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32 minutes | Oct 28, 2021
Deploying AI-Powered Image Analysis in Drug Development
There is so much rich information imbedded in the histologic and molecular features of tissue sections which can be extracted through digital pathology. We seem to be at the convergence of AI-powered image analysis and precision medicine. Our guests are Jonathan Daniels and Ori Zelikov, MD from Nucleai, who are committed to bringing the power of spatial biology to reality by providing pharmaceutical companies and clinicians with AI- powered image analysis applications. We're going to be talking about the promise of digital pathology and image analysis and how these technologies can be leveraged in drug discovery and ultimately patient care. What does the future hold and how a higher throughput of patient biopsies through a digital pathology system will result in a new age of information and discovery analogous to the revolution we have seen in sequencing the human genome. We will also talk about the rich ecosystem in med-tech in Israel and what makes Nucleai unique in its makeup and approach.
40 minutes | Oct 21, 2021
Season 2, Episode 6 - Colin White, PhD and Frank Gannon, MD - Open the Floodgates
The technology in digital pathology has been with us for some time. It now, though, seems we've hit an inflection point and things are accelerating. Perhaps we are even in the perfect storm. There seems to be a certain sense of inevitability and it may be time to open the floodgates and release the promise of digital pathology. Our guests are Colin White - Senior Vice President and General Manager, Advanced Staining & Imaging at Leica Biosystems and Frank Gannon, Professor of Pathology at Baylor College of Medicine in Houston Texas. Colin White is an IVD industry veteran with more than 20 years of experience in conceiving, developing and commercializing systems that advance the practice of pathology. Colin’s passion is innovation and motivating teams to develop solutions that advance patient care whilst also meeting the needs of healthcare providers and regulating bodies. Dr. Gannon has over 25 years’ experience as a practicing pathologist with subspecialty expertise in Orthopedic Pathology. Prior to joining Baylor College of Medicine in Houston Texas, he spent 8 years at the Armed Forces Institute of pathology in Orthopedic Pathology, 2 years as chair of the department. Dr. Gannon is co-author on an Orthopedic Pathology book, numerous book chapters, and over 110 publications in peer reviewed journals. We’re going to be talking about the value proposition of digital pathology. What are the challenges to implementation? What’s been holding us back and are these barriers beginning to crumble? What does digital pathology mean for patient involvement? And we're going to be talking about artificial intelligence, machine learning, remote sign out, remote case sharing and what going digital means in terms of workflows for the typical pathology department.
36 minutes | Oct 14, 2021
Season 2, Episode 5 - Esther Abels - Regulatory Update and Path Visions 2021
Our guest is Esther Abels, Chief Clinical Officer and Chief Regulatory Officer at Visiopharm, as well as the president-elect of the Digital Pathology Association. Esther also leads the regulatory and standards task force at the DPA with a focus on FDA collaborations to drive regulatory and standard classifications for interoperability and computational pathology in the field of digital pathology. We're going to be talking about standardization in digital pathology - not only in preanalytical factors such as fixation and staining - but also in the interpretive or analytic component, as well which is becoming increasingly important to ensure optimal diagnostic results for patients and incorporation of digital pathology data into diagnostic and drug discovery programs. We discuss regulation. What are some misconceptions about regulation how can we use regulation as a tool to protect patients and better develop and provide products and services? And how can we partner with regulators to help advance the science. What is the DPA working on now and what is their long-term vision for the future of the field? The annual meeting of the Digital Pathology Association, Pathology Visions is going to be held this October in Las Vegas.
34 minutes | Oct 7, 2021
SEASON 2, EPISODE 4 - Elizabeth Neyens, DVM, DABT - Preparing Your Disaster Plan in Digital Pathology
Is your lab or institution ready for a disaster? Dr. Elizabeth Neyens has over 15 years of experience in translational drug development and has held various staff pathology positions in contract research organizations, the pharmaceutical industry and as well as research institutes worldwide. Dr. Neyens currently supports academia, biotechnology and pharmaceutical companies with a variety of nonclinical services at Flanders ToxPath Consulting. She is an active scientist on social media and keeps a blog and has been a regular on podcasts about Pathology & Toxicology. We are talking about preparing your disaster plan in digital pathology. What is data Integrity and why is it important? How do we keep our data safe? What types of threats do we face in the areas of drug development and digital pathology? We talk about cloud computing - the bad, the good and the ugly. And how can we prepare for the unexpected such as climate disasters and pandemics where stakeholders are suddenly shifted from an office environment to working from home?
30 minutes | Sep 30, 2021
SEASON 2, EPISODE 3 - David Tulman, PhD - Beyond Paraffin
With digital pathology, we are utilizing new methods to view images acquired from a very old technology - Hematoxylin and Eosin stained sections from formalin fixed paraffin embedded tissue, which have been prepared the same way for over 100 years. This method actually adds steps, time and expense. But what if we could also reinvent the way we handle tissue to instantaneously view images from samples without having to process to fix and process them in the traditional way? Can we move beyond paraffin? David Tulman is a biomedical engineer, cancer researcher, and entrepreneur. He earned a PhD in Bioinnovation from Tulane University, focusing on the development of novel microscopy systems for point-of-care pathology evaluations. David is a founder of Instapath, a company that formed in 2017 to build and commercialize systems that image pathology tissue without fixing or cutting. Instapath operates out of the Texas Medical Center in Houston. Instapath introduces an innovative solution utilizing optical scanning microscopy to evaluate the composition of the entire fresh sample within minutes at the point-of-procedure and preserve it for downstream testing. David is also the host of beyond the scope of the podcast from the digital pathology association will talk to him about that as well as the upcoming DPA annual meeting, Pathology Visions, this October in Las Vegas.
33 minutes | Sep 24, 2021
SEASON 2, EPISODE 2 - JOHN WALLER, PHD - ENHANCING DECISION MAKING IN R&D WITH DIGITAL PATHOLOGY
Our Guest is John Waller, PhD, Chief Operations Officer & Founder of Oracle Bio. John has over of 15 years as a biology project leader in the pharmaceutical industry, for companies including AstraZeneca and Merck & Co. He has expertise in the integration of translational biomarkers into drug discovery programs and considerable experience in developing in vitro, ex vivo and in vivo models involving image analysis across numerous therapeutic areas. OracleBio is a global leader in quantitative digital pathology, providing image analysis services to Pharma and Biotech clients worldwide. Leveraging multiple software platforms, the company delivers robust data packages within a quality management framework to support clinical trials and translational research. As image analysis experts, OracleBio specializes in cellular phenotyping of multiplex stained tissue and has built a strong reputation as the go-to company for complex image analysis. Their mission is to enhance decision making within R&D by leveraging Digital Pathology to deliver robust data and actionable insights. We are talking about the role of digital pathology in drug development and drug discovery. What are machine learning and deep learning? How are they different from artificial intelligence? And what role do they play in image analysis and digital pathology? How is Multiplexing evolving, what are its limits and how is it going to change what we do? What is the need for cloud computing in digital pathology? What are the advantages and disadvantages of putting our data and processes into the cloud?
28 minutes | Sep 17, 2021
Season 2, Episode 1 - Jonhan Ho, MD - Democratizing Pathology
One of the missing links in this digital transformation has been robust platforms for pathologists to interact with one another to share images and cases. KIKO, which stands for “knowledge in, knowledge out” is a slide hosting and sharing platform with many uses, including education, case and other content sharing, the ability to consult with colleagues, and even storing your own cases for later retrieval. Sites like KIKO help to democratize pathology and knowledge, which has been one of the key themes of this digital transformation. It also serves to enhance the careers of individual pathologists. Dr. Jonhan Ho is the Director of the Dermatopathology Division and the Fellowship Director at the University of Pittsburgh Medical Center. Throughout his career, he has trained hundreds of pathology and dermatology residents, and dermatopathology fellows. Having experienced the joy of teaching but also the frustrations of institutional silos, he founded KiKo, to democratize medical training and teaching in an easy-to-use platform. His hope is that through KiKo, doctors can begin to take back medical knowledge instantly and privately in order to make each other better.
27 minutes | May 27, 2021
Episode 35 - Leo Grady, PhD - Making Digital Pathology AI Native
We're talking with Leo Grady, CEO of Paige, a company developing AI-based solutions in digital pathology to optimize patient outcomes. We're going to be talking about his experiences in diagnostics, radiology, pathology, and artificial intelligence. We’ll discuss the early history of Paige, its relationship with memorial Sloan Kettering, what products Paige is developing, what the future holds, and their strategy for developing partnerships. It’s often said that radiology is at least a decade ahead of pathology in terms of going digital. But is this accurate or fair? Radiology images, after all are digitally native whereas pathology images are not. What do we mean by digitally native? What do we mean by AI native? is it possible to create an AI native environment for digital pathology?
38 minutes | May 20, 2021
Episode 34 - Special Edition - New Guidelines for Validating Whole Slide Imaging - Andrew Evans. MD, PhD and Nicole Thomas, MPH - College of American Pathologists
The College of American Pathologists (CAP), in collaboration with the ASCP and API announced the 2021 update of guidelines for Validating Whole Slide Imaging (WSI) for diagnostic Purposes. We talk with Andrew Evans, MD, PhD, Chair of The Digital and Computational Pathology Committee and Nicole Thomas, MPH, Director of the CAP Center for Evidence Based Guidelines.
23 minutes | May 13, 2021
Episode 33 - Dennis Strenk - The People of Pathology
Dennis Strenk is the host of the People of Pathology Podcast and Pathologists’ Assistant at the Wisconsin Diagnostic Laboratories. Dennis has created a unique podcast to get to know the people in pathology , to understand their motivations, and to hear their stories and learn from their insights. We talk with him about the origins of the People of Pathology Podcast, lessons learned and the surprises along the way. In addition, we talk about digital pathology, gross specimen handling and imaging and how new technologies such as digital pathology can enhance workflows.
31 minutes | May 6, 2021
Episode 32 - Michael Johnson, PhD - Digital Pathology and the Use of 3D Imaging, Multiplexing and Organoids
This episode we speak with Dr. Michael Johnson of Visikol. We will discuss 3D imaging in digital pathology. We will look at the current and future uses of 3D imaging. What is the current state of the art in multiplexing - particularly for clinical use. We will find out more about organoids, what they are and what role they play in research and finally, what Visikol has in store for the future.
40 minutes | Apr 29, 2021
Episode 31 - Jerad Gardner, MD - The Evolving Role of Social Media in Digital Pathology
One of the many features of digital pathology is the capacity for increased connectivity among and between pathologists and the ability to share and collaborate on images and cases. This lends itself very nicely to the use of social media. We will examine the way pathologists use YouTube, Twitter, Facebook and other platforms including pathology specific ones such as PathPresenter and KIKO. We will look at how, in the past 10 years, social media has evolved and helped shape the practice, discuss how social media will continue to enhance the field of pathology as well as the careers of individual pathologists.
15 minutes | Apr 27, 2021
Episode 30 - Special Edition - Gestalt Diagnostics and MindPeak partner to deploy AI in cancer diagnostics
We're speaking with Felix Faber of MindPeak and Lisa-Jean Clifford of Gestalt Diagnostics. With the recently announced partnership between Gestalt, MindPeak, and Leica for the implementation of digital pathology for Bio-Reference Laboratories, we will talk about this real world use of artificial intelligence and algorithms. We discuss how this collaboration will increase workflow efficiency and accuracy for pathologists. We will examine their AI integration for remote breast cancer diagnostics and the algorithms they will be utilizing.
30 minutes | Apr 22, 2021
Episode 29 - Chaim Linhart, PhD - The AI Revolution
Our guest is Chaim Linhart of IBEX Medical Analytics. We will discuss the unique challenges and opportunities for unlocking the tools of digital pathology. We examine the differences between a strong AI and narrow AI and how strong AI can assist pathologists. Why is AI the "killer app" in digital pathology and how did Ibex develop Galen, one of the first AI based solutions to be deployed in actual clinical practice.
27 minutes | Apr 15, 2021
Episode 28 - Anil Parwani, MD, PhD, MBA - Connecting the Dots
With so many use cases and applications in digital pathology, how do we connect the dots and make it all work? Dr. Anil Parwani is Professor of Pathology at The Ohio State University, Vice chair of Pathology and Head of Anatomic Pathology. He is the newly elected president of the Digital Pathology Association (DPA). We will talk about some of the ways to increase adoption and possible use cases for digital pathology. We will examine how algorithms and AI tools might help and what will be the role of pathologists if these algorithms work as promised. We will also look at some of the barriers to adoption including interoperability and storage.
23 minutes | Apr 8, 2021
Episode 27 - Patrick Myles - Image Search and Digitizing the Joint Pathology Center Archives
We are talking with Patrick Myles, the CEO of Huron Digital Pathology. In this episode, we will discuss searching images within digital pathology. We will talk about slide indexing in handling large image databases and how these new searches will open the door to democratizing digital pathology. We will examine image search for new drug discovery, clinical use, and research applications. We will also look at the new project to digitize the Joint Pathology Center's archive of glass slides.
28 minutes | Apr 1, 2021
Episode 26 - Thomas Barr, Industry Innovation
Tom Barr is an industry veteran. He was an early adopter of digital pathology - utilizing various hardware platforms as well as commercial and custom software. We will look at some of the early challenges to whole slide imaging (WSI), software solutions, networking, storage and interoperability Tom was instrumental in developing VIPER (Virtual Imaging for Pathology Education and Research) at Nationwide Children's Hospital and developing the digital pathology network used in clinical trials for many of the large cooperative groups as well as The Cancer Genome Atlas (TCGA)program. He is currently a founder at HyperPath Solutions.
21 minutes | Mar 26, 2021
Episode 25 - Special Edition - Proscia CEO, David West and Ibex Medical Analytics CEO, Joseph Mossel, Discuss Partnership
We are talking with David West, CEO of Proscia and Joseph Mossel, CEO of IBEX Medical Analytics. Recently, Proscia, a leading provider of digital and computational pathology solutions, and IBEX Medical Analytics, a pioneer in artificial intelligence (AI)-based cancer diagnostics, announced a strategic partnership to support pathologists in detecting prostate cancer. In this episode, we will learn about the history of these two companies, examine how this partnership will work to help pathologists and patients and where this will lead digital pathology in the future.
36 minutes | Mar 18, 2021
Episode 24 - Hamid Tizhoosh, PhD - What is AI?
Our guest is Professor Hamid Tizhoosh, the director of the KIMIA Lab (Laboratory for Knowledge Inference in Medical Image Analysis) at the University of Waterloo. We've all heard the hype about Artificial Intelligence (AI), but what exactly is AI? In this episode, we will examine some examples of AI in everyday life. We will discuss the current and future applications of artificial intelligence in digital pathology and image analysis, the "ethics" of artificial intelligence, and why the pathologist will not be replaced anytime soon.
29 minutes | Mar 11, 2021
Episode 23 - Ahmed Hosny - Why AI? Why now? Evaluating the Landscape of AI Startups in Digital Pathology
Our guest is Ahmed Hosny, a machine learning research scientist, author and blogger from the Dana Farber Cancer Institute, who has a developed a framework for evaluating AI startups. This episode, we are talking about artificial intelligence (AI), machine learning (ML), and deep learning. We will touch on the history of AI and how it has been used to train neural networks. Pathology seems to be behind radiology with the number AI start-ups. We will find out some of the reasons why. We will discuss how the lack of format standards in imaging has slowed the growth of AI and we will examine potential uses of AI in clinical, academic and research environments.
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