data to predict infertility from aneuploid egg production. Let's dive into the data! Show notes Edgar, R.C., Taylor, J., Lin, V. et al. Petabase-scale sequence alignment catalyses viral discovery. Nature 602, 142–147 (2022). https://doi.org/10.1038/s41586-021-04332-2 Sun, S., Miller, M., Wang, Y. et al. Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing. Hum Genet 141, 1615–1627 (2022). https://doi.org/10.1007/s00439-022-02450-z Keywords: viruses, genome, patients, prediction, mutations, data, RNA viruses, computational biology, families, human genome, whole exome sequencing, discovery, machine learning, infertility, chromosomes, scientists.
33 minutes | Oct 13, 2022
60. The talk on talent
Within the life sciences industry, there has been a longstanding conversation around one of the industry’s most difficult challenges. That challenge is talent. In more detail, it is that the access to a global talent pool remains difficult. In this longer than usual conversation, Conor and Dodi speak with Darrin Morrissey, CEO of NIBRT, Anne-Cecile Potmans, general manager of Fast Trak and CDMO services at Cytiva, and Nikki Soares, global talent acquisition leader at Cytiva. We discuss how the industry is stepping up its resilience for customers and patients. To find, train, retrain, and retain talent is what matters in this episode of Discovery Matters. Keywords: talent, organization, people, biopharma, industry, life sciences industry, training, global, retaining, companies, skills.
22 minutes | Sep 29, 2022
59. Microscopic eco-warriors
Plastic and pollution are two issues that impact our planet. It would be easy to despair but once again biology has come to save us. The Alper Lab at University of Texas at Austin has engineered a plastic-eating enzyme which can shorten plastic degradation from hundreds of years to 48 hours. We speak to Dr Hal Alper, Professor in Chemical Engineering at UT at Austin, who engineered this heroic enzyme. We also speak to Marco Poletto, director and co-founder of EcoLogic studio, which is a design innovation company specializing in biotechnology for the built environment. He explains his use of microalgae to create streetlights, playgrounds, and biofilms on the outside of buildings which can capture 20 large trees worth of CO2 every day. Keywords: enzyme, plastic, protein, biology, ecologic, engineering, machine learning, organism, planet, algae, biomass, degrade, microorganisms, eco warrior, microscopic. Show notes Timelapse of the plastic degradation, courtesy of University of Texas at Austin.
20 minutes | Aug 25, 2022
58. Wastewater epidemiology: Something in the wastewater
Wastewater-based epidemiology is a relatively new approach to determine the viral make up in any given area. Using chemical analysis of pollutants and biomarkers in raw wastewater, the level of exposure to certain pathogens can be assessed. This technique was used during the pandemic, which has helped realize its potential in public healthcare policy. We speak to Prof. Dominic Frigon, a specialist of biological wastewater resource recovery at McGill University, who used this technique in Quebec through the pandemic to determine areas of vulnerability, including a homeless shelter. We also speak to Dr Kata Farkas, an environmental virologist at Bangor University, to understand the wider applications and importance of this analysis technique. Urine for a treat with this conversation. Keywords: wastewater, viruses, monitoring, pandemic, sewage, samples, population, infection, epidemiology, mutations, surveillance, norovirus.
18 minutes | Jun 30, 2022
57. Special blood and transplants
This episode is all about special blood and transplants. We speak to Jon Adkins, co-founder of XenoTherapeutics, who walks us through their use of xenotransplantation for skin grafts and organ transplantation. We are also joined by Dr. Franck Zal, a marine biologist, CSO and CEO of Hemarina, to discuss the lugworm. His discovery, that the lugworms’ blood is compatible with human blood, means it can be used in medical applications for transplants. Join us for this eye-opening and insightful conversation.
23 minutes | Jun 16, 2022
56. Understanding and treating Alzheimer’s
In this episode, we contemplate the combatting the devastating disease that Alzheimer’s is. According to a recent report by the Alzheimer’s Disease International, an estimated 50 million people are living with dementia due to Alzheimer’s disease. We talk to two experts leading two respective early-stage studies into possible treatments for Alzhemier’s. One study looks at the tackling of tau proteins, another looks at treating aging rather than the disease itself. Join us for this fascinating discussion! Keywords: Alzheimer’s disease, dementia, ageing, disease, patients, tau, study, treatment, brain, discovery, protein, sodium selenate, neurodegenerative diseases, frailty, tauopathies, alzheimer's and brain awareness month.
21 minutes | May 26, 2022
55. The injustice of disease burden and access to vaccines
The pandemic has been a global issue, which has benefitted from the coming together of industry, pharma, academia, non-governmental and governmental support. What the pandemic has also brought into sharp focus is the global imbalance access to healthcare and health inequity between the Global North and Global South. For this important conversation, we are joined by Professor Linda-Gail Bekker, Chief Operating Officer of the Desmond Tutu HIV Foundation about the current situation with HIV and TB in Africa, and the impact COVID-19 has had on patients already suffering from communicable diseases. So, what can we do? Lenias Hwenda, founder and CEO of Medicines for Africa, explains the additional problems of access to medicines and potential solutions for global vaccine inequity, working to make medicines as inexpensive as possible, and improving the supply chain. Transcript Related reading – Dzau, V.J., Balatbat, C.A., Offodile II, A.C., Closing the global vaccine equity gap: equitably distributed manufacturing. The Lancet. 2022;399(10339): 1924-1926. DOI: https://doi.org/10.1016/S0140-6736(22)00793-0 The Global Biopharma Resilience Index How localizing manufacturing is helping the Middle East take control of its vaccine supply? Keywords: equitable access, HIV, human immunodeficiency viruses, Lentivirus, medicines, pandemic, countries, vaccine, TB, epidemic, Africa, supply chain, communicable diseases, middle-income countries, access, low-income countries, Global North, Global South, disease burden.
17 minutes | May 12, 2022
54. Mycoprotein v. cell-cultured seafood
We know meat is problematic for the environment, and seafood has its own issues with overfishing, so do we have to wave goodbye to the foods we love? Well, what if we told you that there are substitutes which you can enjoy without sacrificing taste and texture? We start with mycoprotein, in the form of the well-known meat substitute products of Quorn Foods. Tim Finnigan, Chief Scientific Advisor for Quorn Foods, explains why mycoprotein is such a suitable source of protein, how it is manufactured, the environmental benefits, and how fusarium venenatum, the microfungus, was discovered. And... it's tasty! In the same episode, we ask Dr Lauran Madden, Chief Technology Officer at BlueNalu, to share with you the engineering process, the health and environmental benefits, and the positive impact on the environment of their cell-cultured seafood. This is hugely critical as the populations of marine species have halved since 1970, battling with overfishing, illegal fishing, and the effects of trawling. This cell-cultured seafood comes first...plaice... *sorry*. By the end of this episode, we will hopefully have demonstrated the environmental and health benefits of switching meat out of our diets for better alternatives. Transcript Keywords: cell-culture, microfungus, filamentous, mycoprotein, environment, meat substitute, protein, seafood, yeast, engineering, technologies, fish, fungi, Quorn, BlueNalu.
21 minutes | May 11, 2022
53. The future of GMOs
According to Jacob Moe-Lange from California Cultured, and Natasha Haveman from the UF Space Plant Lab, genetically modified food is the future. Both discuss the way that food is grown and how that is changing. Jacob takes us through cell-cultured chocolate and the environmental and humanitarian benefits. Natasha forces our gaze upwards to the plant experiments happening in spaceflight conditions, where scientists are learning how plants adapt to new environmental stresses. In this episode, Dodi puts forward her argument that plants are better than Conor’s mycelium. Who will win out? Let’s see. Transcript Keywords: cell-culture, chocolate, mycelium, plants in space, climate change, cell, bioprocessing, environment, space, gardeners, stem cells, food, genetic modification, GMOs.
15 minutes | May 11, 2022
52. The magical world of fungi (part 2)
Fungi are amazing in so many ways, and after learning that they could be used to build habitat on Mars, we have this bonus episode to go into home these mushrooms can be used on Earth. Chris Maurer, principal architect at redhouse studios, explains that he has been using mushrooms to make building materials in low-resource environments in Namibia. These materials prove even better than concrete. Join Dodi and Conor for this episode on a truly amazing use of biology to solve our problems. Transcript Keywords: mycelium, building materials, mushrooms, Namibia, carbon, oyster mushrooms, resources, encroach, bush, low-resource environment, Mars, redhouse studios.
19 minutes | May 11, 2022
51. Women in STEM
March is the month of the Woman, and to celebrate International Women’s Day we speak with two agents of change who are passionate about opportunity and diversity within the sciences. Ruchi Sharma, CEO and Founder of Stemnovate Limited, and Sabrina Fleurimé, drug product development scientist and Corporate Partnership Director at BBSTEM, talk to us about what we can all do to become agents of change. Ruchi Sharma is recognized as one of the ones to watch entrepreneurs in the health industry, she is passionate about ensuring equality and equal opportunity. Alongside supporting women in science, she is also a veterinarian and supports inventions for better animal health while reducing animal testing. Sabrina Fleurimé is a drug development scientist who has been working in the pharmaceutical industry for the past 6 years. During her time at AstraZeneca, she met Kayisha Payne, the founder of BBSTEM (Black British in STEM), and later decided to join the non-profit organisation. As BBSTEM’s corporate sponsorship director, she is actively interacting with actors in the STEM field, working towards bridging the gap between talents and opportunities. Transcript Keywords: women, STEM, science, cells, equality, diversity, international women’s day, drug discovery, opportunities, scientists, Stemnovate, BBSTEM.
20 minutes | Feb 24, 2022
50. Biomimicry in space exploration
Sustained life and colonization in space are closer than ever, and biology holds the key. Biomimetic processes have applications for water filtration and for building homes on Mars. Jörg Vogel, VP of Open Innovation at Aquaporin, discusses how their Aquaporin Inside® Membrane Technology will help filter condensate and urine to make drinking water for astronauts. We are also joined by Chris Maurer, an architect and founder of redhouse studios in Cleveland, Ohio. Chris is working on a project with NASA to build homes on Mars using mycelium. Join Dodi and Conor for this truly ‘out-of-this-world’ episode. Transcript Keywords: biomimicry, biomimetic, space, water, fungi, Mars, mycelium, NASA, oxygen, algae, biomass, radiation, condensate, building materials, Aquaporin, redhouse studios.
16 minutes | Jan 27, 2022
49. Discovery Makers: Mustapha Bittaye
Meet Discovery Maker Mustapha Bittaye, now a senior scientist working on diagnostic assay development at Medicines Discovery Catapult, who previously worked as a postdoctoral researcher at the Jenner Institute helping create the Oxford/AstraZeneca vaccine. Born in The Gambia, a scholarship took Mustapha to the UK to study Microbial Proteomics, and from then onwards he has made truly amazing contributions to human health globally. Conor and Dodi examine Mustapha’s story, truly brilliant mind, and how he is looking to the future. Transcript Keywords: vaccine, pandemic, Oxford, Gambia, discovery, trial, AstraZeneca, scientists, COVID-19, scholarship, Jenner Institute, microbial proteomics.
22 minutes | Jan 13, 2022
48. Discovery Makers: Sebastian Falk
What better way to start off 2022 than with a return to our Discovery Makers series. We celebrate discovery by talking to the scientists changing the world one day at a time. This time we are joined by Sebastian Falk. What drives a scientist? Well, according to Sebastian Falk, it is curiosity that drives him. Sebastian is a structural biologist who is leading a research group at the Max Perutz Labs investigating the structure and function of proteins, and how they work in RNA metabolism. In line with his curiosity-driven mindset, Sebastian also teaches at the University of Vienna where he is educating the next generation of up-and-coming scientists. As part of our Discovery Makers series, Conor and Dodi discuss why Sebastian went into his research field, what motivates him, why he enjoys teaching, and what future research Sebastian is looking into. Transcript Keywords: structural biology, proteins, science, discoveries, mentoring, serendipity, nucleic acid, discovery, experimenting, art, curiosity, hypothesis, research, RNAi, biogenesis.
16 minutes | Dec 23, 2021
47. Best of 2021
As 2022 rolls around the corner, we look back on the amazing topics we covered in 2021. Conor and Dodi were set an assignment to choose their favorite episode of the year, but as this was such a jam-packed year it made it very hard for them to complete their assignment. But as in all things, they delivered. From fungi forays to an eye-opening conversation with Dr Joan Reede, President of the BSCP, Dodi and Conor discuss the best moments of the year, with a little input from the production team. Our podcast planner intern, Bethany shares her favorite episode, as does Thomas Henley our podcast editor and sound designer. Stay to the end for a little surprise from us to you for the holiday season… Transcript Keywords: insects, recombinant factor c, pupae, biotech, fats, discovery, favorite, industry, BSCP, fungi, horseshoe crab.
18 minutes | Dec 9, 2021
46. The pulse of the industry - BioPlan and the Biopharma Resilience Index
For this episode of Discovery Matters we are focusing on industry surveys and what they can tell us. This includes BioPlan and the Biopharma Resilience Index. Both huge reports providing insight into both the issues and opportunities facing the industry today. Firman Ghouze, Cytiva’s Marketing Director in APAC, explains how the Biopharma Resilience Index came about, the industry issues it uncovers and potential solutions. We are also joined by Eric Langer, from BioPlan Associates, to discuss the BioPlan findings and how they echo many of the same themes. Finally, it was a delight to talk to Dr. Richard Wang, the founder and CEO of Neukio Biotherapeutics, who shares his insights as an industry leader. This episode is an informative and accessible discussion on the state of the biopharma industry today. We discuss ways to tackle the most pressing challenges and how, if possible, we can best plan for the future. Learn more about the Biopharma Resilience Index here. Check out bioplanassociates.com. Transcript Keywords: industry, manufacturing, index, talent, biopharma, resilience, capacity, supply chain, talent pool, capital flows, pandemic, biopharma resilience index.
17 minutes | Nov 11, 2021
45. Detecting sepsis: the role of single-cell
Single-cell sequencing is a technology that is giving us new genomic capabilities. Dr. Luciano Martelotto joins us to explain how single-cell sequencing allows scientists to understand cells as building blocks, much like LEGO™, which form part of a much bigger structure such as an organ, a tissue, a disease, and so forth. Dr. James McLaren utilizes this technology to look at septicemia; in his work he is using single-cell analysis to better understand sepsis and to develop a rapid diagnostic test. Single-cell sequencing could hold the key to understanding why the body reacts to infections, and overall to help us advance healthcare. Join Dodi, Conor and their guests, Dr. Luciano Martelotto, Scientific Director of Single Cell Lab at Harvard Medical School, and Dr. James McLaren, Systems Immunity lecturer at Cardiff University, in the latest episode of Discovery Matters. Transcript Keywords: single-cell, sepsis, sequencing, diagnostic, infection, lab-on-a-chip, detection, technology, cellular.
Terms of Service
Do Not Sell My Personal Information
© Stitcher 2022