In the United States, over two million people are addicted to opioids and an average of 115 people die every day from opioid overdoses. It is a complicated issue that requires multifaceted solutions, with engagement and action from many stakeholders. In this episode, Dr. Kelly Henning, Bloomberg Philanthropies’ Public Health Program Lead, speaks with Dr. Joshua Sharfstein, Vice Dean for Public Health Practice and Community Engagement at the Johns Hopkins Bloomberg School of Public Health. He is also director of the school's Bloomberg American Health Initiative, which was launched with a $300 million gift from Bloomberg Philanthropies. Dr. Henning and Dr. Sharfstein dive deeper into the opioid epidemic, addressing the factors that contributed to increased opioid use in America, harm reduction strategies and treatment options that can be implemented in American healthcare systems, and lessons-learned by American and global communities.