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AudioAbstracts by ReachMD provides an easy-to-digest distillation of important medical literature in combination with digital linkage to in-depth information supporting the audio synopsis. AudioAbstracts harnesses the ReachMD digital network to broadcast the spoken synopsis and related digital links through its on-air, online, onsite, and mobile distribution network. Combining quick-read audio synopses with links to source material, AudioAbstracts is the smarter, faster way to stay current on medical literature.
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Tissue-Specific Protein Clusters May Help Predict Risk of Alzheimer’s Disease
3 days ago
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease Rosie Freer, Pietro Sormanni, Giulia Vecchi, Prajwal Ciryam, Christopher M. Dobson, and Michele Vendruscolo Science Advances 10 Aug 2016: Vol. 2, no. 8, e1600947 DOI: 10.1126/sciadv.1600947 Abstract: In Alzheimer’s disease, aggregates of Aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. We report a transcriptional analysis of healthy brains and identify an expression signature that predicts—at ages well before the typical onset—the tissue-specific progression of the disease. We obtain this result by finding a quantitative correlation between the histopathological staging of the disease and the expression patterns of the proteins that coaggregate in amyloid plaques and neurofibrillary tangles, together with those of the protein homeostasis components that regulate Aβ and tau. Because this expression signature is evident in healthy brains, our analysis provides an explanatory link between a tissue-specific environmental risk of protein aggregation and a corresponding vulnerability to Alzheimer’s disease.