92 minutes | Apr 16, 2021

BI 102 Mark Humphries: What Is It Like To Be A Spike?

Mark and I discuss his book, The Spike: An Epic Journey Through the Brain in 2.1 Seconds. It chronicles how a series of action potentials fire through the brain in a couple seconds of someone’s life. Starting with light hitting the retina as a person looks at a cookie, Mark describes how that light gets translated into spikes,  how those spikes get processed in our visual system and eventually transform into motor commands to grab that cookie. Along the way, he describes some of the big ideas throughout the history of studying brains (like the mechanisms to explain how neurons seem to fire so randomly), the big mysteries we currently face (like why do so many neurons do so little?), and some of the main theories to explain those mysteries (we’re prediction machines!). A fun read and discussion. This is Mark’s second time on the podcast – he was on episode 4 in the early days, talking more in depth about some of the work we discuss in this episode! The Humphries Lab.Twitter: @markdhumphriesBook: The Spike: An Epic Journey Through the Brain in 2.1 Seconds.Related papersA spiral attractor network drives rhythmic locomotion. Timestamps: 0:00 – Intro3:25 – Writing a book15:37 – Mark’s main interest19:41 – Future explanation of brain/mind27:00 – Stochasticity and excitation/inhibition balance36:56 – Dendritic computation for network dynamics39:10 – Do details matter for AI?44:06 – Spike failure51:12 – Dark neurons1:07:57 – Intrinsic spontaneous activity1:16:16 – Best scientific moment1:23:58 – Failure1:28:45 – Advice
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