The Ironman Executive
About This Show
Daniel Stickler, MD is the Ironman Executive. He selects topics that are all about advances designed to enhance human performance and upgrade our function. He explores the science and medical advances that will help all of us to become the ironman executive.
Most Recent Episode
The Epigenetics of Well-Being With Dr. Steven Cole
5 days ago
Dr. Steven Cole is the Director the UCLA Social Genomics Laboratory. He has been pioneering human social genomics as a Professor of Medicine and Psychiatry and Behavioral Science at the UCLA School of Medicine. Dr. Cole’s studies have concentrated on Genomics and computational bioinformatics to map the biological pathways by which social environments affect gene expression by viral cancer and immune cell genomes. Epigenetics of Wellbeing Biological effects of stress Our bodies are not built to be stressed out and miserable all of the time. We are only capable of handling stress in short bursts. Yes, some stress may be good for us but over time, increased amounts of stress can lead to damage of our immune systems and molecules that affect our natural ability to maintain the balance of ‘Fight or Flight’ and ‘Rest and Digest’. Looking at the genomics of humans Naturally, we have about 20,000 DNA molecules, what Dr. Cole likes to call ‘menu items’ in which our body can decide to ‘order-up’. During certain states, our bodies natural turn these items on or off. Our DNA is being transcribed into RNA and produces proteins that do the work of a cell. Physically, our bodies recognize what our bodies need. Some examples of the tasks of these proteins are: - To understand our environment (aka. Our senses) - To make up the inside of our skull - To control the transcription of genes and ‘self-write’ the ‘book’ of a single person. Only about half of our genes are actively transcribed into RNA. When a cell needs to change which, proteins are expressed and active the DNA is called and transcribed. The problem is, if we are always in fight or flight mode and more cells are needed to be transcribed, we will be losing out on many other proteins. An example of a functional cell change is when we are very hungry and haven’t been able to eat for a while. Our bodies understand that our metabolism needs to change and typically, in this case, it would slow. Other biological systems that are affected are our immune responses which allow for more infections. Many times, the symptoms we get are caused by our immune responses producing these cells. For instance, when you roll an ankle, your body’s response is to swell up to protect it. [Tweet “The human genome has options. It needs to decide which genes to express and which genes not to express”] Social Environm
Rated 5 out of
Really awesome show
Have only listened to the first few shows but really enjoying what I am hearing; good info, quality guests, and good interactions.
Date published: 2014-08-14