Focus on Geriatric Medicine and Aging
About This Show
As our population grows older, new medical innovations serve to preserve the symbiosis of the body and mind. Are novel therapies for Alzheimer's on the horizon? How do we approach joint replacement surgery for an active 92-year-old? What about research frontiers focused on promoting longevity? ReachMD gathers top medical experts and opinion leaders for a month-long discussion of geriatric medicine and the aging process.
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Tissue-Specific Protein Clusters May Help Predict Risk of Alzheimer’s Disease
Oct 24 16
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease Rosie Freer, Pietro Sormanni, Giulia Vecchi, Prajwal Ciryam, Christopher M. Dobson, and Michele Vendruscolo Science Advances 10 Aug 2016: Vol. 2, no. 8, e1600947 DOI: 10.1126/sciadv.1600947 Abstract: In Alzheimer’s disease, aggregates of Aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. We report a transcriptional analysis of healthy brains and identify an expression signature that predicts—at ages well before the typical onset—the tissue-specific progression of the disease. We obtain this result by finding a quantitative correlation between the histopathological staging of the disease and the expression patterns of the proteins that coaggregate in amyloid plaques and neurofibrillary tangles, together with those of the protein homeostasis components that regulate Aβ and tau. Because this expression signature is evident in healthy brains, our analysis provides an explanatory link between a tissue-specific environmental risk of protein aggregation and a corresponding vulnerability to Alzheimer’s disease.